scholarly journals Clinical Analysis of Targeted Navel Drops in the Treatment of Diabetes Mellitus

2021 ◽  
Vol 5 (5) ◽  
pp. 194-198
Author(s):  
Yueping Zhu
Keyword(s):  
Blood Glucose ◽  
Research Group ◽  
Fasting Blood Glucose ◽  
Effective Rate ◽  
Postprandial Blood Glucose ◽  
Control Group ◽  
Diabetic Patients ◽  
Group 2 ◽  
And Control ◽  
Group 1

Objective: To analyze and evaluate the clinical efficacy of targeted navel drops in the treatment of diabetes mellitus. Methods: The time span of the study was from September 2020 to April 2021, and 288 diabetic patients were selected from our hospital. The patients were divided into research group (n = 96) group, control group 1 (n = 96) and control group 2 (n = 96) by random number table. Control group 1 was managed with diet and exercise alone, control group 2 was treated with metformin on the basis of control group 1, and based on the treatment plan of the two control groups, the research group was treated with targeted navel drops. The relevant indexes of the three groups were compared and analyzed. Results: There was no significant difference in the fasting blood glucose and 2-hour postprandial blood glucose among the three groups (p > 0.05) before the treatment. After treatment, the fasting blood glucose and 2-hour postprandial blood glucose of the research group were significantly lower than those of control group 1 and control group 2 (p < 0.05). The total effective rate of the research group was 95.8%, that of control group 1 was 85.4%, and that of control group 2 was 79.2%. The total effective rate of the research group was significantly higher than that of control group 1 and control group 2 (p < 0.05). Conclusion: There is a significant effect of targeted navel drops on diabetic patients in reducing their blood sugar levels, and its curative effect is better than using a single hypoglycemic therapy belonging to western medicine. It can be widely promoted at all levels in medical institutions.

Analysis of the Effect of Miglitol in the Treatment of Diabetes Mellitus Based on Ag+ Disinfectant Sampling Needle

2020 ◽  
Vol 12 (4) ◽  
pp. 550-555
Author(s):  
Ling Zhao ◽  
Liping Tan ◽  
Guoliang Cheng ◽  
Yuanyuan Miao ◽  
Xiangming Zhou ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Adverse Reactions ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Insulin Level ◽  
Lipoprotein Cholesterol ◽  
Postprandial Blood Glucose ◽  
Control Group ◽  
Diabetic Patients ◽  
Study Group

The present work selected 120 patients, affected by diabetes, as control subjects in the Affiliated Hospital of Kunming Medical University. According to the principle of random distribution, two groups were established, miglitol study group (65 cases) and metformin control group (55 cases). The Ag + disinfectant sampling needle is a rapid detection tool to evaluate the efficacy of diabetes in both groups. The related biochemical indexes of the patients were measured before and after treatment at the 3rd, 6th, and 12th weeks. The test results showed that there were significant differences in fasting blood glucose value (FBG) and postprandial blood glucose value (2hFBG) among the two groups after 3-, 6-, and 12-month treatment. With the extension of treatment, the blood glucose level of diabetic patients gradually stabilized. Fasting insulin level (FINS) and postprandial two-hour insulin level (2hINS) increased gradually. At the 12th week, by measuring the HbA1c level of the patients, it was found decreasing significantly. In detail, the study group decreased more significantly than the control group, and the incidence of adverse reactions during treatment was 10.8% and 23.6%, respectively, with a significant statistical significance (P < 0 05). Meanwhile, we measured other biochemical indexes of patients from both groups after drug treatment. At the 6th week, the levels of glycosylated glycoprotein (HbA1c), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) in the study group decreased more than in the control group. Therefore, miglitol shows a better hypoglycemic effect on type 2 diabetes, and the gastrointestinal adverse reactions are lesser than metformin, which is more worthy in clinical application.

scholarly journals The Effect of A New Mixture of Sugar and Sugar-Alcohol (Lacritose) on Blood Glucose and Lipids and the Possible Adverse Reactions in Patients with Type 2 Diabetes: A Triple-Blind Randomized Clinical Trial

2021 ◽  
Author(s):  
Masoud Rahmanian ◽  
Zohreh Mozafari ◽  
Danial Chaleshi ◽  
Marzieh Shukohifar ◽  
Saeedeh Jam-Ashkezari
Keyword(s):  
Clinical Trial ◽  
Blood Glucose ◽  
Randomized Clinical Trial ◽  
Fasting Blood Glucose ◽  
Resistance Index ◽  
Primary Data ◽  
Control Group ◽  
Diabetic Patients ◽  
Diabetes Research

Background: A new sweetener with the commercial name of Lacritose has been recently produced, which is a combination of four simple sugars (lactose, fructose, sucrose, erythritol), with specific ingredients and percentages. This study aimed to assess glycemic response and short term gastrointestinal reactions in type 2 diabetic patients. Methods: In this triple-blind randomized clinical trial, 30 diabetic patients referred to Yazd Diabetes Research Center in 2018 were included. After collecting the primary data, they were assigned into three groups, including sucrose consumers as the control group, sucrose-lactose, and lacritose as the groups of consumers group. They were followed for two weeks, and fasting blood glucose (FBG), 2-hour postprandial test (2HPP), fructose amine, SGOT, SGPT, urea, creatinine, and insulin resistance index (HOMA-IR) were assessed. Results: In lacritose consumers, significant reductions were seen in FBG and 2HPP (P < 0.001 and P = 0.05, respectively), although changes among the groups were not significant. In sucrose-lacritose consumers, FBG and cholesterol levels decreased (P = 0.04 and P = 0.03, respectively). In sucrose consumers, no reduction was seen. HOMA-IR did not significantly decrease, but intergroup changes were obvious. Conclusion: The lacritose effects on FBG and 2HPP were significantly evident, but the other metabolic indices did not show any significant change.

scholarly journals EVALUATION OF OXIDATIVE STRESS AND ANTIOXIDANT STATUS BETWEEN TYPE II DIABETES PATIENTS AND HEALTHY POPULATIONS

2018 ◽  
Vol 11 (9) ◽  
pp. 264
Author(s):  
Sudharshan Reddy Nelli ◽  
Nilesh Kumar Sharma ◽  
Manoj Kumar P ◽  
Surya S Singh
Keyword(s):  
Blood Glucose ◽  
Type Ii Diabetes ◽  
Fasting Blood Glucose ◽  
Serum Levels ◽  
Diabetes Patient ◽  
Postprandial Blood Glucose ◽  
Control Group ◽  
Case Group ◽  
Type Ii ◽  
South Indian

Introduction: The aim of the present study is to profile the serum antioxidative enzymes, catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD) level in Type II diabetes mellitus patients in comparison to healthy volunteers in the South Indian population.Methodology: A prospective, observational, case–control study was conducted for 1 year with a total of 120 patients including 90 Type II diabetes patients (case group) and 30 healthy volunteers (control group). Blood was collected from these volunteers, and serum levels of CAT, GPx, and SOD were estimated. In addition, they were also monitored for the fasting blood glucose, glycated hemoglobin (HbA1c), and postprandial blood glucose. Data were statistically analyzed applying unpaired t-test and Pearson correlation with the statistical significance of p<0.05.Results: The diabetes patient group showed significant higher levels of glycated hemoglobin, fasting blood glucose and postprandial blood glucose (p<0.0001). There was asignificant lower level in the RBC levels of superoxide dismutase in case group compared to control group 3859.00±381.8 (mean+SD) and 5862.7±209.45 (mean+SD) Units per gram Hb, (t-value 27.35, p-Value <0.0001). Catalase and Glutathione peroxidase RBC levels also showed significant lower levels in the case group compared to the control group (catalase 212.7±19.08 (mean±SD) and 396.47±10.83 (mean±SD) Units per gram Hb; T value=50.07 and p<0.0001)(Glutathione peroxidase11.7 ±01.09 (mean +SD) and 18.6 ± 01.00 (mean +SD) Units per gram Hb; t value=30.26 and p<0.0001).Conclusion: A significant reduction in serum levels of antioxidative enzymes, CAT, GPx, and SOD was observed in the South Indian Type II diabetes patient population.

Impact of Severity of Illness Bias and Control Group Misclassification Bias in Case-Control Studies of Antimicrobial-Resistant Organisms

2005 ◽  
Vol 26 (4) ◽  
pp. 342-345 ◽  
Author(s):  
Anthony D. Harris ◽  
Yehuda Carmeli ◽  
Matthew H. Samore ◽  
Keith S. Kaye ◽  
Eli Perencevich
Keyword(s):  
Severity Of Illness ◽  
Case Control ◽  
Severe Illness ◽  
Control Group ◽  
Case Control Studies ◽  
Clinical Culture ◽  
Methodologic Problem ◽  
Group 2 ◽  
And Control ◽  
Group 1

AbstractBackground:Case-control studies often analyze risk factors for antibiotic resistance. Recently published articles have illustrated that randomly selected control-patients may be preferable to those with the susceptible phenotype of the organism. A possible methodologic problem with randomly selected control-patients is potential bias due to control group misclassification. This occurs if some control-patients did not have clinical cultures performed and thus might have been unidentified case-patients. If this bias exists, these studies might be expected to report lower odds ratios (ORs) because control-patients would be more like case-patients.Objective:To analyze potential biases that might arise due to control group misclassification and potentially larger selection biases that may be introduced if control-patients are required to have at least one clinical culture.Patients:One hundred twenty case-patients, 770 control-patients in group 1, and 510 control-patients in group 2.Methods:Two case-control studies. Case-patients had clinical cultures positive for imipenem-resistant Pseudomonas aeruginosa. The first group of control-patients were random. The second group of control-patients were identical to those in group 1 except being required to have at least one clinical culture.Results:Univariate analyses showed higher ORs for case-patients versus control-patients in group 1 (imipenem [OR, 12.5], piperacillin-tazobactam [OR, 3.7], and vancomycin [OR, 4.7]) as compared with case-patients versus control-patients in group 2 (imipenem [OR, 8.0], piperacillin-tazobactam [OR, 2.5], and vancomycin [OR, 3.0]).Conclusion:Requiring control-patients to have at least one clinical culture introduces a selection bias likely because it eliminates patients with less severe illness.

scholarly journals Herb-Drug Interaction: Effects of Relinqing® Granule on the Pharmacokinetics of Ciprofloxacin, Sulfamethoxazole, and Trimethoprim in Rats

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Yuan Lu ◽  
ZiPeng Gong ◽  
YuMin Xie ◽  
Jie Pan ◽  
Jia Sun ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Pharmacokinetic Parameters ◽  
Control Group ◽  
Urinary System ◽  
Blood Samples ◽  
Sd Rats ◽  
Chinese Patent ◽  
Group 2 ◽  
And Control ◽  
Group 1

Relinqing granule (RLQ) is the best-selling Chinese patent drug for treatment of urinary system diseases. In this study, the effects of RLQ on the pharmacokinetics of ciprofloxacin, sulfamethoxazole, and trimethoprim in SD rats were investigated. Rats were randomly divided into control group 1, control group 2, RLQ group 1, and RLQ group 2. RLQ group 1 and RLQ group 2 were treated orally with RLQ for 7 days, and rats were treated with the same volume of water in control group 1 and control group 2. Then, RLQ group 1 and control group 1 were given intragastrically ciprofloxacin on day 8, while RLQ group 2 and control group 2 were given intragastrically sulfamethoxazole and trimethoprim on day 8. Blood samples were collected and determined. There was no significant influence of pharmacokinetic parameters of trimethoprim on two groups. But some pharmacokinetic parameters of ciprofloxacin and sulfamethoxazole in RLQ pretreated rats were evidently altered (P < 0.05), which indicated that absorption of ciprofloxacin and sulfamethoxazole in RLQ pretreated rats was significantly affected. It indicated the coadministration of RLQ would have an influence on the efficacy of ciprofloxacin and sulfamethoxazole, and the doses of ciprofloxacin tablet and compound sulfamethoxazole tablet need adjustment.

Cytomorphometric and Morphological Analysis in Women with Trichomonas vaginalis Infection: Micronucleus Frequency in Exfoliated Cervical Epithelial Cells

2015 ◽  
Vol 59 (3) ◽  
pp. 258-264 ◽  
Author(s):  
Zehra Safi Oz ◽  
Banu Doğan Gun ◽  
Mustafa Ozkan Gun ◽  
Sukru Oguz Ozdamar
Keyword(s):  
Epithelial Cells ◽  
Trichomonas Vaginalis ◽  
Control Group ◽  
Study Group ◽  
Control Groups ◽  
The Mean ◽  
The Difference ◽  
Group 2 ◽  
And Control ◽  
Group 1

Objectives: The aim of this study was to explore the cytomorphometric and morphological effects of Trichomonas vaginalis in exfoliated epithelial cells. Study Design: Ninety-six Pap-stained cervical smears were divided into a study group and two control groups as follows: T. vaginalis cases, a first control group with inflammation, and a second control group without inflammation. Micronucleated, binucleated, karyorrhectic, karyolytic, and karyopyknotic cells and cells with perinuclear halos per 1,000 epithelial cells were counted. Nuclear and cellular areas were evaluated in 70 clearly defined cells in each smear using image analysis. Results: The frequencies of morphological parameters in the T. vaginalis cases were higher than the values of the two control groups, and the difference among groups was found to be significant (p < 0.05). The nuclear and cytoplasmic areas of epithelial cells were diminished in patients with trichomoniasis. The mean nucleus/cytoplasm ratio in T. vaginalis patients was higher than the value in the control groups, and the difference between the study group and control group 1 was significant. However, there was no statistically significant increase between the study group and control group 2. Conclusions:T. vaginalis exhibited significant changes in the cellular size and nuclear structure of the cells. The rising frequency of micronuclei, nuclear abnormalities, and changing nucleus/cytoplasm ratio may reflect genotoxic damage in trichomoniasis.

Effect of cortexin on the quality of life in the early rehabilitative period after hemispheric ischemic stroke

2016 ◽  
Vol 94 (2) ◽  
pp. 138-143
Author(s):  
Ludmila A. Belova ◽  
V. V. Mashin ◽  
V. V. Abramova ◽  
A. N. Proshin ◽  
A. N. Ovsyannikova
Keyword(s):  
Quality Of Life ◽  
Ischemic Stroke ◽  
Low Dose ◽  
Neuroprotective Effect ◽  
Control Group ◽  
Sf 36 ◽  
Group 2 ◽  
And Control ◽  
Group 1

Aim. To study the neuroprotective effect of a repeated course of low dose cortexin therapy on the quality of life in the early rehabilitative period after hemispheric ischemic stroke (IS). Materials and methods. 90 patients were divided into group 1 treated with cortexin (10 mg i/m twice daily (morning and afternoon) in addition to basal treatment, group 2 given the repeated course of the same treatment, and control group (basal therapy alone). The standard SF-36 questionnaire was used to assess the quality of life. Results. Treatment of patients following acute hemispheric ischemic stroke with cortexin (10 mg i/m twice daily) and the repeated course of the same treatment after 10 days resulted in the accelerated and more complete normalization of the quality of life in the early rehabilitation petriod (starting from days 21-27 days after the onset of disease) than in the patients given a single course of cortexin therapy or basal treatment alone.

scholarly journals Comparison of the results of percutaneous nephrolithotomy in different age groups

2018 ◽  
Vol 5 (12) ◽  
pp. 3888
Author(s):  
Ali Borekoglu ◽  
Ibrahim Atilla Aridogan ◽  
Mutlu Deger ◽  
Onur Karsli ◽  
Volkan Izol
Keyword(s):  
Blood Transfusion ◽  
Percutaneous Nephrolithotomy ◽  
Preoperative Evaluation ◽  
Control Group ◽  
Perioperative Bleeding ◽  
Significant Difference ◽  
The Mean ◽  
Group 2 ◽  
And Control ◽  
Group 1

Background: Evaluation of feasibility, safety and effectiveness of percutaneous nephrolithotomy (PCNL) in different age groups.Methods: Between July 1997-October 2012, 233 patients who were 65 years old and older were included in this study. These patients were divided into two age subgroups used in gerontology research. Group 1 was defined as patients 65-74 years old, Group 2 was older than 74 years old. Data from patient records, including demographic characteristics, preoperative evaluation, operative details, and complications were retrospectively analyzed and compared with control group data.Results: The mean age of 233 patients was 69.7±4.6 years. The mean operative times for Group 1, group 2 and the control group were 76.2±47.3mins, 92.9±47.6mins, 77±44mins, respectively and there was no statistically significant difference between groups 1 and 2 and the control group (p>0.05). Twenty-eight of the 233 patients (12%) needed blood transfusion due to perioperative bleeding. The transfusion rates of groups 1 and 2 were 11.3% and 16.7%, respectively. There was no statistically significant difference between the study groups and control group for blood transfusion rates (p>0.05). There was no statistically significant difference in complications between the study and control groups (p>0.05).Conclusions: In geriatric patients, stone-free rates, transfusion rates and other operation parameters are similar to younger populations when experienced surgeons perform PCNL. Despite comorbidities and decreased body reserve, PCNL can be performed without a significant increase in complications in different ages.

scholarly journals Changes in the Levels of Biochemical Markers Following Coronavirus Infection in Patients with Liver Disease, Renal Disease and Diabetes Mellitus as Compared to Control Participants: A Cross Sectional Study

2021 ◽  
pp. 141-148
Author(s):  
Osama J. Ahmed ◽  
Estabraq A. Al-Wasiti ◽  
Dina Jamil ◽  
Hayder A. Al-Aubaidy
Keyword(s):  
Liver Disease ◽  
Blood Glucose ◽  
Renal Disease ◽  
Liver Enzymes ◽  
Fasting Blood Glucose ◽  
Serum Levels ◽  
Study Groups ◽  
Control Group ◽  
Group 3 ◽  
Group 1

Background & Aim of the Study: Increased levels of many biomarkers, including liver enzymes, blood urea and serum creatinine as well as glycemic markers have been reported following coronavirus (COVID-19) infection, leading to the development of acute disease. This study aims to measure and follow-up the following biomarkers (fasting blood glucose, blood urea, serum creatinine, total serum bilirubin, as well as the liver enzymes AST, ALT, and ALP) in otherwise healthy participants and patients with liver disease, renal disease and diabetes following COVID-19 infection. Materials and Methods: This is cross section study, included 144 participants who were infected with COVID-19 and admitted to the Sheikh Zayed Hospital, Baghdad, Iraq. Participants were divided into 4 study groups, Group 1: 46 participants with no pre-existing medical condition (Control), Group 2: 30 patients with existing liver disease. Group 3: 28 patients with existing renal disease and Group 4: 40 patients with diabetes mellitus. Participants were followed up for 14 days following COVID-19 infection to monitor the progression of the biochemical markers. Results: There were significant changes in serum levels of all the markers of this study between the four study groups (p<0.001). Serum ALP levels were not significantly changed within any of the four study groups. However, both ALT and AST levels were significantly changed within all the four study groups (p<0.001). The levels of TSB changes significantly within the renal group (Group 3), (p=0.017). The levels of S. Creatinine showed significant changes in all the study groups except the renal group (Group 3). The levels change significantly within all the study groups except the control group (Group 1), while fasting blood glucose levels changes significantly in the control group only (Group 1), (p=0.004). Conclusions: Following COVID-19 infection, there were significant changes in the levels of ALT, AST, S. Creatinine and B.Urea after 14 days of the disease progression. While in patients with existing renal disease, there were significant changes in the levels of TSB, AST, ALT and B. Urea following COVID-19 infection. In diabetic patients, there were significant increase in the level of   fasting blood glucose after 14 days of COVID-19 infection. there were no significant changes in serum levels of ALP and FBG in patients with chronic illnesses (liver disease, renal disease, and diabetes) when compared to control group.

scholarly journals Implementation of teleHealth using SKEDit for protein diet education for diabetes patients

2021 ◽  
Vol 4 (4) ◽  
pp. 277
Author(s):  
Khoirul Rista Abidin ◽  
Eka Riana
Keyword(s):  
Blood Glucose ◽  
Lipid Profile ◽  
Protein Diet ◽  
Control Group ◽  
Diabetic Patients ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Post Test ◽  
Quasi Experimental ◽  
And Control

A protein diet is an alternative to control hyperglycemia and hyperlipidemia conditions in diabetic patients. However, for the program to run optimally, the implementation of technology in the form of TeleHealth is needed to help educate patients on a regular and flexible basis. The purpose of this study was to analyze the effectiveness of implementing TeleHealth using the SKEDIt application for protein diet education in diabetic patients. Methods: This research is a quasi-experimental study, pre and post-test with a control group. The subjects involved were 20 diabetic patients, divided into 2 groups (intervention and control). Parameters analyzed were lipid profile and blood glucose levels. There was no difference in lipid profile and blood glucose levels between the intervention and control groups (p > 0.05). However, there was a difference between the pre and post-test on cholesterol parameters in the lipid profile examination of the control group: p=0.031 and LDL p=0.021 (p <0.05). Implementation of TeleHealth using SKEDit may be an effective recommendation to support health education methods but needs to be supported by good patient compliance.

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