scholarly journals Solid-pseudopapillary neoplasia of the pancreas (analysis of three cases)

2021 ◽  
Vol 180 (4) ◽  
pp. 41-45
Author(s):  
V. M. Durleshter ◽  
S. R. Heinrich ◽  
D. S. Kirakosyan
Keyword(s):  
Postoperative Complications ◽  
Early Diagnosis ◽  
Tumor Size ◽  
Malignant Tumors ◽  
Clinical Manifestations ◽  
Sufficient Information ◽  
Tumor Patients ◽  
The Past ◽  
Observation Period ◽  
Clinical Cases

The objective was to improve the early diagnosis efficiency of large pseudopapillary tumor of pancreas through the demonstration and analysis of three clinical cases.Methods and materials. In this work, the observation period was two years, in which three cases were diagnosed and treated a large number of pseudopapillary tumors.Results. With sufficient information on the characteristics of this disease, over the past 5 years we have had an opportunity to determine a diagnosis in two patients before the tissue examination.Conclusion. The age of patients, clinical manifestations, tumor size and the age of tumor patients are not reliable criteria for predicting the possibility of malignant tumors. Performing the operation in compliance with the principles of radicalism provide the best opportunity for recovery and reduces the early incidence of postoperative complications.

scholarly journals CLINICAL CASES OF BULLOUS EPIDERMOLYSIS IN NEWBORNS

2020 ◽  
Vol 10 (4(38)) ◽  
pp. 87-91
Author(s):  
O. Rubina ◽  
K. Bertsun ◽  
O. Izyumetsʹ ◽  
R. Gomon ◽  
A. Zadorozhna
Keyword(s):  
Basement Membrane ◽  
Malignant Tumors ◽  
Clinical Manifestations ◽  
Multidisciplinary Care ◽  
Basal Membrane ◽  
Dna Diagnosis ◽  
Optimal Care ◽  
Mucous Membranes ◽  
Genes Encoding ◽  
Clinical Cases

Summary. Hereditary bullous epidermolysis (BE) is a group of genetically and clinically heterogeneous diseases characterized by the formation of blisters and erosion due to injury on the skin and mucous membranes. Different forms of BE can be accompanied by various extracutaneous complications, such as blisters and erosion on the cornea and mucous membranes, stenoses and strictures of the respiratory system, gastrointestinal tract, urinary system, muscular dystrophy, and malignant tumors. Hereditary bullous epidermolysis is divided into three types, depending on the level of blister formation: simple, borderline, and dystrophic. Simple BE is characterized by the stratification of epidermis due to the keratinocyte cytolysis.  Borderline BE means that blisters are formed at the border of the epidermis and dermis due to the splitting of the lamina of the basement membrane (lamina lucida), while dystrophic BE has blisters that are formed under the dense plate of the basement membrane (lamina densa), which exfoliates the dermis. Currently, mutations have been identified in more than 10 genes encoding the structural proteins of keratinocytes and the basal membrane of the skin and mucous membranes. A common feature of these proteins is their involvement in the formation of strong bonds between the epithelium and the basement membrane. The nature of the mutations and their localization determine the severity of the clinical manifestations of BE. Mutation information is a prerequisite for effective medical and genetic counseling, prenatal and preimplantation DNA diagnosis. Therefore diagnosis and prescribing appropriate treatment and follow-up care is an important task for neonatologists and pediatric dermatologists. As manifestations of hereditary BE are numerous, a specialized center is required for optimal care, where multidisciplinary care will be provided (neonatologists, pediatric surgeons, pediatric dermatologists, etc.). The purpose of clinical observation is to pay attention of specialists to this rare disease, and to present 2 clinical cases of bullous epidermolysis in newborns who were admitted to the anesthesiology and intensive care unit of newborns of Vinnytsia Regional Children's Clinical Hospital almost at the same time.

scholarly journals CLINICAL CASE OF MENTAL DISORDERS IN THE DEBUTOF MULTIPLE SCLEROSIS

2017 ◽  
Vol 9 (3) ◽  
pp. 114-120
Author(s):  
S N Zhulev ◽  
A A Toropova ◽  
O N Nemykin ◽  
M V Fomintseva ◽  
Yu O Garyshina ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Mental Disorders ◽  
Early Diagnosis ◽  
Clinical Case ◽  
Clinical Course ◽  
Clinical Manifestations ◽  
Neurologic Deficit ◽  
Appropriate Treatment ◽  
Observation Period

In a course of multiple sclerosis neurologic deficit could be overshadowed by psychotic signs such as catatonia, depression and dementia. Thus, ignoring these clinical manifestations can pre- vent early diagnosis of multiple sclerosis. Subsequently, an appropriate treatment will be delayed. In our article we report a case of multiple sclerisos in patient presented initially with catatonia, depression and dementia. Psychiatric, neurological, MRI picture and treatment impact thoroughly throughout the whole observation period are described. This case illustrates that catatonia can be dominating feature in the clinical course of multiple sclerosis and can overshadow other neurologic signs.

scholarly journals Research Progress of Circulating Tumor Cells in the Evaluation of Early Cholangiocarcinoma

2021 ◽  
Vol 5 (5) ◽  
pp. 41-46
Author(s):  
Quan Zheng ◽  
Ying Xiong ◽  
Jinku Zhang
Keyword(s):  
Early Diagnosis ◽  
Tumor Cell ◽  
Tumor Cells ◽  
Late Stage ◽  
Clinical Manifestations ◽  
Epidemiological Data ◽  
Circulating Tumor Cell ◽  
Research Progress ◽  
Extrahepatic Cholangiocarcinoma ◽  
The Past

Epidemiological data show that the incidence rate of cholangiocarcinoma (CCA) has been increasing over the past 20 years. Due to its concealment of clinical manifestations, most patients are diagnosed with CCA at a late stage. On this premise, this review not only discusses the research progress related to CCA diagnosis, but also focuses on the concept of circulating tumor cell (CTC), its evaluation value, application, and prospects for the early diagnosis of extrahepatic cholangiocarcinoma.

Type V Bekesy Pattern: Interpretation and Clinical Utility

1967 ◽  
Vol 10 (4) ◽  
pp. 733-744 ◽  
Author(s):  
William F. Rintelmann ◽  
Earl R. Harford
Keyword(s):  
Clinical Utility ◽  
The Past ◽  
Type V ◽  
Clinical Cases

Recent studies indicate there is some disagreement concerning the interpretation and clinical utility of the Type V Bekesy pattern. Bekesy tracings obtained over the past six years from a sample of clinical cases were analyzed and a definition was established for the Type V pattern. This definition was applied to Bekesy tracings obtained from normal listeners, hypoacusics, and pseudohypoacusics. The Type V pattern was found frequently among pseudohypoacusics and only rarely among other individuals.

PROSPECTS OF ARTIFICIAL INTELLIGENCE IN CARRYING OUT THE ONCOLOGICAL COMPONENT OF MEDICAL EXAMINATION OF THE POPULATION

2019 ◽  
Vol 65 (2) ◽  
pp. 234-237
Author(s):  
Vyacheslav Cherenkov ◽  
A. Petrov ◽  
I. Gulkov ◽  
A. Kostyukov
Keyword(s):  
Artificial Intelligence ◽  
Early Diagnosis ◽  
Mass Screening ◽  
Malignant Tumors ◽  
Risk Groups ◽  
Modern World ◽  
Pilot Program ◽  
Urgent Problem ◽  
Gender And Age ◽  
Group Version

Diagnosis of malignant tumors is an urgent problem of the modern world. Early diagnosis depends on General practitioners. The doctor should conduct a systematic examination of the patient regularly, taking into account the risk groups, gender and age. With mass screening, signs of dysplasia or an early focus, developing cancer can «slip away» [1]. Optimization of analysis and examination algorithms is required, which is not always possible for one person. Positive application of the digital program with elements of imaging in Oncology, we were able to create such a class of tasks for the preliminary subjective-objective survey of patients in three versions: with a widescreen screen and consoles for patients (group version up to 15 or more patients), interactive (touch) and tablet. The results of the survey are sent through the accepted channels to the doctor with recommendations for further examination, and the patient is given a coupon. The pilot program showed that the system of such robotic technologies in the future can replace the oncologist in its development to artificial intelligence at the stage of the primary link.

Scrub typhus (Orientia tsutsugamushi), A rapidly spreading epidemic in Chennai - A standalone lab experience

2016 ◽  
Vol 5 (09) ◽  
pp. 4896
Author(s):  
Sripriya C.S.* ◽  
Shanthi B. ◽  
Arockia Doss S. ◽  
Antonie Raj I. ◽  
Mohana Priya
Keyword(s):  
Scrub Typhus ◽  
Clinical Symptoms ◽  
Clinical Manifestations ◽  
Febrile Illness ◽  
Orientia Tsutsugamushi ◽  
The Past ◽  
Igm Elisa ◽  
The Mean ◽  
Specific Symptoms ◽  
Symptoms And Signs

Scrub typhus (Orientia tsutsugamushi), is a strict intracellular bacterium which is reported to be a recent threat to parts of southern India. There is re-emergence of scrub typhus during the past few years in Chennai. Scrub typhus is an acute febrile illness which generally causes non-specific symptoms and signs. The clinical manifestations of this disease range from sub-clinical disease to organ failure to fatal disease. This study documents our laboratory experience in diagnosis of scrub typhus in patients with fever and suspected clinical symptoms of scrub typhus infection for a period of two years from April 2014 to April 2016 using immunochromatography and IgM ELISA methods. The study was conducted on 648 patients out of whom 188 patients were found to be positive for scrub typhus. Results also showed that pediatric (0 -12 years) and young adults (20 – 39 years) were more exposed to scrub typhus infection and female patients were more infected compared to male. The study also showed that the rate of infection was higher between September to February which also suggested that the infection rate is proportional to the climatic condition. Statistical analysis showed that the mean age of the patients in this study was 37.6, standard deviation was 18.97, CV % was 50.45. 

Apresentação e Evolução Atípicas da Granulomatose de Wegener: Relato de Caso/Atypical Presentation and Evolution of Wegener's Granulomatosis: Case Report

1970 ◽  
Vol 5 (3) ◽  
pp. 53-67
Author(s):  
Aline Dos Santos ◽  
Ana Caroline Balducci Scafi ◽  
Luciene Azevedo Morais ◽  
Pablo Girardelli Mendonça Mesquita
Keyword(s):  
Renal Failure ◽  
Renal Function ◽  
Case Report ◽  
Chronic Renal Failure ◽  
Early Diagnosis ◽  
Wegener’S Granulomatosis ◽  
Immunosuppressive Treatment ◽  
Clinical Manifestations ◽  
Wegener's Granulomatosis ◽  
Creatinine Concentration

RESUMOIntrodução: A Granulomatose de Wegener (GW) é uma vasculite rara e idiopática associada à presença do anticorpo Anticitoplasma de Neutrófilo (ANCA) que acomete, preferencialmente, os pequenos vasos. As manifestações clínicas são diversas, ocorrendo em mais de 90% dos casos, sintomas do trato respiratório. O comprometimento renal é tardio e preditor de mau prognóstico.  Sua morbidade a médio e longo prazo inclui insuficiência renal crônica. A probabilidade de sucesso de manutenção da função renal depende da concentração sérica de creatinina ao início do tratamento, o que indica a importância do diagnóstico e terapêutica adequada precoces. Casuística: Relata-se o caso de uma paciente do sexo feminino, 61 anos, portadora de GW com comprometimento renal avançado à apresentação não precedido por sintomas pulmonares esperados. O tratamento imunossupressor associado a plasmaferese permitiu a melhora da função renal da paciente poupando-a de tornar-se dialítica- dependente. Discussão: A paciente iniciou a doença através de insuficiência renal assintomática, com valores de função renal compatíveis com o estágio mais avançado de doença renal crônica, ultrassonografia dos rins sem alterações compatíveis e sem os sintomas respiratórios esperados. Segundo a literatura, a combinação de imunossupressores e plasmaferese associa-se à recuperação renal em três meses com sobrevivência sem necessidade de diálise por 12 meses, no caso relatado, obteve-se tal resultado em 22 dias sem a necessidade de diálise após um ano. Conclusão: Devido ao diagnóstico precoce, o tratamento adequado foi instalado rapidamente proporcionando à paciente um aumento da expectativa e da qualidade de vida, evitando dependência de terapia renal substitutiva.Palavras-Chave: Granulomatose de Wegener, Plasmaferese, Doença renal crônica.  ABSTRACTIntroduction: The Wegener's Granulomatosis (WG) is a rare and idiopathic vasculitis associated with the presence of Antineutrophil Cytoplasmic Antibody (ANCA), that affects, preferentially, the small vessels. The clinical manifestations are diverse, occurring in over 90% of cases, symptoms in the respiratory tract. Kidney damage is a late and bad prognostic predictor. Morbidity in the medium and long term includes chronic renal failure. The probability of renal function maintenance success depends on serum creatinine concentration at the beginning of treatment that indicates the importance of early diagnosis and deployment of an appropriate therapy. Case Report: We present a case of a 61-year-old female patient, carrier of GW with advanced renal impairment presentation, not preceded by expected pulmonary symptoms. The immunosuppressive treatment associated with plasmapheresis allowed the improvement of the patient’s renal function, saving her from becoming dialysis-dependent Discussion: The patient developed the disease through asymptomatic renal failure, renal function with values that are compatible with the most advanced stage of chronic kidney disease, ultrasound of the kidneys without compatible changes and without the expected respiratory symptoms. According to the literature, the combination of immunosuppressive drugs and plasmapheresis is associated with renal recovery in three months with survival without dialysis for 12 months. In this case, a result was obtained in 22 days without the need for dialysis after one year. Conclusion: Due to the early diagnosis, appropriate treatment was quickly installed giving the patient increased life expectancy and quality, preventing dependence on renal replacement therapy.Keywords: Wegener’s granulomatosis, Plasmapheresis, Chronic renal failure.

scholarly journals Oral and Maxillo-Facial Manifestations of Systemic Diseases: An Overview

Medicina ◽  
2021 ◽  
Vol 57 (3) ◽  
pp. 271
Author(s):  
Saverio Capodiferro ◽  
Luisa Limongelli ◽  
Gianfranco Favia
Keyword(s):  
Early Diagnosis ◽  
Oral Cavity ◽  
Head And Neck ◽  
Clinical Outcomes ◽  
Systemic Disease ◽  
Clinical Manifestations ◽  
Systemic Diseases ◽  
Special Issue ◽  
Hard Tissues ◽  
Current Special Issue

Many systemic (infective, genetic, autoimmune, neoplastic) diseases may involve the oral cavity and, more generally, the soft and hard tissues of the head and neck as primary or secondary localization. Primary onset in the oral cavity of both pediatric and adult diseases usually represents a true challenge for clinicians; their precocious detection is often difficult and requires a wide knowledge but surely results in the early diagnosis and therapy onset with an overall better prognosis and clinical outcomes. In the current paper, as for the topic of the current Special Issue, the authors present an overview on the most frequent clinical manifestations at the oral and maxillo-facial district of systemic disease.

Penile Lymphoepithelioma-Like Carcinoma: A Rare Case With PD-L1 Expression

2021 ◽  
pp. 106689692098834
Author(s):  
Raquel Machado-Neves ◽  
Bernardo Teixeira ◽  
Elsa Fonseca ◽  
Pedro Valente ◽  
Joaquim Lindoro ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Tumor Cells ◽  
Rare Case ◽  
Malignant Tumors ◽  
Squamous Cell Carcinomas ◽  
The Third ◽  
The Past ◽  
First Case ◽  
Lymphoplasmacytic Infiltrate

Most malignant tumors of the penis are squamous cell carcinomas (SCC), being divided in 2 groups, one human papillomavirus (HPV)-related and another non-HPV-related, with lymphoepithelioma-like carcinoma (LELC) being one of the rarest HPV-related SCC. In this article, we report a case of a 50-year-old man who presented testicular swelling and pain for the past 3 months. A penile mass was identified, and the patient was submitted to a total penectomy. The penectomy specimen showed an ulcerated lesion at the glans reaching the cavernous bodies. Microscopic examination showed undifferentiated epithelial cells with syncytial growth pattern mix with a dense lymphoplasmacytic infiltrate, consistent with LELC. The tumor cells expressed p16 and all 3 different clones of PDL1 (22C3, SP263, and SP142). The patient is alive and well with a follow-up of 3 months. To our knowledge, this is the third LELC of the penis reported in literature and the first case reported with PDL1 expression.

scholarly journals Noncompaction Cardiomyopathy—History and Current Knowledge for Clinical Practice

2021 ◽  
Vol 10 (11) ◽  
pp. 2457
Author(s):  
Birgit J. Gerecke ◽  
Rolf Engberding
Keyword(s):  
Clinical Practice ◽  
Current Knowledge ◽  
Clinical Manifestations ◽  
Clinical Patient ◽  
Noncompaction Cardiomyopathy ◽  
The Past ◽  
Wide Range ◽  
Morphological Variants ◽  
A Current ◽  
Healthy Persons

Noncompaction cardiomyopathy (NCCM) has gained increasing attention over the past twenty years, but in daily clinical practice NCCM is still rarely considered. So far, there are no generally accepted diagnostic criteria and some groups even refuse to acknowledge it as a distinct cardiomyopathy, and grade it as a variant of dilated cardiomyopathy or a morphological trait of different conditions. A wide range of morphological variants have been observed even in healthy persons, suggesting that pathologic remodeling and physiologic adaptation have to be differentiated in cases where this spongy myocardial pattern is encountered. Recent studies have uncovered numerous new pathogenetic and pathophysiologic aspects of this elusive cardiomyopathy, but a current summary and evaluation of clinical patient management are still lacking, especially to avoid mis- and overdiagnosis. Addressing this issue, this article provides an up to date overview of the current knowledge in classification, pathogenesis, pathophysiology, epidemiology, clinical manifestations and diagnostic evaluation, including genetic testing, treatment and prognosis of NCCM.

Sign in / Sign up

Export Citation Format

Share Document