scholarly journals Spontaneous angina bullosa hemorrhagica of tongue: An unusual problem following prosthodontic procedure

2017 ◽  
Vol 29 (2) ◽  
Author(s):  
Suresh Kumar Sachdeva ◽  
Ashwani Sachdeva ◽  
Swati Saggar Sachdeva ◽  
Ashok Galav
Keyword(s):  
Topical Therapy ◽  
Upper Airway ◽  
Lateral Border ◽  
Spicy Food ◽  
Secondary Infections ◽  
Systemic Disorder ◽  
Uncommon Condition ◽  
Management Method ◽  
High Level ◽  
Unusual Problem

Introduction: Angina Bullosa Hemorrhagica (ABH) is the term used to describe benign subepitilial oral mucosal blood filled blisters, which are not attributed to any systemic disorder. It is a very uncommon condition, mostly seen in elderly patients. The exact etiopathogenesis of the ABH is not known. Herewith, we present a case of 50-year-old male patient who developed ABH on right lateral border of the tongue, following prosthodontics impression making for completely edentulous mouth. Methods: The case management method was topical application of chlorhexidine gel (1%) and lignocaine gel (2%) with avoidance of hot and spicy food. Result and discussion: After one week in treating with topical therapy, the lesion became normal.  The diagnosis of ABH is difficult in patients because of its asymptomatic nature. The early diagnosis of the lesion is very important as a rapidly expanding blood-filled bulla in the oropharynx can cause upper airway obstruction. Therefore, a high level of suspicion is warranted on part of dentists who may the first to encounter the lesion.  Conclusion: Spontaneous Angina Bullosa Hemorrhagica of tongue was an unusual problem that can occur following prosthodontic procedure. The management of the lession were intended to reduce pain or discomfort and prevent secondary infections.

1. Fatal Acute Hepatitis in Infectious Mononucleosis in a Forensic Setting

2005 ◽  
Vol 45 (3) ◽  
pp. 261-264 ◽  
Author(s):  
Anny Sauvageau ◽  
Stéphanie Racette
Keyword(s):  
Acute Hepatitis ◽  
Infectious Mononucleosis ◽  
Splenic Rupture ◽  
Upper Airway ◽  
Neurological Complications ◽  
Bleeding Complications ◽  
Respiratory Obstruction ◽  
First Case ◽  
Secondary Infections ◽  
Forensic Setting

Mononucleosis is generally considered a benign, self-limited disease. However, though uncommon, fatal complications are sometimes encountered. Deaths from liver failure, splenic rupture, respiratory obstruction, neurological complications, secondary infections and bleeding complications have been described. In the forensic setting, there are a few reports of sudden and unexplained deaths from splenic rupture and upper airway obstruction. We report here the first case of sudden and unexplained death from acute hepatitis in infectious mononucleosis presenting as a suspicious death.

scholarly journals A business intelligence software made in Romania: A solution for Romanian companies during the economic crisis

2014 ◽  
Vol 11 (2) ◽  
pp. 809-823
Author(s):  
Eduard Edelhauser ◽  
Andreea Ionică
Keyword(s):  
Economic Crisis ◽  
Business Intelligence ◽  
Daily Life ◽  
Current Period ◽  
Computer Based ◽  
Management Method ◽  
High Level ◽  
Made In

The paper focuses on a modern prospective of IT&C sector. The methodology used is both quantitative and qualitative, and the results were obtained with the use of a questionnaire. Our purpose was to demonstrate some hypothesis concerning the size of the organization, the management method and the IT&C based decision. The study is limited to the SIVECO companies portfolio and has a high level of originality, such a study has been never conducted before for computer based advanced management methods implementation. The present interest of the approach consists in the powerful impact IT&C technologies have upon the development of nowadays organizations as well as upon the daily life of each individual; nevertheless, one should not ignore the special condition Romanian economy and especially Romanian society as a whole is confronted with during the current period.

scholarly journals Ectropion and Conjunctival Mass in a Patient with Primary Bilateral Conjunctival Amyloidosis

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Alessandro Meduri ◽  
Miguel Rechichi ◽  
Cosimo Mazzotta ◽  
Sergio Zaccharia Scalinci ◽  
Mahmoud O. Jaroudi
Keyword(s):  
Systemic Disease ◽  
Lower Eyelid ◽  
The Body ◽  
Clinical Presentations ◽  
Histopathologic Evaluation ◽  
Clinical Consequences ◽  
Systemic Disorder ◽  
Uncommon Condition ◽  
Work Up ◽  
Conjunctival Lesion

Background. Amyloidosis is a group of disorders characterized by deposition of an extracellular protein, known as amyloid, in an abnormal fibrillar form with highly characteristic histopathologic staining properties. The clinical presentation can vary from a focal, localized lesion where amyloidosis has minor clinical consequences to extensive systemic disease that can involve any organ system of the body. Ocular amyloidosis can occur as a localized lesion or as a part of a systemic disorder. Conjunctival amyloidosis is an uncommon condition that is rarely associated with systemic disease. It may be a manifestation of an immunologic disorder. Case Report. We report the case of a patient with bilateral conjunctival amyloidosis who was referred to us with the suspicion of a malignant conjunctival lesion. Examination of both eyes showed a yellow-pink mass with prominent intrinsic vessels, subconjunctival hemorrhage, and ectropion of the left lower eyelid. Diagnosis of primary localized conjunctival amyloidosis was made based on histopathologic evaluation of incisional biopsy and negative systemic work-up. Conclusion. Ocular amyloidosis is a rare disease that is slowly progressive and has a wide variety of clinical presentations. Consequently, the clinical diagnosis is often overlooked or delayed. Definitive diagnosis is achieved through histopathologic evaluation of biopsy specimen.

scholarly journals Kisspeptin-10 inhibits OHSS by suppressing VEGF secretion

Reproduction ◽  
2017 ◽  
Vol 154 (4) ◽  
pp. 355-362 ◽  
Author(s):  
Junyu Zhai ◽  
Jiansheng Liu ◽  
Shigang Zhao ◽  
Han Zhao ◽  
Zi-Jiang Chen ◽  
...  
Keyword(s):  
Lung Tissue ◽  
Granulosa Cells ◽  
Umbilical Vein ◽  
Vascular Endothelial ◽  
Rat Models ◽  
Systemic Disorder ◽  
Main Regulator ◽  
Umbilical Vein Endothelial Cells ◽  
High Level ◽  
Endothelial Growth Factor

The aim of the present study was to elucidate the effects of kisspeptin-10 (Kp-10) on ovarian hyperstimulation syndrome (OHSS) and its related mechanism in OHSS rat models, human umbilical vein endothelial cells (HUVECs) and human luteinized granulosa cells. OHSS is a systemic disorder with high vascular permeability (VP) and ovarian enlargement. KISS1R (KISS1 receptor) is the specific receptor of kisspeptin. The kisspeptin/KISS1R system inhibits the expression of vascular endothelial growth factor (VEGF), which is the main regulator of VP. In our study, decreased expression of Kiss1r was observed in both ovaries and lung tissue of OHSS rats. Injection of exogenous Kp-10 inhibited the increase of VP and VEGF while promoting the expression of Kiss1r in both the ovarian and lung tissue of OHSS rats. Using HUVECs, we revealed that a high level of 17-β estradiol (E2), a feature of OHSS, suppressed the expression of KISS1R and increased VEGF and nitric oxide (NO) through estrogen receptors (ESR2). Furthermore, KISS1R mRNA also decreased in the luteinized human granulosa cells of high-risk OHSS patients, and was consistent with the results in rat models and HUVECs. In conclusion, Kp-10 prevents the increased VP of OHSS by the activation of KISS1R and the inhibition of VEGF.

Role of respiratory control mechanisms in the pathogenesis of obstructive sleep disorders

2008 ◽  
Vol 105 (5) ◽  
pp. 1389-1405 ◽  
Author(s):  
Magdy Younes
Keyword(s):  
Sleep Disorders ◽  
Present Report ◽  
Sleep Onset ◽  
Respiratory Control ◽  
Upper Airway ◽  
Maximum Flow ◽  
Control Mechanisms ◽  
Arousal Threshold ◽  
Obstructive Sleep ◽  
High Level

Obstructive sleep disorders develop when the normal reduction in pharyngeal dilator activity at sleep onset occurs in an individual whose pharynx requires a relatively high level of dilator activity to remain sufficiently open. They range from steady snoring, to slowly evolving hypopneas, to fast-recurring obstructive hypopneas and apneas. A fundamental observation is that the polysomnographic picture differs substantially among subjects with the same pharyngeal collapsibility, and even in the same subject at different times, indicating that the type and severity of the disorder is determined to a large extent by the individual's response to the obstruction. The present report reviews the various mechanisms involved in the response to sleep-induced obstructive events. When the obstructive event takes the form of mild-moderate flow limitation, compensation can take place through an increase in the fraction of time spent in inspiration (Ti/Ttot) without any increase in maximum flow (V̇MAX). With more severe obstructions, V̇MAX must increase. Recent data indicate that the obstructed upper airway can reopen reflexly, without arousal, if chemical drive is allowed to reach a threshold (TER) but that this is often preempted by a low arousal threshold. The relation between TER and arousal threshold, as well as the lung-to-carotid circulation time and the rate of rise of chemical drive during the obstructive event, determine the magnitude of ventilatory overshoot at the end of an event and, by extension, whether initial obstructive events will be followed by stable breathing, slow evolving hypopneas with occasional arousals, or repetitive events.

Topical Therapy for Peristomal Pyoderma Gangrenosum

2004 ◽  
Vol 8 (4) ◽  
pp. 220-223 ◽  
Author(s):  
Hanne Nybaek ◽  
A. G. Olsen ◽  
T. Karlsmark ◽  
G. B. E. Jemec
Keyword(s):  
Pyoderma Gangrenosum ◽  
Topical Treatment ◽  
Topical Therapy ◽  
Significant Proportion ◽  
Case Series ◽  
Base Plate ◽  
Randomized Controlled ◽  
Uncommon Disease ◽  
Uncommon Condition ◽  
Stoma Care

Background: Pyoderma gangrenosum (PG) is an uncommon condition. Literature on the management of peristomal PG (PPG) is sparse. In the absence of randomized controlled trials the reporting of case series is potentially helpful to the management of this uncommon disease. Objective: In this study we report our experience with topical corticosteroid therapy for 14 consecutive cases of PPG. Methods: A clinical diagnosis PPG was made by a trained dermatologist using the appropriate investigations where necessary. Results: The majority of the cases presented were managed with simple topical corticosteroids, occasionally in combination with a change of dressing. In 8/14 (57%) cases ulcer resolution was achieved within 3 months with topical treatment alone or topical treatment plus a change of dressing to a silicone-based product applied directly to the wound under the normal base plate of the stoma bag. Conclusion: Our experience suggests that a significant proportion of PPG can be managed by topical treatment alone. The simple topical treatment allows the patient to continue use of stoma care products while minimizing the potential for side effects.

scholarly journals The prospects of finding new treatments for acne

2021 ◽  
pp. 42-47
Author(s):  
A. V. Kryzhanovska ◽  
I. Y. Sidko ◽  
V. M. Shkarupa ◽  
A. O. Dudar ◽  
S. M. Gorbatyuk
Keyword(s):  
Antimicrobial Agents ◽  
Topical Therapy ◽  
Effective Means ◽  
Antagonistic Effect ◽  
Diffusion Method ◽  
Bacteriological Study ◽  
Number Of Microorganisms ◽  
High Level ◽  
New Treatments ◽  
Staphylococcus Spp

An important role in the development of acne is played by the activity of the skin microflora (namely the bacteria Propionibacterum acnes) and members of the genus Staphylococcus. In the schemes of complex treatment of patients with this disease, antibiotics from among macrolides or lincosamides are mainly used. It is of interest to study the current state of susceptibility of staphylococci and propionic bacteria to these drugs, as well as to other antimicrobial agents in order to determine the prospects for expanding the arsenal of methods for treating acne. The aim of the study was to study the susceptibility of microorganisms involved in the development of acne to antimicrobials and antagonistic effects of probiotic strains of lactobacilli. We conducted a bacteriological study of the content of rash elements in 60 patients with acne. The biological characteristics of 40 strains of Staphylococcus spp. and 15 strains of Propionibacterum acnes isolated and researched. The sensitivity of microorganisms to antibiotics and antiseptics was determined by the disco-diffusion method and the method of serial double dilutions of drugs in a liquid nutrient medium. Determination of the sensitivity of acne pathogens to the antagonistic effect of lactobacilli was performed by the method of two-layer agar by reducing the number of microorganisms. The results of the study made it possible to establish that the isolated strains of bacteria show a low level of sensitivity to antimicrobials, which in medical practice are most often used for topical therapy of acne. Only 17.5 % of isolated staphylococcal strains were sensitive to erythromycin, only 45.0 % of strains of this species were sensitive to clindamycin. Strains of Propionibacterum acnes showed a higher level of sensitivity to antibiotics than staphylococci. However, the established indicators do not allow to consider highly effective means for treatment of acne on their basis. At the same time, a high level of sensitivity of acne pathogens to antiseptic drugs decamethoxine and Aeroplysinin 1 and antagonistic effect of Lactobacillus acidophilus was established. Thus, the strains of Propionibacterum acnes and Staphylococcus spp., involved in the development of acne, are characterized by high levels of resistance to erythromycin, clindamycin, chloramphenicol, benzoyl peroxide, which are now the basis of the arsenal of topical therapy for patients with this disease. There is a need to find new effective drugs for the etiotropic therapy of acne.

scholarly journals 217 PROFIL PIODERMA PADA ANAK DI POLIKLINIK KULIT DAN KELAMINRSUP PROF. DR. R. D. KANDOU MANADO PERIODE JANUARI-DESEMBER 2012

e-CliniC ◽  
2015 ◽  
Vol 3 (1) ◽  
Author(s):  
Caren C.a Pangow ◽  
Herry E. J. Pandaleke ◽  
Renate T. Kandou
Keyword(s):  
Nutritional Status ◽  
Skin Infection ◽  
Skin Diseases ◽  
Topical Therapy ◽  
Secondary Data ◽  
Infected Group ◽  
Number Of Patients ◽  
High Level ◽  
Infectious Skin Diseases ◽  
Systemic Antibiotics

Abstract: Pyoderma is a skin infection caused byeither or both of staphylococcus and streptococcus bacteria. This infectious skin diseases are still the main problem of high level morbidity cases in children, especially indeveloping countries with topical climate including Indonesia. This study’s goal to gain pyoderma patients profile in children at the dermatovenereology clinic of Prof. Dr R. D. Kandou General Hospital Manado during the period from January - December 2012. This is a retrospectivedescriptive study from the secondary data of pyoderma’spatient in children, based on the number of patients, sex, age, diagnose, nutritional status, and therapy. The results showed that of pyoderma’s cases in children during January - Decemberwas fifty three cases (16,51%). The distribution based on sex mostly on female (56,6%), based on age infected group mostly on 1-4 years old (43,4%). The majortypes of pyoderma isimpetigo (58,5%). The distributionbased on nutritional status mostly on well-nourished (64,7%). There were thirty fivepatients (66%) givensystemic antibiotic with topical therapy.The most systemic antibiotics therapy used was erythromycin (62,2%), and the most topical therapy used was fusidic acid (34 %).Keywords: pyoderma, childrenAbstrak: Pioderma adalah infeksi kulit yang disebabkan oleh kuman staphylococcus, streptococcus atau keduanya.Penyakit infeksi kulit masih merupakan masalah utama penyebab tingginya angka morbiditas pada anak-anak terutama di negara-negara berkembang dan wilayah beriklim tropis, termasuk di Indonesia.Tujuan penelitian ini untuk mengetahui profil pasien pioderma pada anak di Poliklinik Kulit dan Kelamin RSUP Prof. Dr. R. D. Kandou Manado periode Januari 2012 – Desember 2012. Penelitian ini merupakan penelitian deskriptif retrospektif dari data sekunder pasien pioderma anak (umur 0-14 tahun) berdasarkan jumlah pasien, umur, jenis kelamin, diagnosis, status gizi, dan terapi. Hasil penelitian menunjukkan bahwa pioderma pada anak periode januari – desember 2012 sebanyak 53 kasus (16,51%). Distribusi menurut jenis kelamin terbanyak pada perempuan (35,6 %) dan menurut umur terbanyak adalah kelompok umur 1-4 tahun (43,4%). Jenis pioderma terbanyak adalah impetigo (58,5%). Distribusi menurut status gizi terbanyak adalah bergizi baik (64,7%). Sebanyak 35 pasien (66%) diberikan terapi antibiotik sistemik dengan topikal. Terapi antibiotik sistemik terbanyak yang digunakan adalah eritromisin (62,2%), dan topikal yang paling sering digunakan adalah asam fusidat (34%).Kata kunci: pioderma, anak

Ethical Decision Making: Coding and Compliance Dilemmas for Speech-Language Pathologists

2019 ◽  
Vol 4 (6) ◽  
pp. 1289-1297
Author(s):  
Dee Adams Nikjeh
Keyword(s):  
Decision Making ◽  
Health Care Professionals ◽  
Ethical Decision ◽  
Ethical Decision Making ◽  
Upper Airway ◽  
Speech Language Pathologists ◽  
Business Operations ◽  
Insurance Reimbursement ◽  
Language Pathology ◽  
High Level

Purpose Speech-language pathologists (SLPs) are nationally credentialed health care professionals with the responsibility to conduct clinical activities and business operations ethically, legally, and with a high level of integrity. What are the ethical and legal responsibilities of being a credentialed professional? This clinical focus article provides an overview of relevant federal laws that govern waste, abuse, and fraudulent billing behaviors and highlights some of the American Speech-Language-Hearing Association's professional policies that characterize speech-language pathology practice standards, govern professional integrity, and guide ethical decision making. The American Speech-Language-Hearing Association's 2018 document, Issues in Ethics: Misrepresentation of Services for Insurance Reimbursement, Funding, or Private Payment , will be applied to professional coding and compliance dilemmas unique to SLPs who provide and bill for behavioral and qualitative evaluations, instrumental assessments, and therapeutic intervention for individuals with voice and upper airway disorders. Conclusion Every practicing SLP has the professional and ethical responsibility to seek the latest information on payment systems, coding changes, and reimbursement updates regardless of practice setting or the population served.

scholarly journals Feasibility Assessment of Parathyroid Hormone Adsorption by Using Polysaccharide-Based Multilayer Film Systems

Polymers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 2070
Author(s):  
Ruey-Shin Juang ◽  
Xing Su ◽  
I-Chi Lee
Keyword(s):  
Parathyroid Hormone ◽  
Multilayer Film ◽  
Blood Compatibility ◽  
Surface Hydrophobicity ◽  
Multilayer Films ◽  
Feasibility Assessment ◽  
Hemolysis Test ◽  
Systemic Disorder ◽  
Good Biocompatibility ◽  
High Level

Chronic kidney disease (CKD) is a systemic disorder that combines complex bone and mineral abnormalities. The high level of parathyroid hormone (PTH) in the blood causes irreversible renal dysfunction and cardiovascular disease. Therefore, it is necessary to reduce level of PTH in the blood of patients with uremic state. In this study, chitosan and heparin were chosen to form polysaccharide-based multilayer films based on their antibacterial ability, good biocompatibility and hemocompatibility. In addition, a previous study has revealed that PTH is a heparin/polyanion binding protein because of the similarity of heparin to the cell surface proteoglycans. Subsequently, the surface properties including thickness, surface hydrophobicity and surface charge of a series of multilayer films were analyzed. The PTH adsorption rate of a series of multilayer films was also assessed. The results revealed that the optimizing condition is (CHI/HEP)2.5 and 60 min in both PBS only and PBS with the addition of bovine serum albumin, which demonstrated the specific adsorption of PTH on the materials. Furthermore, the hemolysis test also revealed that (CHI/HEP)2.5 shows good blood compatibility. It is considered that polysaccharide-based multilayer films may provide an alternative for the surface modification of hemodialysis membranes and equipment.

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