scholarly journals Timolol for Treatment of Recalcitrant Pyogenic Granulomas: a Case Report and Review of the Literature

2017 ◽  
Vol 1 (3) ◽  
pp. 150-155
Author(s):  
Paige Hoyer ◽  
Priscilla Ly ◽  
Lindy Ross ◽  
Michael Wilkerson
Keyword(s):  
Current Literature ◽  
Treatment Options ◽  
Ophthalmic Solution ◽  
Pyogenic Granuloma ◽  
Vascular Tumor ◽  
Current Treatment ◽  
Multiple Form ◽  
The Face ◽  
Therapy Option ◽  
A Site

Importance: Pyogenic Granuloma (PG) is a benign vascular tumor that forms commonly on the face, oral mucosa, or a site of previous injury. Though some PGs resolve spontaneously, most require some-to-multiple form(s) of treatment to prevent bleeding, ulceration, and scarring. Current treatment options for PGs include cryotherapy, laser, electrodessication, curettage or shave excision, sclerotherapy, corticosteroid injections, and imiquimod 5% cream. Timolol 0.5% ophthalmic solution has been used as a noninvasive topical treatment for PG in the pediatric population.Objective: To present a case of successful treatment of a recalcitrant PG with topical timolol, and to report on the current literature for similar cases.Case Presentation: We present a case of a 40-year-old healthy female who developed a biopsy-proven PG on her index finger. This is the first reported case to successfully use tangential biopsy and electrodessication followed by twice daily topical Timolol to treat recalcitrant PG.Conclusions: This case supports the use of 0.5% Timolol ophthalmic solution and demonstrates that it is a safe and economical therapy for adult patients with recurrent PGs. A review of the current literature is discussed, and supports timolol as an easy and economical therapy option.

scholarly journals Therapeutic vanish in pyogenic granuloma: a case series

2020 ◽  
Vol 6 (4) ◽  
pp. 553
Author(s):  
Deepthi Ravishankar ◽  
Mamatha S. Kusagur
Keyword(s):  
Case Report ◽  
Oral Mucosa ◽  
Index Finger ◽  
Case Series ◽  
Pyogenic Granuloma ◽  
Vascular Tumour ◽  
Mucous Membranes ◽  
The Face ◽  
Sodium Tetradecyl Sulphate ◽  
A Site

<p class="abstract">Pyogenic granuloma (PG) is a common benign vascular tumour which affect both skin and mucous membranes, occurring commonly on the face, oral mucosa, or a site of previous injury in all ages. Though some PGs resolve spontaneously, most requires treatment to prevent bleeding, ulceration, and scarring. We presented a case report of 4 patients who developed PG on index finger, forehead and nose. Our findings demonstrated the use of sclerotherapy using 3% sodium tetradecyl sulphate which is a safe and economical therapy for adult patients.</p>

Fat Embolism After Autologous Facial Fat Grafting

2021 ◽  
Author(s):  
Nicolas S Dhooghe ◽  
Sebastiaan Maes ◽  
Bernard Depypere ◽  
Karel E Y Claes ◽  
Renaat Coopman ◽  
...  
Keyword(s):  
Preventive Measures ◽  
Improve Patient Safety ◽  
Treatment Options ◽  
Fat Embolism ◽  
Current Treatment ◽  
Fat Grafting ◽  
Safe Procedure ◽  
Online Databases ◽  
Raising Awareness ◽  
The Face

Abstract Background Autologous facial fat grafting has gained popularity in recent years and is considered to be safe. We present the case of a patient who died due to massive cerebral micro fat embolism after facial fat grafting. Objectives Raising awareness and providing more evidence on prevention and treatment of this potentially lethal complication of facial fat grafting. Methods A detailed report was made of the case. Two online databases were searched for similar cases of facial fat embolism resulting in neurological and/or visual symptoms. Thereafter a literature search was conducted to verify the etiology, current treatment options, and preventive measures. Results Forty-nine cases with similar events were found in the literature. The most common injected area was the glabella (36.1%), and an average of 16.7 ml fat was injected. The main complications are visual impairment, of which 88.5 % remained blind, and neurological symptoms, who never fully recover. Seven cases were fatal. Fat embolism can occur in veins and arteries of the face. Two possible pathways for fat embolism exist: the macroscopic, mechanical pathway with immediate signs and the microscopic, biochemical pathway with delayed symptoms. Mechanical embolectomy and corticosteroids are suggested treatment options but lack evidence. Several different preventive measures are described. Conclusions Although facial fat grafting is considered a safe procedure, one should be aware of the risk for fat embolism. Underreporting of this adverse event is likely. With no effective treatment and often detrimental outcome, preventive measures are of utmost importance to improve patient safety.

scholarly journals Sclerotherapy for Oral Pyogenic Granuloma – A case report

2017 ◽  
Vol 13 (2) ◽  
pp. 290-292 ◽  
Author(s):  
Pragya Regmee ◽  
Jyotsna Rimal ◽  
Iccha Kumar Maharjan ◽  
Sushma Pandey ◽  
Deepa Niroula ◽  
...  
Keyword(s):  
Case Report ◽  
Surgical Resection ◽  
Treatment Options ◽  
Pyogenic Granuloma ◽  
Vascular Tumor ◽  
Intralesional Injection ◽  
Sodium Tetradecyl Sulfate ◽  
Inflammatory Mass ◽  
Complete Surgical Resection ◽  
One Year

First described by Hullihen in 1844, Pyogenic granuloma (PG) is a benign, exophytic vascular tumor. It is not infective, purulent or granulomatous but a reactive inflammatory mass of blood vessels with few fibroblasts within the mucosa or skin. Without any general agreement, there exist a variety of treatment options (complete surgical resection, cryosurgery, curettage, lasers etc). However, recurrence has been frequently reported.  Sclerotherapy in PG (a vascular tumor) is not as commonly reported as in cases of hemangioma.Herein, we present a case of twenty-eight years old female with a clinical diagnosis of PG, treated with intralesional sodium tetradecyl sulfate (STS). Intralesional injection of 0.2 ml of undiluted STS was given for three visits between 10th of January and 21st of February 2016. The lesion healed completely at the patient’s fourth visit and recurrence was not reported till the patient was followed up for one year, i.e February 2017. 

Rosacea

2021 ◽  
pp. 1-8
Author(s):  
Tamara Searle ◽  
Firas Al-Niaimi ◽  
Faisal R Ali
Keyword(s):  
Beta Blockers ◽  
Treatment Options ◽  
Current Treatment ◽  
Treatment Modalities ◽  
Modified Release ◽  
Ocular Rosacea ◽  
The Face ◽  
Brimonidine Tartrate ◽  
New Treatment ◽  
General Guidance

Rosacea is a common cutaneous condition affecting predominantly the face. It is historically characterised into four subtypes: erythematotelangiectatic, papulopustular, phymatous and ocular rosacea. This article describes the pathophysiology, clinical features and current treatment options for rosacea, and discusses updated diagnostic criteria. General guidance is required on the need to avoid possible triggers including dietary and environmental triggers. The strongest evidence supports the use of 0.75% metronidazole, topical azelaic acid or topical ivermectin for inflammatory rosacea. Erythema should be treated with brimonidine tartrate gel, oral medication such as beta blockers or vascular laser and light-based therapy. Oral doxycycline 40 mg modified release can be used as monotherapy or in combination with other treatments for recalcitrant disease. Further understanding of the pathogenesis of rosacea could allow identification and targeted avoidance of triggers and the development of new treatment modalities.

scholarly journals Penyakit Periodontal pada Masa Kehamilan dan Perawatannya

e-GIGI ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 229
Author(s):  
Gabriela C. Slat ◽  
Johanna A. Khoman ◽  
Janno B. B. Bernadus
Keyword(s):  
Literature Review ◽  
Periodontal Disease ◽  
Yttrium Aluminum Garnet ◽  
Lactobacillus Reuteri ◽  
Economic Status ◽  
Treatment Options ◽  
Pyogenic Granuloma ◽  
Current Treatment ◽  
Yttrium Aluminium Garnet ◽  
Hormonal Changes

Abstract: Hormonal changes occur during pregnancy and affect the response of periodontal tissue to local factors, therefore, the risk of periodontal disease increases. Dentists have to know the treatment options that can be given to pregnant patients with periodontal disease especially the current treatments. This study was aimed to summarize the triggering factors that could worsen and the current treatment of periodontal disease during pregnancy. This was a literature review study using databases of Google scholar, Pubmed, and Science direct. After selection, there were 10 literatures; seven literatures discussed about the worsening factors of periodontal disease during pregnancy and three literatures discussed about the current treatment. The results showed several factors that could worsen periodontal disease during pregnancy, as follows: plaque, gestational age, caries, maternal age, education level, knowledge, oral hygiene behavior, treatment costs, frequency and time of tooth brushing, socio-economic status, occupation, irregular arrangement of teeth, and tobacco use. Current treatments of periodontal disease during pregnancy included the consumption of Lactobacillus reuteri-containing lozenges for preg-nancy gingivitis, a water-cooled Nd: YAG (neodymium-doped yttrium aluminum garnet) pulsed laser, and transarterial embolisation for pregnancy pyogenic granuloma. In conclusion, periodontal treatment can improve periodontal status, therefore, pregnant woman with periodontal disease need to be treated.Keywords: pregnancy; periodontal disease; worsening factors; recent treatment  Abstrak: Selama kehamilan terjadi perubahan hormonal yang memengaruhi respons jaringan periodontal terhadap faktor lokal sehingga risiko terjadinya penyakit periodontal semakin besar. Dokter gigi perlu mengetahui pilihan perawatan yang dapat diberikan kepada pasien hamil dengan penyakit periodontal khususnya perawatan terkini. Penelitian ini bertujuan untuk merangkum faktor-faktor yang dapat memperburuk dan perawatan terkini penyakit periodontal pada masa kehamilan. Jenis penelitian ini ialah suatu literature review menggunakan tiga database yaitu Google cendekia, Pubmed dan Science direct. Setelah melalui tahapan seleksi studi, didapatkan 10 literatur; tujuh literatur mengenai faktor-faktor yang dapat memperburuk penyakit periodontal pada masa kehamilan dan tiga literatur lainnya membahas perawatan terkini. Hasil penelitian mendapatkan bahwa terdapat beberapa faktor yang dapat memperburuk penyakit periodontal pada masa kehamilan yakni: plak, usia kehamilan, karies, usia ibu hamil, tingkat pendidikan, pengetahuan, perilaku kebersihan gigi dan mulut, biaya perawatan, frekuensi dan waktu menyikat gigi, status sosial-ekonomi, pekerjaan, susunan gigi yang tidak beraturan, dan penggunaan tembakau. Perawatan terkini penyakit periodontal pada masa kehamilan dapat berupa konsumsi tablet hisap yang mengandung Lactobacillus reuteri untuk gingivitis kehamilan, laser berdenyut Nd: YAG (neodymium-doped yttrium aluminium garnet) berpendingin air, dan embolisasi transarterial untuk granuloma piogenik kehamilan. Simpulan penelitian ini ialah perawatan periodontal dapat memperbaiki status periodontal sehingga wanita hamil dengan penyakit periodontal perlu menerima perawatan.Kata kunci: penyakit periodontal; kehamilan; faktor yang memperburuk; perawatan terkini

An Overview of Dementias

2012 ◽  
Vol 21 (3) ◽  
pp. 75-84
Author(s):  
Venkata Vijaya K. Dalai ◽  
Jason E. Childress ◽  
Paul E Schulz
Keyword(s):  
Clinical Presentation ◽  
Treatment Options ◽  
Current Treatment ◽  
Great Variability ◽  
Health Concern ◽  
Public Health Concern ◽  
Life Threatening ◽  
The Common ◽  
Neurodegenerative Dementias ◽  
Made In

Dementia is a major public health concern that afflicts an estimated 24.3 million people worldwide. Great strides are being made in order to better diagnose, prevent, and treat these disorders. Dementia is associated with multiple complications, some of which can be life-threatening, such as dysphagia. There is great variability between dementias in terms of when dysphagia and other swallowing disorders occur. In order to prepare the reader for the other articles in this publication discussing swallowing issues in depth, the authors of this article will provide a brief overview of the prevalence, risk factors, pathogenesis, clinical presentation, diagnosis, current treatment options, and implications for eating for the common forms of neurodegenerative dementias.

Antiretroviral Treatment-Associated Labia Majora Lipohypertrophy: A Rare Case and Plastic Surgical Treatment Options

2017 ◽  
Vol 2 (1) ◽  
pp. 43
Author(s):  
Akmal Hisham ◽  
Devananthan Ilenghoven ◽  
Wan Syazli Wan Ahmad Kamal ◽  
Salina Ibrahim ◽  
Shah Jumaat Mohd Yussof
Keyword(s):  
Highly Active Antiretroviral Therapy ◽  
Daily Living ◽  
Treatment Options ◽  
Hiv Positive ◽  
Highly Active ◽  
Labia Majora ◽  
The Face ◽  
Central Fat

The emergence of highly active antiretroviral therapy (HAART) has revolutionized the prognosis of HIV-infected patients. However, the extended use of HAART is associated with a disfiguring complication termed lipodystrophy, a disorder of body fat maldistribution causing peripheral fat loss (lipoatrophy) and central fat accumulation (lipohypertrophy). Lipoatrophy commonly affects the face, legs, buttocks and arm, whilst lipohypertrophy frequently favours the abdomen, breast and dorsocervical region. To our knowledge, we present only the second documented case in the literature of a labia majora lipohypertrophy in a HIV-positive patient receiving long-term HAART. The severity of labial abnormality caused significant physical and functional morbidities. Labiaplasty with dermolipectomy of the labia majora and excisional lipectomy of the mons pubis was successfully performed. At a 6-month follow-up, patient had no recurrence with resolution of symptoms and resumption of normal activities of daily living (ADL).

Initiation of Clozapine Therapy in a Patient With Preexisting Leukopenia: A Discussion of the Rationale of Current Treatment Options

2001 ◽  
Vol 13 (4) ◽  
pp. 233-237 ◽  
Author(s):  
Roger Boshes ◽  
Theo Manschreck ◽  
Jean Desrosiers ◽  
Steven Candela ◽  
Meredith Hanrahan-Boshes
Keyword(s):  
Treatment Options ◽  
Current Treatment ◽  
Clozapine Therapy

Nano Drug Delivery in Treatment of Oral Cancer, A Review of the Literature

2019 ◽  
Vol 20 (10) ◽  
pp. 1008-1017 ◽  
Author(s):  
Vandita Kakkar ◽  
Manoj Kumar Verma ◽  
Komal Saini ◽  
Indu Pal Kaur
Keyword(s):  
Drug Delivery ◽  
Oral Cancer ◽  
Treatment Options ◽  
Oral Submucous Fibrosis ◽  
Survival Rates ◽  
Cancer Therapeutics ◽  
Developed Countries ◽  
Current Treatment ◽  
Poor Overall Survival ◽  
Hereditary Disorders

Oral Cancer (OC) is a serious and growing problem which constitutes a huge burden on people in more and less economically developed countries alike. The scenario is clearly depicted from the increase in the expected number of new cases in the US diagnosed with OC from 49,670 people in 2016, to 49,750 cases in 2017. The situation is even more alarming in India, with 75,000 to 80,000 new cases being reported every year, thus making it the OC capital of the world. Leukoplakia, erythroplakia, oral lichen planus, oral submucous fibrosis, discoid lupus erythmatosus, hereditary disorders such as dyskeratosis congenital and epidermolisys bullosa are highlighted by WHO expert working group as the predisposing factors increasing the risk of OC. Consumption of tobacco and alcohol, genetic factors, and human papilloma virus are assigned as the factors contributing to the aetiology of OC. On the other hand, pathogenesis of OC involves not only apoptosis but also pain, inflammation and oxidative stress. Inspite of current treatment options (surgery, radiotherapy, and chemotherapy), OC is often associated with recurrence and formation of secondary primary tumours resulting in poor overall survival rates (∼50%). The intervention of nano technology-based drug delivery systems as therapeutics for cancers is often viewed as a cutting edge for technologists. Though ample literature on the usefulness of nano-coutured cancer therapeutics, rarely any product is in pipeline. Yet, despite all the hype about nanotechnology, there are few ongoing trials. This review discusses the current and future trends of nano-based drug delivery for the treatment of OC.

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