RISK FACTORS AND PROTECTION FACTORS FOR THE COVID-19 EPIDEMIC AND VACCINATION AS A POSSIBLE MEANS OF CONTROLLING THE EPIDEMIC

2017 ◽  
Author(s):  
Oksana Romaniv ◽  
◽  
Bohdan Klyapchuk ◽  
Keyword(s):  
Risk Factors ◽  
Economic Integration ◽  
Herd Immunity ◽  
Vaccination Program ◽  
Special Method ◽  
Vaccination Programs ◽  
Regional Dynamics ◽  
Spatio Temporal ◽  
The Impact

A study of the impact of especially contextual on COVID-19 factors of the epidemic (geopolitical, climatic, socio-economic integration, social, including religious, demographic and others) was conducted. The regional dynamics of the epidemic in the Scandinavian countries was analyzed. The spatio-temporal changes of the epidemic indicators in the conditions of loyalty to risk factors (Sweden) and in the conditions of controlled risks (in other countries of the Scandinavian region) were revealed. The current research of scientists on the formation of herd immunity in the population with and without vaccination programs was generalized. The article evaluated the quality of the vaccination program in Ukraine. The threshold indicator "herd immunity" and the number of months to achieve herd immunity in Ukraine without vaccination were calculated according to a special method.

scholarly journals AB0602 IMPACT OF SOCIOECONOMIC FACTORS ON PAIN AND FUNCTION IN KNEE OSTEOARTHRITIS: A SYSTEMATIC LITERATURE REVIEW

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1337.2-1337
Author(s):  
T. W. Swinnen ◽  
M. Willems ◽  
I. Jonkers ◽  
F. P. Luyten ◽  
J. Vanrenterghem ◽  
...  
Keyword(s):  
Risk Factors ◽  
Literature Review ◽  
Knee Osteoarthritis ◽  
Socioeconomic Factors ◽  
Systematic Literature Review ◽  
Intervention Effects ◽  
Socioeconomic Outcomes ◽  
And Function ◽  
The Impact

Background:The personal and societal burden of knee osteoarthritis (KOA) urges the research community to identify factors that predict its onset and progression. A mechanistic understanding of disease is currently lacking but needed to develop targeted interventions. Traditionally, risk factors for KOA are termed ‘local’ to the joint or ‘systemic’ referring to whole-body systems. There are however clear indications in the scientific literature that contextual factors such as socioeconomic position merit further scientific scrutiny, in order to justify a more biopsychosocial view on risk factors in KOA.Objectives:The aims of this systematic literature review were to assess the inclusion of socioeconomic factors in KOA research and to identify the impact of socioeconomic factors on pain and function in KOA.Methods:Major bibliographic databases, namely Medline, Embase, CINAHL, Web of Science and Cochrane, were independently screened by two reviewers (plus one to resolve conflicts) to identify research articles dealing with socioeconomic factors in the KOA population without arthroplasty. Included studies had to quantify the relationship between socioeconomic factors and pain or function. Main exclusion criteria were: a qualitative design, subject age below 16 years and articles not written in English or Dutch. Methodological quality was assessed via the Cochrane risk of bias tools for randomized (ROB-II) and non-randomized intervention studies (ROBIN-I) and the Newcastle-Ottawa Scale for assessing the quality of non-randomised studies. Due to heterogeneity of studies with respect to outcomes assessed and analyses performed, no meta-analysis was performed.Results:Following de-duplication, 7639 articles were available for screening (120 conflicts resolved without a third reader). In 4112 articles, the KOA population was confirmed. 1906 (25%) were excluded because of knee arthroplasty and 1621 (21%) because of other issues related to the population definition. Socioeconomic factors could not be identified in 4058 (53%) papers and were adjusted for in 211 (3%) articles. In the remaining papers covering pain (n=110) and/or function (n=81), education (62%) and race (37%) were most frequently assessed as socioeconomic factors. A huge variety of mainly dichotomous or ordinal socioeconomic outcomes was found without further methodological justification nor sensitivity analysis to unravel the impact of selected categories. Although the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) was the most popular instrument to assess pain and function, data pooling was not possible as socioeconomic factors estimates were part of multilevel models in most studies. Overall results showed that lower education and African American race were consistent predictors of pain and poor function, but those effects diminished or disappeared when psychological aspects (e.g. discrimination) or poverty estimates were taken into account. When function was assessed using self-reported outcomes, the impact of socioeconomic factors was more clear versus performance-based instruments. Quality of research was low to moderate and the moderating or mediating impact of socioeconomic factors on intervention effects in KOA is understudied.Conclusion:Research on contextual socioeconomic factors in KOA is insufficiently addressed and their assessment is highly variable methodologically. Following this systematic literature review, we can highlight the importance of implementing a standardised and feasible set of socioeconomic outcomes in KOA trials1, as well as the importance of public availability of research databases including these factors. Future research should prioritise the underlying mechanisms in the effect of especially education and race on pain and function and assess its impact on intervention effects to fuel novel (non-)pharmacological approaches in KOA.References:[1]Smith TO et al. The OMERACT-OARSI Core Domain Set for Measurement in Clinical Trials of Hip and/or Knee Osteoarthritis J Rheumatol 2019. 46:981–9.Disclosure of Interests:None declared.

scholarly journals Estimating asymptomatic, undetected and total cases for the COVID-19 outbreak in Wuhan: a mathematical modeling study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Xi Huo ◽  
Jing Chen ◽  
Shigui Ruan
Keyword(s):  
Disease Transmission ◽  
Large Scale ◽  
Transmission Rate ◽  
Control Strategies ◽  
Herd Immunity ◽  
Antibody Prevalence ◽  
Screening Process ◽  
Vaccination Programs ◽  
Prevalence Level ◽  
The Impact

Abstract Background The COVID-19 outbreak in Wuhan started in December 2019 and was under control by the end of March 2020 with a total of 50,006 confirmed cases by the implementation of a series of nonpharmaceutical interventions (NPIs) including unprecedented lockdown of the city. This study analyzes the complete outbreak data from Wuhan, assesses the impact of these public health interventions, and estimates the asymptomatic, undetected and total cases for the COVID-19 outbreak in Wuhan. Methods By taking different stages of the outbreak into account, we developed a time-dependent compartmental model to describe the dynamics of disease transmission and case detection and reporting. Model coefficients were parameterized by using the reported cases and following key events and escalated control strategies. Then the model was used to calibrate the complete outbreak data by using the Monte Carlo Markov Chain (MCMC) method. Finally we used the model to estimate asymptomatic and undetected cases and approximate the overall antibody prevalence level. Results We found that the transmission rate between Jan 24 and Feb 1, 2020, was twice as large as that before the lockdown on Jan 23 and 67.6% (95% CI [0.584,0.759]) of detectable infections occurred during this period. Based on the reported estimates that around 20% of infections were asymptomatic and their transmission ability was about 70% of symptomatic ones, we estimated that there were about 14,448 asymptomatic and undetected cases (95% CI [12,364,23,254]), which yields an estimate of a total of 64,454 infected cases (95% CI [62,370,73,260]), and the overall antibody prevalence level in the population of Wuhan was 0.745% (95% CI [0.693%,0.814%]) by March 31, 2020. Conclusions We conclude that the control of the COVID-19 outbreak in Wuhan was achieved via the enforcement of a combination of multiple NPIs: the lockdown on Jan 23, the stay-at-home order on Feb 2, the massive isolation of all symptomatic individuals via newly constructed special shelter hospitals on Feb 6, and the large scale screening process on Feb 18. Our results indicate that the population in Wuhan is far away from establishing herd immunity and provide insights for other affected countries and regions in designing control strategies and planing vaccination programs.

scholarly journals Flattening the Curve of COVID-19 Vaccine Rejection—An International Overview

Vaccines ◽  
2021 ◽  
Vol 9 (1) ◽  
pp. 44
Author(s):  
Wojciech Feleszko ◽  
Piotr Lewulis ◽  
Adam Czarnecki ◽  
Paweł Waszkiewicz
Keyword(s):  
Czech Republic ◽  
General Population ◽  
Herd Immunity ◽  
Vaccination Program ◽  
Vaccination Programs ◽  
National Surveys ◽  
Legislative Power ◽  
Preventive Vaccination ◽  
Very High ◽  
Socioeconomic Benefits

Background: If globally implemented, a safe coronavirus disease 2019 (COVID-19) vaccination program will have broad clinical and socioeconomic benefits. However, individuals who anticipate that the coronavirus vaccine will bring life back to normality may be disappointed, due to the emerging antivaccination attitude within the general population. Methods: We surveyed a sample of adult Polish citizens (n = 1066), and compared it with the data on international COVID-19 vaccine reluctance. Results: In 20 national surveys, the vaccine averseness for the anticipated COVID-19 vaccine varied from meager (2–6% China) to very high (43%, Czech Republic, and 44%, Turkey) and in most countries was much higher than regular vaccination reluctance, which varies between 3% (Egypt) and 55% (Russia). Conclusions: These results suggest that a 67% herd immunity may be possible only if mandatory preventive vaccination programs start early and are combined with coordinated education efforts supported by legislative power and social campaigns.

scholarly journals Urinary Incontinence and Quality of Life in Female Patients with Obesity

2018 ◽  
Vol 40 (09) ◽  
pp. 534-539 ◽  
Author(s):  
Christiana Nygaard ◽  
Lucas Schreiner ◽  
Thiago Morsch ◽  
Rodrigo Saadi ◽  
Marina Figueiredo ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Risk Factors ◽  
Urinary Incontinence ◽  
Vaginal Delivery ◽  
Short Form ◽  
Female Patients ◽  
International Consultation ◽  
Independent Risk Factors ◽  
The Impact

Objective To analyze the prevalence of urinary incontinence (UI) in female patients with an indication for bariatric surgery, to investigate the potential risk factors and the impact on quality of life. Methods A cross-sectional study with female patients with obesity. The evaluation consisted of a structured interview, a specific study form and quality of life questionnaires. The Poisson regression was performed to identify independent risk factors related to UI. Results A total of 221 patients were enrolled; 118 of the study participants (53.4%) reported UI episodes. Mixed UI (MUI), stress UI (SUI) only, and urgency UI (UUI) only were reported by 52.5% (62), 33.9% (40) , and 13.5% (16) of these patients respectively. The prevalence of UI was increased by 47% among the women who had given birth vaginally and by 34% of the women who had entered menopause. Vaginal delivery and menopause were identified as independent risk factors related to UI. The mean International Consultation on Incontinence Questionnaire - Short Form (ICIQ-SF) score was 9.36 ± 4.9. The severity of symptoms was considered moderate in 53.3% (63) of the patients with UI. Conclusion Urinary incontinence impacts quality of life negatively, and the prevalence of UI is high among obese patients. In the present study, vaginal delivery and menopause were independently associated with UI.

scholarly journals The Impact of Structured Self-Monitoring of Blood Glucose Combined With Intensive Education on HbA1c Levels, Hospitalizations, and Quality-of-Life Parameters in Insulin-Treated Patients With Diabetes at Primary Care in Serbia: The Multicenter SPA-EDU Study

2016 ◽  
Vol 11 (4) ◽  
pp. 746-752 ◽  
Author(s):  
Nebojša M. Lalić ◽  
Katarina Lalić ◽  
Aleksandra Jotić ◽  
Dejan Stanojević ◽  
Dragana Živojinović ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Risk Factors ◽  
Primary Care ◽  
Blood Glucose ◽  
Self Monitoring ◽  
Intensive Education ◽  
Distress Scale ◽  
The Impact ◽  
Hba1c Levels

Background: We assessed the effect of structured self-monitoring of blood glucose (SMBG), in combination with intensive education, on metabolic control, SMBG frequency, hospitalizations, cardiovascular risk factors, and quality-of-life parameters in patients with insulin-treated diabetes in primary health care settings in Serbia. Methods: This 6-month, observational, noninterventional study, followed 346 insulin-treated diabetes patients (type 1 diabetes [T1D], n = 57; type 2 diabetes [T2D], n = 289) from 28 primary care centers. Patients attended a 10-day course at the specialized educational center and were followed monthly by their primary care physicians. Patients used a simple paper tool to document 3-day, 7-point glucose profiles prior to each monthly clinic visit. Physicians reviewed the completed forms at each visit and used a standardized education program to provide remedial training. Changes in HbA1c levels, SMBG frequency, metabolic risk factors, and Diabetes Distress Scale (DDS) were assessed. Results: Mean (± SD) HbA1c within the full cohort was significantly improved from baseline at 6 months (8.85 ± 1.17% vs 7.91 ± 1.24%, P < .01). Significant increases in average SMBG frequency per week were seen at 6 months versus baseline (14.6/week vs 4.3/week, P < .001). The mean (± SE) number of hospitalizations due to metabolic conditions was significantly lower during the 6-month study compared to the 6-month period prior to the study (0.14 ± 0.04 vs 0.59 ± 0.09). DDS scores decreased from 39.6 ± 13.9 to 33.9 ± 14.5, P < .01. Conclusion: The use of structured SMBG combined with intensive education was associated with clinically significant reductions in HbA1c, increased SMBG frequency, and improved quality of life.

scholarly journals “You Can Get Prepared, But It’s Still Scary Walking Out The Door”: Exploring the Role of Dynamic Re-entry Factors in Release Planning for High-Risk Offenders

2021 ◽  
Author(s):  
◽  
Chelsea M. Richards
Keyword(s):  
Risk Factors ◽  
New Zealand ◽  
High Risk ◽  
Management Tool ◽  
Short Term ◽  
Release Planning ◽  
Dynamic Risk ◽  
Indirect Relationship ◽  
The Impact

<p>The task of preparing high-risk prisoners for the multitude of challenges they will face once released is vital to their chances of successful re-entry. Recent research in New Zealand has found that developing good quality plans for life after prison is associated with reduced rates of reoffending after release – but how? One suggestion is that release plans help to ameliorate risks in offenders’ release environments. However, research examining how these risk factors are affected by the quality of release plans is scarce. This thesis investigates whether release planning has an indirect relationship with recidivism through its influence on dynamic risk and protective factors in re-entry, as measured by a risk management tool used by Community Probation Services in New Zealand: the Dynamic Risk Assessment for Offender Re-entry (DRAOR; Serin, 2007). A coding protocol to assess the quality of release plans was developed and retrospectively applied to a sample of 303 high-risk male parolees. Outcomes of interest were “short-term recidivism” (within 100 days of release) and “longer-term recidivism” (within one year of release) across four different indices. Results indicated that parolees who did not reoffend within the first 100 days of release had significantly better quality release plans than those who did reoffend. Better quality release plans also predicted greater stability in acute risk factors, and greater improvements in overall DRAOR scores, within the first 100 days of release. Logistic mediation analyses confirmed that release planning had an indirect relationship with both short-term and longer-term recidivism through its influence on DRAOR total scores. Together, these findings suggest that release planning may facilitate successful re-entry by reducing the impact of acute triggers or destabilisers in the release environment, thus protecting against a potential relapse. Theoretical and practical implications of these findings are discussed, along with limitations of the study and suggested directions for future research.</p>

scholarly journals Participation Rate of Employees of RS X In The Covid-19 Vaccination Program to Break The Chain The Spread of Covid-19

2021 ◽  
Vol 1 (1) ◽  
pp. 205-210
Author(s):  
Kristianto Kristianto
Keyword(s):  
Side Effects ◽  
Health Workers ◽  
Herd Immunity ◽  
Participation Rate ◽  
Vaccination Program ◽  
Vaccination Programs ◽  
Negative Context ◽  
Religious Reasons ◽  
Motivation To Participate

The COVID-19 vaccination aims to reduce the transmission of COVID-19, reduce morbidity and mortality due to COVID-19, achieve herd immunity, and protect the community from COVID-19 to remain socially and economically productive. The role of social media in the era of digital technology can bring positive things as well as negative things, in a positive context there are invitations in the form of motivation to participate in vaccination programs. Meanwhile, in a negative context, the COVID-19 vaccination has become a cornering or scary hoax. However, this news cannot be verified. However, this news greatly influences a person's decision to participate or not in the vaccination program in addition to doubts about the safety of vaccines, doubts about the effectiveness of vaccines, distrust of vaccines, fears of side effects such as fever and pain, and religious reasons. This study will explain the level of participation of workers who work in Hospital X in receiving a prioritized vaccination program for health workers. The research method used is descriptive, where data is collected in the period from January 29, 2021, to May 10, 2021. The vaccination program which is an alternative to breaking the chain of the spread of COVID-19 is welcomed by its implementation in Hospital X with the participation rate of the results. reached 92%. The remaining 8% were not vaccinated because they did not receive a recommendation from a doctor or refused the vaccine because they were worried about the side effects.

scholarly journals Spatiotemporal dynamics of foot and mouth disease outbreaks in India, 2008-2016

2021 ◽  
Author(s):  
Umanga Gunasekera ◽  
Jitendra Biswal ◽  
Gustavo Machado ◽  
Rajeev Ranjan ◽  
Saravanan Subramaniam ◽  
...  
Keyword(s):  
Antibody Titer ◽  
Foot And Mouth Disease ◽  
Spatiotemporal Dynamics ◽  
Mouth Disease ◽  
Mass Vaccination ◽  
Vaccination Program ◽  
Post Vaccination ◽  
Vaccination Programs ◽  
Foot And Mouth ◽  
The Impact

Foot-and-mouth disease (FMD) is endemic in India, where circulation of serotypes O, A and Asia 1 is frequent. In the past two decades, many of the most widespread and significant FMD lineages globally have emerged from the South Asia region. Here, we provide an epidemiological assessment of the ongoing mass vaccination programs in regard to post-vaccination monitoring and outbreak occurrence. The objective of this study was to quantify the spatiotemporal dynamics of FMD outbreaks and to assess the impact of the mass vaccination program between 2008 to 2016 with available antibody titer data from the vaccination monitoring program, alongside other risk factors that facilitate FMD spread in the country. We first conducted a descriptive analysis of epidemiological outcomes of governmental vaccination programs in India, focusing on antibody titer data from >1 million animals sampled as part of pre- and post-vaccination monitoring and estimates of standardized incidence ratios calculated from reported outbreaks per state/administrative unit. The percent of animals with inferred immunological protection (based on ELISA) was highly variable across states, but there was a general increase in the overall percent of animals with inferred protection through time. In addition, the number of outbreaks in a state was negatively correlated with the percent of animals with inferred protection. Because standardized incidence ratios of outbreaks were heterogeneously distributed over the course of eight years, we analyzed the distribution of reported FMD outbreaks using a Bayesian space-time model to map high-risk areas. This model demonstrated a ~50% reduction in the relative risk of outbreaks in states that were part of the vaccination program. In addition, states that did not have an international border experienced reduced risk of FMD outbreaks. These findings help inform risk-based control strategies for India as the country progresses towards reducing reported clinical disease.

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