Myofascial Tissue and Depression

Background The myofascial system plays a fundamental role in the mechanics of the body, in body tension regulation and the etiology of pathological states like chronic pain. Moreover, it contains contractile elements and preliminary evidence suggests that its properties are linked to psychological factors. The aim of the present research was to investigate characteristics of the myofascial tissue in patients with Major Depressive Disorder (MDD) and to examine whether the state of the myofascial tissue causally affects pathopsychological processes in MDD. Methods In Study 1, stiffness and elasticity of the myofascial tissue of 40 inpatients suffering from MDD measured with a tissue compliance meter were compared with those of 40 matched never-depressed participants. In Study 2, 69 MDD patients were randomly assigned to single-session self-myofascial release intervention (SMRI) or a placebo intervention. Effects on memory bias and affect were investigated. Results Results showed that MDD patients displayed heightened stiffness and reduced elasticity of the myofascial tissue and that patients in the SMRI group showed a reduced negative memory bias and more positive affect compared to patients in the placebo condition. Conclusions The preliminary results of our studies indicate that the myofascial tissue might be part of a dysfunctional body-mind dynamic that maintains MDD.

Allergic Rhinitis Improvement in Asthmatic Children After Using Acaricidal Bait: A Randomized, Double-Blind, Cross-Placebo Study

Objective: This study aimed to evaluate the effects of acaricidal bait use on the house dust mite (HDM) allergen concentration and occurrence of allergic rhinitis (AR) and asthma symptoms in children sensitized to HDMs.Study Design: Sixty-six children (3–12 years old) with AR and asthma sensitized to HDMs were randomly assigned to receive an acaricidal bait intervention for 8 weeks and a placebo intervention for 8 weeks separated by a 4-week washout period. The visual analog scale (VAS) score, rhinitis control assessment test (RCAT) score, rhinoconjunctivitis quality of life questionnaire (RQLQ) score, asthma control questionnaire-5 (ACQ-5) score and HDM allergen levels were monitored.Results: HDM allergen levels were significantly decreased after 8 weeks (Δder p2+f2 2.282 (3.516) μg/g vs. 0.147 (0.25) μg/g, P < 0.05) in the acaricidal bait group compared with the placebo group. The VAS, RCAT and RQLQ scores in the acaricidal bait group were also significantly improved (ΔVAS 7.5 (16) vs. 3 (18), P < 0.05; ΔRCAT−3 (5) vs. 0 (7), P < 0.05; ΔRQLQ 4.5 (8) vs. 1 (8), P < 0.05), but the ACQ-5 score did not improve (ΔACQ-5 0.2 (0.4) vs. 0 (0.65), P > 0.05).Conclusion: Acaricidal bait reduced HDM exposure and improved rhinitis symptoms. This trial is registered at www.chictr.org.cn.

A study of intradermotherapy with needles in facial rejuvenation

Background: Intradermotherapy is considered a minimally invasive procedure, which works through applications of diluted pharmacological drugs, resulting in facial rejuvenation. Methods: 18 women were divided equally into two groups and evaluated before and after treatment (at 45 and 90 days). Four applications were made to the facial region at 15-day intervals; for group 1, traditional injections were given to introduce the anti-ageing substance, and, for group 2, a placebo intervention (0.9% saline application) was given. Results: In the analysis of the group 1 photos, greater filling of the nasogenian groove was observed after two sessions, and the presence of less deep wrinkles in the perioral area was also observed after four treatment sessions. Subjects in both groups complained of pain during the application, even with the use of anaesthetic. Most of the volunteers in group 1 said that the texture of the skin seemed much firmer and classified the therapy as an ‘excellent treatment’. Conclusion: Intradermotherapy shows favourable results in the treatment of facial rejuvenation in women, which is more evident 90 days after the initial application.

Relaxation Effects of Aromatherapy Intervention on Female and Male Anxiety: A Randomized Control Trial

Background: The control or reduction of anxiety before surgery is one of the most important components of preoperative care. The question is whether anxiety differs in male and female candidates for surgery. Objectives: The current study aimed to evaluate the effect of aromatherapy with Citrus aurantium on anxiety in men and women candidates for surgery. Methods: This single-blind randomized clinical trial was performed on 60 patients and controlled by placebo. The patients were divided into 30 subjects in the control group and 30 subjects in the aromatherapy group (inhaling C. aurantium essential oil). The patients completed the Spielberger state-trait anxiety inventory before and after the intervention. After collecting information, the questionnaire information was analyzed using SPSS software (version 16). Results: After aromatherapy, 20% of men had mild state and trait anxiety. Moreover, 80% of men had relatively mild state and trait anxiety. In the group of women, 20% of the cases had mild state and trait anxiety. Furthermore, 73.3% of women had relatively mild state and trait anxiety. Additionally, 6.7% of women had relatively severe anxiety. Anxiety reduced after the intervention among men and women (P < 0.001). In addition, the severity of anxiety among women in the control group increased after placebo intervention (P < 0.05). Moreover, the effect of C. aurantium aroma was further observed in women than men; however, there was no statistically significant difference (P > 0.05). Conclusions: The results of this study indicated that inhaling the C. aurantium aroma reduces anxiety in patients. Aromatherapy also has the potential to be replaced by chemical drugs due to fewer side effects and risks, and cost-effectiveness.

L-DOPA enhances hippocampal direction signals in younger and older adults

Previous studies indicate a role of dopamine in hippocampus-dependent spatial navigation. Although neural representations of direction are an important aspect of spatial cognition, it is not well understood whether dopamine directly affects these representations, or only impacts other aspects of spatial brain function. Moreover, both dopamine and spatial cognition decline sharply during age, raising the question which effect dopamine has on directional signals in the brain of older adults. To investigate these questions, we used a double-blind cross-over L-DOPA/Placebo intervention design in which 43 younger and 37 older adults navigated in a virtual spatial environment while undergoing functional magnetic resonance imaging (fMRI). We studied the effect of L-DOPA, a DA precursor, on fMRI activation patterns that encode spatial walking directions that have previously been shown to lose specificity with age. This was done in predefined regions of interest, including the early visual cortex, retrosplenial cortex, and hippocampus. Classification of brain activation patterns associated with different walking directions was improved in the hippocampus and the retrosplenial cortex following L-DOPA administration. This suggests that DA enhances the specificity of neural representations of walking direction in these areas. In the hippocampus these results were found in both age groups, while in the RSC they were only observed in younger adults. Taken together, our study provides evidence for a mechanistic link between DA and the specificity of neural responses during spatial navigation.Significance StatementThe sense of direction is an important aspect of spatial navigation, and neural representations of direction can be found throughout a large network of space-related brain regions. But what influences how well these representations track someone’s true direction? Using a double-blind cross-over L-DOPA/Placebo intervention design, we find causal evidence that the neurotransmitter dopamine impacts the fidelity of direction selective neural representations in the human hippocampus and retrosplenial cortex. Interestingly, the effect of L-DOPA was either equally present or even smaller in older adults, despite the well-known age related decline of dopamine. These results provide novel insights into how dopamine shapes the neural representations that underlie spatial navigation.

An overview of the comparison of inhalation aromatherapy on emotional distress of female and male patients in preoperative period

Objectives Many patients experience anxiety and stress before surgery. Anxiety is also different in men and women so that the prevalence of anxiety disorders in women is higher than men. The present study aimed to compare the effect of inhalation aromatherapy on emotional distress of men and women before surgery. Methods This study conducted as a randomized, single blind, placebo-controlled, prospective and clinical trial. It was performed in hospitals affiliated to Shiraz University of Medical Sciences. 90 patients were selected as candidates for surgery and were divided into two intervention groups and one control group. Patients completed the State-Trait Anxiety Inventory questionnaire before the intervention. Patients completed the State-Trait Anxiety Inventory questionnaire (STAI) after 20 min of intervention. Then the data were analyzed using SPSS software, version 16. The significance level in all testes was set at <0.05. Results Relatively severe anxiety was not observed in men after intervention with lavender and spring orange. In women, relatively severe anxiety was not observed after the intervention with lavender, but in the spring orange group, only in 6.7% of people, relatively severe anxiety and traits were observed, which has decreased compared to before the intervention. In addition, the severity of anxiety in women in the control group increased after placebo intervention (p<0.05). Conclusions The results showed that inhalation of Citrus aurantium and lavender aroma reduces anxiety in male and female patients.

Personal Metaphors as Motivational Resources: Boosting Anticipated Incentives and Feelings of Vitality Through a Personal Motto-Goal

Motto-goals describe a desired mind-set and provide a person with a guiding principle of how to approach a personal goal or obligation (e.g., with the inner strength of a bear I am forging ahead). We propose that motto-goals can be conceptionalized as individually created metaphors and that the figurative, metaphorical language and the characteristics of the formation process make them effective in changing the perception of unpleasant personal obligations as more inherently enjoyable and raise vitality levels. To test whether a newly devised minimalistic motto-goal intervention can make goal striving more attractive (stronger anticipation of activity related incentives) and energize goal-oriented action (increase vitality) in relation to an unpleasant obligation, two experimental studies were conducted. In Study 1 the motto-goal condition led to stronger anticipation of activity related incentives and vitality compared to a distraction task. The effect on vitality was partially mediated by a change in feelings of autonomy. Study 2 replicated the effects compared to a placebo intervention and further found motto-goals to be specifically effective in increasing the anticipation of activity related incentives as opposed to outcome related incentives. The results support that applying motto-goals built with a newly developed minimalist motto-goal intervention can influence the subjective experience of individuals faced with a previously unpleasant obligation.

The Effect of Brain Game on Cognitive Function in Stroke Patients

The decline in cognitive function has been a disorder frequently experienced by stroke patients. The present studyaimed to determine the effect of android-based brain games on cognitive function in stroke patients. Brain games inthis study are designed using an exploratory approach to various cognitive function domains that are damaged. Thequasi experiment using two groups pretest and posttest design involved 15 individuals for each group recruited froma hospital in West Java through purposive sampling with a sample calculation formula using a paired numericalanalytical research formula. The intervention group received an android-based brain games three times a week forone month, the control group received placebo intervention (mentioning colors of different words) three times aweek for one month. The FACT-Cog Version 3 questionnaire utilized as the measuring instrument. Measurementswere taken every week after the intervention for one month. The results indicated that there was a signifcant changein cognitive function scores before and after the intervention in the intervention group (p = 0.000). Meanwhile,in the control group there is no signifcant change (p = 0.164). Moreover, the results of cognitive function scoreanalysis after intervention between the intervention and control group exhibit a signifcant difference (p = 0.000).The brain game intervention has a signifcant effect on cognitive function after the third treatment in the frst week(p <0.05). Also, the results exhibit the potential effect of brain games on the cognitive function level of strokepatients. Some of the things that make the intervention in this study effective in improving cognitive functionare that the respondents included in this study are only those who have a score greater than or equal to 46, whichmay be different when applied to patients with lower scores. In addition, the intervention was carried out onrespondents who had experienced a stroke for the frst time and may be different if applied to people who have hadseveral strokes. Therefore, it is important to expand the criteria for respondents in further research. Furthermore,this can be used as an option of the nursing intervention to manage cognitive problems among stroke patients.

Super Placebos: A Feasibility Study Combining Contextual Factors to Promote Placebo Effects

Background: Ample evidence demonstrates that placebo effects are modulated by contextual factors. Few interventions, however, attempt to combine a broad range of these factors. Here, we explore the therapeutic power of placebos by leveraging factors including social proof, positive suggestion, and social learning. This study aimed to test the feasibility of an elaborate “super placebo” intervention to reduce symptoms of various disorders in a pediatric population.Methods: In a single-arm qualitative study, participants entered an inactive MRI scanner which they were told could help their brain heal itself through the power of suggestion. The sample included 11 children (6–13 years old) diagnosed with disorders known to be receptive to placebos and suggestion (Attention Deficit Hyperactivity Disorder, Tourette Syndrome, chronic skin picking, and migraines). The children were given positive suggestions during 2–4 placebo machine sessions over the span of approximately 1 month. We assessed open-ended treatment outcomes via recorded interviews and home visits.Results: The procedure was feasible and no adverse events occurred. Ten of the 11 parents reported improvements in their children after the intervention, ranging from minor transient changes to long-term reductions in subjective and objective symptoms (e.g., migraines and skin lesions).Discussion: These preliminary findings demonstrate the feasibility and promise of combining a broad range of contextual factors in placebo studies. Future research is needed to assess the causal effects of such interventions.

A single session with a roller massager improves hamstring flexibility in healthy athletes: a randomized placebo-controlled crossover study

Purpose The aim of this randomized placebo-controlled crossover study was to compare the acute effect on young athletes of a single session of roller massager (RM) with that obtained from passive static stretching (PSS) and a placebo intervention (PL) on hamstring flexibility and on strength. Methods Twenty-nine (23 male, 6 female) young athletes completed the study. Maximal voluntary contraction (MVC) and two-leg sit-and-reach test were performed before and immediately after PL, PSS and RM on three different days. Results Results showed that all three interventions increased the flexibility of the hamstring muscles compared to the pre-test measurements (Wilcoxon signed-rank test, p < 0.05). Only the RM intervention was significantly higher than the PL intervention (sham ultrasound). Stretching intervention was not significantly different from either of the other two interventions. None of the three interventions significantly changed the muscle strength in the short term. Conclusions RM can be considered as an effective alternative to stretching to increase the flexibility of the hamstring. This could be meaningful when stretching is contraindicated or evokes pain.