Effectiveness of LED/Laser Irradiation on In-Office Dental Bleaching after Three Years

2018 ◽  
Vol 43 (1) ◽  
pp. 31-37 ◽  
Author(s):  
RFL Mondelli ◽  
FAP Rizzante ◽  
ER Rosa ◽  
AFS Borges ◽  
AY Furuse ◽  
...  
Keyword(s):  
Color Change ◽  
Color Stability ◽  
The Other ◽  
Lower Sensitivity ◽  
Activation Time ◽  
Tooth Sensitivity ◽  
Dental Bleaching ◽  
Lower Activation

SUMMARY The present in vivo randomized, triple-blinded, and split-mouth clinical study evaluated the effectiveness of a hybrid light (HL) source on the color change, stability, and tooth sensitivity in patients submitted to different in-office bleaching techniques. Twenty volunteers were divided into two groups and four subgroups. A split-mouth design was conducted to compare two in-office bleaching techniques (with and without light activation): 35% Lase Peroxide Sensy (LPS) + HL: 35% hydrogen peroxide (HP) + HL; 35% LPS: 35% HP; 25% LPS + HL: 25% HP + HL; and 35% Whiteness HP (WHP): 35% HP. For the groups activated with HL, the HP was applied on the enamel surface three consecutive times using a 3 × 2-minute protocol (three HL activations for two minutes each, with a 30-second interval for a total of seven minutes and 30 seconds) for each gel application, totaling 22 minutes and 30 seconds. For the other groups, HP was applied 3 × 15 minutes, totaling 45 minutes. A spectrophotometer was used to measure the color change (ΔE) before the treatment and 24 hours, one week, and one, 12, and 36 months after. A visual analog scale was used to evaluate the tooth sensitivity before the treatment, immediately following treatment, 24 hours, and one week after. Analysis of variance, Tukey's, Kruskall-Wallis, and Wilcoxon tests, all with α = 0.05 were performed. Statistical analysis did not reveal any significant differences (ΔE) between the in-office bleaching techniques with or without HL in the periods evaluated; the activation with HL required 50% less time to achieve such results. The groups without HL presented statistical differences for ΔE when comparing 24 hours with the other follow-up times (intergroup) and an increase in tooth sensitivity in the initial periods. All techniques and bleaching agents were effective on bleaching during a 36-month evaluation of color stability. The groups activated with HL presented lower sensitivity and required a lower activation time.

scholarly journals Does the temperature of beverages affect the surface roughness, hardness, and color stability of a composite resin?

2013 ◽  
Vol 07 (02) ◽  
pp. 165-171 ◽  
Author(s):  
Duygu Tuncer ◽  
Emel Karaman ◽  
Esra Firat
Keyword(s):  
Surface Roughness ◽  
Composite Resin ◽  
Color Change ◽  
Artificial Saliva ◽  
Color Stability ◽  
The Other ◽  
Control Group ◽  
Baseline Values ◽  
Hardness Values ◽  
Properties Of Composites

ABSTRACT Objective: To investigate the effect of beverages′ temperature on the surface roughness, hardness, and color stability of a composite resin. Materials and Methods: Fifty specimens of the Filtek Z250 composite (3M ESPE, Dental Products, St.Paul, MN, USA) were prepared and initial roughness, microhardness, and color were measured. Then the specimens were randomly divided into five groups of 10 specimens each: Coffee at 70°C, coffee at 37°C, cola at 10°C, cola at 37°C, and artificial saliva (control). After the samples were subjected to 15 min × 3 cycles per day of exposure to the solutions for 30 days, the final measurements were recorded. Results: After immersion in beverages, the artificial saliva group showed hardness values higher than those of the other groups (P < 0.001) and the microhardness values were significantly different from the initial values in all groups except for the control group. Both cola groups showed roughness values higher than the baseline values (P < 0.05), while the other groups showed values similar to the baseline measurements. When ΔE measurements were examined, the 70°C coffee group showed the highest color change among all the groups (P < 0.05). Conclusion: High-temperature solutions caused alterations in certain properties of composites, such as increased color change, although they did not affect the hardness or roughness of the composite resin material tested.

scholarly journals Effects of Light Activation, Agent Concentration, and Tooth Thickness on Dental Sensitivity After Bleaching

2013 ◽  
Vol 38 (5) ◽  
pp. 467-476 ◽  
Author(s):  
G Moncada ◽  
D Sepúlveda ◽  
K Elphick ◽  
M Contente ◽  
J Estay ◽  
...  
Keyword(s):  
Analysis Of Covariance ◽  
Light Activation ◽  
Cervical Lesions ◽  
Tooth Sensitivity ◽  
Dental Bleaching ◽  
Anterior Teeth ◽  
Group A ◽  
Group B ◽  
The Relationship

SUMMARY Examining three bleaching systems, this in vivo clinical trial evaluated the relationship among tooth sensitivity, light activation, and agent concentration, and it correlated dental sensitivity with tooth thickness. Materials and Methods: Eighty-seven volunteer patients were included. Inclusion criteria were the presence of anterior teeth without restorations as well as the absence of a previous bleaching experience and absence of noncarious cervical lesions or dental pain. Exclusion criteria included pregnancy or breastfeeding, a maximum of TF3 hypoplasia, tetracycline-fluorosis stains, malpositioned teeth, orthodontic treatment, periodontal disease, and/or analgesic/anti-inflammatory intake. Patients were randomly assigned to three bleaching groups: Group A (n=25) was treated with 15% H2O2 and nitrogenous-titanium-dioxide and was light activated (Lase Peroxide Lite, DMC, SaoCarlos, Sao Paulo, Brazil); Group B (n=27) was treated with 35% H2O2 and was light activated (Lase Peroxide Sensy, DMC); and Group C (n=35) was treated with 35% H2O2 (White Gold Office, Dentsply, 38West Clark Ave., Milford, USA) without light activation. Tooth sensitivity (TS) was self-reported by the patients using the visual analog scale (VAS) at baseline (TS0), immediately after treatment (TSI), and at seven days after treatment (TS7). In 46 patients, tooth thickness was determined by computed tomography. TS0, TSI, and TS7 were compared between the A and B groups to determine the effect of concentration and between the B and C groups to determine the effect of light using analysis of covariance. The correlation between tooth thickness and TSI was determined by Spearman Rho test (SPSS 15). Results: Eighty-seven patients were evaluated at baseline, and 61 were evaluated at seven days. Separated by groups, tooth sensitivity, expressed as VAS value at the time points TS0, TSI, and TS7, respectively, were as follows: Group A: 13.76 ± 13.53, 24.40 ± 25.24, and 5.94 ± 5.5; Group B: 15.07 ± 18.14, 42.4 ± 31.78, and 8.68 ± 17.99; and Group C: 10.80 ± 14.83, 31.51 ± 29.34, and 7.24 ± 9.2. Group A showed significantly lower tooth sensitivity than group B at TSI (p=0.032). No differences were observed in the tooth sensitivities between groups B and C. No correlation was encountered between tooth thickness and tooth sensitivity immediately after treatment (Rho=−0.088, p=0.563). The median tooth thickness was 2.78 ± 0.21 mm. Conclusions: Increases in the concentration of bleaching agents directly affect tooth sensitivity, and LED/laser activation and tooth thickness are not correlated with tooth sensitivity after dental bleaching.

scholarly journals In Vitro Evaluation of Physical and Mechanical Properties of Light-Curing Resin Cement: A Comparative Study

2020 ◽  
Vol 14 (01) ◽  
pp. 152-156
Author(s):  
Luís Felipe Espíndola-Castro ◽  
Oscar Felipe Fonseca de Brito ◽  
Larissa Gabrielle Assis Araújo ◽  
Izabella Luiza Aragão Santos ◽  
Gabriela Queiroz De Melo Monteiro
Keyword(s):  
Color Change ◽  
Surface Hardness ◽  
Color Stability ◽  
Resin Cement ◽  
The Other ◽  
Distilled Water ◽  
Water Control ◽  
Mean Values ◽  
Significance Level

Abstract Objective The aim of study was to evaluate in vitro the surface hardness, sorption, solubility, and color stability of three light-cured resin cements, namely RelyX Veneer (RLX), Variolink Veneer (VLK), and All Cem Veneer (ACV). Materials and Methods Cylindrical samples (15 × 1 mm) were made for each group using a metallic mold (n = 10). Vickers microhardness test was performed, and average hardness was calculated from three indentations (300 gf/15s) per sample. The sorption and solubility of the materials were evaluated according to ISO 4049:2009 based on three samples weighing: initial (m 1), after immersion in distilled water for 7 days (m 2), and final (after removal of all moisture [m 3]). The color change was observed using a digital spectrophotometer, at three different time points, baseline, 1 day, and 1 week of immersion in coffee and distilled water (control). Statistical Analysis Shapiro–Wilk test was used to analyze the normality of the data, and groups were compared using Kruskal–Wallis and Mann–Whitney tests. A significance level of 5% was used. Results RLX showed the highest microhardness mean values (36.96 VHN), but higher sorption (23.2 µg/mm3) and solubility (2.40 µg/mm3), with statistically significant differences with the other groups. For color stability, higher ∆E was observed for the samples immersed in coffee (p = 0.009). The VLK resin cement presented statistically significant differences from the other groups, with higher color changes in coffee at 1 day (15.14) and after 1 week (23.65). Conclusion RLX resin cement showed better hardness results. All materials tested performed satisfactorily for sorption and solubility according to ISO 4049:2009. All materials showed high-staining values after 1 week of immersion in coffee.

scholarly journals Bleaching Stained Arrested Caries Lesions: In vivo Clinical Study

2020 ◽  
Author(s):  
Sarah S. Al-Angari ◽  
Mashael AlHadlaq ◽  
Noor Abahussain ◽  
Njood AlAzzam
Keyword(s):  
Hydrogen Peroxide ◽  
Color Change ◽  
Conservative Approach ◽  
Dental Bleaching ◽  
B Values ◽  
Visual Color ◽  
Before And After ◽  
Caries Lesions ◽  
Paired T Test

Abstract Objective Conservative approaches to esthetically treat stained arrested caries lesions (s-ACLs) have not been explored in clinical studies. This study aims to investigate the efficacy of in-office dental bleaching agent, as a conservative approach, to esthetically treat s-ACLs. Materials and Methods Twelve patients (n = 46) presented with s-ACLs were treated with 40% hydrogen peroxide (in-office bleaching protocol; 20 minutes × 3). Color values were measured using a spectrophotometer (CIE L*a*b*), aided with digital photography to assess visual color change clinically. Measurements were taken for each specimen at baseline and immediately after bleaching. Statistical Analysis The color change calculated before and after bleaching for each dental substrate was analyzed using paired t-test (α = 0.05). Results The bleached s-ACLs had a significant increase in L* values (p < 0.001), and a significant decrease in both a* (p = 0.001) and b* (p = 0.007) values, indicating lighter color improvement (bleaching efficacy). The baseline mean L*, a*, and b* values were 61.5, 2, and 15.4, respectively, and after bleaching were 67.7, 1.4, and 13.3, respectively, with a mean increase in ∆E of >7.9, which resulted in a visible clinical stain improvement as orange/light brown stains were removed completely, while gray/black stains improved to a lesser extent. Conclusion Significant color improvement was observed when the in-office bleaching protocol (40% hydrogen peroxide) was used in orange/brown s-ACLs. However, it showed lesser improvement in gray/black s-ACLs.

Tooth Sensitivity After Dental Bleaching With a Desensitizer-containing and a Desensitizer-free Bleaching Gel: A Systematic Review and Meta-analysis

2019 ◽  
Vol 44 (2) ◽  
pp. E58-E74 ◽  
Author(s):  
M Rezende ◽  
FM Coppla ◽  
K Chemin ◽  
AC Chibinski ◽  
AD Loguercio ◽  
...  
Keyword(s):  
Systematic Review ◽  
Latin American ◽  
Risk Ratio ◽  
Color Change ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Tooth Sensitivity ◽  
Dental Bleaching ◽  
Gingival Irritation

SUMMARY Objectives: A systematic review and meta-analysis were performed to evaluate the risk and intensity of tooth sensitivity (TS) after dental bleaching with a desensitizer-containing and a desensitizer-free bleaching gel in adult patients. Color change and risk of gingival sensitivity was also evaluated. Methods: A comprehensive search was performed MEDLINE via PubMed, Scopus, Web of Science, Latin American and Caribbean Health Sciences Literature database (LILACS), Brazilian Library in Dentistry (BBO), EMBASE and Cochrane Library, and System for Information on Grey Literature in Europe (SIGLE) without restrictions to identify randomized clinical trials. Abstracts from the annual conference of the International Association for Dental Research (1990–2016), unpublished and ongoing trials registries, dissertations, and theses were also searched. The quality of the evidence was rated using the Grading of Recommendations: Assessment, Development and Evaluation (GRADE) approach. Data: After duplicates were removed, 1352 articles were identified. After title and abstract screening, only 47 studies remained for qualitative evaluation. Most of the studies had unclear risk of bias. No difference between groups were observed for the risk ratio of TS (risk ratio = 0.99; 95% confidence interval [CI] = 0.74–1.33); intensity of TS (standardized difference in means [SMD] = 0.04; 95% CI = 0.79–0.70); color change in shade guide units (SMD – 0.04; 95% CI = 0.50–0.42); color change in ΔE* (SMD = 0.41 (95% CI = 0.07–0.89); and risk ratio of gingival irritation (SMD = 1.05; 95% CI = 0.81–1.36). Except for the risk of TS, graded as moderate quality of evidence, all other outcomes were rated as low and very low quality. Conclusions: Incorporating desensitizers in the bleaching gel did not reduce the risk of TS, and the quality of this evidence was considered moderate. On the other hand, the intensity of TS, color change, and risk of gingival irritation was similar between groups, but the quality of the evidence for these outcomes was graded as low or very low, thus reducing the level of confidence in these outcomes.

Efficacy of Home-use Bleaching Agents Delivered in Customized or Prefilled Disposable Trays: A Randomized Clinical Trial

2017 ◽  
Vol 42 (1) ◽  
pp. 30-40 ◽  
Author(s):  
NR Carlos ◽  
EC Bridi ◽  
FLB Amaral ◽  
FMG França ◽  
CP Turssi ◽  
...  
Keyword(s):  
Color Change ◽  
The Other ◽  
Bleaching Agent ◽  
Application Time ◽  
Carbamide Peroxide ◽  
Analog Scale ◽  
Tooth Sensitivity ◽  
Whitening Agent ◽  
Time Periods ◽  
Gingival Irritation

SUMMARY The purpose of this study was to evaluate bleaching methods containing hydrogen peroxide (HP) or carbamide peroxide (CP), dispensed in customized or prefilled trays, in terms of color change, tooth sensitivity, gingival irritation, acceptance, and comfort. Seventy-five volunteers were randomly selected and distributed according to the whitening agent (n=25): 10% HP dispensed in prefilled trays (Opalescence Go 10%) and 9.5% HP (Pola Day) and 10% CP both delivered in customized trays (Opalescence PF 10%). HP was applied for 30 min/d for 14 days (d), and CP for 8 h/d for 14 days. Evaluations were performed at baseline and at 7 days and 14 days of treatment. Color change was measured with Commission internationale de l'éclairage color coordinates (L*, a*, b*), Vita Classical, and 3D Master scales. A visual analog scale was used to assess tooth sensitivity, acceptance of the method and degree of comfort of the tray. Gingival irritation was evaluated as present or absent and localized or generalized. Regarding gingival irritation, tray acceptance, and tooth sensitivity, no differences were observed among the groups at any time (p&gt;0.05). As for degree of comfort, 10% HP showed lower scores (comfortable) than 10% CP, with significant differences (p&lt;0.05) from the other groups (comfortable to very comfortable). In terms of ΔL, Δa, and ΔE, no difference was observed among the groups or between the time periods (p&gt;0.05). The Δb average was higher at 14 days (p&lt;0.05), and there was no difference among the groups (p&gt;0.05). Localized gingival irritation was observed in both tray methods. Mild tooth sensitivity was observed with time, regardless of the bleaching agent concentration or the application time. Color change was similar for all the groups at 7 days and 14 days, but there was a greater reduction in the yellow hue at 14 days. All the bleaching methods were highly accepted and effective in promoting whitening. Although prefilled trays are generally comfortable, they proved less comfortable than customized trays.

Assessment of the Effect of Casein Phosphopeptide–amorphous Calcium Phosphate on Postoperative Sensitivity Associated With In-office Vital Tooth Whitening

2014 ◽  
Vol 39 (3) ◽  
pp. 239-247 ◽  
Author(s):  
GA Maghaireh ◽  
H Alzraikat ◽  
A Guidoum
Keyword(s):  
Calcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Daily Basis ◽  
The Other ◽  
Intensity Level ◽  
Tooth Whitening ◽  
Tooth Sensitivity ◽  
Therapeutic Benefits ◽  
Casein Phosphopeptide

SUMMARY The aim of this study was to evaluate the efficacy of tooth mousse containing 10% casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) in reducing tooth sensitivity associated with in-office vital tooth whitening. In-office tooth whitening was performed for 51 participants using 35% hydrogen peroxide gel in a single visit. After the procedure, each participant was randomly assigned to one of three groups: gel without desensitizing agent (n=17), gel with 2% sodium fluoride (n=17), gel with 10% CPP-ACP (n=17). A small amount of the desensitizing gel assigned for each participant was applied directly on the labial surfaces of teeth and left undisturbed for three minutes. The participants were asked to apply the gel assigned to them for three minutes twice daily after brushing their teeth, and to continue this for 14 days. The participants were asked to return for follow-up visits after 24 hours and on days 3, 7, and 14, at which time teeth shade changes were assessed by one evaluator using a value-oriented Vita classic shade guide. The incidence, duration, and intensity of tooth sensitivity experienced was self-assessed on a daily basis for the 14-day study period using a visual analog scale (VAS). The effect of the three gels on tooth sensitivity was assessed using one-way analysis of variance and a χ2 test (α=0.05). The general linear model was used to compare intensity-level differences in the three studied groups and for shade stability over the follow-up period. The results of this study showed that all three gels decreased the intensity of sensitivity associated with tooth whitening. The intensity of sensitivity was lower in the fluoride group than in the other two groups; however, it was not statistically significant (p=0.112 and p=0.532 on day 1 and day 2, respectively). The average shade change was 6.8. None of the tested materials affected the efficacy of tooth whitening, but the shade change among the fluoride group showed more color stability than that of the other two groups. This study suggested that using a gel after tooth whitening can reduce the intensity of tooth sensitivity associated with in-office whitening procedures without affecting the efficiency of tooth whitening. However, it failed to demonstrate that using a 10% CPP-ACP could provide additional therapeutic benefits.

scholarly journals The Effects of Natural Weathering on Color Stability of Impregnated and Varnished Wood Materials

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Turkay Turkoglu ◽  
Ergun Baysal ◽  
Hilmi Toker
Keyword(s):  
Scots Pine ◽  
Color Change ◽  
Color Stability ◽  
The Other ◽  
Natural Weathering ◽  
Color Changes ◽  
Oriental Beech ◽  
Total Color Change ◽  
Dark Color ◽  
Copper Arsenate

The aim of this study was to investigate effects of natural weathering on color stability of Scots pine (Pinus sylvestrisL.) and Oriental beech (Fagus orientalisL.) impregnated with some chemicals [tanalith-E (TN-E), adolit-KD5 (AD-KD5), and chromated copper arsenate (CCA)] and then varnished [synthetic varnish (SV) and polyurethane varnish (PV)]. While applying varnish increased lightness, impregnation decreased lightness of the wood specimens before natural weathering. Natural weathering caused greenish, bluish, and dark color tones of the wood surface. Total color change was increased with increasing exposure times in natural weathering. Untreated (control) wood specimens exhibited higher color changes than the other wood specimens in all the stages of natural weathering. The total color changes of untreated Oriental beech specimens were less than untreated Scots pine specimens. The color stability of impregnated and varnished wood specimens gave better results than untreated and solely varnished wood specimens after natural weathering. The best color stability was obtained from both Oriental beech and Scots pine wood impregnated with TN-E before PV coating.

scholarly journals Prevention of Viral Infections after T Cell Depleted Allogeneic Stem Cell Transplantation By Infusion of Multi-Antigen Specific T Cell Products

Blood ◽  
2016 ◽  
Vol 128 (22) ◽  
pp. 1228-1228 ◽  
Author(s):  
Marthe C.J. Roex ◽  
Peter Van Balen ◽  
Lois Hageman ◽  
Esther Van Egmond ◽  
Sabrina A.J. Veld ◽  
...  
Keyword(s):  
T Cells ◽  
Stem Cell ◽  
T Cell ◽  
Stem Cell Transplantation ◽  
Cd8 T Cells ◽  
Viral Infections ◽  
The Other ◽  
Cell Compartment

Abstract Opportunistic viral infections and relapse are major complications in patients after T cell depleted allogeneic stem cell transplantation (TCD alloSCT). Since the application of unmodified donor lymphocyte infusion (DLI) early after alloSCT results in a high risk of graft versus host disease (GVHD), infusion of selected populations of virus-specific donor T cells can be an effective approach to safely restore anti-viral immunity early after alloSCT. As part of the EU FP7 consortium T Control, in this phase I/II study the feasibility and safety of the generation and administration of selected populations of donor-derived T cells targeting multiple antigens (Ag) is assessed. The multi Ag-specific T cell products contained T cells targeting cytomegalovirus (CMV), Epstein Bar virus (EBV) and adenovirus (AdV) as well as T cells targeting tumor associated Ag (TAA) and minor histocompatibility Ag (MiHA) to boost the graft versus leukemia (GVL) reactivity. To assess efficacy, in-vivo appearance or expansion of Ag-specific T cells, and the effect on viral reactivations and/or disease relapse was evaluated for 20 weeks after infusion until regular DLI was applied. HLA-A*02+ patients treated for a hematological malignancy with an HLA-matched TCD alloSCT from a CMV and/or EBV seropositive donor were included in this study. 6-8 weeks after alloSCT, T-cells directed against HLA-A*02-restricted peptides of CMV, EBV and AdV, and the TAA NY-eso, WT-1, RHAMM, PRAME and proteinase 3 were isolated using the reversible streptamer-nanobead technology (Juno) by cliniMACS selection out of the naïve and/or memory T cell compartment from 2*10^9 donor PBMC. Depending on the HLA-typing of the patient/donor additional streptamers targeting viral peptides in A*01, A*24, B*07 or B*08 were added to the selection procedure. In case of patient/donor MiHA disparity in the GvL direction, the HLA-A*0201/HA-1h streptamer was also added. This procedure allows purification of T cells under GMP conditions in 1 day. 20 multi Ag-specific T cell products were generated of which 19 met the release criteria. These products consisted of 0.5-12*10^6 cells containing purities of 46,0-94,3% target Ag-specific CD8+ T cells within the T cell compartment. In all products CMV and/or EBVas well as AdV virus-specific memory T cells were isolated comprising 99% of the target Ag-specific CD8+ T cells, while the other 1% included the TAA and MiHA specificities or CMV specific T cells from seronegative donors. 17 products were administered without infusion-related complications or GVHD; 2 patients experienced GVHD before infusion and did not receive their product. Of the 14 patients evaluated at this stage, 13 completed the follow-up period until DLI and 1 patient died during follow-up. No product-related adverse events were reported. In all 5 CMV- patients and in 3/9 CMV+ patients no CMV reactivation and no expansion of CMV-specific T cells was observed. The other 6 CMV+ patients experienced CMV reactivations. In 2/6 patients who received the product from a CMV+ donor CMV-specific T cells were detected with tetramer analysis and CMV was cleared. From the other 4 reactivating patients with CMV- donors 3 had circulating CMV-specific T cells already at the moment of infusion, whereas in 1 patient CMV-specific T cells clearly expanded after infusion, resulting in viral clearance in all 4 patients. All 14 donors were EBV+. In 7 patients EBV reactivations were observed, which coincided in 2/7 patients with the appearance of EBV-specific T cells and subsequent clearance of the virus. In 4/7 patients EBV reactivation was cleared without clear expansion of EBV-specific T cells. However, 1 patient required treatment for an EBV-PTLD, although ultimately EBV-specific T cells appeared and EBV was cleared. In none of the patients AdV DNA loads were detected in the follow-up period, while in 1 patient expansion of AdV-specific T cells was observed. Expansion of TAA and MiHA-specific T cells could not be demonstrated in-vivo using tetramer staining. More sensitive techniques will be required to visualize these cells. 2 patients showed relapse of their malignancy before DLI infusion. In this clinical study, we have shown that the reversible streptamer technology based generation and adoptive transfer of donor-derived multi Ag-specific T cell products is feasible and safe and can be used as a strategy to prevent viral infections in the interval between TCD alloSCT and DLI. Disclosures Germeroth: Juno Therapeutics: Employment.

Comparison of the Effects of In-office Bleaching Times on Whitening and Tooth Sensitivity: A Single Blind, Randomized Clinical Trial

2016 ◽  
Vol 41 (2) ◽  
pp. 138-145 ◽  
Author(s):  
C Kose ◽  
AL Calixto ◽  
JRO Bauer ◽  
A Reis ◽  
AD Loguercio
Keyword(s):  
Color Change ◽  
Absolute Risk ◽  
The Other ◽  
Bleaching Agent ◽  
Tooth Sensitivity ◽  
Anterior Teeth ◽  
Verbal Scale ◽  
The Absolute ◽  
Shade Guide ◽  
Single Blind

SUMMARY Objectives: The objective of the present study was to compare the bleaching efficacy (BE) and tooth sensitivity (TS) of in-office bleaching applied under different time protocols. Methods and Materials: Fifty-three patients were randomly distributed into three groups: the bleaching agent was applied in one (1×15), two (2×15), or three (3×15) 15-minute applications. The labial surfaces of the anterior teeth were bleached using a 35% hydrogen peroxide gel. Two bleaching sessions with a one-week interval between were performed. The shade evaluation was performed with a visual shade guide and spectrophotometer before and 30 days after bleaching. Participants recorded TS with a five-point verbal scale. Color change was analyzed by one-way analysis of variance and Tukey tests. The absolute risk of TS and TS intensity were evaluated by the Fisher exact and Friedman/Kruskal-Wallis tests, respectively (α= 0.05). Results: Significant whitening was observed in all groups, with statistically lower BE for the 1×15 group (p&lt;0.05). The absolute risk of TS (95% confidence interval) was lower for the 1×15 group than for the other groups (p&lt;0.05). The TS intensity of the 3×15 group was statistically higher than that associated with the other protocols (p&lt;0.05). Conclusions: A single 15-minute application produced less TS but reduced BE. The protocol with 2×15 produced a degree of BE similar to that of the 3×15 group, but with reduced overall TS intensity.

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