scholarly journals Review: Hepatoprotector Compounds in Plant Extracts

2019 ◽  
Vol 8 (1) ◽  
Author(s):  
DICHY NURYADIN ZAIN ◽  
Riezki Amalia ◽  
Jutti Levita
Keyword(s):  
Free Radicals ◽  
Plant Extracts ◽  
Hepatoprotective Activity ◽  
Crocus Sativus ◽  
Keywords Liver ◽  
Melastoma Malabathricum ◽  
Hepatoprotector Activity

Many plants have been reported to possess hepatoprotective activity. The mechanism has not yet been revealed, but it was predicted due to the antioxidants that could prevent the formation of free radicals produced by hepatotoxins. Of the 30 plants studied, Crocus sativus gave the largest hepatoprotector activity at a dose of 20 mg / kg, followed by Uncaria gambier Roxb. with a dose of 30 mg / kg and Melastoma malabathricum Leaf at a dose of 50 mg / kg. Keywords: Liver, CYP450, antioxidant, free radicals

Biological and Phytochemical Screening of Tephrosia purpurea extract on Chemically Induced Hepatocellular Carcinoma with Reference to Biochemical Parameters

2019 ◽  
Vol 10 (02) ◽  
Author(s):  
Irfan Aziz ◽  
Birendra Shrivastava ◽  
Chandana Venkateswara Rao ◽  
Sadath Ali
Keyword(s):  
Free Radicals ◽  
Ethanolic Extract ◽  
Hepatoprotective Activity ◽  
Control Group ◽  
Marker Enzymes ◽  
Tephrosia Purpurea ◽  
Single Intraperitoneal Injection ◽  
Chemically Induced ◽  
Ccl4 Treatment ◽  
Dose Dependent

Tephrosia purpurea possesses hepatoprotective activity as evidenced by the significant and dose dependent restoring the activities of entire liver cancer marker enzymes, diminution in tumor incidence, decrease in lipid peroxidation (LPO) and increase in the level of antioxidant enzymes (GSH, CAT, SOD, GPx and GST) through scavenging of free radicals, or by enhancing the activity of antioxidant, which then detoxify free radicals. These factors protect cells from ROS damage in NDEA and CCl4-induced hepatocarcinogenesis. Histopathological observations of liver tissues too correlated with the biochemical observations. Thus, present investigation suggested that the Tephrosia purpurea would exert a chemoprotective effect by reversing the oxidant-antioxidant imbalance during hepatocarcinogenesis induced by NDEA and CCl4. Besides Tephrosia purpurea is very much effective in preventing NDEA-induced multistage hepatocarcinogenesis possibly through antioxidant and antigenotoxic nature, which was confirmed by various liver injury and biochemical tumour markers enzymes. The hepatoprotective activity of aTephrosia purpurea of 50 % ethanolic extract was studied using rats. The animals received a single intraperitoneal injection of N-nitrosodiethylamine 200mg/kg body wt followed by subcutaneous injection of CCl4 in a dose of 3 ml/kg body wt.Tephrosia purpureaextract dose dependently and significantly the increase in serum hepatic enzyme levels after NDEAand CCl4 treatment compared to the toxin control group. The results of this study confirmed the antioxidant and hepatoprotective activity of the Tephrosia purpurea extract against carbon tetrachlorideand N-nitrosodiethylamine induced hepatotoxicity in rats.

Biological and Phytochemical Screening of Fumaria indica extract on Chemically Induced Hepatocellular Carcinoma with Reference to Biochemical Parameters

2019 ◽  
Vol 10 (02) ◽  
Author(s):  
Irfan Aziz ◽  
Birendra Shrivastava ◽  
Chandana Venkateswara Rao2 ◽  
Sadath Ali
Keyword(s):  
Free Radicals ◽  
Liver Disease ◽  
Liver Cancer ◽  
Early Stage ◽  
Food Additives ◽  
Ethanolic Extract ◽  
Hepatoprotective Activity ◽  
Control Group ◽  
Industrial Chemicals ◽  
Toxic Industrial Chemicals

Liver disease or liver cancer is the sixth most common cancer and the third leading cause of cancer mortality in the world. Hepatitis viral infection, food additives, alcohol, fungal toxins (aflatoxins), toxic industrial chemicals, air and water pollutants are the major risk factors of liver cancer. Moreover, due to high tolerance of liver, HCC is seldom detected at an early stage and once detected treatment faces a poor prognosis in most cases.Fumaria indica possesses hepatoprotective activity as evidenced by the significant and dose dependent restoring the activities of entire liver cancer marker enzymes, diminution in tumor incidence, decrease in lipid peroxidation (LPO) and increase in the level of antioxidant enzymes (GSH, CAT, SOD, GPx and GST) through scavenging of free radicals, or by enhancing the activity of antioxidant, which then detoxify free radicals. These factors protect cells from ROS damage in NDEA and CCl4-induced hepatocarcinogenesis. Histopathological observations of liver tissues too correlated with the biochemical observations. Thus, present investigation suggested that the Fumaria indica would exert a chemoprotective effect by reversing the oxidant-antioxidant imbalance during hepatocarcinogenesis induced by NDEA and CCl4. Besides Fumaria indicais very much effective in preventing NDEA-induced multistage hepatocarcinogenesis possibly through antioxidant and antigenotoxic nature, which was confirmed by various liver injury and biochemical tumour markers enzymes. The hepatoprotective activity of a Fumaria indicaof 50 % ethanolic extract was studied using rats. The animals received a single intraperitoneal injection of N-nitrosodiethylamine 200mg/kg body wt followed by subcutaneous injection of CCl4 in a dose of 3 ml/kg body wt. Fumaria indica extract dose dependently and significantly the increase in serum hepatic enzyme levels after NDEAand CCl4 treatment compared to the toxin control group. The results of this study confirmed the antioxidant and hepatoprotective activity of the Fumaria indicaextract against carbon tetrachlorideand N-nitrosodiethylamine induced hepatotoxicity in rats. In addition to this, studies on molecular aspect of hepatoprotective therapy will give mechanistic information in hepatoprotective therapy and also critical balance should be there between the animal model and clinical research. The hepatoprotective properties of Fumaria indicashould provide useful information in the possible application in hepatic liver disease.

scholarly journals A Tell-Tale Heartwood

1999 ◽  
Vol 7 (2) ◽  
pp. 18-21
Author(s):  
Eric C. Kellar
Keyword(s):  
Plant Extracts ◽  
Ninth Century ◽  
Crocus Sativus ◽  
Natural Plant ◽  
Medieval Europe ◽  
Printing Inks ◽  
Caesalpinia Echinata

In Medieval Europe, manuscripts and formulas on the preparation of colors and dyes used by chemists and artists contained many references to natural plant extracts, The yellow stigmas of aromatic saffron (Crocus sativus) were crushed and used both as a medicine and colorant as far back as the ninth century BCE. In 1437 CE, a manual was written by Cennini, II Libro del Arte, a collection of recipes on the preparation of tempera and block-printing inks from saffron and brazilwood (Caesalpinia echinata), Finely divided brazil wood was prepared by scraping sticks with a knife.

scholarly journals Abortifacient and Antioxidant Activities of Avicennia marina

2015 ◽  
Vol 33 ◽  
pp. 12-26
Author(s):  
Muppaneni Srikanth ◽  
Battu Ganga Rao ◽  
Mallikarjuna Rao Talluri ◽  
T. Rajananda Swamy
Keyword(s):  
Antioxidant Activity ◽  
Ascorbic Acid ◽  
Free Radicals ◽  
Plant Extracts ◽  
Antioxidant Activities ◽  
Avicennia Marina ◽  
Standard Drug ◽  
Hydroalcoholic Extract ◽  
Pure Compounds ◽  
Post Implantation

The current study was intended to evaluate abortifacient and antioxidant activity of Avicennia marina leaves extracts. Abortifacient activity was evaluated in rats, compared with standard drug (Mifepristone) and antioxidant activity was evaluated by using three free radicals (Superoxide, Hydroxyl and DPPH) compared with Ascorbic acid. The extracts were showed pre implantation loss, post implantation loss of implantations and decreased the survival ration of foetuses. Among all extracts hydroalcoholic extract showed better activity. The selected plant extracts showed concentration dependent percentage inhibition of free radicals. Among three extracts hydroalcoholic extract showed better activity with IC50 values on superoxide, hydroxyl and DPPH radicals were 203μg, 237μg and 143μg. From the results obtained during the study it the hydroalcoholic extract was used for the isolation of pure compounds, and isolated the different compounds (β-sitosterol, Lupeol and Betulinic acid).

scholarly journals The Effect of Saffron (Crocus Sativus) on Oxymetholone-induced Hepatic and Renal Injury in Rats

2021 ◽  
Vol 15 (4) ◽  
pp. 233-240
Author(s):  
Reza Kheirandish ◽  
◽  
Mehdi Saberi ◽  
Shahrzad Azizi ◽  
Reza Khakdan ◽  
...  
Keyword(s):  
Free Radicals ◽  
Treatment Group ◽  
Muscle Growth ◽  
Antioxidant Properties ◽  
Degenerative Changes ◽  
Crocus Sativus ◽  
Protective Effects ◽  
Negative Effects ◽  
Male Wistar Rats ◽  
Histopathological Results

Background: Oxymetholone, an anabolic-androgenic steroid, has been used to treat some diseases. The abuse of this compound, especially for muscle growth, has severe oxidative side effects on the liver and kidneys. Oxidative stress and free radicals are responsible for the development of various diseases. Phytochemicals are sources of polyphenols, flavonoids, saponins, etc. and may act as scavengers of free radicals. Saffron (Crocus sativus) has considerable antioxidant properties, which may be useful in reversing or preventing these negative effects. Methods: To evaluate the effects of saffron on the liver and kidneys degenerative changes induced by oxymetholone, 24 male Wistar rats were used. The rats were randomly divided into four groups of six rats each as: a) sham (normal saline, 40 mg/kg/day), b) saffron control (40 mg/kg/day), c) oxymetholone (50 mg/rat), and d) treatment group [saffron (40 mg/kg/day)+oxymetholone (50 mg/rat)]. The course of examination was 30 days. Results: After one month, the sham and saffron control groups had normal histological findings. The treatment group with saffron showed a significant reduction in the hepatic and renal degenerative changes induced by oxymetholone compared to those observed in group. Conclusion: Based on the histopathological results, the use of saffron produced protective effects against the degenerative changes in rats’ liver and kidneys induced by oxymetholone.

scholarly journals The Potential of Plant-Based Bioactive Compounds on Inhibition of Aflatoxin B1 Biosynthesis and Down-regulation of aflR, aflM and aflP Genes

Antibiotics ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. 728
Author(s):  
Nassim Safari ◽  
Mehran Mirabzadeh Ardakani ◽  
Roghayeh Hemmati ◽  
Alessia Parroni ◽  
Marzia Beccaccioli ◽  
...  
Keyword(s):  
Gene Expression ◽  
Plant Extracts ◽  
Aflatoxin B1 ◽  
Regulatory Gene ◽  
Crop Protection ◽  
Crocus Sativus ◽  
Great Promise ◽  
Anethum Graveolens ◽  
Down Regulation ◽  
Regulation Of Expression

The use of plant extracts in pre- and post-harvest disease management of agricultural crops to cope with aflatoxin B1 contamination has shown great promise due to their capability in managing toxins and safe-keeping the quality. We investigated the anti-aflatoxigenic effect of multiple doses of eight plant extracts (Heracleum persicum, Peganum harmala, Crocus sativus, Trachyspermum ammi, Rosmarinus officinalis, Anethum graveolens, Berberis vulgaris, Berberis thunbergii) on Aspergillus flavus via LC-MS and the down-regulatory effect of them on aflR, aflM and aflP genes involved in the aflatoxin B1 biosynthesis pathway using RT-qPCR analyses. Our results showed that H. persicum (4 mg/mL), P. harmala (6 mg/mL) and T. ammi (2 mg/mL) completely stopped the production of aflatoxin B1, without inducing significant changes in A. flavus growth. Furthermore, our findings showed a highly significant correlation between the gene expression and the aflatoxin B1 biosynthesis, such that certain doses of the extracts reduced or blocked the expression of the aflR, aflM and aflP and consequently reduced the synthesis of aflatoxin B1. Interestingly, compared to the regulatory gene (aflR), the down-regulation of expression in the structural genes (aflM and aflP) was more consistent and correlated with the inhibition of aflatoxin B1 production. Overall, this study reveals the anti-aflatoxigenic mechanisms of the selected plant extracts at the gene expression level and provides evidence for their use in plant and crop protection.

scholarly journals Hepatoprotective Activity of Cassia Auriculata against Carbon Tetrachloride-Induced Hepatotoxicity in Rats

2021 ◽  
Vol 12 (1) ◽  
pp. 594-601
Author(s):  
Jenila Jose Jancy V ◽  
Kalaichelvan V ◽  
Balakrishnan N
Keyword(s):  
Antioxidant Activity ◽  
Free Radicals ◽  
Developed Countries ◽  
Hepatoprotective Activity ◽  
Cellular Damage ◽  
The People ◽  
Previous Decade ◽  
Medicinal Properties ◽  
The Developed Countries ◽  
Natural Drugs

In previous decade the herbal drugs have been investigated for their medicinal properties for the natural therapy. About half of the people around the world, even in the developed countries had been using the medicinal plants and natural drugs as treatment of diseases. In this regard the herbs should also be investigated for their pharmacological properties, safety concerns and efficacy too. In the present investigation, we have believed medicine and inhibiting potential effects of extract of C. auriculata was investigated for the hepatoprotective activity. This study facilitated to rediscover the new ancient medication for the treatment of liver diseases. The plant C.auriculata  showed very good activity in terms of the hepatoprotective nature against the liver injury by chornic use of drugs which is due to the anti-inflammatory properties added to the antioxidant activity of the herbs. These were to prevent the CCl4 induced free radicals and damage. The formation of cellular damage and free radicals was inhibited. The data that we procured from the investigation shows that the antioxidant activity of the plant in both extracts of plant helped for the activity. It may contain large amounts of the phenols and flavonoids that showed free radial scavenging activity which might be responsible for the hepatoprotective activity also. 

Sign in / Sign up

Export Citation Format

Share Document