scholarly journals Perbaikan Penanganan Pascapanen Asparagus (Asparagus officinalis) dari Petani di Kecamatan Petang hingga Pengecer di Denpasar

2019 ◽  
Vol 7 (4) ◽  
pp. 521
Author(s):  
Luh Gede Arista Pradnyani ◽  
Bambang Admadi Harsojuwono ◽  
I Wayan Gede Sedana Yoga
Keyword(s):  
Asparagus Officinalis ◽  
First Line ◽  
Distribution Lines ◽  
Postharvest Handling ◽  
Postharvest Loss ◽  
The Impact

The aim of this study were to determine the number of asparagus distribution lines and types of distribution, find out the impact of postharvest handling and to determine the impact of improvements postharvest on asparagus damage from farmers in Petang district to retailers in Denpasar. Postharvest improvements in this study by replacing the packaging using styrofoam box and placing the asparagus vertically. There are three lines in the distribution of asparagus. The first line (Farmers ? Cooperative ? Suppliers ? Retailer ? Consumer), line II (Farmer ? Middleman ? Suppliers ? Retailer ? Consumer) and line III (Farmer ? Middleman ? Suppliers ? Consumer). Postharvest handling includes harvesting, cleaning, cutting, sorting, grading, binding, storage, packaging, distribution and displaying. The impact of handling postharvest loss in the sorting stage at the farmers level is 2.5% (non significant), cooperative level is 1.8% (non significant), middleman level is 4% (insignificant), supplier level is 5.4% (significant) and retailers level is 6.69% (significant). Postharvest improvement by changing the packaging could reduce the level defect of asparagus to 7.81%.  Keywords: asparagus, styrofoam packaging, CSAM, postharvest handling, improvements

scholarly journals APLIKASI COMMODITY SYSTEM ASSESSMENT METHOD (CSAM) PADA PENANGANAN PASCAPANEN BAWANG MERAH (Allium ascalonicum L.) DARI PETANI DI KECAMATAN KINTAMANI SAMPAI DENPASAR

2018 ◽  
Vol 6 (3) ◽  
pp. 234
Author(s):  
I Putu Gede Angga Dian Pratama ◽  
Bambang Admadi ◽  
Sri Mulyani
Keyword(s):  
Research Method ◽  
Survey Instrument ◽  
Assessment Method ◽  
Survey Method ◽  
Farm Level ◽  
Postharvest Handling ◽  
System Assessment ◽  
Postharvest Loss ◽  
The Impact ◽  
And Storage

This research were aimed to 1) find out amount and kind of red onion (Allium Ascalonicum L.) distribution lines from farmers in Kintamani District Bangli regency area until Denpasar city, 2) to identify what factors are identified in the red onion (Allium Ascalonicum L.)  handler in Kintamani sub-district of Bangli Regency, and 3) know the impact of post-harvest handling when the distribution of red onion (Allium Ascalonicum L.)  loss from farmers in Bangli District Kintamani District. The research method used is survey method, with CSAM (Commodity System Assessment Method) application and using survey instrument in the form of questionnaires distributed to farmers, pegepul, merchants and red onion retailers in Kintamani sub-district to Denpasar. The were four distributions lines of  red onion (Allium Ascalonicum L.) handler from farmer at Kintamani District, namely line Line I (Farmer?retailer), Line II (Farme?collector?retailer), Line III (Farme?collector?retailer), and lines IV (Farme?collector?traders?retailer). Identification Postharvest handling factors at the farm level include cleaning and sorting. At the collecting level include transportation and storage, at the merchant level includes cleaning, sorting and transport, and at the retailer level includes cleaning, sorting and display. Impact on Postharvest loss on the farmers level is at the sorting reaches 6% (significant). At the sorter level the collector reaches 5%, at the sorter seller level reaches 5%, and at the sorter retailer level reaches 6% (significant). Keywords : CSAM application, onion, aplication

scholarly journals Smallholder Farmer Perceptions of Postharvest Loss and Its Determinants in Fijian Tomato Value Chains

Horticulturae ◽  
2019 ◽  
Vol 5 (4) ◽  
pp. 74
Author(s):  
Salesh Kumar ◽  
Steven J. R. Underhill
Keyword(s):  
Decision Making ◽  
Value Chain ◽  
Direct Determination ◽  
Sub Saharan Africa ◽  
Value Chains ◽  
Smallholder Farmer ◽  
Postharvest Handling ◽  
Postharvest Loss ◽  
On Farm ◽  
The Impact

The Fiji Islands, like many small Pacific island nations, are thought to incur high rates of postharvest loss. Little work has been undertaken to quantify the amount of loss within Pacific horticultural value chains, or identify the key determinants. This study sought to quantify postharvest loss within Fijian smallholder tomato value chains and to examine the relative importance of current on-farm practices as possible contributors to this loss. A semi-structured survey of 115 smallholder tomato farmers in Sigatoka Valley and eastern Viti Levu was undertaken, covering socio-economic and demographic parameters, production and postharvest handling practice, and postharvest loss based on farmer recall. On-farm postharvest loss for smallholder farmer tomato value chains was between 26.1% in Sigatoka Valley and 27.6% in eastern Viti Levu. This finding was consistent with quantification of postharvest loss in Fijian tomato chains by direct determination, but is relatively high when compared to smallholder tomato value chain loss in Sub-Saharan Africa. When Fijian tomato value chains were segregated according to specific postharvest handling practice, the contributors to postharvest loss were often associated with on-farm decision-making. Those value chains that only harvested once a week, or in the early morning (before 7 am) or mid-day onwards, stored harvest product in the field for more than three hours, did not sort or grade prior to on-farm ripening, or used packing sheds that had relatively open designs, all had consistently higher levels of postharvest loss. The prevalence of specific postharvest handling practice in both locations is further reported. While this study highlights the impact of current on-farm postharvest handling practices on tomato value chain loss, what remain unclear are the underlying drivers associated with current postharvest handling behaviour and the decision-making that shapes quality and logistic control activities.

scholarly journals JALUR DISTRIBUSI DAN UPAYA PERBAIKAN PASCAPANEN BUNGA POTONG KRISAN (Dendrathema grandiflora) DARI PETANI DESA PANCASARI BULELENG SAMPAI PENGECER

2018 ◽  
Vol 6 (4) ◽  
pp. 288
Author(s):  
Yohana Putri Lumbantoruan ◽  
Bambang Admadi Harsojuwono ◽  
Sri Mulyani
Keyword(s):  
Assessment Method ◽  
Sodium Metabisulfite ◽  
Snowball Sampling ◽  
Cut Flowers ◽  
Flower Stalk ◽  
Level 3 ◽  
Postharvest Handling ◽  
System Assessment ◽  
Postharvest Loss ◽  
The Impact

The purpose of this study was 1) to determine the number of chrysanthemum distribution lines and distribution types from farmers in Pancasari to retailers, 2) to find out the system, people, and the impact of chrysanthemum postharvest handling in distribution from farmers in Pancasari to retailers, 3) to determine the impact of improvements postharvest on chrysanthemum damage from farmers in Pancasari to retailers with soaking treatment using sodium metabisulfite solution. The method used is the snowball sampling method in the form of surveys and interviews with the Commodity System Assessment Method (CSAM) application using a questionnaire. Treatment of postharvest repair by soaking the flower stalk in sodium metabisulfite solution. There are two lines in the distribution, lane I (Farmers ? Wholesalers ? Retailer ? Consumer) and lane II (Farmers ? Retailer ? Consumer). Postharvest handling includes harvesting, sorting, binding, wrapping, soaking, storing, packaging, distributing, and displaying. Impact of handling postharvest loss in the sorting stage at the farm level 2% (insignificant), wholesaler level 3% (insignificant), and retailer level 8% (significant) Post-harvest improvement can prolong the duration of freshness of flowers.Using water, chrysanthemum cut flowers can last 2.38 days, using sodium metabisulfite can last 6.25 days. Keywords : Chrysanthemum, sodium metabisulfite, CSAM, postharvest improvements.

Test of Mediation and Moderation between Employee Empathy and Customers’ Advocacy

2020 ◽  
Author(s):  
Sajjad Ahmad Afridi ◽  
Asad Shahjehan ◽  
Maqsood Haider ◽  
Dr Uzma Munawar
Keyword(s):  
Factor Analysis ◽  
Customer Loyalty ◽  
Service Sector ◽  
Mediating Effect ◽  
First Line ◽  
Private Hospitals ◽  
Proposed Model ◽  
Confirmatory Factor ◽  
The Impact ◽  
Significant Moderator

This study examined the impact of employee empathy on customers’ advocacy directly and indirectly through customers’ loyalty. Moreover, the interacting effect of customers’ trust was verified between the association of customers’ loyalty and advocacy. The attributes of the proposed model were examined in the context of first line employee and patients’ interactions. A total of 220 responses were collected for analysis from the private hospitals of Peshawar. The model fitness was confirmed through confirmatory factor analysis and hypotheses were examined. Findings confirmed the positive and significant impact of employee empathy on customers’ advocacy. Further, the mediating effect was examined and found that loyalty partially mediates employee empathy and customers’ advocacy. Additionally, trust was found a significant moderator between the association of customer loyalty and advocacy. Furthermore, findings revealed that trust based loyalty significantly and positively mediates employee empathy and customers’ advocacy. Findings of the present study provide understanding for the service sector, particularly in healthcare, to enhance customers’ loyalty, advocacy, and trust through service employee’s empathic aptitude. Keywords: Employee empathy, Service Eco-system, Customers’ Loyalty, Customers’ Advocacy, Trust-Based Loyalty, Healthcare, S-D Logic

Individuality and Beyond

2019 ◽  
Author(s):  
Benedetta Zavatta
Keyword(s):  
Moral Autonomy ◽  
First Line ◽  
Philosophical Interpretation ◽  
Individual Personality ◽  
The World ◽  
Regulative Ideal ◽  
Personal Library ◽  
The Many ◽  
The Individual ◽  
The Impact

Based on an analysis of the marginal markings and annotations Nietzsche made to the works of Emerson in his personal library, the book offers a philosophical interpretation of the impact on Nietzsche’s thought of his reading of these works, a reading that began when he was a schoolboy and extended to the final years of his conscious life. The many ideas and sources of inspiration that Nietzsche drew from Emerson can be organized in terms of two main lines of thought. The first line leads in the direction of the development of the individual personality, that is, the achievement of critical thinking, moral autonomy, and original self-expression. The second line of thought is the overcoming of individuality: that is to say, the need to transcend one’s own individual—and thus by definition limited—view of the world by continually confronting and engaging with visions different from one’s own and by putting into question and debating one’s own values and certainties. The image of the strong personality that Nietzsche forms thanks to his reading of Emerson ultimately takes on the appearance of a nomadic subject who is continually passing out of themselves—that is to say, abandoning their own positions and convictions—so as to undergo a constant process of evolution. In other words, the formation of the individual personality takes on the form of a regulative ideal: a goal that can never be said to have been definitively and once and for all attained.

scholarly journals Review of Treatment Options for the Management of Advanced Stage Hodgkin Lymphoma

Cancers ◽  
2021 ◽  
Vol 13 (15) ◽  
pp. 3745
Author(s):  
Hélène Vellemans ◽  
Marc P. E. André
Keyword(s):  
Hodgkin Lymphoma ◽  
New Drugs ◽  
Western World ◽  
Tumor Control ◽  
Advanced Stage ◽  
Line Treatment ◽  
First Line ◽  
Remission Rates ◽  
The Impact ◽  
First Line Treatment

Hodgkin lymphoma (HL) is a lymphoid-type hematologic disease that is derived from B cells. The incidence of this lymphoid malignancy is around 2–3/100,000/year in the western world. Long-term remission rates are linked to a risk-adapted approach, which allows remission rates higher than 80%. The first-line treatment for advanced stage classical HL (cHL) widely used today is doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) or escalated bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone (BEACOPPesc) chemotherapy. Randomized studies comparing these two regimens and a recently performed meta-analysis have demonstrated consistently better disease control with BEACOPPesc. However, this treatment is not the standard of care, as there is an excess of acute hematological toxicities and therapy-related myeloid neoplasms. Moreover, there is a recurrent controversy concerning the impact on overall survival with this regimen. More recently, new drugs such as brentuximab vedotin and checkpoint inhibitors have become available and have been evaluated in combination with doxorubicin, vinblastine, and dacarbazine (AVD) for the first-line treatment of patients with advanced cHL with the objective of tumor control improvement. There are still major debates with respect to first-line treatment of advanced cHL. The use of positron emission tomography-adapted strategies has allowed a reduction in the toxicity of chemotherapy regimens. Incorporation of new drugs into the treatment algorithms requires confirmation.

scholarly journals Differential influence of antibiotic therapy and other medications on oncological outcomes of patients with non-small cell lung cancer treated with first-line pembrolizumab versus cytotoxic chemotherapy

2021 ◽  
Vol 9 (4) ◽  
pp. e002421
Author(s):  
Alessio Cortellini ◽  
Massimo Di Maio ◽  
Olga Nigro ◽  
Alessandro Leonetti ◽  
Diego L Cortinovis ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Objective Response ◽  
Multivariable Analysis ◽  
Small Cell ◽  
Small Cell Lung ◽  
First Line ◽  
Metastatic Nsclc ◽  
The Impact

BackgroundSome concomitant medications including antibiotics (ATB) have been reproducibly associated with worse survival following immune checkpoint inhibitors (ICIs) in unselected patients with non-small cell lung cancer (NSCLC) (according to programmed death-ligand 1 (PD-L1) expression and treatment line). Whether such relationship is causative or associative is matter of debate.MethodsWe present the outcomes analysis according to concomitant baseline medications (prior to ICI initiation) with putative immune-modulatory effects in a large cohort of patients with metastatic NSCLC with a PD-L1 expression ≥50%, receiving first-line pembrolizumab monotherapy. We also evaluated a control cohort of patients with metastatic NSCLC treated with first-line chemotherapy. The interaction between key medications and therapeutic modality (pembrolizumab vs chemotherapy) was validated in pooled multivariable analyses.Results950 and 595 patients were included in the pembrolizumab and chemotherapy cohorts, respectively. Corticosteroid and proton pump inhibitor (PPI) therapy but not ATB therapy was associated with poorer performance status at baseline in both the cohorts. No association with clinical outcomes was found according to baseline statin, aspirin, β-blocker and metformin within the pembrolizumab cohort. On the multivariable analysis, ATB emerged as a strong predictor of worse overall survival (OS) (HR=1.42 (95% CI 1.13 to 1.79); p=0.0024), and progression free survival (PFS) (HR=1.29 (95% CI 1.04 to 1.59); p=0.0192) in the pembrolizumab but not in the chemotherapy cohort. Corticosteroids were associated with shorter PFS (HR=1.69 (95% CI 1.42 to 2.03); p<0.0001), and OS (HR=1.93 (95% CI 1.59 to 2.35); p<0.0001) following pembrolizumab, and shorter PFS (HR=1.30 (95% CI 1.08 to 1.56), p=0.0046) and OS (HR=1.58 (95% CI 1.29 to 1.94), p<0.0001), following chemotherapy. PPIs were associated with worse OS (HR=1.49 (95% CI 1.26 to 1.77); p<0.0001) with pembrolizumab and shorter OS (HR=1.12 (95% CI 1.02 to 1.24), p=0.0139), with chemotherapy. At the pooled analysis, there was a statistically significant interaction with treatment (pembrolizumab vs chemotherapy) for corticosteroids (p=0.0020) and PPIs (p=0.0460) with respect to OS, for corticosteroids (p<0.0001), ATB (p=0.0290), and PPIs (p=0.0487) with respect to PFS, and only corticosteroids (p=0.0033) with respect to objective response rate.ConclusionIn this study, we validate the significant negative impact of ATB on pembrolizumab monotherapy but not chemotherapy outcomes in NSCLC, producing further evidence about their underlying immune-modulatory effect. Even though the magnitude of the impact of corticosteroids and PPIs is significantly different across the cohorts, their effects might be driven by adverse disease features.

scholarly journals Disease-associated DNA methylation signatures in esophageal biopsies of children diagnosed with Eosinophilic Esophagitis

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Caterina Strisciuglio ◽  
Felicity Payne ◽  
Komal Nayak ◽  
Marialuisa Andreozzi ◽  
Alessandra Vitale ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Eosinophilic Esophagitis ◽  
Field Potential ◽  
Line Treatment ◽  
Food Impaction ◽  
First Line ◽  
Genome Wide ◽  
Epigenetic Signatures ◽  
The Impact ◽  
First Line Treatment

AbstractEosinophilic esophagitis (EoE) is a leading cause of dysphagia and food impaction in children and adults. The diagnosis relies on histological examination of esophageal mucosal biopsies and requires the presence of > 15 eosinophils per high-powered field. Potential pitfalls include the impact of biopsy sectioning as well as regional variations of eosinophil density. We performed genome-wide DNA methylation analyses on 30 esophageal biopsies obtained from children diagnosed with EoE (n = 7) and matched controls (n = 13) at the time of diagnosis as well as following first-line treatment. Analyses revealed striking disease-associated differences in mucosal DNA methylation profiles in children diagnosed with EoE, highlighting the potential for these epigenetic signatures to be developed into clinically applicable biomarkers.

Incorporation of plasma-based next-generation sequencing to improve guideline-concordant molecular testing in patients with newly diagnosed metastatic nonsquamous non-small cell lung cancer.

2021 ◽  
Vol 39 (28_suppl) ◽  
pp. 14-14
Author(s):  
Charu Aggarwal ◽  
Melina Elpi Marmarelis ◽  
Wei-Ting Hwang ◽  
Dylan G. Scholes ◽  
Aditi Puri Singh ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Practice Change ◽  
Molecular Testing ◽  
Tier 2 ◽  
Newly Diagnosed ◽  
Next Generation ◽  
First Line ◽  
Tier 1 ◽  
Tier 3 ◽  
The Impact

14 Background: Current NCCN guidelines recommend comprehensive molecular profiling for all newly diagnosed patients with metastatic non-squamous NSCLC to enable the delivery of personalized medicine. We have previously demonstrated that incorporation of plasma based next-generation gene sequencing (NGS) improves detection of clinically actionable mutations in patients with advanced NSCLC (Aggarwal et al, JAMA Oncology, 2018). To increase rates of comprehensive molecular testing at our institution, we adapted our clinical practice to include concurrent use of plasma (P) and tissue (T) based NGS upon initial diagnosis. P NGS testing was performed using a commercial 74 gene assay. We analyzed the impact of this practice change on guideline concordant molecular testing at our institution. Methods: A retrospective cohort study of patients with newly diagnosed metastatic non-squamous NSCLC following the implementation of this practice change in 12/2018 was performed. Tiers of NCCN guideline concordant testing were defined, Tier 1: complete EGFR, ALK, BRAF, ROS1, MET, RET, NTRK testing, Tier 2: included above, but with incomplete NTRK testing, Tier 3: > 2 genes tested, Tier 4: single gene testing, Tier 5: no testing. Proportion of patients with comprehensive molecular testing by modality (T NGS vs. T+P NGS) were compared using one-sided Fisher’s exact test. Results: Between 01/2019, and 12/2019, 170 patients with newly diagnosed metastatic non-Sq NSCLC were treated at our institution. Overall, 98.2% (167/170) patients underwent molecular testing, Tier 1: n = 100 (59%), Tier 2: n = 39 (23%), Tier 3/4: n = 28 (16.5%), Tier 5: n = 3 (2%). Amongst these patients, 43.1% (72/167) were tested with T NGS alone, 8% (15/167) with P NGS alone, and 47.9% (80/167) with T+P NGS. A higher proportion of patients underwent comprehensive molecular testing (Tiers 1+2) using T+P NGS: 95.7% (79/80) compared to T alone: 62.5% (45/72), p < 0.0005. Prior to the initiation of first line treatment, 72.4% (123/170) patients underwent molecular testing, Tier 1: n = 73 (59%), Tier 2: n = 27 (22%) and Tier 3/4: n = 23 (18%). Amongst these, 39% (48/123) were tested with T NGS alone, 7% (9/123) with P NGS alone and 53.6% (66/123) with T+P NGS. A higher proportion of patients underwent comprehensive molecular testing (Tiers 1+2) using T+P NGS, 100% (66/66) compared to 52% (25/48) with T NGS alone (p < 0.0005). Conclusions: Incorporation of concurrent T+P NGS testing in treatment naïve metastatic non-Sq NSCLC significantly increased the proportion of patients undergoing guideline concordant molecular testing, including prior to initiation of first-line therapy at our institution. Concurrent T+P NGS should be adopted into institutional pathways and routine clinical practice.

Impact of KRAS mutational status on outcomes in patients with pancreatic cancer (PDAC).

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 4142-4142
Author(s):  
Lucy Xiaolu Ma ◽  
Gun Ho Jang ◽  
Amy Zhang ◽  
Robert Edward Denroche ◽  
Anna Dodd ◽  
...  
Keyword(s):  
Proportional Hazards ◽  
Advanced Disease ◽  
Cox Proportional Hazards ◽  
Prognostic Impact ◽  
First Line ◽  
Kras Mutations ◽  
Kaplan Meier ◽  
Mutational Status ◽  
Translational Research Program ◽  
The Impact

4142 Background: KRAS mutations (m) (KRASm) are present in over 90% of pancreatic adenocarcinomas (PDAC) with a predominance of G12 substitutions. KRAS wildtype (WT) PDAC relies on alternate oncogenic drivers, and the prognostic impact of these remains unknown. We evaluated alterations in WT PDAC and explored the impact of specific KRASm and WT status on survival. Methods: WGS and RNAseq were performed on 570 patients (pts) ascertained through our translational research program from 2012-2021, of which 443 were included for overall survival (OS) analyses. This included 176 pts with resected and 267 pts with advanced PDAC enrolled on the COMPASS trial (NCT02750657). The latter cohort underwent biopsies prior to treatment with first line gemcitabine-nab-paclitaxel or mFOLFIRINOX as per physician choice. The Kaplan-Meier and Cox proportional hazards methods were used to estimate OS. Results: KRAS WT PDAC (n = 52) represented 9% of pts, and these cases trended to be younger than pts with KRASm (median age 61 vs 65 years p = 0.1). In resected cases, the most common alterations in WT PDAC (n = 23) included GNASm (n = 6) and BRAFm/fusions (n = 5). In advanced WT PDAC (n = 27), alterations in BRAF (n = 11) and ERBB2/3/4 (n = 6) were most prevalent. Oncogenic fusions (NTRK, NRG1, BRAF/RAF, ROS1, others) were identified in 9 pts. The BRAF in-frame deletion p.486_491del represented the most common single variant in WT PDAC, with organoid profiling revealing sensitivity to both 3rd generation BRAF inhibitors and MEK inhibition. In resected PDAC, multivariable analyses documented higher stage (p = 0.043), lack of adjuvant chemotherapy (p < 0.001), and the KRAS G12D variant (p = 0.004) as poor prognostic variables. In advanced disease, neither WT PDAC nor KRAS specific alleles had an impact on prognosis (median OS WT = 8.5 mths, G12D = 8.2, G12V = 10.0, G12R = 12.0, others = 9.2, p = 0.73); the basal-like RNA subtype conferred inferior OS (p < 0.001). A targeted therapeutic approach following first line chemotherapy was undertaken in 10% of pts with advanced PDAC: MMRd (n = 1), homologous recombination deficiency (HRD) (n = 19), KRASG12C (n = 1), CDK4/6 amplification (n = 3), ERBB family alterations (n = 2), BRAF variants (n = 2). OS in this group was superior (14.7 vs 8.8 mths, p = 0.04), mainly driven by HRD-PDAC where KRASm were present in 89%. Conclusions: In our dataset, KRAS G12D is associated with inferior OS in resected PDAC, however KRAS mutational status was not prognostic in advanced disease. This suggests that improved OS in the WT PDAC population can only be achieved if there is accelerated access to targeted drugs for pts.

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