scholarly journals Anti-Diabetic Properties of Bitter Gourd

2020 ◽  
Vol 7 (1) ◽  
pp. 021-024
Author(s):  
Shweta Sharma ◽  
◽  
Viveka Katoch ◽  
Keyword(s):  
Bioactive Compounds ◽  
Clinical Studies ◽  
Momordica Charantia ◽  
The Body ◽  
Bitter Gourd ◽  
Health It ◽  
Glucose Levels ◽  
Traditional Remedy ◽  
Treatment Of Diabetes

Bitter gourd (Momordica charantia L.) is a fruit that traditionally believe to have benefits on health. It is a widely used traditional remedy for the treatment of diabetes. Bitter gourd is suggested for hyperglycemia treatment due to its ability to reduce glucose levels in the body. Some of the bioactive compounds present in it possess anti diabetic effects. It contains phytochemicals with anti-diabetic properties such as charantin, p-insulin and vicine. Hypoglycemic effects of bitter gourd have been shown in clinical studies. This review will focus on the hyperglycemic properties of bitter gourd.

Momordica charantia Extracts in Selected Media:Screening of Phytochemical Content and In vitro Evaluation of Anti-Diabetic Properties

2016 ◽  
Vol 53 (2) ◽  
pp. 164 ◽  
Author(s):  
Flora-Glad Chizoba Ekezie ◽  
W. Jessie Suneetha ◽  
K. Uma Maheswari ◽  
T. N. V. K. V. Prasad ◽  
B. Anila Kumari
Keyword(s):  
Diabetes Mellitus ◽  
Citric Acid ◽  
Ethanol Extract ◽  
Momordica Charantia ◽  
Bitter Gourd ◽  
Phytochemical Content ◽  
Patients With Diabetes ◽  
Potential Applications ◽  
Treatment Of Diabetes

Diabetes mellitus is a multifunctional disorder which is increasing rapidly in most parts of the world. It has been estimated that up to one third of patients with diabetes mellitus use some form of complementary and alternative medicine. One plant that has received the most attention for its anti-diabetic properties is Momordica charantia commonly referred to as bitter gourd. In this study, bitter gourd was extracted in various media i.e. ethanol, water, citric acid, sodium carbonate and sodium chloride. The samples were evaluated for their in-vitro ability to inhibit α-amylase and α-glucosidase enzymes activity. Ethanol extract was observed to have maximum inhibition against these enzymes. The IC<sub>50</sub> values recorded for inhibition of α-amylase activity were 81.34, 87.56, 83.89, 97.71 and 83.12 μg/ml respectively for crude extracts of ethanol, water, citric acid, Na<sub>2</sub>CO<sub>3</sub> and NaCl. Similarly, the ability of extracts to inhibit α-glucosidase was reflected in the result pattern ethanol&lt;Na<sub>2</sub>CO<sub>3</sub>&lt;NaCl&lt;aqueous&lt;citric acid (i.e. 72.81&lt;75.66&lt;80.15&lt;81.22&lt;83.85 μg/ml). Therefore, ethanol extract has potential applications in developing drug therapy for the treatment of diabetes using bitter gourd.

scholarly journals Bioactive compounds and the antioxidant capacities of seed oils from pomegranate (Punica granatum L.) and bitter gourd (Momordica charantia L.)

2019 ◽  
Vol 39 (suppl 2) ◽  
pp. 571-580 ◽  
Author(s):  
Luciana Tedesco YOSHIME ◽  
Illana Louise Pereira de MELO ◽  
José Augusto Gasparotto SATTLER ◽  
Rosângela Pavan TORRES ◽  
Jorge MANCINI-FILHO
Keyword(s):  
Bioactive Compounds ◽  
Punica Granatum ◽  
Momordica Charantia ◽  
Bitter Gourd ◽  
Seed Oils ◽  
Antioxidant Capacities ◽  
Punica Granatum L

scholarly journals Ascorbic Acid-Rich Moringa oleifera Lam. Extract Inhibits Hepatorenal Toxicity and Enhances the Endogenous Antioxidant Levels in Streptozotocin-Induced Type II Diabetes

2019 ◽  
pp. 25-35
Author(s):  
Vikas Kumar ◽  
Ankit Sahoo ◽  
Prakash Khadka ◽  
Deeksha Chauhan ◽  
Azizah Salim Bawadood ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Plasma Insulin ◽  
Moringa Oleifera ◽  
Density Lipoprotein ◽  
Diabetic Rats ◽  
The Body ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Treatment Of Diabetes ◽  
Moringa Oleifera Lam

Background. The cases of diabetes increase day by day due to unhealthy lifestyle, food habit, and less food intake. Novel drugs for the treatment of diabetes are urgently needed. Most researchers are looking for alternative drugs (plant-based drugs) for the treatment of diabetes. Objective. The current experiment was designed to examine the hepatic and renal beneficial effect of Moringa oleifera Lam. (MO) extract in the streptozotocin (STZ)-induced diabetes. Methods. Antidiabetic potential of the MO extract was estimated in terms of blood glucose levels, plasma insulin, hexokinase, and glucose-6-phosphate. Antihyperlipidemic effects of MO extract were evaluated through the estimation of low-density lipoprotein (LDL) cholesterol, total cholesterol (TC), triglyceride (TG), very LDL (VLDL) cholesterol, and high-density lipoprotein (HDL) level whereas the antioxidant effects were evaluated through estimation of catalase (CAT), superoxide dismutase (SOD), malondialdehyde (MDA), and glutathione peroxidase (GPx) levels in diabetic rats. Results. Dose-dependent treatment using MO extract significantly increased the body weight, hexokinase, plasma insulin, HDL, SOD, CAT, and GPx levels (P < 0.001) and significantly decreased the levels of fasting blood glucose, TC, TGs, LDL, VLDL, MDA, fructose-1,6-bisphosphate, glucose-6-phosphate, and glycated hemoglobin in STZ-induced diabetic rats (P < 0.001). Conclusion. MO can be used as a therapeutic agent in the management of elevated blood glucose levels through the alterations in the blood glucose level, plasma level of insulin, and various biochemical parameters.

scholarly journals Evidence of the hypoglycemic capacity of some natural products for the alternative treatment of diabetes mellitus type 2

2020 ◽  
Vol 8 (16) ◽  
pp. 56-64
Author(s):  
Karla Guadalupe Perez-Avila ◽  
Cruz Vargas-De-León ◽  
José Antonio Morales-González ◽  
Eduardo Madrigal-Santillán
Keyword(s):  
Diabetes Mellitus ◽  
Natural Products ◽  
Alternative Treatment ◽  
The Body ◽  
In Vitro Assays ◽  
Glucose Levels ◽  
Natural Treatment ◽  
Treatment Of Diabetes

Diabetes mellitus is a disease that is characterized by the chronic presence of blood glucose levels caused by a defect in the secretion of insulin or in the action of this hormone in the body which must be treated integrally with a multidisciplinary approach. The natural treatment of this disease is a common practice around the world, especially in Latin America, there are several clinical studies, in vivo or in vitro assays that focus on assessing the hypoglycemic capacity of various natural products used empirically by the population for years for the phytotherapeutic treatment of the disease as well as the chemicals related to the mechanism of action that produces the hypoglycaemic effect. In the present article, a brief review of the evidence of the hypoglycemic capacity of some natural products for the alternative treatment of diabetes mellitus 2

Bitter gourd (Momordica charantia L.) seed oil as a naturally rich source of bioactive compounds for nutraceutical purposes

Nutrire ◽  
2016 ◽  
Vol 41 (1) ◽  
Author(s):  
Luciana Tedesco Yoshime ◽  
Illana Louise Pereira de Melo ◽  
José Augusto Gasparotto Sattler ◽  
Eliane Bonifácio Teixeira de Carvalho ◽  
Jorge Mancini-Filho
Keyword(s):  
Bioactive Compounds ◽  
Seed Oil ◽  
Momordica Charantia ◽  
Rich Source ◽  
Bitter Gourd

scholarly journals Drug-Herb Interaction between Metformin and Momordica charantia in Diabetic Mice

2019 ◽  
Vol 3 (2) ◽  
pp. 81
Author(s):  
Asri Dwi Endah Dewi Pramesthi ◽  
Mirhansyah Ardana ◽  
Niken Indriyanti
Keyword(s):  
Fruit Juice ◽  
Negative Control ◽  
Momordica Charantia ◽  
Bitter Gourd ◽  
Diabetic Mice ◽  
Once Daily ◽  
Glucose Lowering ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Significant Difference

Background: Bitter gourd has various metabolites, such as momordicosides, polypeptide-P, v-insulin, charantin, and vicine that have antidiabetic effect. It has synergistically effect while combined with oral diabetic drugs, such as metformin as glucose lowering agent. The aim of this study is to investigate the interaction of bitter gourd fruit juice and metformin as glucose lowering agent in mice.Materials and Methods: Alloxan-induced diabetic mice were treated with bitter gourd fruit juice, metformin, and the combination of those two for 21 days. Glucose level was checked on first and last day of treatment.Results: Furthermore, blood glucose levels measurement showed no significant difference between groups compared with negative control, which was p>0.05. The stomach of groups that treated with metformin and bitter gourd fruit juice histopathologically showed no significant differences.Conclusion: The use of bitter gourd once daily together with metformin is a better choice, while twice daily might induce hypoglycemia and mice death. There is no interaction between them on lowering blood glucose.Keywords: metformin, Momordica charantia, diabetes mellitus

scholarly journals Timing of Bisphosphonate Initiation After Fracture: What Does the Data Really Say?

2020 ◽  
Vol 11 ◽  
pp. 215145932098036
Author(s):  
David W. Barton ◽  
C. Taylor Smith ◽  
Amit S. Piple ◽  
Sterling A. Moskal ◽  
Jonathan J. Carmouche
Keyword(s):  
Fracture Healing ◽  
Clinical Studies ◽  
Osteoporosis Treatment ◽  
The Body ◽  
Non Union ◽  
Increased Risk ◽  
Level I ◽  
Timing Of Initiation ◽  
The Impact ◽  
Published Research

Introduction: Osteoporosis is often not clinically recognized until after a fracture occurs. Individuals who have 1 fracture are at increased risk of future fractures. Prompt initiation of osteoporosis treatment following fracture is critical to reducing the rate of future fractures. Antiresorptives are the most widely used class of medications for the prevention and treatment of osteoporosis. Many providers are hesitant to initiate antiresorptives in the acute post-fracture period. Concerns include interference with bone remodeling necessary for successful fracture healing, which would cause increased rates of non-union, malunion, and refracture. While such concerns should not extend to anabolic medications, physicians may also hesitate to initiate anabolic osteoporosis therapies due to high cost and/or lack of familiarity. This article aims to briefly review the available data and present a digestible narrative summary to familiarize practicing orthopaedic surgeons with the essential details of the published research on this topic. Results: The results of 20 clinical studies and key pre-clinical studies related to the effect of anti-resorptive medications for osteoporosis on fracture healing are summarized in the body of this narrative review. Discussion & Conclusions: While few level I studies have examined the impact of timing of initiation of osteoporosis medications in the acute post-fracture period, the few that have been published do not support these concerns. Specifically, data from level I clinical trials indicate that initiating bisphosphonates as early as 2 weeks post-fracture does not increase rates of non-union or malunion. By reviewing the available data, we hope to give clinicians the confidence to initiate osteoporosis treatment promptly post-fracture.

scholarly journals Advanced Research in Food Digestion

Foods ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 122
Author(s):  
Ana Andrés ◽  
Ana Heredia
Keyword(s):  
Bioactive Compounds ◽  
The Body ◽  
Food Digestion

Food digestion is the key process for delivering nutrients and bioactive compounds to the body [...]

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