scholarly journals Interactive Video Acquisition and Learning System for Motor Assessment of Parkinson's Disease

2021 ◽  
Author(s):  
Yunyue Wei ◽  
Bingquan Zhu ◽  
Chen Hou ◽  
Chen Zhang ◽  
Yanan Sui
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Interactive Video ◽  
Learning System ◽  
Video Acquisition ◽  
Video Recordings ◽  
Quality Video ◽  
Patient Groups ◽  
Correct Understanding ◽  
High Quality Video

Diagnosis and treatment for Parkinson's disease rely on the evaluation of motor functions, which is expensive and time consuming when performing at clinics. It is also difficult for patients to record correct movements at home without the guidance from experienced physicians. To help patients with Parkinson’s disease get better evaluation from in-home recorded movement videos, we developed an interactive video acquisition and learning system for clinical motor assessments. The system provides real-time guidance with multi-level body keypoint tracking and analysis to patients, which guarantees correct understanding and performing of clinical tasks. We tested its effectiveness on healthy subjects, and the efficiency and usability on patient groups. Experiments showed that our system enabled high quality video recordings following clinical standards, benefiting both patients and physicians. Our system provides a novel learning-based telemedicine approach for the care of patients with Parkinson’s disease.

scholarly journals Pallidal stimulation as treatment for camptocormia in Parkinson’s disease

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Yijie Lai ◽  
Yunhai Song ◽  
Daoqing Su ◽  
Linbin Wang ◽  
Chencheng Zhang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Case Reports ◽  
Structural Connectivity ◽  
Video Recordings ◽  
Lead Placement ◽  
Pallidal Stimulation ◽  
The Impact ◽  
Deep Brain

AbstractCamptocormia is a common and often debilitating postural deformity in Parkinson’s disease (PD). Few treatments are currently effective. Deep brain stimulation (DBS) of the globus pallidus internus (GPi) shows potential in treating camptocormia, but evidence remains limited to case reports. We herein investigate the effect of GPi-DBS for treating camptocormia in a retrospective PD cohort. Thirty-six consecutive PD patients who underwent GPi-DBS were reviewed. The total and upper camptocormia angles (TCC and UCC angles) derived from video recordings of patients who received GPi-DBS were used to compare camptocormia alterations. Correlation analysis was performed to identify factors associated with the postoperative improvements. DBS lead placement and the impact of stimulation were analyzed using Lead-DBS software. Eleven patients manifested pre-surgical camptocormia: seven had lower camptocormia (TCC angles ≥ 30°; TCC-camptocormia), three had upper camptocormia (UCC angles ≥ 45°; UCC-camptocormia), and one had both. Mean follow-up time was 7.3 ± 3.3 months. GPi-DBS improved TCC-camptocormia by 40.4% (angles from 39.1° ± 10.1° to 23.3° ± 8.1°, p = 0.017) and UCC-camptocormia by 22.8% (angles from 50.5° ± 2.6° to 39.0° ± 6.7°, p = 0.012). Improvement in TCC angle was positively associated with pre-surgical TCC angles, levodopa responsiveness of the TCC angle, and structural connectivity from volume of tissue activated to somatosensory cortex. Greater improvement in UCC angles was seen in patients with larger pre-surgical UCC angles. Our study demonstrates potential effectiveness of GPi-DBS for treating camptocormia in PD patients. Future controlled studies with larger numbers of patients with PD-related camptocormia should extend our findings.

scholarly journals Schizophrenia as Potential Trigger for Melanoma Development and Progression! The Psycho-Neuro-Endocrine-Oncology (P.N.E.O) Network!

2018 ◽  
Vol 6 (8) ◽  
pp. 1442-1445
Author(s):  
Georgi Tchernev ◽  
Ilia Lozev ◽  
Ivanka Temelkova ◽  
Svetoslav Chernin ◽  
Irina Yungareva
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Nervous Tissue ◽  
World Literature ◽  
Careful Analysis ◽  
Potential Trigger ◽  
Patient Groups ◽  
Neuroectodermal Origin ◽  
High Level ◽  
First Time

BACKGROUND: Skin, nervous tissue, dopamine and melanoma share a common neuroectodermal origin. Hence, processes that modulate nervous tissue formation, patient mental status, motor regulation of individuals, and skin cancerogenesis are inextricably linked. Psycho-neuro-endocrine oncology (or dermato-oncology), i.e. P.N.E.O., is a new model or trend in medicine and science presented for the first time in the world literature by us, that aims to examine the relationship between the mental state, the hormones and the malignant transformation. Schizophrenia and Parkinson’s disease are the two main patterns of disease where the main symptoms are related to dopamine levels in the human body. According to our analyses of the available literature, the amount of dopamine is related to the incidence of melanocytic or non-melanocytic cutaneous tumours in patients with central nervous system diseases and those affecting the motor function and coordination. Such patterns of interaction are extremely indicative of the elucidation of the ubiquitous hypothesis or statement: “My illness is on a mental basis, caused by stress ...”CASE PRESENTATION: We present a 44-year-old patient with untreated schizophrenia for approximately 25 years, associated with advanced acral localised melanoma. Schizophrenia is generally associated with a higher level of dopamine, which is also a key precursor to melanin synthesis. After a careful analysis of all literature on melanoma in patients with 1) treated and untreated schizophrenia, 2) those with untreated and untreated forms of Parkinson’s disease, it would be logical to conclude that the high level of dopamine in the described patient groups is a risk factor for the development of melanoma.CONCLUSIONS: The possible mechanisms for the occurrence of malignant melanoma within the so-called psycho/neuro/endocrine oncology (P.N.E.O.), as well as the effective methods of prevention, are under discussion.

scholarly journals Connectivity of EEG synchronization networks increases for Parkinson’s disease patients with freezing of gait

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Eitan E. Asher ◽  
Meir Plotnik ◽  
Moritz Günther ◽  
Shay Moshel ◽  
Orr Levy ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Freezing Of Gait ◽  
Motor Task ◽  
Frequency Bands ◽  
Hand Tapping ◽  
Patient Groups ◽  
Beta Frequency ◽  
Relationship Of ◽  
Insight Into

AbstractFreezing of gait (FoG), a paroxysmal gait disturbance commonly experienced by patients with Parkinson’s disease (PD), is characterized by sudden episodes of inability to generate effective forward stepping. Recent studies have shown an increase in beta frequency of local-field potentials in the basal-ganglia during FoG, however, comprehensive research on the synchronization between different brain locations and frequency bands in PD patients is scarce. Here, by developing tools based on network science and non-linear dynamics, we analyze synchronization networks of electroencephalography (EEG) brain waves of three PD patient groups with different FoG severity. We find higher EEG amplitude synchronization (stronger network links) between different brain locations as PD and FoG severity increase. These results are consistent across frequency bands (theta, alpha, beta, gamma) and independent of the specific motor task (walking, still standing, hand tapping) suggesting that an increase in severity of PD and FoG is associated with stronger EEG networks over a broad range of brain frequencies. This observation of a direct relationship of PD/FoG severity with overall EEG synchronization together with our proposed EEG synchronization network approach may be used for evaluating FoG propensity and help to gain further insight into PD and the pathophysiology leading to FoG.

Possible selves and illness: A comparison of individuals with Parkinson's disease, early-stage Alzheimer's disease, and healthy older adults

2003 ◽  
Vol 27 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Leslie D. Frazier ◽  
Victoria Cotrell ◽  
Karen Hooker
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Parkinson’S Disease ◽  
Alzheimer's Disease ◽  
Parkinson's Disease ◽  
Possible Selves ◽  
Early Stage ◽  
Healthy Older Adults ◽  
Patient Groups ◽  
The Impact

This study examined how future self-representations are affected by two different chronic illnesses, one focused on cognitive losses, early-stage Alzheimer's disease (AD), and one focused on physical losses, Parkinson's disease (PD). The impact of illness on possible selves (perceptions of self in the future) was made salient by a comparison with healthy older adults in order to better understand developmental issues in later life. Findings show that although there were no differences in the total number of domains reported by the groups, specific domains were reported differently by patient groups and all domains were likely to become infused with illness. As expected, patient groups had less self-efficacy and lower outcome expectancies for their future selves, and PD patients reported less distance from their feared selves. Although these findings are intuitive, this is the first empirical effort to document the impact of illness on older adults' self-representations. Group differences are explained in terms of disease context, and the importance of possible selves and self-regulatory functions as therapeutic mechanisms for adaptation to illness are emphasised.

Parkinson’s Disease Affects Functional Connectivity within the Olfactory-Trigeminal Network

2020 ◽  
Vol 10 (4) ◽  
pp. 1587-1600
Author(s):  
Cécilia Tremblay ◽  
Behzad Iravani ◽  
Émilie Aubry Lafontaine ◽  
Jason Steffener ◽  
Florian Ph.S Fischmeister ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Functional Connectivity ◽  
Brain Network ◽  
Specific Pattern ◽  
Olfactory Dysfunction ◽  
Patient Groups ◽  
Network Modularity ◽  
Specific Alteration ◽  
Trigeminal Sensitivity

Background: Olfactory dysfunction (OD) is a frequent symptom of Parkinson’s disease (PD) that appears years prior to diagnosis. Previous studies suggest that PD-related OD is different from non-parkinsonian forms of olfactory dysfunction (NPOD) as PD patients maintain trigeminal sensitivity as opposed to patients with NPOD who typically exhibit reduced trigeminal sensitivity. We hypothesize the presence of a specific alteration of functional connectivity between trigeminal and olfactory processing areas in PD. Objective: We aimed to assess potential differences in functional connectivity within the chemosensory network in 15 PD patients and compared them to 15 NPOD patients, and to 15 controls. Methods: Functional MRI scanning session included resting-state and task-related scans where participants carried out an olfactory and a trigeminal task. We compared functional connectivity, using a seed-based correlation approach, and brain network modularity of the chemosensory network. Results: PD patients had impaired functional connectivity within the chemosensory network while no such changes were observed for NPOD patients. No group differences we found in modularity of the identified networks. Both patient groups exhibited impaired connectivity when executing an olfactory task, while network modularity was significantly weaker for PD patients than both other groups. When performing a trigeminal task, no changes were found for PD patients, but NPOD patients exhibited impaired connectivity. Conversely, PD patients exhibited a significantly higher network modularity than both other groups. Conclusion: In summary, the specific pattern of functional connectivity and chemosensory network recruitment in PD-related OD may explain distinct behavioral chemosensory features in PD when compared to NPOD patients and healthy controls.

Lessons learned during the INSURRECT project (INteractive SURgical Teaching at REmote CeNtres)

1997 ◽  
Vol 3 (1_suppl) ◽  
pp. 38-40 ◽  
Author(s):  
M Hobsley ◽  
R Mccloy ◽  
D G Jameson ◽  
S Buckton ◽  
P O'hanlon
Keyword(s):  
Interactive Video ◽  
Lessons Learned ◽  
First Year ◽  
Distance Teaching ◽  
High Quality ◽  
Quality Video ◽  
Audience Interaction ◽  
Surgical Teaching ◽  
Course Material ◽  
High Quality Video

The INSURRECT project began in 1993 as a collaboration between six UK universities in distance teaching of undergraduate surgery. The first year was spent in testing the network and preparing the course material. This was followed by a two-year pilot teaching course. During this phase, 108 teaching sessions were conducted, involving more than 1300 students in all. It was found that successful teaching depended on increasing the amount of audience interaction as much as possible and transmitting high-quality video pictures. Although the time taken to deliver material by interactive video was greater than for convention al lectures, both students and teachers responded favourably to the project.

Interactive video conferencing: A means of providing interim care to parkinson's disease patients

1993 ◽  
Vol 8 (3) ◽  
pp. 380-382 ◽  
Author(s):  
Jean P. Hubble ◽  
Rajesh Pahwa ◽  
Debra K. Michalek ◽  
Calvina Thomas ◽  
William C. Koller
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Interactive Video ◽  
Video Conferencing

scholarly journals Texture-based markers from structural imaging correlate with motor handicap in Parkinson’s disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Nacim Betrouni ◽  
Caroline Moreau ◽  
Anne-Sophie Rolland ◽  
Nicolas Carrière ◽  
Marie Chupin ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Early Stage ◽  
Morphological Changes ◽  
Texture Features ◽  
Nigrostriatal Pathway ◽  
Treatment Conditions ◽  
Patient Groups ◽  
Weighted Sequences ◽  
Motor Handicap

AbstractThere is a growing need for surrogate biomarkers for Parkinson’s disease (PD). Structural analysis using magnetic resonance imaging with T1-weighted sequences has the potential to quantify histopathological changes. Degeneration is typically measured by the volume and shape of morphological changes. However, these changes appear late in the disease, preventing their use as surrogate markers. We investigated texture changes in 108 individuals, divided into three groups, matched in terms of sex and age: (1) healthy controls (n = 32); (2) patients with early-stage PD (n = 39); and (3) patients with late-stage PD and severe L-dopa-related complications (n = 37). All patients were assessed in off-treatment conditions. Statistical analysis of first- and second-order texture features was conducted in the substantia nigra, striatum, thalamus and sub-thalamic nucleus. Regions of interest volumetry and voxel-based morphometry were performed for comparison. Significantly different texture features were observed between the three populations, with some showing a gradual linear progression between the groups. The volumetric changes in the two PD patient groups were not significantly different. Texture features were significantly associated with clinical scores for motor handicap. These results suggest that texture features, measured in the nigrostriatal pathway at PD diagnosis, may be useful in predicting clinical progression of motor handicap.

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