Effect of methanol on the ultrastructure of chorioretinal complex of rats’ eyes in the early stages of the experiment
Electron-microscopic structure of the chorioretinal complex were investigated (СRC), [choriocapillaries (HC) – retinal pigment epithelium (RPE) – photoreceptor cells (FC)], of white rats in a period of 40 min. to 3 days after a single intraperitoneal dose of methanol 0.75 g/kg body weight. It has been established that RPE cells are the most responsiveto the dose of the methanol used. In the dynamics (from 40 min. up to 3 days), they grew destructive changes of mitochondria and elements of smooth endoplasmic reticulum, the smoothness of the basal folds and patchy destruction of the apical microvilli. The changes in CC and FC were similar. By the end of the observation period, these phenomena in the CRC structure spread to a larger number of cells. At the same time, during the whole period of the study, and, in particular, after a day, some signs of recovery of compensatory nature were obvious. Attention is drawn to pronounced reaction of mitochondria, which are energy forming structures of a cell.