scholarly journals Eczema: tactics of choice external therapy

2018 ◽  
Vol 94 (3) ◽  
pp. 56-66 ◽  
Author(s):  
D. V. Zaslavsky ◽  
Е. S. Tulenkova ◽  
K. N. Monakhov ◽  
N. A. Kholodilova ◽  
Yu. S. Kondratieva ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Demographic Data ◽  
Objective Assessment ◽  
Drug Application ◽  
Clinical Manifestations ◽  
Life Quality ◽  
Clinical History ◽  
Therapeutic Effects ◽  
Good Tolerability ◽  
Anti Inflammatory

The therapeutic effects of synthetic tannins are based on their binding action, as well as on their anti-pruritic, antimicrobial and anti-inflammatory effects. Materials and methods. A clinical study of Neotanin spray, Neotanin lotion (suspension) and Neotanin cream was carried out in 8 clinical centres during the period from June, 2017 to January, 2018. The study had an open and non-comparative character. The study included 68 patients of both sex es aged from 1 month to 80 years suffering from eczema dermatosis in the acute weeping phase, including cases with complications after secondary infections (including eczema elements localized on the face). Before the study, information on the clinical history, demographic data, co-morbidities, physical examination data of the patients was collected. The treatment regimen included 2 stages: 1) Neotanin in the spray or lotion (suspension) form 3–4 times per day during 1–5 days, up to the full drying of eczema elements; 2) Neotanin in the cream form 3 times per day, up to the disappearance of the clinical manifestations of skin dermatosis. The duration of the study ranged from 5 to 14 days: the study was completed when a patient had achieved remission. The criteria for assessing the drug efficacy were as follows: dynamics of subjective complaints, objective assessment of the patient's condition (the presence and severity of clinical symptoms), dynamics of the Dermatology Life Quality Index (DLQI). Results. Neotanin preparations showed a high efficacy in the acute and subacute stages of the inflammatory process as an antipruritic agent. Itching stopped within 5 minutes after the drug application, with the antipruritic effect lasting for an average of 3–4 hours. In 85 % of the patients, marked excoriations were absent on the 3rd day of treatment. Neotanin demonstrated a pronounced anti-inflammatory effect. In 92 % of the patients, the symptoms of erythema and edema were significantly reduced one week after the beginning of treatment, with the manifestations of inflammatory exudation being conclusively decreased. One week following the beginning of treatment, 100 % of the patients demonstrated no oozing lesions. The absence of serious undesirable effects in the patients during the study evidences to the good tolerability and safety of this drug.

scholarly journals Comparison of the clinical manifestations between different age groups of patients with overseas imported COVID-19

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0243347
Author(s):  
Yujuan Han ◽  
Zujin Luo ◽  
Wenliang Zhai ◽  
Yue Zheng ◽  
Huan Liu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Clinical Symptoms ◽  
Demographic Data ◽  
Disease Onset ◽  
Age Groups ◽  
Clinical Manifestations ◽  
Symptom Improvement ◽  
Group A ◽  
Group B

The current study investigated the clinical manifestations and outcomes of different age groups of patients with overseas imported COVID-19. In total, 53 COVID-19 patients admitted to the designated Beijing Xiaotangshan Hospital between March 16 and April 15 of 2020 were included. Based on the percentage of disease aggravation during hospital stay according to CT, the patients were divided into two groups: ≤40 years (group A; n = 41) and >40 years (group B; n = 12). The demographic data, epidemiological history, disease courses, potential complications, clinical symptoms, lab indices, chest CT outcomes, treatment protocols and turnovers of the two groups were compared. According to clinical typing, compared with group A, group B had a significantly greater proportion of the common type of COVID-19 (P<0.05) and greater comorbidity of type 2 diabetes (P<0.001). The two groups presented significantly different lab indices. Group B showed significantly more frequent CT abnormalities, with greater proportions of multiple lesions and bilateral lung involvement (P<0.05). During hospitalization, group B had a greater proportion of disease aggravation according to CT (P<0.01). Compared with group A, group B received a significantly greater proportion of antiviral therapy and presented a significantly greater occurrence of adverse drug reactions (P<0.05). The two groups did not significantly differ in time from admission to clinical symptom improvement or from disease onset to negative outcomes according to nucleic acid testing, the appearance of IgG or the appearance of IgM. They also did not significantly differ in length of stay. Older imported COVID-19 patients, particularly those with type 2 diabetes, showed a broader pulmonary extent and faster development of the disease, more severe pathogenetic conditions and a greater risk of developing a critically severe type. Increased attention should be given to this population in clinical practice.

scholarly journals Experience of using metaprebiotics in the treatment of certain functional gastrointestinal disorders

2020 ◽  
pp. 105-111
Author(s):  
O. N. Minushkin ◽  
L. V. Maslovskiy ◽  
M. I. Bulanova ◽  
E. S. Gordienko ◽  
T. B. Topchiy ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Functional Gastrointestinal Disorders ◽  
Clinical Manifestations ◽  
Scientific Data ◽  
Biologically Active ◽  
Gastrointestinal Disorders ◽  
Good Tolerability ◽  
Before And After ◽  
Stool Form ◽  
The Impact

Introduction. Functional gastrointestinal disorders (FGID) occupy one of the leading positions among intestinal pathologies. At present, scientific data indicate the lack of efficiency of existing methods of FGID treatment and the need for further research. This study is devoted to the assessment of the impact of STIM Lax and STIM treatment on clinical manifestations in patients with FC and FD.Aim of the study. Evaluation of the effectiveness of biologically active additives (BAA) STIM and STIM Laks in 39 patients with functional gastrointestinal disorders. Objectives of the study: to evaluate the effect of the drug on clinical symptoms according to an individual diary and using specialized questionnaires with a score of symptoms before and after treatment.Materials of the research. 39 patients divided into two groups were admitted to the research. Of these, 20 patients were with FC (4 men and 16 women; mean age – 40.3 ± 8.9 years). Monotherapy with STIM Laks was conducted (1 tablet 3 times a day for 30 days), and 19 FD patients (10 men and 9 women; mean age – 36.9 ± 14.1 years). Before and after the course of treatment a carbolene sample was conducted, stool form and frequency, intensity of flatulence, purring, transfusion, abdominal pain were clinically evaluated.Results. Therapy of FС and FD with STIM and STIM Laks effectively reduces the frequency and intensity of clinical symptoms, normalizes the transit time of the carbolene sample, the frequency of stool. Increase of flatulence was observed in 7 (17.9%) patients, its resolution within 1–3 days led to a decrease in the dose of the drug, without affecting the end result.Conclusions. This study indicates a high efficacy and good tolerability of treatment with STIM Laks and STIM in patients with FGID.

scholarly journals Who Bites Me? A Tentative Discriminative Key to Diagnose Hematophagous Ectoparasites Biting Using Clinical Manifestations

Diagnostics ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 308 ◽  
Author(s):  
Mohammad Akhoundi ◽  
Denis Sereno ◽  
Anthony Marteau ◽  
Christiane Bruel ◽  
Arezki Izri
Keyword(s):  
Clinical Symptoms ◽  
Clinical Manifestations ◽  
Clinical History ◽  
Tsetse Flies ◽  
Bed Bugs ◽  
Biting Midges ◽  
Clinical Disorders ◽  
Pathogenic Agents ◽  
Hematophagous Arthropods ◽  
Epidemiological Information

Arthropod blood feeders are vectors of several human pathogenic agents, including viruses (e.g., yellow fever, chikungunya, dengue fever), parasites (e.g., malaria, leishmaniasis, lymphatic filariasis), or bacteria (e.g., plague). Besides their role as a vector of pathogens, their biting activities cause a nuisance to humans. Herein, we document clinical symptoms associated with the biting of ten clusters of hematophagous arthropods, including mosquitoes, biting midges and sandflies, lice, ticks, tsetse flies, blackflies, horse flies, fleas, triatomine and bed bugs. Within the framework of clinical history and entomo-epidemiological information, we propose a tentative discriminative key that can be helpful for practicing physicians in identifying hematophagous arthropods biting humans and delivering treatment for the associated clinical disorders.

scholarly journals Potent Antiarthritic Properties of Phloretin in Murine Collagen-Induced Arthritis

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Shun-Ping Wang ◽  
Shih-Chao Lin ◽  
Shiming Li ◽  
Ya-Hsuan Chao ◽  
Guang-Yuh Hwang ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Bone Destruction ◽  
Joint Inflammation ◽  
Flavonoid Compound ◽  
Therapeutic Effects ◽  
Potential Candidate ◽  
Collagen Induced Arthritis ◽  
Hind Limbs ◽  
Collagen Antibodies ◽  
Anti Inflammatory

In the exploration of potential therapeutic agents for rheumatoid arthritis (RA), DBA/1J mice are used as the RA model of collagen-induced arthritis (CIA). Phloretin, a flavonoid compound extracted fromPrunus mandshurica, has been found to exhibit anti-inflammatory activity, making it a potential candidate for treatment of RA. The objective of this study was to evaluate the therapeutic effects of phloretin on CIA mice. CIA mice were dosed daily with phloretin at either 50 or 100 mg/kg among two treatment groups. CIA treated mice showed mitigation of clinical symptoms of RA in addition to reduced inflammation of hind-limbs compared to mice who did not receive phloretin. Histological analysis showed that phloretin suppressed the severity of RA and effectively mitigated joint inflammation and cartilage- and bone-destruction via reducing proinflammatory cytokine productions (TNF-α, IL-6, IL-1β, and IL-17). This was at least partially mediated by causing inadequate splenocyte activation and proliferation. Moreover, phloretin-treated CIA mice showed decreased oxidative stress and diminished levels of malondialdehyde (MDA) and hydrogen peroxide (H2O2) in paw tissues as well as reduced productivity of anti-collagen antibodies in serum. We have concluded that phloretin could be a potent and effective antiarthritis agent, demonstrating anti-inflammatory, antioxidative, and immunomodulatory effects in CIA mice.

scholarly journals A study on clinical profile of paediatric HIV infection in the age group of 18 months to 12 years and its correlation with CD4 count

2017 ◽  
Vol 4 (4) ◽  
pp. 1232
Author(s):  
Sureshkumar Ramaswamy ◽  
Murali Thandavarayan ◽  
Sivaraman Thirumalaikumarasamy ◽  
Aparna Sureshkumar
Keyword(s):  
Hiv Infection ◽  
Clinical Symptoms ◽  
Demographic Data ◽  
Clinical Manifestations ◽  
Skin Lesions ◽  
Cd4 Count ◽  
Clinical Profile ◽  
Pediatric Hiv ◽  
Age Group ◽  
College Hospital

Background: The aim of the study was to assess the clinical profile of pediatric HIV infection in the age group of 18 month to 12 years and to correlate the clinical features with their CD4 count.Methods: This descriptive study was conducted over a period of 1 year from October 2007 to October 2008 at Govt. Mohan Kumaramangalam Medical College Hospital, Salem and included 100 children (aged between 18 months-12 years) diagnosed HIV by using rapid antigen tests or ELISA. Demographic data, clinical manifestations correlating with CD4 count and nutritional status of the children were recorded in predesigned proforma and analysed.Results: 100 children were included (males-65 and females-35) in the study. 22 children were asymptomatic and 78 were symptomatic. Clinical symptoms like skin lesions in 29, oral lesions in 10, lymphadenopathy in 46 children were observed. The respiratory (13%), central nervous (12%) and haemotological systems (16%) were most commonly involved organs systems. Children in stage III and IV disease were into Grade I-IV PEM classification (for weight) and majority of stage I-IV children were in Grade II according to Mclaren’s classification (for height).Conclusions: Majority of children with HIV infection presented with various clinical manifestations, malnutrition and immunosuppression. Hence, early identification of the disease and proper management in children helps in improving the immunological status and thereby life span of the child. 

scholarly journals Comparison of Clinical Characteristics for Distinguishing COVID-19 From Influenza During the Early Stages in Guangdong, China

2021 ◽  
Vol 8 ◽  
Author(s):  
Yongzhi Li ◽  
Huan He ◽  
Yuhan Gao ◽  
Zejin Ou ◽  
Wenqiao He ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Influenza A ◽  
Proportional Hazards Model ◽  
Clinical Symptoms ◽  
Demographic Data ◽  
Characteristic Curve ◽  
Clinical Manifestations ◽  
Cox Proportional Hazards Model ◽  
Categorical Variables ◽  
Continuous Variables

Background: To explore the differences in clinical manifestations and infection marker determination for early diagnosis of coronavirus disease-2019 (COVID-19) and influenza (A and B).Methods: A hospital-based retrospective cohort study was designed. Patients with COVID-19 and inpatients with influenza at a sentinel surveillance hospital were recruited. Demographic data, medical history, laboratory findings, and radiographic characteristics were summarized and compared between the two groups. The chi-square test or Fisher's exact test was used for categorical variables, and Kruskal–Wallis H-test was used for continuous variables in each group. Receiver operating characteristic curve (ROC) was used to differentiate the intergroup characteristics. The Cox proportional hazards model was used to analyze the predisposing factors.Results: About 23 patients with COVID-19 and 74 patients with influenza were included in this study. Patients with influenza exhibited more symptoms of cough and sputum production than COVID-19 (p &lt; 0.05). CT showed that consolidation and pleural effusion were more common in influenza than COVID-19 (p &lt; 0.05). Subgroup analysis showed that patients with influenza had high values of infection and coagulation function markers, but low values of blood routine and biochemical test markers than patients with COVID-19 (mild or moderate groups) (p &lt; 0.05). In patients with COVID-19, the ROC analysis showed positive predictions of albumin and hematocrit, but negative predictions of C-reactive protein (CRP), procalcitonin (PCT), lactate dehydrogenase (LDH), hydroxybutyrate dehydrogenase (HBDH), and erythrocyte sedimentation rate. Multivariate analysis revealed that influenza might associate with risk of elevated CRP, PCT, and LDH, whereas COVID-19 might associated with high HBDH.Conclusion: Patients with influenza had more obvious clinical symptoms but less common consolidation lesions and pleural effusion than those with COVID-19. These findings suggested that influenza likely presents with stronger inflammatory reactions than COVID-19, which provides some insights into the pathogenesis of these two contagious respiratory illnesses.

scholarly journals Topical diclofenac for the treatment of the musculoskeletal diseases

2018 ◽  
pp. 98-104
Author(s):  
G. R. Imametdinova ◽  
E. V. Igolkina
Keyword(s):  
Musculoskeletal System ◽  
Clinical Studies ◽  
Musculoskeletal Diseases ◽  
Clinical Manifestations ◽  
Economic Problem ◽  
Symptomatic Therapy ◽  
Good Tolerability ◽  
Antiinflammatory Therapy ◽  
Wide Range ◽  
Anti Inflammatory

Treatment of diseases of the musculoskeletal system to date remains not only a serious medical, but also socio-economic problem. Chronic diseases of the joints and spine are one of the most common causes of disability in patients. The main clinical manifestations of most diseases of the musculoskeletal system are pain and inflammation, which requires adequate antiinflammatory therapy. The data on various mechanisms of action of non-steroidal anti-inflammatory drug (NSAID) diclofenac (Voltaren), as well as the results of clinical studies and meta-analyses confirming its effectiveness and good tolerability are presented. The data of experimental and clinical studies of the efficacy and safety of local forms of diclofenac-Voltaren Emulgel (diclofenac-diethylamine) –are presented. Provides information about the form of the Voltaren Emulgel 2% for 12 hours. It is shown that a wide range of analgesic and anti-inflammatory effects of diclofenac (Voltaren), and good tolerance can be used as symptomatic therapy in the treatment of diseases of the musculoskeletal system. 

scholarly journals The Anti-Inflammatory and Anti-Pruritus Mechanisms of Huanglian Jiedu Decoction in the Treatment of Atopic Dermatitis

2021 ◽  
Vol 12 ◽  
Author(s):  
Yubin Xu ◽  
Saizhen Chen ◽  
Lingling Zhang ◽  
Guirong Chen ◽  
Jinguang Chen
Keyword(s):  
Atopic Dermatitis ◽  
Protein Expression ◽  
Transient Receptor Potential ◽  
Clinical Symptoms ◽  
Clinical Manifestations ◽  
Lymphocyte Activation ◽  
Receptor Potential ◽  
Histamine H4 Receptor ◽  
Cell Percentage ◽  
Anti Inflammatory

Atopic dermatitis (AD) is a common chronic skin disease driven by a T-cell-mediated immune response, with inflammation and pruritus being its main clinical manifestations. Huanglian Jiedu decoction (HLJDT), which is an ancient Chinese medicine herbal formula derived from Wai-Tai-Mi-Yao, is a potentially effective treatment for AD. We aimed to clarify the anti-inflammatory and anti-pruritus mechanisms of HLJDT in AD treatment. We performed immunohistochemistry, Western blotting, reverse transcriptase-polymerase chain reaction, Luminex-based direct multiplex immunoassay, enzyme-linked immunosorbent assays, and flow cytometry to address the abovementioned aims. HLJDT significantly reduced clinical symptoms and ear swelling in AD-like mice by inhibiting the production of cytokines [histamine, interleukin (IL)-3, IL-4, IL-5, IL-13, IL-17A, IL-31, and IL-33], substance P (SP), transient receptor potential cation channel subfamily V member 1 (TRPV-1), and gastrin-releasing peptide (GRP). Additionally, HLJDT significantly suppressed the protein expression levels and positive cell percentage of CD28, CD80, CD86, CD207, CD326, MHCII, and OX40 in the lymphoid nodes. Moreover, HLJDT significantly suppressed mRNA and protein expression of tyrosine–protein kinase (JAK1), histamine H4 receptor, and IL-4Rα, as well as the protein expression of GRP, SP, and TRPV-1 in the root ganglion. Our findings indicate that HLJDT can treat AD by regulating the antigen presentation function of dendritic cells, weakening T-lymphocyte activation, and subsequently exerting anti-inflammatory and anti-pruritus effects.

Incidence, characteristics, and outcomes among inpatient, outpatient, and emergency department with reported high critical serum potassium values

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Wei-Hung Kuo ◽  
Huey-Ling You ◽  
Wan-Ting Huang ◽  
Yueh-Ting Lee ◽  
Terry Ting-Yu Chiou ◽  
...  
Keyword(s):  
Emergency Department ◽  
Serum Potassium ◽  
Clinical Symptoms ◽  
Demographic Data ◽  
Clinical Manifestations ◽  
High Serum ◽  
Total Serum ◽  
Laboratory Values ◽  
Short Period ◽  
Comorbidity Burden

Abstract Objectives Severe hyperkalemia can cause life-threatening arrhythmia, cardiac arrest, or death. This study aimed to investigate the incidence and the associated factors relevant to critical hyperkalemia (≥6 mmol/L) among inpatients, outpatients, and emergency department. Their clinical outcomes were also analyzed. Methods All patients whose high serum potassium values had been reported as critical laboratory values in 2016 were enrolled. Their demographic data, comorbidities, clinical symptoms, biochemical data, and outcomes were reviewed and collected. The Charlson comorbidity score (CCS) and glomerular filtration rate (GFR) were computed to assess the comorbidity burden and renal function. Patients were divided into groups according to different settings, potassium and GFR levels, and their survival. Results Of the 293,830 total serum potassium tests, 1,382 (0.47%) reports were listed as critical laboratory values. The average reply time was 6.3 min. Their mean age was 67.2 years, while the average GFR was 12.2 mL/min/1.73 m2. The overall mortality rate was 34%. Patients in the emergency department had the highest incidence (0.92%), while inpatients had the worst outcome (51% mortality). The leading cause of mortality was septic shock. The fatal group had higher rates of clinical symptoms, higher potassium values, CCS, and eGFR (all p<0.05). Conclusions Most of the responses for the reports were obtained within a short period of time. Patients with reported high critical serum potassium values were characterized by high rates of comorbidity, reduced eGFR, and mortality. The incidence, clinical manifestations, and outcomes varied in the different clinical settings.

PRECLINICAL STUDY OF THE VETERINARY DRUGS TOXICITY

1970 ◽  
pp. 61-64
Author(s):  
E. K. Rakhmatullin ◽  
O. D. Sklyarov
Keyword(s):  
Lethal Dose ◽  
Clinical Manifestations ◽  
Preclinical Study ◽  
Veterinary Drugs ◽  
Toxic Effects ◽  
Laboratory Animals ◽  
Therapeutic Effects ◽  
Significant Information ◽  
Important Indicator ◽  
Organ Systems

Preclinical study of the drugs toxicity was analysed it allows predicting the safety of veterinary drugs in laboratory animals. The fundamental normative instruments in the field of preclinical study of drugs for veterinary medicine and animal husbandry are Order of the Ministry of Agriculture of the Russian Federation dated 06.03.2018 N 101 and GOST 33044-2014 Principles of Good Laboratory Practice. An important indicator of the preclinical study of the veterinary drugs is the determination (calculation) of median lethal dose value (lethal dose for half of the animals tested) or concentration (LD50 or LC50). Existing methods for determining this indicator make it possible at the initial study stage to determine the degree and class the drug of toxicity. Studying the symptoms of intoxication in the analysis of pharmacological substances one obtains significant information about the nature of the action of the future drug. The clinical manifestations of intoxication with damage to various organ systems are presented. As criteria for assessing the toxic effects of veterinary drugs it is recommended to determine LD50, cumulation coefficient, latitude index of therapeutic effects, dose level of toxic effects in the experiment which allows predicting the nature and degree of toxic effects of the drug even at the stage of preclinical veterinary drugs study.

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