scholarly journals Topical therapy in the treatment of patients with acute rhinosinusitis in adults

2021 ◽  
Vol 23 (3) ◽  
pp. 210-215
Author(s):  
Svetlana V. Starostina ◽  
◽  
Dmitrii A. Sivokhin ◽  
Keyword(s):  
Nasal Mucosa ◽  
Paranasal Sinuses ◽  
Topical Therapy ◽  
Mild Form ◽  
Drug Induced ◽  
Acute Rhinosinusitis ◽  
Inflammatory Processes ◽  
Acute Bacterial Rhinosinusitis ◽  
Further Development

Acute rhinosinusitis is one of the most common diseases in the world, characterized by acute inflammatory processes in the nasal cavity and paranasal sinuses, lasting less than 4 weeks. According to statistics, in Russia, this disease is recorded in 6–15% of the population annually, in European countries in every seventh person, while there is a tendency to an increase in the incidence. Acute viral rhinosinusitis has the highest incidence among all rhinosinusitis and occurs in most patients in a mild form, however, untimely treatment of inflammation of the nasal mucosa can lead to obstruction of the natural anastomoses, impaired physiological ventilation and drainage of the paranasal sinuses, stagnation of secretions with further development acute bacterial rhinosinusitis. The overuse of local vasoconstrictor drugs (intranasal decongestants) leads to the development of drug-induced rhinitis, long-term imbalance of autonomic innervation of the nasal mucosa and edema, called "rebound syndrome". In the article we consider the issues of etiology, pathogenesis, features of the course of rhinosinusitis. The principles of differential diagnosis of viral and bacterial rhinosinusitis are stated, taking into account the latest recommendations and research in this area. The features of the use of the most frequently used topical preparations in acute rhinosinusitis in the practice of an ENT doctor have been analyzed.

scholarly journals The place of topical mucoactive drugs in the comprehensive treatment of acute paranasal sinusitis

2021 ◽  
Vol 5 (7) ◽  
pp. 508-512
Author(s):  
T.A. Mashkova ◽  
◽  
A.B. Maltsev ◽  
Keyword(s):  
Mucous Membrane ◽  
Paranasal Sinuses ◽  
Drug Exposure ◽  
Rapid Development ◽  
Topical Therapy ◽  
Control Group ◽  
Comprehensive Treatment ◽  
Surgical Interventions ◽  
Paranasal Sinusitis ◽  
Acute Rhinosinusitis

Rhinology rapid development, the emergence of new and improvement of already known methods of diagnosis and treatment of paranasal sinuses (PNS) inflammatory diseases almost did not affect the prevalence growth rate of this pathology. Surgical interventions did not contribute to reducing the frequency of recurrence and chronicity of paranasal sinusitis, while the need for drug therapy is steadily increasing. The availability of the mucous membrane for drug exposure, its continuity in both the upper and lower respiratory tract, high reflexogenic response allow topically stimulating secretory activity, causing dehydration of all glandular components of the mucous membrane. The article presents the experience of using the drug, an extract of Cyclamen europaeum, in the treatment of acute rhinosinusitis. Clinical examples show the efficacy of its use both as monotherapy and in combination with systemic antibiotics. The significant drainage effect of the drug allows avoiding invasive methods of PNS lavage (puncture, intubation, etc.) in the complex therapy of this pathology and reducing the treatment duration by 3–4 days compared to the control group. Therefore, it can be recommended for wider use in the treatment of catarrhal processes and purulent inflammation of the nasal mucosa and PNS. KEYWORDS: acute rhinosinusitis, topical therapy, plant extracts, European cyclamen, efficacy, computed tomography, pneumatization, paranasal sinuses. FOR CITATION: Mashkova T.A., Maltsev A.B. The place of topical mucoactive drugs in the comprehensive treatment of acute paranasal sinusitis. Russian Medical Inquiry. 2021;5(7):508–512 (in Russ.). DOI: 10.32364/2587-6821-2021-5-7-508-512.

Phototherapy is a pathogenetic method in the treatment of acute sinusitis

2020 ◽  
pp. 34-39
Author(s):  
Arsen Korkmazov
Keyword(s):  
Nasal Mucosa ◽  
Local Effect ◽  
Nasal Secretion ◽  
Visible Range ◽  
Neutrophil Granulocytes ◽  
Physical Treatment ◽  
Local Immunity ◽  
Acute Rhinosinusitis ◽  
Therapeutic Measures ◽  
Effect Of Light

Currently, physical treatment methods, in particular use of photochromotherapy in the treatment of sinusitis, are of interest. Is to investigate the local effect of light in the visible range (450 nm) on the factors of local infection protection of the nasal mucosa. The study involved 50 patients with a diagnosis of acute rhinosinusitis at the age of 27.23±3.29 years. Exposure of the mucous membrane of the nasal cavity was carried out in accordance with the parameters: 450 nm wavelength (monochromatic non-polarized blue light), during 5 minutes for each nostril. Sessions of photochromotherapy were carried out according to the "Sanitary norms and rules for the design and operation of lasers" No. 5804-91. Inclusion of photochromotherapy in the complex of therapeutic measures for patients with acute rhinosinusitis helps to reduce the total number of neutrophils in nasal secretion, normalize their lysosomal activity, NBT-reducing activity, activity and intensity of phagocytosis. Restoration of local immunity factors in nasal mucosa, expressed in normalizing the functional and metabolic status of neutrophil granulocytes of the nasal secretion, can serve as one of the criteria for the effectiveness of treatment using photochromotherapy

scholarly journals Applications, challenges, and needs for employing synthetic biology beyond the lab

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Sierra M. Brooks ◽  
Hal S. Alper
Keyword(s):  
Synthetic Biology ◽  
Great Promise ◽  
Long Term Storage ◽  
Autonomous Function ◽  
Recent Advances ◽  
Resource Limited ◽  
Major Application ◽  
Further Development ◽  
Probiotic Delivery

AbstractSynthetic biology holds great promise for addressing global needs. However, most current developments are not immediately translatable to ‘outside-the-lab’ scenarios that differ from controlled laboratory settings. Challenges include enabling long-term storage stability as well as operating in resource-limited and off-the-grid scenarios using autonomous function. Here we analyze recent advances in developing synthetic biological platforms for outside-the-lab scenarios with a focus on three major application spaces: bioproduction, biosensing, and closed-loop therapeutic and probiotic delivery. Across the Perspective, we highlight recent advances, areas for further development, possibilities for future applications, and the needs for innovation at the interface of other disciplines.

scholarly journals Sustaining Trade during COVID-19 Pandemic: Establishing a Conceptual Model Including COVID-19 Impact

2021 ◽  
Vol 13 (10) ◽  
pp. 5418
Author(s):  
Nashwan M. A. Saif ◽  
Jianping Ruan ◽  
Bojan Obrenovic
Keyword(s):  
International Trade ◽  
Bilateral Trade ◽  
Production Costs ◽  
Research Directions ◽  
Economic Distance ◽  
Conceptual Paper ◽  
Sudden Decrease ◽  
Further Development ◽  
Conceptual Research

The conceptual research aims to identify antecedents conducive to bilateral trade during the COVID-19 pandemic. Considering the relevance of bilateral trade for foreign policy and economy studies, there is a need for a renewed framework in times of extreme economic instability. As international commerce is essential for improving the country’s economy, we have examined how economic distance, population, trade percentage of GDP, exchange rate, and political changes interconnect and relate to COVID-19, influencing trade flows. This conceptual paper illustrates the likely impact of COVID-19 on international trade by exploring pandemics’ effects on standard trading parameters such as GDP, distance, policy stability, and population. We model the resulting shock as a multifaceted variable reflected in capital underutilization, manufacturing output decline, international trade costs inflation, production costs inflation, decrease in demand for certain services and shift from everyday needs towards activities that exclude the proximity between people, e.g., proclivity towards virtual market products. The sudden decrease in GDP and bilateral trade, as well as FDI, is amplified by further development of pandemics’ long-term consequences. We take COVID-19 to be a technological, financial, and policy shock significantly influencing international trade and economic development and argue that it will have a varying impact on diverse sectors and economies. The paper offers preliminary insight into the pandemic-related economics that are unfolding and deduce recommendations on positive changes in trading policy to fully leverage on arising trading opportunities and point to potential research directions.

scholarly journals Subthreshold Micropulse Laser Modulates Retinal Neuroinflammatory Biomarkers in Diabetic Macular Edema

2021 ◽  
Vol 10 (14) ◽  
pp. 3134
Author(s):  
Luisa Frizziero ◽  
Andrea Calciati ◽  
Giulia Midena ◽  
Tommaso Torresin ◽  
Raffaele Parrozzani ◽  
...  
Keyword(s):  
Macular Edema ◽  
Laser Treatment ◽  
Diabetic Macular Edema ◽  
Metabolic Pathways ◽  
Treatment Method ◽  
Micropulse Laser ◽  
Subthreshold Micropulse Laser ◽  
Inflammatory Processes ◽  
Standardized Parameters

Subthreshold micropulse laser treatment has become a recognized option in the therapeutic approach to diabetic macular edema. However, some yet undefined elements pertaining to its mechanism of action and most effective treatment method still limit its clinical diffusion. We reviewed the current literature on subthreshold micropulse laser treatment, particularly focusing on its effects on the modulation of retinal neuroinflammation. Subthreshold micropulse laser treatment seems to determine a long-term normalization of specific retinal neuroinflammatory metabolic pathways, contributing to the restoration of retinal homeostasis and the curtailing of local inflammatory processes. Optimized and standardized parameters ensure effective and safe treatment.

scholarly journals The Impact of COVID-19 on Hospitality Industry in Greece and Its Treasured Santorini Island

2021 ◽  
Vol 13 (14) ◽  
pp. 7906
Author(s):  
Nikola Medová ◽  
Lucie Macková ◽  
Jaromir Harmacek
Keyword(s):  
Social Impact ◽  
Tourism Sector ◽  
Challenges And Opportunities ◽  
Multiple Variables ◽  
Hospitality Sector ◽  
Tourism And Hospitality ◽  
The Impact ◽  
Further Development

This paper focuses on the dynamic of the recent upheaval in the tourism and hospitality sector due to the COVID-19 epidemic in Greece and Santorini island. It uses the case study of a country one-fourth of whose GDP consists of tourism. We compare the available statistical data showing the change in variables in the previous years with 2020 and look into the new challenges and opportunities posed by the drop in the numbers of visitors and flights. We focus mainly on the economic and social impact on the destination and possible future scenarios for further development in the area. Data show a significant effect of the pandemic on multiple variables, such as the long-term trend of the importance of tourism sector in GDP in Greece, the number of flights and visitors to Greece and Santorini island, and the contribution of tourism and travel to GDP. Based on the available data, we also construct three foresight scenarios that describe the possible futures for Santorini island in terms of the pandemic evolution. These scenarios may help various stakeholders and policymakers to be better prepared for different developments that may appear.

scholarly journals Long-Term Histologic Changes in Nasal Mucosa after Total Laryngectomy

2010 ◽  
Vol 2010 ◽  
pp. 1-4 ◽  
Author(s):  
Çiğdem Tepe Karaca ◽  
Erdoğan Gültekin ◽  
M. Kürşat Yelken ◽  
Ayşenur Akyıldız İğdem ◽  
Mehmet Külekçi
Keyword(s):  
Cancer Patients ◽  
Nasal Mucosa ◽  
Laryngeal Cancer ◽  
Total Laryngectomy ◽  
Group 3 ◽  
Histopathologic Changes ◽  
Group 2 ◽  
The Relationship ◽  
Histopathologic Findings

Objective. To determine the long-term histopathologic changes in nasal mucosa and the relationship between progression of the histopathologic changes and the duration without air current stimulation.Material and Method. Biopsies were taken from the inferior turbinates of 11 laryngeal cancer patients after total laryngectomy. Specimens were stained with hematoksilen-eosin and several histopathologic parameters were examined under light microscopy.Results. All of the patients demonstrated at least one histopathologic abnormality (100%,n=11). Goblet destruction and stromal fibrosis were the most common findings (81%,n=9), followed by focal epithelial atrophy and subepithelial seromusinous gland destruction (45%,n=5), neovascularization and congestion (36%,n=4), complete epithelial atrophy and mixoid degeneration (27%,n=3). According to the duration between laryngectomy and biopsy, patients were grouped in to three: group 1; less than 12 months (36%,n=4), group 2; 12–36 months (18%,n=2), and group 3; more than 36 months (45%,n=5). Only congestion was found to be decreased as the duration increased (P<.005).Conclusion. In laryngeal cancer patients histopathologic changes occur in nasal mucosa eventuate due to the cessation of air current stimulation, however there was no relation between progression of the histopathologic findings and the duration of cessation.

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