scholarly journals A Camouflaged Case of Disseminated Tuberculosis Presenting as Adrenal Crisis

2021 ◽  
Vol 3 (3) ◽  
pp. 12-15
Author(s):  
Saquib Navid Siddiqui
Keyword(s):  
Adrenal Glands ◽  
The Body ◽  
Adrenal Crisis ◽  
Adrenal Failure ◽  
Endocrine Glands ◽  
Common Site ◽  
Diagnostic Challenge ◽  
Extra Pulmonary Tuberculosis ◽  
Disseminated Tuberculosis ◽  
Multiple Organs

Lymphohematogenous spread of mycobacterium tuberculosis to multiple organs presents a complex diagnostic challenge to any physician. A holistic and vigilant approach is required in the quest to diagnose disseminated tuberculosis causing adrenal failure. Although tuberculosis can affect various endocrine glands of the body yet adrenal remains the most common.[1] It is also the fifth most common site for extra-pulmonary tuberculosis.[2] The incidence of tuberculous Addison’s disease has lowered courtesy of anti-tubercular medications accounting for only 7-20% of cases.[1] Here we showcase a rare incidence where a 39 years old gentleman with no constitutional symptoms and no known co-morbidities presenting with neck pain went into adrenal crisis and eventually was found to be due to disseminated tuberculosis which affected his lungs, adrenal glands, cervical spine, and brain.

scholarly journals A Narrative Review of the Complex Relationship between Pregnancy and Eye Changes

Diagnostics ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1329
Author(s):  
Nicoleta Anton ◽  
Bogdan Doroftei ◽  
Ovidiu-Dumitru Ilie ◽  
Roxana-Elena Ciuntu ◽  
Camelia Margareta Bogdănici ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Adrenal Glands ◽  
The Body ◽  
Endocrine Glands ◽  
Corneal Sensitivity ◽  
Eye Disorders ◽  
Ophthalmic Pathology ◽  
Ocular Changes ◽  
Caucasian Women

Pregnancy is a condition often characterized by changes that occur in different parts of the body. Generally, the eyes suffer several changes during pregnancy that are usually transient but may become permanent at times. This may occur due to the release of placental hormones and those of maternal endocrine glands and fetal adrenal glands. Due to hormonal influences, physiological ocular changes during pregnancy have been shown in Caucasian women, so corneal sensitivity, refractive status, intraocular pressure, and visual acuity may change during pregnancy. Within this review, all studies that referred to physiological aspects and to changes of ocular pathology of pregnancy, the effect of the pregnancy on pre-existing (diabetic retinopathy, neuro-ophthalmic disorders) eye disorders, postpartum ocular changes, the intraocular pressure and the effect of hypotensive ophthalmic medicine during pregnancy, the connection between pregnancy and the neuro-ophthalmic pathology, as well as the role of anesthesia were analyzed.

On the role of the adrenal glands in the biochemistry of the body

1929 ◽  
Vol 25 (9) ◽  
pp. 888-896
Author(s):  
S. A. Shcherbakov ◽  
V. S. Zimnitsky ◽  
V. R. Dmitriev
Keyword(s):  
Adrenal Glands ◽  
The Body ◽  
Endocrine Glands

Anyone who runs the risk of stepping on the shaky soil of the endocrine glands must walk on it carefully, since there is nothing more disastrous, says Nobekur. II indeed, we know that despite the colossal amount of research accumulated in the endocrinological literature, we all have a number of conflicting opinions and hypotheses, sometimes mutually exclusive of each other.

scholarly journals Disseminated Tuberculosis in a Postpartum Young Women Presenting as Isolated Optic Neuritis

2018 ◽  
Vol 1 (1) ◽  
pp. 46-48
Author(s):  
Priya Sivakumar
Keyword(s):  
Optic Neuritis ◽  
Post Partum ◽  
World Health ◽  
Diagnostic Challenge ◽  
Extra Pulmonary Tuberculosis ◽  
Disseminated Tuberculosis ◽  
Competent Person ◽  
The World ◽  
Health Organization ◽  
Hiv 1

Tuberculosis (TB) is the first infectious disease declared by the World Health Organization as a global health mergency. It remains the leading cause of death among infectious diseases causing more deaths worldwide than uman immune deficiency virus (HIV) [1]. The following case report highlights the occult and non specific  resentations of the disease which makes it a diagnostic challenge. We report a case of extensively disseminated tuberculosis in an immune competent post partum young woman presenting as isolated optic neuritis. Extra pulmonary tuberculosis is commoner among immune compromised patients. Co-existence of military and intracranial tuberculosis in an immune competent person is extremely rare.

Ultrastructural diagnosis of peritoneal malignant mesothelioma

1994 ◽  
Vol 52 ◽  
pp. 234-235
Author(s):  
S. Siew
Keyword(s):  
Malignant Mesothelioma ◽  
Common Type ◽  
Abdominal Discomfort ◽  
The Body ◽  
Metastatic Adenocarcinoma ◽  
Common Site ◽  
Primary Malignancy ◽  
Peritoneal Implant ◽  
Morphological Diagnosis ◽  
Malignant Neoplasia

Mesothelial cells constitute the lining of the three serous sacs of the body i.e. the pleura, pericardium and peritoneum. The more common type of malignant neoplasia of the serous sacs is seeding by metastatic tumors and primary malignancy of the mesothelium is unusual. Of the three sacs, the pleura is the most common site of malignant mesothelioma. Involvement of the peritoneum is extremely rare.We report 3 cases of malignant mesothelioma of the peritoneum. All of them were female. Their ages were 57, 67 and 72 years, respectively. The patients presented with abdominal discomfort and/or ascites. The extent of the tumors ranged from a peritoneal implant to widespread infiltration of the peritoneum and omentum. Histologic examination in Case 1 showed the presence of a diffusely infiltrating papillary mesothelioma without a sarcomatoid component. A mesodermal element was present in the other two cases. In order to establish a morphological diagnosis of malignant mesothelioma, the possibility has to be excluded of a metastatic adenocarcinoma.

scholarly journals Role of Mitochondria in Viral Infections

Life ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 232
Author(s):  
Srikanth Elesela ◽  
Nicholas W. Lukacs
Keyword(s):  
Viral Infections ◽  
Mitochondrial Dynamics ◽  
The Body ◽  
Viral Diseases ◽  
Multiple Organs ◽  
Innate Immune Signaling ◽  
Mitochondrial Functions ◽  
Host Virus Interactions ◽  
Virus Interactions

Viral diseases account for an increasing proportion of deaths worldwide. Viruses maneuver host cell machinery in an attempt to subvert the intracellular environment favorable for their replication. The mitochondrial network is highly susceptible to physiological and environmental insults, including viral infections. Viruses affect mitochondrial functions and impact mitochondrial metabolism, and innate immune signaling. Resurgence of host-virus interactions in recent literature emphasizes the key role of mitochondria and host metabolism on viral life processes. Mitochondrial dysfunction leads to damage of mitochondria that generate toxic compounds, importantly mitochondrial DNA, inducing systemic toxicity, leading to damage of multiple organs in the body. Mitochondrial dynamics and mitophagy are essential for the maintenance of mitochondrial quality control and homeostasis. Therefore, metabolic antagonists may be essential to gain a better understanding of viral diseases and develop effective antiviral therapeutics. This review briefly discusses how viruses exploit mitochondrial dynamics for virus proliferation and induce associated diseases.

scholarly journals MORPHOLOGICAL STUDIES IN EXPERIMENTAL CRETINISM

1913 ◽  
Vol 17 (6) ◽  
pp. 636-652 ◽  
Author(s):  
Arthur L. Tatum
Keyword(s):  
Adrenal Glands ◽  
The Body ◽  
The Other ◽  
Degenerative Changes ◽  
Morphological Studies ◽  
Cellular Changes ◽  
Anatomical Basis ◽  
Parenchymatous Organ ◽  
Islands Of Langerhans

In summarizing the findings of this paper it may be said that degenerative changes have been noted in practically every parenchymatous organ. Among these the most striking has been that of serous imbibition by the most active cells of these organs. In regard to the changes in the glands of internal secretion, the findings corroborate the statements of Cushing in regard to hypophysectomy, that removal of one gland of internal secretion results in changes in all the other glands. In this case, degenerative changes predominate in the hypophysis, thymus, ovary, and testis, while hyperplasia is seen in the islands of Langerhans and the medullas of the adrenal glands. Finally, in the rabbit athyroidism is responsible for grave degenerative changes in practically all organs and tissues of the body, and many of the symptoms of cretinism have an anatomical basis in organic cellular changes.

ON THE SURVIVAL AND METABOLISM OF NORMAL AND HYPOTHERMIC PRE-VIABLE HUMAN FOETUSES

1961 ◽  
Vol 23 (1) ◽  
pp. 69-77 ◽  
Author(s):  
S. KULLANDER ◽  
B. SUNDÉN
Keyword(s):  
Body Temperature ◽  
Survival Time ◽  
Glycogen Content ◽  
Adrenal Glands ◽  
Early Stage ◽  
The Body ◽  
Protein Nitrogen ◽  
Different Temperatures ◽  
Human Foetuses ◽  
General Reduction

SUMMARY A total of twenty-three human pre-viable foetuses (7–400 g.) were removed by abdominal hysterotomy (legal abortions) and studied during survival in an anoxic state at different temperatures. The duration of survival, as judged by ECG waves, at 37° c was about 3 hr.; it was longer for female foetuses than for males, and longer for large foetuses than for small ones. General reduction of the body-temperature to 4° c during periods varying between 30 min. and 6 hr. with subsequent rewarming to and maintenance at 37° c increased the survival time by a further 1–2 hr. The blood sugar did not decrease either during the period of survival or during hypothermia, but the non-protein nitrogen increased, while acidosis and hyperkalaemia developed. The glycogen content of the liver decreased during the anoxic period of survival and diminished further during hypothermia. The adrenal glands produced adrenaline in addition to noradrenaline during the anoxic phase, and this may occur in a very early stage of intrauterine life.

scholarly journals Tuberculosis in Otorhinolaryngology: Clinical Presentation and Diagnostic Challenges

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Rajiv C. Michael ◽  
Joy S. Michael
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Pulmonary Tuberculosis ◽  
Clinical Presentation ◽  
Extrapulmonary Tuberculosis ◽  
Common Type ◽  
The Body ◽  
Diagnostic Challenge ◽  
Cervical Adenitis ◽  
Important Form

Tuberculosis affects all tissues of the body, although some more commonly than the others. Pulmonary tuberculosis is the most common type of tuberculosis accounting for approximately 80% of the tuberculosis cases. Tuberculosis of the otorhinolaryngeal region is one of the rarer forms of extrapulmonary tuberculosis but still poses a significant clinical and diagnostic challenge. Over three years, only five out of 121 patients suspected to have tuberculosis of the otorhinolaryngeal region (cervical adenitis excluded) hadMycobacterium tuberculosisculture-proven disease. Additional 7 had histology-proven tuberculosis. Only one patient had concomitant sputum-positive pulmonary tuberculosis. We look at the various clinical and laboratory aspects of tuberculosis of the otorhinolaryngeal region that would help to diagnose this uncommon but important form of extrapulmonary tuberculosis.

Staphylococcal infection and pathomurfological characteristic of the pituitary-adrenal-thyroid system

2020 ◽  
Vol 03 (04) ◽  
pp. 69-73
Author(s):  
Samira Mammadhasan Yagubova ◽  
◽  
Elchin Chingiz Akbarov ◽  
Tarana Nadir Mirzayeva ◽  
◽  
...  
Keyword(s):  
Structural Changes ◽  
Adrenal Glands ◽  
Early Stage ◽  
Morphological Changes ◽  
Endocrine System ◽  
Staphylococcal Infection ◽  
The Body ◽  
Glandular Cells ◽  
Exogenous Factors ◽  
Specific Symptoms

During the staphylococcal infection, changes in the interaction of glandular cells, dystrophic and disorganizing pathologies in tissues, especially acute structural and hemodynamic changes in the stroma of the glands in the pituitary-adrenal-thyroid system, develop from the first day of the experiment. At the end of the experiment, on the background of a decrease in exudative processes, fibroplastic reactions are significantly activated, resulting in signs of incomplete regeneration – mainly sclerotic processes and cystic-atrophic changes in the parenchyma. Structural changes in tissues in the early stages of staphylococcal infection and the dynamics of development are characterized by specific symptoms in each of the glands. Since the pituitary gland is exposed to endogenous and exogenous factors earlier and more often than the adrenal glands, and the adrenal glands are earlier than the thyroid gland, dystrophic and destructive changes in the pituitary and adrenal glands are more pronounced at the early stage of the experiment. These morphological changes can change the hormonal status of the body and lead to dysfunction of the endocrine system as a whole – a decrease in the functional activity of the glands to some extent, and even inhibition of adenohypophyseal cells. Key words: staphylococcal infection, peritonitis, pituitary, adrenal and thyroid glands

A Cross-Sectional Study on Prevalence of Musculoskeletal Pain in Dhol Players in India

2021 ◽  
Vol 36 (2) ◽  
pp. 72-77
Author(s):  
Prachita Walankar ◽  
Ninisha Patil
Keyword(s):  
Musculoskeletal Pain ◽  
Specific Area ◽  
Cross Sectional Study ◽  
The Body ◽  
Body Region ◽  
Targeted Prevention ◽  
Low Back ◽  
Sectional Study ◽  
Common Site ◽  
Cross Sectional

OBJECTIVE: To explore the prevalence of musculoskeletal pain in dhol players in India. METHODS: A cross-sectional study was conducted in 96 dhol players. A self-administered questionnaire comprising of demographic profile, dhol player characteristics, presence of musculoskeletal pain, and specific area of pain according to the body region was used to collect information from the dhol players. RESULTS: The mean age and duration of playing dhol experience were 22.26+3.05 and 6.08+1.27 years, respectively. Among 96 dhol players, 93 (96.9%) and 55 (57.3%) reported presence of musculoskeletal pain with respect to the 12-month prevalence and 7-day prevalence, respectively. In 12-month prevalence, the most common site of pain was the low back (67.7%), followed by shoulder (54.2%) and wrist and hand (24%). In 7-day prevalence, the most common site of pain was the low back (41.7%), followed by shoulder (24%) and upper back (15.6%). Logistic regression analysis revealed that age (p=0.002) and duration of playing dhol (p<0.001) were associated with 7-day prevalence of musculoskeletal pain. CONCLUSION: The findings of this study indicated high prevalence of musculoskeletal pain in dhol players. Low back, shoulder, wrist/hand, and upper back were common sites of pain. Identification of these factors in dhol players may assist in further research on targeted prevention, scientific recommendations, and rehabilitation.

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