Prevalence of Oral Lesions in Patients with Psoriasis

Background: Psoriasis is a common chronic inflammatory condition that affects mainly skin and joints which has a genetic and immunological background with unknown etiology. Objective: To determine the prevalence of oral findings and possible association with disease severity in psoriatic patients attending the Erbil Dermatology Teaching Center in Erbil city, Kurdistan Region-Iraq. Patients and Methods: This cross-sectional study was conducted on 120 cases of psoriasis attending Erbil Dermatology Teaching Center in Erbil city, Kurdistan Region-Iraq. Psoriasis Area and Severity Index (PASI) scored was used for each patient and all participants were examined for observing oral lesions. The Statistical Package for Social Sciences (SPSS, version25) was used for analyzing the data. Chi-square test and Fisher’s exact tests were applied as descriptive statistics tests. A p-value of ≤ 0.05 was considered statistically significant. Results: Among the 120 cases, 50 cases were males and 70 were females, their mean age ± SD was 30.24 ± 14.82 years, and the age range was 6-65 years. Oral lesions were detected in 50 (41.7%) cases, and the most common oral findings were fissured tongue 39 (32.5%) cases and geographic tongue 5 (4.2%). The Psoriasis Area and Severity Index (PASI) score for the majority of the cases were mild and the oral manifestations were strongly associated with the disease severity (p = 0.001). Conclusion: Both fissured tongue and geographic tongue are the two most frequent oral findings in psoriatic patients in this study, the prevalence of these findings increased with the disease severity. Routine examinations of the oral cavity are necessary for all psoriatic patients. Keywords: Psoriasis, oral manifestations, oral lesions, PASI score

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Geographic Tongue and Fissured Tongue in 348 Patients with Psoriasis: Correlation with Disease Severity

The Scientific World JOURNAL ◽

10.1155/2015/564326 ◽

2015 ◽

Vol 2015 ◽

pp. 1-7 ◽

Cited By ~ 23

Author(s):

Bruna L. S. Picciani ◽

Thays T. Souza ◽

Vanessa de Carla B. Santos ◽

Tábata A. Domingos ◽

Sueli Carneiro ◽

...

Keyword(s):

Disease Severity ◽

Psoriasis Vulgaris ◽

Oral Lesions ◽

Healthy Controls ◽

Cutaneous Lesions ◽

Pasi Score ◽

Psoriasis Severity ◽

Fissured Tongue

Geographic tongue (GT) and fissured tongue (FT) are the more frequent oral lesions in patients with psoriasis. The aims of this study were to compare the prevalence of GT/FT between psoriasis group (PG) and healthy controls (HC) and investigate the correlation between GT/FT and psoriasis severity using the PASI and age of psoriasis onset. Three hundred and forty-eight PG and 348 HC were selected. According to the age of psoriasis onset, the individuals were classified as having early psoriasis and late psoriasis. The severity of vulgaris psoriasis was determined according to PASI. A follow-up was conducted in patients with psoriasis vulgaris (PV) with GT to evaluate the progression of oral and cutaneous lesions. The FT and GT were more frequent in PG than in HC. The incidence of GT was higher in patients with early psoriasis and that of FT in late-psoriasis. There is association between psoriasis intensity and GT; and a higher monthly decrease of PASI score in patients without GT. The presence of GT and FT is higher in PG than in the HC. GT is associated with disease severity and may be a marker of the psoriasis severity.

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Association of Pathogenic Th17 Cells with the Disease Severity and Its Potential Implication for Biological Treatment Selection in Psoriasis Patients

Mediators of Inflammation ◽

10.1155/2020/8065147 ◽

2020 ◽

Vol 2020 ◽

pp. 1-16

Author(s):

Cristina Aguilar-Flores ◽

Octavio Castro-Escamilla ◽

Elizabeth M. Ortega-Rocha ◽

César Maldonado-García ◽

Fermín Jurado-Santa Cruz ◽

...

Keyword(s):

Disease Severity ◽

Peripheral Blood ◽

Th17 Cells ◽

Life Quality ◽

Severity Index ◽

Experimental Models ◽

Cutaneous Lesions ◽

Potential Implication ◽

Th17 Lymphocytes ◽

Pasi Score

Psoriasis is an inflammatory autoimmune disease characterized by cutaneous lesions in plaques. It has been proposed that the immune response has a key role in the disease progression. Particularly, the Th17 cells through IL-17 can contribute to maintain the inflammatory process. The pathogenic Th17 phenotype has been described in human diseases and associated with high severity in inflammatory experimental models. However, it is not clear if the pathogenic phenotype could be present in the skin and peripheral blood as well as its possible association to severity in psoriasis. In the lesional skin, we found high infiltration of Th17 cells and the pathogenic phenotype, finding a correlation between the frequency of Th17 cells and the Psoriasis Area and Severity Index (PASI) score. In peripheral blood, we observed a pool of Th17 lymphocytes with potential to acquire pathogenic features. Interestingly, the percentage of pathogenic Th17 cells (CD4+ RORγt+ IFN-γ+) correlates with disease severity. Moreover, we distinguished three groups of patients based on their IL-17/IFN-γ production by Th17 lymphocytes, which seems to be related with a dynamic or stable potential to express these cytokines. Remarkably, we evaluated the cytokine production by Th17 cells as an immunological marker for the adequate selection of biologic therapy. We found that patients analyzed by this immunological approach and treated with antibodies against IL-17 and TNFα showed great improvement depicted by reduction in PASI and Dermatology Life Quality Index (DLQI) score as well as the percentage of Body Surface Area (BSA). Altogether, our results highlight the importance of the assessment of the pathogenic phenotype in Th17 cells as an immune personalized analysis with the potential to support the therapy choice in the clinical practice.

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EVALUATION OF NONIONIC SURFACTANTS FOR CONTROL OF CLUBROOT OF CABBAGE USING BAREROOT AND PLUG TRANSPLANTS OF TWO CULTIVARS

HortScience ◽

10.21273/hortsci.27.6.607b ◽

1992 ◽

Vol 27 (6) ◽

pp. 607b-607

Author(s):

W. Tietjen ◽

P.J. Nitzsche ◽

W.P. Cowgill ◽

M.H. Maletta ◽

S.A. Johnston

Keyword(s):

Brassica Oleracea ◽

Disease Severity ◽

Nonionic Surfactants ◽

Plasmodiophora Brassicae ◽

Severity Index ◽

Effective Control ◽

Disease Severity Index

`Market Prize' and `Bravo' cabbage (Brassica oleracea Var. capitata L.), transplanted as peat plug and bareroot plants into a field naturally infested with Plasmodiophora brassicae, Woronin, were treated immediately after planting with a liquid or a granular surfactant. APSA 80™, applied in transplant water, significantly reduced percent clubbing and disease severity index (DSI) compared to control treatments. Miller Soil Surfactant Granular™ did not significantly reduce percent clubbing or DSI. There was a significant effect of cultivar on percent clubbing and DSI. There was no significant effect of transplant type on percent clubbing or DSI. This year's study culminates five years of investigation of surfactants for clubroot control. Specific surfactants have proven to be an effective control of clubroot in cabbage. Chemical names used: nonylphenoxypolyethoxyethanol (APSA 80™); alpha-alkanoic-hydro omega-hydroxy poly (oxyethylene) (Miller Soil Surfactant Granular™).

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Strain specific response of mice to IMQ-induced psoriasis

Journal of Basic and Clinical Physiology and Pharmacology ◽

10.1515/jbcpp-2020-0112 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Murali Badanthadka ◽

Lidwin D’Souza ◽

Fathima Salwa

Keyword(s):

Body Weight ◽

Disease Severity ◽

Histopathological Examination ◽

Redox System ◽

Mechanistic Study ◽

Strain Effect ◽

Skin Thickness ◽

Specific Response ◽

Psoriasis Area Severity Index ◽

Pasi Score

Abstract Objectives Psoriasis is an autoimmune, inflammatory disease that needs a reliable animal model. Imiquimod (IMQ)-induced psoriasis is a widely used preclinical tool for psoriasis research. However, this model is sensitive to the genetic variation of mice. The present study explores mice’s genetic background on disease stability and severity induced by IMQ. Methods Three distinct strains of mice (Balb/c, C57BL/6, and Swiss albino) were divided into four groups (Vaseline, IMQ, IMQ+Clobetasol, and IMQ+Curcumin). Psoriasis area severity index (PASI) score, ear/back skin thickness, body weight alterations, and histopathological examination were employed to analyze disease severity. The spleen index studied the systemic effect. Strain effect on oxidative stress induced by IMQ was evaluated by estimating antioxidant factors, superoxide dismutase (SOD), catalase, and glutathione (GSH). Results IMQ application resulted in increased PASI score, thickness, and alterations in body weight, confirming disease development in all the mice. However, the disease stability/severity between these strains was not identical. Although IMQ application caused splenomegaly, IMQ+curcumin treated C57BL/6 mice demonstrated a synergistic effect of IMQ and curcumin on the spleen resulting in increased splenomegaly. Decreased cellular enzyme activity in SOD, Catalase, and levels of GSH was observed in IMQ challenged mice, indicating the participation of the redox system in the genesis of the disease that was comparable among the strains. Conclusions These results indicate the existence of strain-dependent development of the disease. The Swiss model was found to be better in terms of disease severity and stability than other models. Further, a detailed mechanistic study might help to explain the pathological difference between these strains.

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Summer Heat and Low Soil Organic Matter Influence Severity of Hazelnut Cytospora Canker

Phytopathology ◽

10.1094/phyto-05-13-0136-r ◽

2014 ◽

Vol 104 (4) ◽

pp. 387-395 ◽

Cited By ~ 4

Author(s):

Jay Ram Lamichhane ◽

Alfredo Fabi ◽

Leonardo Varvaro

Keyword(s):

Organic Matter ◽

Soil Organic Matter ◽

Disease Severity ◽

Severity Index ◽

Stress Factors ◽

Disease Severity Index ◽

Positive Correlation ◽

Summer Heat ◽

Production Areas ◽

Cytospora Canker

Cytospora canker, caused by the fungus Cytospora corylicola, is present in hazelnut production areas worldwide. The disease is widespread throughout the main production areas of Italy. The causal agent is considered to be a secondary invader of damaged tissue that attacks mainly stressed plants. However, little is known of disease severity and stress factors that predispose plants to infection. In particular, the role of pedoclimatic factors was investigated. Direct survey indicated that disease severity varied across several study sites. Geostatistics showed a strong positive correlation between disease severity index and summer heat (r = 0.80 and 0.91 for July and August, respectively) and strong negative correlation between disease severity index and soil organic matter (r = –0.78). A moderate positive correlation between disease severity index and magnesium/potassium ratio (r = 0.58) and moderate negative correlations between disease severity index and total soil nitrogen (r = –0.53), thermal shock (r = –0.46), and rainfall (r = –0.53) were determined. No significant correlation between disease severity index and soil aluminum (r = –0.35), soil pH (r = –0.01), and plant age (r = –0.38) was found.

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Prevalence Of Developmental Oral Mucosal Lesions Among A Sample Of Denture Wearing Patients Attending College Of Dentistry Clinics In Aljouf University

European Scientific Journal ESJ ◽

10.19044/esj.2016.v12n24p352 ◽

2016 ◽

Vol 12 (24) ◽

pp. 352 ◽

Cited By ~ 1

Author(s):

Abdalwhab M.A . Zwiri ◽

Santosh Patil ◽

Fadi AL- Omair ◽

Mohammed Assayed Mousa ◽

Ibrahim Ali Ahmad

Keyword(s):

Personal Information ◽

Statistical Tests ◽

Later Life ◽

Oral Lesions ◽

Ministry Of Health ◽

Dental Patients ◽

Oral Mucosal Lesions ◽

Mucosal Lesions ◽

And Gender ◽

Fissured Tongue

Introduction: developmental oral lesions represent a group of normal lesions that can be found at birth or evident in later life. These lesions include fissured and geographic tongue, Fordyce’s granules and leukoedema. Study aims: to investigate the prevalence of some developmental oral mucosal lesions among dental patients wearing dentures who were attending college of dentistry clinics in Aljouf University, and specialized dental center of ministry of health. Methods and subjects: a retrospective design was conducted to collect data from 344 wearing denture dental patients who were attending college of dentistry clinics in Aljouf University, and specialized dental center of ministry of health. A working excel sheet was created for patients and included data related to personal information such as age and gender; and oral developmental lesions. The software SPSS version 20 was used to analyze data. Statistical tests including frequency, percentages, and One way Anova were used to describe data. Significance was considered at alpha level <0.05. Study findings: the majority of participants were males (86%), the mean age was 51.60+ 3.51years. The prevalence of fissured tongue was 10.2%, geographic tongue 11.3%, Fordyce’s granules 7%, and leukoedema 7.3%. Age was significantly associated with fissured tongue (p=0.04), and Fordyce’s granules (p=0.003). Gender was not associated significantly with any of the studied lesions. Conclusion: developmental oral lesions among dental patients wearing dentures exist with varying rates of prevalence as well as it provides valuable basic data about the prevalence of oral mucosal lesions among patients seeking dental care in Aljouf area.

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The relationship between SPAD chlorophyll and disease severity index in Ganoderma-infected oil palm seedlings

Journal of the Bangladesh Agricultural University ◽

10.3329/jbau.v17i3.43211 ◽

2019 ◽

Vol 17 (3) ◽

pp. 355-358 ◽

Cited By ~ 1

Author(s):

M.R.M. Rakib ◽

A.H. Borhan ◽

A.N. Jawahir

Keyword(s):

Chlorophyll Content ◽

Disease Severity ◽

Oil Palm ◽

Single Photon ◽

Linear Trend ◽

Severity Index ◽

Quadratic Model ◽

Wood Block ◽

Disease Severity Index ◽

The Relationship

Establishment of disease in oil palm seedlings through artificial inoculation of Ganoderma are widely used for studies of various aspects of plant pathology, including epidemiology, etiology, disease resistance, host-parasite interaction and disease control. The estimation of chlorophyll content in the infected seedlings possibly could provide a good indicator for degree of disease or infection, and changes during pathogenesis. Thus, the objective of this study was to evaluate the relationship between disease severity index (DSI) and chlorophyll content in Ganoderma infected oil palm seedlings. Three-month-old oil palm seedlings were infected with Ganoderma inoculum on rubber wood block (RWB), where 44 isolates of Ganoderma were tested. Disease severity index (DSI) and chlorophyll content using a single-photon avalanche diode (SPAD) meter were recorded at 4 weeks interval for a period of 24 weeks after inoculation (WAI). Pearson's correlation analysis and regression analysis were performed to evaluate the relationship between the variables. It was found that the relationship between DSI and SPAD chlorophyll value was inversely proportional (R = -0.92) in a linear trend (R2 = 0.85). Furthermore, the increasing trend of the DSI across the weeks were fitted in a quadratic model (R2 = 0.99). In contrast, the SPAD chlorophyll value declined in a linear trend (R2 = 0.98). The SPAD chlorophyll value could be considered as a better alternative over the DSI as the SPAD chlorophyll value was strongly related to DSI, as well as able to detect physiological changes in the infected oil palm seedlings at the early stages of pathogenesis. J Bangladesh Agril Univ 17(3): 355–358, 2019

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COVID-19: Oral Manifestations-A Dentist's Perspective

International Healthcare Research Journal ◽

10.26440/ihrj/0502.05411 ◽

2021 ◽

Vol 5 (2) ◽

pp. RV1-RV5

Author(s):

Ruhee Sangha ◽

Sumanjit ◽

Ramandeep Sandhu ◽

Mohit Bansal ◽

Simran

Keyword(s):

Health Care ◽

Early Diagnosis ◽

Inflammatory Response ◽

Oral Hygiene ◽

Acute Respiratory Infection ◽

Facial Pain ◽

Opportunistic Infections ◽

Oral Lesions ◽

Oral Manifestations ◽

Global Pandemic

Covid-19 is a global pandemic disease which has crippled health care system and economics worldwide. According to WHO, an acute respiratory infection, fever and cough are the most valid diagnostic clinical features. Some common orofacial manifestations of this viral infection may contribute to early diagnosis of covid-19 infection. Oral manifestations include olfactory and gustatory disturbances, dry mouth, facial pain, vesicobullous lesions such as erosion, pustule, macule, papule, plaque, pigmentation and depapilliated tongue with whitish areas, hemorrhagic crust, necrosis, swelling and erythema. The most common sites of involvement in descending order are tongue (38%), labial mucosa (26%), and palate (22%). Oral lesions are symptomatic in 68% of the cases who test positive for SARS Co-V. Lack of oral hygiene, opportunistic infections, stress, immunosuppression, vasculitis, and hyper-inflammatory response secondary to COVID-19 are the most important predisposing factors for onset of oral lesions in COVID-19 patients.

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The Effect of Systemic Methotrexate and Cyclosporine Combination Therapy inPsoriasis Vulgaris Patients in Bandung, Indonesia

Berkala Ilmu Kesehatan Kulit dan Kelamin ◽

10.20473/bikk.v33.3.2021.200-204 ◽

2021 ◽

Vol 33 (3) ◽

pp. 200

Author(s):

Oki Suwarsa ◽

Fatima Aulia Khairani ◽

Syawalika Ulya Isneny ◽

Erda Avriyanti ◽

Hartati Purbo Dharmadji ◽

...

Keyword(s):

Retrospective Study ◽

Side Effects ◽

Adverse Effects ◽

Combination Therapy ◽

Combination Treatment ◽

Psoriasis Vulgaris ◽

Severity Index ◽

Dermatology Clinic ◽

Significant Difference ◽

Pasi Score

Background: Methotrexate (MTX) and cyclosporine have been used as effective systemic mono-therapy for psoriasis. Several factors are considered to switch monotherapy to combination therapy because monotherapy is no longer effective and has higher side effects. Hence,clinicians have avoided systemic therapy combinations due to its toxicity. However, some studies showed that this combination therapy could be usedeffectively for psoriasis patients. Purpose: This study aimed to analyze the efficacy and adverse effects of systemic MTX and cyclosporine combination therapy in Indonesian psoriasis vulgaris patients. Methods: The retrospective study assessed the effectiveness of 3 monthsmono-therapyand combination therapy of systemic MTX and cyclosporine in psoriasisvulgaris patients from 2016–2017 in Dermatology Clinic, Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia. Result: Psoriasis area and severity index (PASI) score 90 were achieved in the group MTX (50%) and cyclosporine group (50%), while none in the combination group.However, eight patients (50%) in group MTX and cyclosporine reached the primary endpoint of PASI 50. One patient in cyclosporine group had adverse effects on kidney profiles. Nonetheless, other patients had no biochemical changes. But, there was no significant difference in the change of PASI between each group (p=0.102). Conclusion: We propose that combination therapy of MTX and cyclosporine is relatively safe and efficacious in treating Indonesian psoriasis vulgaris patients. This combination treatment isas effective as MTX or cyclosporinemono-therapy.

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Assessment of Lipocalin 2, Clusterin, Soluble Tumor Necrosis Factor Receptor-1, Interleukin-6, Homocysteine, and Uric Acid Levels in Patients with Psoriasis

Disease Markers ◽

10.1155/2014/541709 ◽

2014 ◽

Vol 2014 ◽

pp. 1-7 ◽

Cited By ~ 18

Author(s):

Arzu Ataseven ◽

Recep Kesli ◽

Gulcan Saylam Kurtipek ◽

Perihan Ozturk

Keyword(s):

Uric Acid ◽

Tumor Necrosis Factor ◽

Interleukin 6 ◽

Tumor Necrosis ◽

Tumor Necrosis Factor Receptor ◽

Severity Index ◽

Serum Levels ◽

Lipocalin 2 ◽

Pasi Score ◽

Necrosis Factor

Background. Chronic inflammation may play a role in psoriasis pathogenesis. Lipocalin 2, clusterin, soluble tumor necrosis factor receptor-1 (sTNFR-1), interleukin-6, homocysteine, and uric acid are inflammatory and/or biochemical markers. However, both the roles of these markers and the pathogenesis of psoriasis are unknown.Objective. The aim of this study was to investigate serum levels of lipocalin 2, clusterin, sTNFR-1, interleukin-6, homocysteine, and uric acid in patients and controls groups.Methods. Fifty-six patients with psoriasis and 33 healthy controls were included in the study. Serum concentrations of the markers were evaluated by ELISA. The Psoriasis Area and Severity Index (PASI) was evaluated in all psoriasis patients. Body mass index (BMI) was calculated by dividing weight (kg) by height (m) squared.Results. The serum value of lipocalin and sTNFR-1 were significantly higher in psoriasis patients than in controls (resp.,P<0.001,P<0.05). The others showed no significant differences between psoriasis and the control groups (all of themP>0.05). The mean PASI score in the patient group was8.3±6.5.Conclusions. These findings suggest that lipocalin 2 and sTNFR-1 might play a role in the pathogenesis of psoriasis and can be used as markers of the disease.

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