scholarly journals INTERVENTION EFFECT OF FOLIC ACID AND VITAMIN B12 ON VASCULAR COGNITIVE IMPAIRMENT COMPLICATED WITH HYPERHOMOCYSTEINEMIA / EFEKAT INTERVENCIJE FOLNOM KISELINOM I VITAMINOM B12 NA VASKULARNI KOGNITIVNI POREMEĆAJ KOMPLIKOVAN HIPERHOMOCISTEINEMIJOM

2013 ◽  
Vol 33 (2) ◽  
pp. 169-174 ◽  
Author(s):  
Bo Jiang ◽  
Chengyun Ding ◽  
Guoen Yao ◽  
Cunshan Yao ◽  
Yunyan Zhang ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Folic Acid ◽  
Cognitive Function ◽  
Intervention Group ◽  
Vascular Cognitive Impairment ◽  
Event Related Potential ◽  
Control Group ◽  
Before And After ◽  
And Control ◽  
Cognitive Impairment No Dementia

Summary Background: Hyperhomocysteinemia (HHcy) may be corre- lated with cognitive function. Although intervention with folic acid and VitB12 can decrease the homocysteine (Hey) level, its effect on cognitive function remains uncertain. This prospective study aimed to explore the effects of folic acid and VitB/!2 on the ^су an<^ cognitive function in patients with vascular cognitive impairment-no dementia (VCIND) complicated with HHcy. Methods: A total of 120 patients with VCIND complicated fcy HHcy were randomly selected. They were divided into inter- vention and control groups. The intervention group was given 5 mg of folic acid per day and 500 цд of VitB^ thrice per day apart from conventional therapy. Folic acid, V'itBl2, and Hey were determined and Montreal cognitive assess- ment (MoCA) and event-related potential P300 determination were performed before and after treatment. Results: Before treatment, no significant differences in the folic acid, VitB^, Hey, MoCA, and P300 parameters were observed between the groups. After treatment, the folic acid and VitBl2 levels increased and the Hey level decreased in the intervention group compared with that before treatment and in the control group. At 24 weeks, the MoCA score and P300 outcomes in the intervention group improved com- pared with those before treatment and in the control group. Conclusions: Folic acid and VitB^ effectively decrease the Hey level in VCIND patients and improve their cognitive functions.

scholarly journals The Effect of Brain Game on Cognitive Function in Stroke Patients

2021 ◽  
Vol 9 (1) ◽  
pp. 61
Author(s):  
Novi Malisa ◽  
Yuke Kirana
Keyword(s):  
Cognitive Function ◽  
Intervention Group ◽  
Nursing Intervention ◽  
Potential Effect ◽  
Control Group ◽  
Stroke Patients ◽  
Before And After ◽  
Placebo Intervention ◽  
And Control ◽  
Cognitive Problems

The decline in cognitive function has been a disorder frequently experienced by stroke patients. The present studyaimed to determine the effect of android-based brain games on cognitive function in stroke patients. Brain games inthis study are designed using an exploratory approach to various cognitive function domains that are damaged. Thequasi experiment using two groups pretest and posttest design involved 15 individuals for each group recruited froma hospital in West Java through purposive sampling with a sample calculation formula using a paired numericalanalytical research formula. The intervention group received an android-based brain games three times a week forone month, the control group received placebo intervention (mentioning colors of different words) three times aweek for one month. The FACT-Cog Version 3 questionnaire utilized as the measuring instrument. Measurementswere taken every week after the intervention for one month. The results indicated that there was a signifcant changein cognitive function scores before and after the intervention in the intervention group (p = 0.000). Meanwhile,in the control group there is no signifcant change (p = 0.164). Moreover, the results of cognitive function scoreanalysis after intervention between the intervention and control group exhibit a signifcant difference (p = 0.000).The brain game intervention has a signifcant effect on cognitive function after the third treatment in the frst week(p <0.05). Also, the results exhibit the potential effect of brain games on the cognitive function level of strokepatients. Some of the things that make the intervention in this study effective in improving cognitive functionare that the respondents included in this study are only those who have a score greater than or equal to 46, whichmay be different when applied to patients with lower scores. In addition, the intervention was carried out onrespondents who had experienced a stroke for the frst time and may be different if applied to people who have hadseveral strokes. Therefore, it is important to expand the criteria for respondents in further research. Furthermore,this can be used as an option of the nursing intervention to manage cognitive problems among stroke patients.

scholarly journals Protocol for thiamine and folic acid in the treatment of cognitive impairment in maintenance haemodialysis patients: a prospective, randomised, placebo-controlled, double-blind, multicentre study

BMJ Open ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. e050605
Author(s):  
Renhua Lu ◽  
Le-Yi Gu ◽  
Weiming Zhang ◽  
Yongping Guo ◽  
Xiujuan Zang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cognitive Impairment ◽  
Folic Acid ◽  
Cognitive Function ◽  
Treatment Group ◽  
Control Group ◽  
Double Blind ◽  
Maintenance Haemodialysis ◽  
Secondary Endpoints ◽  
And Control

IntroductionCognitive impairment (CI) is the common complications in maintenance haemodialysis (MHD) patients. Recently, the pathogenesis of CI has been discussed and oxidative stress is one of the main mechanisms in these patients. Thiamine and folic acid, which play an important role in relieving the production of reactive oxygen species, reducing homocysteine levels, improving oxidative stress in the nervous system. In pilot study, cognitive function was significantly improved in the group with thiamine and folic supplementation. Based on this result, we hypothesise that thiamine combined with folic acid supplementation may improve cognitive function in patients with MHD.Methods and analysisIn this prospective, randomised, placebo-controlled, double-blind, multicentre study, we will enrol patients undergoing haemodialysis who has the Montreal Cognitive Assessment score lower than 26 to treatment group (thiamine 90 mg/day combined with folic acid 30 mg/day) or control group (thiamine placebo 90 mg/day combined with folic acid placebo 30 mg/day). All subjects will be followed up for 96 weeks. The primary endpoint is the comparison of Alzheimer’s Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) score between treatment group and control group at 96 weeks of follow-up. The secondary endpoints include serum thiamine, folate, homocysteine levels, cranial functional MRI and survival. The central randomisation method will be adopted and the principles of placebo-controlled, double-blind randomised control will be followed. The comparisons among ADAS-Cog scores and other secondary endpoints over time within subjects is conducted by using repeated measure analysis of variance (ANOVA) or generalised estimating equations (GEE). Pairwise t-test with Bonferroni adjustment is performed for multiple comparisons. On the other hand, for comparisons between treatment and control group, simple one-way ANOVA, GEE or Wilcoxon rank sum test is used. The χ2 method is used for statistical analysis of the categorical data. Kaplan-Meier survival curve is used for survival analysis. A p<0.05 is considered statistically significant difference.Ethics and disseminationThis trial has been approved by Shanghai Jiao Tong University School of Medicine, Renji Hospital Ethics Committee (KY2019-199). After publication of study results, trial report will be published in peer-reviewed journals and/or in national or international conferences.Trial registration numberChiCTR2000029297.

scholarly journals Toe Clearance Rehabilitative Slippers for Older Adults With Fall Risk: A Randomized Controlled Trial

2021 ◽  
Vol 12 ◽  
pp. 215145932110291
Author(s):  
Atsuko Satoh ◽  
Yukoh Kudoh ◽  
Sangun Lee ◽  
Masumi Saitoh ◽  
Miwa Miura ◽  
...  
Keyword(s):  
Older Adults ◽  
Fall Risk ◽  
Controlled Trial ◽  
Intervention Group ◽  
Berg Balance Scale ◽  
Control Group ◽  
Mobility Assessment ◽  
Before And After ◽  
Day Services ◽  
And Control

Introduction: To evaluate fall-prevention rehabilitative slippers for use by self-caring, independent older adults. Materials and Methods: This assessor-blinded, randomized, and controlled 1-year study included 59 self-caring, independent participants (49 women) who attended day services. The mean age of participants was 84.0 ± 5.3 years. Participants were randomly selected from 8 nursing homes. We tested slippers top-weighted with a lead bead (200, 300, or 400 g). Intervention group participants walked while wearing the slippers for 10-20 min, 1-3 days/week at the day service center. Fall risk was measured using the Berg Balance Scale and the Tinetti Performance-Oriented Mobility Assessment (POMA) before and at 3-month intervals after the intervention/control phase. Results: After 12 months, the intervention group demonstrated significant improvement. Berg Balance and POMA compared to the control group ( p < .05 p < .01, respectively). Mobility scores improved significantly for both measurements in the intervention group before and after ( p < .01), but the control group had significantly lower scores. Discussion: Overall, falls decreased in the intervention group from 10 to 7, and control group falls increased from 9 to 16 ( p = .02). No adverse events related to the intervention were reported. Conclusions: Rehabilitation training slippers may reduce falls in older adults.

The effectiveness of emotional freedom techniques (EFT) on depression of postmenopausal women: a randomized controlled trial

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Asieh Mehdipour ◽  
Parvin Abedi ◽  
Somayeh Ansari ◽  
Maryam Dastoorpoor
Keyword(s):  
Randomized Controlled Trial ◽  
Postmenopausal Women ◽  
Controlled Trial ◽  
Intervention Group ◽  
Control Group ◽  
Randomized Controlled ◽  
Moderate Depression ◽  
Before And After ◽  
The Mean ◽  
And Control

Abstract Objectives Postmenopausal women are at greater risk of depression. Depression may negatively affect the quality of life of women. An emotional freedom technique (EFT) is an evidence-based therapy combining cognitive and exposure components with acupressure. This study aimed to evaluate the effect of EFT on depression in postmenopausal women. Methods This was a randomized controlled trial in which 88 women with mild to moderate depression recruited from a menopausal clinic in Ahvaz, Iran, and randomly assigned into two groups of EFT (n=44) and control for sham therapy (n=44). Women in the EFT group received two sessions of training and asked to continue EFT for 8 weeks, one time per day. The Beck Depression Inventory (BDI2) completed by women before and after the intervention. The control group received training on sham acupressure points similar to the intervention group. Data collected using a demographic and BDI2. Women requested to complete the BDI2 before and after the intervention. The independent t-test, chi-square, and ANCOVA were used to analyze data. Results The mean depression score in the intervention group reduced from 20.93 ± 4.6 to 10.96 ± 4.38 in comparison to the control group that reduced from 19.18 ± 2.79 to 17.01 ± 6.05 after intervention (p=0.001). After the 8 week intervention, the frequency of moderate depression decreased from 56.8 to 9.35% in the intervention and from 50 to 29.5% in the control group. In total, 63.4 and 34.15% in the intervention and control groups were free of depression respectively after the intervention (p<0.001). Conclusions The results of this study showed that using EFT for 8 weeks could significantly reduce the mean score of depression in postmenopausal women. Using this method in public health centers for postmenopausal women is recommended.

scholarly journals A Pilot Study on Controlling Coronavirus Disease 2019 (COVID-19) Inflammation Using Melatonin Supplement

2021 ◽  
Author(s):  
Zahra Alizadeh ◽  
Nastaran Keyhanian ◽  
Sara Ghaderkhani ◽  
Simin Dashti-Khavidaki ◽  
Raheleh Shokouhi Shoormasti ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Intervention Group ◽  
Control Group ◽  
Low Light ◽  
Reactive Protein ◽  
Significant Difference ◽  
Before And After ◽  
And Control ◽  
To Receive ◽  
Chest Ct Scan

No effective antiviral drugs and vaccines are available for the treatment of patients with severe coronavirus 2019 (COVID-19). Therefore, available, safe, and inexpensive drugs and supplements such as melatonin are among the proposed options for controlling inflammation. We did a randomized, single-blind study in Imam Khomeini Hospital between June 30, 2020, and August 5, 2020. Mild to moderate COVID-19 patients aged 25-65 years were eligible to enter the study based on chest CT scan, clinical symptoms, and physician diagnosis. The intervention group was prescribed 6 mg of oral melatonin for 2 weeks, which consumed half an hour before bedtime every night in low light conditions. Clinical symptoms and C-reactive protein (CRP) were measured before and after treatment in the melatonin received and control (regular medications) groups. Among screened patients with COVID-19, 14 patients were assigned to receive melatonin, and 17 patients were considered as controls. A significant difference (p=0.005) between CRP 1 and CRP 2 levels (before and after using melatonin) was found in the melatonin group while this difference (p=0.069) was not significant in the control group. Also, the percentage of recovery (based on symptoms) in patients who took melatonin was higher than that of patients in the control group (85.7% VS 47.1%).  The result of this study confirmed the effectiveness of melatonin in mild to moderate outpatients with COVID-19. More clinical trials on elderly, diabetic, obese patients and severe cases are suggested in future studies.   

scholarly journals OPTIMALISASI POSISI JANIN MELALUI PRENATAL YOGA TERHADAP OUTPUT PERSALINAN DI PUSKESMAS WILAYAH KOTA CIREBON

2020 ◽  
Vol 8 (3) ◽  
pp. 396
Author(s):  
Nurasih Nurasih ◽  
Endang Nurrochmi
Keyword(s):  
Intervention Group ◽  
T Test ◽  
Control Group ◽  
P Value ◽  
Test Results ◽  
Chi Square ◽  
Control Group Design ◽  
Before And After ◽  
Chi Square Test ◽  
And Control

In Indonesia, Yoga is currently one of the most popular sports, not only for the general public but also for pregnant women. Many benefits can be obtained from prenatal yoga including the mother feeling comfortable and relaxed throughout pregnancy and during childbirth, training the pelvic floor muscles and perineum, keeping the body's muscles relaxed, balanced during childbirth, reducing stress, increasing and improving oxygen circulation to the body and fetus. . This study aims to determine the effect of prenatal yoga on optimizing fetal position on third trimester Primigravida maternal delivery output at Puskesmas Cirebon City. This research is a quasi-experimental research pre post control group design and only post control group design with T test and Chi Square test. Paired T Test results of the intervention group (mean difference = 3.111, P value = 0.000, control group (mean difference = 0.833, P value = 0.318). Independent T Test results obtained (average difference = -1.944, P value = 0.024), Chi Square test obtained a value of P = 0.73. There is a difference in the average anxiety before and after the intervention in the intervention group, there is no difference in average anxiety before and after the intervention in the control group. There is a difference in the average anxiety between the intervention and control groups. There is a difference in mean Long I stage between the intervention and control groups There was no effect of prenatal yoga on the type of labor.

scholarly journals Implementation of Coaching on Nursing Motivation and Workplace for Nurses to Reduce Burnout

2019 ◽  
Vol 2 (2) ◽  
pp. 84-93
Author(s):  
Florentina Dhiana Sri Setyohariyati ◽  
Emiliana Tarigan ◽  
Havids Aima
Keyword(s):  
Work Experience ◽  
Quantitative Methods ◽  
Intervention Group ◽  
Control Group ◽  
Before And After ◽  
Coaching Training ◽  
Quasi Experimental ◽  
Implementation Of Coaching ◽  
And Control ◽  
Conflict Of Value

Introduction. Burnout is a symptom that is often experienced by nurses, especially in the operating room, intensive unit and emergency room. Burnout is characterized by fatigue of heavy workloads, lack of control and appreciation, unfair treatment as employees, lack of social support at work, and conflict of value values that cause Emotional Exhausting, Depersonalization, Personal Accreditation. Coaching implementation by mentors to the implementing nurses is expected to reduce burnout. Methods. This study aims to analyze the description of the differences and influence of coaching implementation by mentor to the executor nurse burnout at Siloam Hospitals Group. Research uses quantitative methods with quasi experimental designs, pretest-posttest control group and causal research. The sample in the study was chosen by consecutve sampling in all respondents included in the inclusion criteria. The sample in this study amounted to 117 nurses, who were divided into 2 groups ie inetrvensi group with 88 respondents and control group with 29 respondents. Coaching implementation is given within 12 weeks with the frequency of meetings 3-4 times. Results. The results of this study showed that there was a decrease in burnout before and after intervention with paired t test in the intervention group and control group, with value (p = 0.002). Conclusion. The results of the intervention analysis on the implementation of coaching training simultaneously have an effect on motivation, workplace, age, gender, education and work experience simultaneously with a contribution of F 3,316 with a significance number of 0.005 <0.05. This study recommends the need for further research.

scholarly journals Pengaruh kompres hangat terhadap nyeri leher pada penderita hipertensi esensial di wilayah Puskesmas Depok I, Sleman Yogyakarta

2019 ◽  
Vol 8 (1) ◽  
Author(s):  
Siti Fadlilah
Keyword(s):  
Essential Hypertension ◽  
Neck Pain ◽  
Intervention Group ◽  
Control Group ◽  
P Value ◽  
Control Group Design ◽  
Before And After ◽  
Post Test ◽  
Headache Pain ◽  
And Control

Hypertension is increased blood pressure in the artery. Signs and indication arise from this disease are a dizzy, headache, pain in the nape of the neck (neck pain), easily angered, and hard to breathe. This neck pain can offend essential hypertension in daily patient activities. One of the non-pharmacological actions to decrease or overcome the neck pain is by a warm compress. The warm compress is giving a sense of warm/heat in a certain area. This research is purposed to find out the influence of warm compress towards neck pain in essential hypertension patients. This research is carried out in Puskesmas Depok I area, Sleman, Yogyakarta. Type of this research is quasi-experiment with pre-test post-test with control group design. Several samples consist of 40 respondents and divided into two groups, which are 20 respondents of the intervention group and 20 respondents of the control group. Statistic test used in this research is Wilcoxon and Mann Whitney tests. Before applying pre-test, 12 respondents (60%) are having moderate pain, and after giving warm compress (post-test), 17 respondents (75%) are having minor pain. There is a significant scale of neck pain before and after the warm compress treatment (p-value = 0,003) as well as contrast scale of neck pain between intervention group and control group (p-value = 0,000). There is the influence of warm compress towards neck pain in essential hypertension patients in Puskesmas Depok I area, Sleman, Yogyakarta.

The Effect of Relaxation Technique (Jacobsen and Benson) on Depression, Anxiety, and Stress in Patients with Multiple Sclerosis

2021 ◽  
Vol 16 (3) ◽  
pp. 213-219
Author(s):  
Ali Akbari ◽  
Forouzan Ahmadi ◽  
Ebrahim Jalili ◽  
Salman Khazaei
Keyword(s):  
Multiple Sclerosis ◽  
Intervention Group ◽  
Routine Care ◽  
Relaxation Technique ◽  
Control Group ◽  
Central Nervous System Depression ◽  
Before And After ◽  
Neurology Clinic ◽  
The Central Nervous System ◽  
And Control

Background: Multiple sclerosis (MS) is a chronic disease that affects the central nervous system. Depression, anxiety and stress are the most common psychiatric comorbidities in MS, which can have adverse consequences. The aim of this study was to determine the effect of relaxation (Jacobson and Benson) technique on depression, anxiety and stress in MS patients. Methods: This clinical trial was conducted since December 2016 to March 2017 in the Multiple Sclerosis Association and the Neurology Clinic of Farshchian Hospital (Sina) in Hamadan. Sixty patients with multiple sclerosis were randomly assigned to two experimental (n=30) and control (n=30) groups. The control group received routine care and experimental group received the relaxation technique (Jacobson and Benson) in 8 sessions of 60-minute twice a week for 4 weeks in addition to receiving routine care. The DASS-21 scale was completed by samples before and after the intervention. Results: Results of the study showed that in the intervention group, the scores of depression, anxiety and stress after using relaxation (Jacobson and Benson) was decreased significantly (P<0.05), while in the control group no significant decrease was observed (P<0.05). Conclusion: The results of this study showed that relaxation (Jacobson and Benson) is effective in reducing depression, anxiety and stress in patients with multiple sclerosis. Therefore, in addition to prescribing medication, it is suggested that complementary therapies be performed for these patients.

Palliating oncologists: A pilot study on primary palliative care development in hematology-oncology trainee outpatient clinics.

2014 ◽  
Vol 32 (31_suppl) ◽  
pp. 21-21
Author(s):  
Erin R. Alesi ◽  
Sherri Rauenzahn ◽  
Laurel Lyckholm
Keyword(s):  
Palliative Care ◽  
Intervention Group ◽  
Symptom Burden ◽  
Symptom Assessment ◽  
Comfort Level ◽  
Control Group ◽  
Before And After ◽  
And Control ◽  
Short Answer Questions

21 Background: Primary Palliative Care (PPC) denotes basic PC competencies; whereas secondary PC (SPC) denotes consultant expertise. PPC competency includes basic symptom assessment/management; fundamental communication skills; and identification of patients for SPC. ASCO recommends early concurrent PC in advanced cancer/high symptom burden as it improves quality of life, symptom management, and care satisfaction. Because PC need exceeds availability of SPC providers, PPC proficiency by oncologists is essential. To enhance Hematology-Oncology (HO) fellows’ clinical experience through more effective PC training/utilization, we piloted an integrated fellows’ pre-clinic conference. Methods: HO fellows’ pre-clinic conferences were divided into intervention and control groups. Over 8 weeks, the PC fellow participated in interdisciplinary discussion for 2 weekly 1-hour conferences. The PC fellow provided PPC education via brief formal and informal didactics and identified patients for SPC referral. All HO fellows were surveyed before and after the intervention to assess comfort level with PPC and SPC referral. The survey used Likert-type scales and short-answer questions. Results: All HO fellows (N=10) voluntarily participated: 6 in the intervention group (IG), and 4 in the control group (CG). The IG demonstrated clearly enhanced comfort level with managing symptoms by improving in 100% of PPC categories after the intervention compared to 27% in the CG. Referral to SPC also increased in the IG, while it decreased in the CG. All HO fellows in the IG liked the PC integration, wanted to continue it, and wanted SPC availability in their future practice. Conclusions: This integration not only enhanced HO fellows’ PPC training and increased referral to SPC; it also fostered a partnership between HO and PC providers early in their careers. Such collaborative efforts are likely to improve long-term comprehensive cancer care as well as patient and provider satisfaction. Further study is merited and should include multiple centers and patient evaluations.

Sign in / Sign up

Export Citation Format

Share Document