Nitric oxide role in pathogenesis and treatment of cardio-vascular diseases (literature review)

Literature data concerning the role of endothelium and nitric oxide in the pathogenesis of cardiovascular diseases, administration of L-arginine as a part of a comprehensive therapy of patients suffering from essential hypertension (EH) and ischemic heart disease (IHD) are cited.Objective: to systematize current literature data concerning the role of endothelium and nitric oxide in the pathogenesis of cardiovascular diseases, clinical experience of L-arginine administration in patients with EH and IHD. Conclusion. Nowadays endothelial dysfunction conception is defined with insufficient production of nitric oxide as a central part of EH and IHD pathogenesis. Nitric oxide deficiency occurring with cardiovascular diseases can be compensated by means of NO donors.

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Monocyte function and trafficking in cardiovascular disease

Thrombosis and Haemostasis ◽

10.1160/th12-04-0276 ◽

2012 ◽

Vol 108 (11) ◽

pp. 804-811 ◽

Cited By ~ 13

Author(s):

Evangelia Pardali ◽

Johannes Waltenberger

Keyword(s):

Cardiovascular Diseases ◽

Tissue Repair ◽

Vascular Diseases ◽

Immune Defense ◽

Injury Repair ◽

Disease Marker ◽

Pathological Conditions ◽

Repair Mechanisms ◽

Cardio Vascular

SummaryMonocytes are key effectors of the immune homeostasis and play a crucial role in (vascular) injury repair. Despite their role in immune defense and tissue repair mechanisms, monocytes are also involved in several pathological conditions such as autoimmune and cardiovascular diseases as well as cancer. This suggests that monocytes can be used as diagnostic and as therapeutic targets. A better understanding and characterisation of monocytes and their function in both physiological and pathological situations is thus of great interest. This review focuses on recent advances on the role of monocytes in cardiovascular diseases and describes the value of monocytes as either disease marker or therapeutic target for (cardio)vascular diseases.

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Beneficial Role of Tetrahydrobiopterin on Various Cardiovascular Diseases and Regulation of its Levels under Pathological Conditions

Pteridines ◽

10.1515/pteridines.2006.17.1.5 ◽

2006 ◽

Vol 17 (1) ◽

pp. 5-10

Author(s):

Shunichi Shimizu ◽

Masakazu Ishii ◽

Teruaki Wajima ◽

Tamio Hagiwara ◽

Takaharu Negoro

Keyword(s):

Oxidative Stress ◽

Nitric Oxide ◽

Cardiovascular Diseases ◽

Reperfusion Injury ◽

Vascular Endothelial Cells ◽

Ischemia Reperfusion ◽

Vascular Diseases ◽

Common Mechanism ◽

Pathological Conditions

Abstract 5,6,7,8-Tetrahydrobiopterin (BH4) is an csscntial cofactor for production of nitric oxide (NO) by N O synthase (NOS). Nitric oxide (NO) is an important signaling mo!ecu!e for the regulation o f vita! functions such as vascular tone, neurotransmission and immune surveiüance. Accumu!ated evidences show that although NOS mainly re!eases N O under nonnal conditions, NOS also produces Superoxide anion and hydrogen peroxide when BH4 is decreased, suggesting the possibility that NOS is a source of reactive oxygen species (ROS) under pathological conditions. In fact, supplementation of BH4 restores N O production and availability in various diseases including hyperlipidemia, diabetes, hypertension and ischemia-reperfusion. Moreover, recent studies show that administration o f BH4 protects tissues against ischemia-reperfusion injuiy in heart, stomach and liver. Oxidative stress is a common mechanism underlying the development of vascular diseases and reperfusion injury. Regulation of BH4 levels under oxidative stress is important to understand the role of BH4 on the development of vascular diseases and reperfusion injury. We recently described that oxidative stress transiently decreased BH4 levels, and then markedly increased its levels in vascular endothelial cells. Supplementation of BH4 appears to be important therapeutic strategies in vascular diseases and reperfusion injury, and induction of BH4 synthesis may endogenous defense system against oxidative stress-mediated cardiovascular diseases.

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Role of Emotional Processes in Cardio-vascular Diseases

PsycEXTRA Dataset ◽

10.1037/e670282012-177 ◽

2012 ◽

Author(s):

Suman Balhara ◽

Nov Rattan Sharma ◽

Amrita Yadav

Keyword(s):

Vascular Diseases ◽

Emotional Processes ◽

Cardio Vascular

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Imbalance in the system L-arginin-NO in pathogenesis of obstetric complications and intrauterine growth retardation (Literature review)

HEALTH OF WOMAN ◽

10.15574/hw.2016.111.43 ◽

2016 ◽

pp. 43-47

Author(s):

O.V. Basystyi ◽

Keyword(s):

Nitric Oxide ◽

Literature Review ◽

Growth Retardation ◽

Intrauterine Growth Retardation ◽

Obstetric Complications ◽

Pathogenetic Role ◽

Intrauterine Growth ◽

System L ◽

Nitric Oxide Deficiency

The data of domestic and foreign literature on etiology, pathogenesis and intrauterine growth retardation diagnosis are presented in the paper. It highlights pathogenetic role of nitric oxide deficiency in case of obstetric complications and intrauterine growth retardation. Key words: intrauterine growth retardation (IUGR), system L-arginin–NO, obstetric complications.

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A Review on Heart Disease Detection Techniques

International Journal of Advanced Research in Computer Science and Software Engineering ◽

10.23956/ijarcsse/v7i7/0200 ◽

2017 ◽

Vol 7 (7) ◽

pp. 395

Author(s):

. Anika ◽

Navpreet Kaur

Keyword(s):

Machine Learning ◽

Heart Disease ◽

Review Paper ◽

Vascular Diseases ◽

Disease Detection ◽

Automated Classification ◽

Feature Extraction Method ◽

Detection Techniques ◽

Cardio Vascular ◽

Public Domain Software

The paper exhibits a formal audit on early detection of heart disease which are the major cause of death. Computational science has potential to detect disease in prior stages automatically. With this review paper we describe machine learning for disease detection. Machine learning is a method of data analysis that automates analytical model building.Various techniques develop to predict cardiac disease based on cases through MRI was developed. Automated classification using machine learning. Feature extraction method using Cell Profiler and GLCM. Cell Profiler a public domain software, freely available is flourished by the Broad Institute's Imaging Platform and Glcm is a statistical method of examining texture .Various techniques to detect cardio vascular diseases.

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Nitric Oxide and Immune Responses in Cancer: Searching for New Therapeutic Strategies

Current Medicinal Chemistry ◽

10.2174/0929867328666210707194543 ◽

2021 ◽

Vol 28 ◽

Author(s):

Adeleh Sahebnasagh ◽

Fatemeh Saghafi ◽

Sina Negintaji ◽

Tingyan Hu ◽

Mojtaba Shabani-Boroujeni ◽

...

Keyword(s):

Nitric Oxide ◽

Immune Responses ◽

Therapeutic Potential ◽

Relevant Literature ◽

Cochrane Library ◽

Signaling Molecule ◽

No Donors ◽

The Cochrane Library ◽

Oxide Synthase

: In recent years, there has been an increasing interest in understanding the mysterious functions of nitric oxide (NO) and how this pleiotropic signaling molecule contributes to tumorigenesis. This review attempts to expose and discuss the information available on the immunomodulatory role of NO in cancer and recent approaches to the role of NO donors in the area of immunotherapy. To address the goal, the following databases were searched to identify relevant literature concerning empirical evidence: The Cochrane Library, Pubmed, Medline, EMBASE from 1980 through March 2020. Valuable attempts have been made to develop distinctive NO-based cancer therapy. Although the data do not allow generalization, the evidence seems to indicate that low / moderate levels may favor tumorigenesis while higher levels would exert anti-tumor effects. In this sense, the use of NO donors could have an important therapeutic potential within immunotherapy, although there are still no clinical trials. The emerging understanding of NO-regulated immune responses in cancer may help unravel the recent features of this “double-edged sword” in cancer physiological and pathologic processes and its potential use as a therapeutic agent for cancer treatment. In short, in this review, we discuss the complex cellular mechanism in which NO, as a pleiotropic signaling molecule, participates in cancer pathophysiology. We also debate the dual role of NO in cancer and tumor progression, and clinical approaches for inducible nitric oxide synthase (iNOS) based therapy against cancer.

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A Comprehensive View on Cardiovascular Diseases (CVDs): Genetics, Risk Factors & Preventions

NUST Journal of Natural Sciences ◽

10.53992/njns.v5i1.35 ◽

2021 ◽

Vol 5 (1) ◽

pp. 38-61

Author(s):

Saaim Asif ◽

Maaz Khan ◽

Muhammad Waqar Arshad

Keyword(s):

Risk Factors ◽

Cardiovascular Diseases ◽

Healthy Lifestyle ◽

Saturated Fat ◽

Vascular Diseases ◽

Model Organisms ◽

Balanced Diet ◽

Diet And Exercise ◽

Healthy Lifestyle Interventions

Cardiovascular Diseases (CVDs) are one of the foremost causes of deaths across the world. This review aims to evaluate the genetics and risk factors involved in CVDs and to assess the preventive measures which can be taken for diminishing the chances of developing CVDs. The goal of this review is to provide researchers and clinicians dealing with vascular disorders with a compendium of data about the genetic causes, risk factors, and preventive strategies to combat the development of CVDs. We searched online databases including PubMed for peer-reviewed scientific papers, case studies and review articles related to CVDs, emphasizing on the role of genetics and risk factors like diabetes, hypertension, smoking, alcohol consumption, obesity, age & gender in the progression of CVDs, and reviewing the role of diet and exercise in the prevention of CVDs. Managing the risk factors involved in CVDs is the most essential step for the inhibition of vascular diseases. Healthy lifestyle interventions consisting of a well-balanced diet and physical activity are very critical for the prevention of CVDs. Trials carried out on model organisms have indicated a direct link between diet and exercise on cardiovascular conditions. Strategies involved in the treatment of vascular diseases should also include low-fat diet plans like consumption of whole grains, fruits, vegetables, yogurts and avoiding high-saturated fat-containing foods with the addition of performing moderate aerobic exercises including cycling, swimming, hiking, and running to eliminate the root of the problem.

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Genetics in cardiovascular diseases

Italian Journal of Medicine ◽

10.4081/itjm.2019.1186 ◽

2019 ◽

Vol 13 (3) ◽

pp. 137-151 ◽

Cited By ~ 1

Author(s):

Rudy Celeghin ◽

Gaetano Thiene ◽

Barbara Bauce ◽

Cristina Basso ◽

Kalliopi Pilichou

Keyword(s):

Genetic Testing ◽

Cardiovascular Diseases ◽

Genetic Basis ◽

Vascular Diseases ◽

Current Evidence ◽

Clinical Tool ◽

Wide Group ◽

Next Generation Sequencing Ngs ◽

Probabilistic Nature

Cardiovascular diseases (CVDs) are a wide group of disorders affecting the heart and blood vessels, including coronary artery, valve, pericardial, conduction system, myocardial and vascular diseases, either congenital or acquired, which can be also heritable. The advent of next generation sequencing (NGS) was accompanied by quick advances in understanding the genetic basis of human diseases, prompting translation of genetics to the clinic. Precision medicine is based on these findings and on the role of genetic testing to improve the diagnosis, to identify individuals with previously unrecognized disease and family members at risk of future disease development which require longitudinal follow-up. However, the probabilistic nature of genetic testing and the subjectivity of genetic variants classification weighted on current evidence, making this powerful clinical tool difficult to be applied in precision diagnostics and therapeutics. Here, we reviewed systematically the genetic basis of CVDs with special emphasis on the current role of NGS in clinical diagnosis and risk assessment, underlying the need of multidisciplinary cardio-genetic referral centers.

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Senescence and Cancer: Role of Nitric Oxide (NO) in SASP

Cancers ◽

10.3390/cancers12051145 ◽

2020 ◽

Vol 12 (5) ◽

pp. 1145

Author(s):

Nesrine Mabrouk ◽

Silvia Ghione ◽

Véronique Laurens ◽

Stéphanie Plenchette ◽

Ali Bettaieb ◽

...

Keyword(s):

Nitric Oxide ◽

Cancer Treatment ◽

Cellular Senescence ◽

Negative Effects ◽

No Donors ◽

Cell State ◽

Age Related ◽

A Cell ◽

Secretory Phenotype

Cellular senescence is a cell state involved in both physiological and pathological processes such as age-related diseases and cancer. While the mechanism of senescence is now well known, its role in tumorigenesis still remains very controversial. The positive and negative effects of senescence on tumorigenesis depend largely on the diversity of the senescent phenotypes and, more precisely, on the senescence-associated secretory phenotype (SASP). In this review, we discuss the modulatory effect of nitric oxide (NO) in SASP and the possible benefits of the use of NO donors or iNOS inducers in combination with senotherapy in cancer treatment.

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