scholarly journals Bimbingan Teknis Kinerja Pengawas Tempat Pemungutan Suara pada Pilkada 2020 di Era Pandemi Covid 19

2021 ◽  
Vol 4 (1) ◽  
pp. 10
Author(s):  
Ricky Santoso Muharam
Keyword(s):  
Presidential Elections ◽  
Code Of Ethics ◽  
Phase 1 ◽  
Local Elections ◽  
Phase 2 ◽  
Preparatory Stage ◽  
Two Stages ◽  
Regional Elections ◽  
Technical Guidance ◽  
Selection Of

Understanding of duty as a supervisor of polling places certainly needs to be given a thorough of various materials ranging from regulations on the selection of regional heads, regulations on the supervision of regional head elections during the Covid-19 pandemic, the code of ethics and the use of the election surveillance system (SIWASLU) need to be clearly understood.  This activity is carried out in two stages, namely technical guidance phase 1 and technical guidance phase 2 starting from the preparatory stage, material briefing, practice, posttest and questionnaire filling.  The results of this activity resulted in understanding for members of the polling station supervisor (PTPS) in carrying out their responsibilities   from regulatory understanding, supervision of health protocols as supervisors, code of ethics and commitment to contribute to becoming PTPS.   PTPS commitment to be able to contribute back to become a member of the TPS election supervisor for the 2024 elections correspondents answered 28 people (47.5%) willing to return to become PTPS in the   upcoming   elections or local elections, 28 people (47.5%) answer still in doubt or maybe willing to return to become PTPS and 3 people or about (5.1%) do not want to join the PTPS for the 2024 regional elections or presidential elections.

Design of clinical trials in rheumatology

2013 ◽  
pp. 227-236
Author(s):  
Vibeke Strand ◽  
Jeremy Sokolove ◽  
Alvina D. Chu
Keyword(s):  
Lupus Erythematosus ◽  
Trial Design ◽  
Phase 1 ◽  
Population Sample ◽  
Phase 2 ◽  
Composite Outcome ◽  
Efficacy And Safety ◽  
Treatment Allocation ◽  
Development And Validation ◽  
Selection Of

Development of new therapies for rheumatic diseases requires a series of randomized controlled trials (RCTs) progressing from phase 1, ’first-in-human’ to generate initial safety, pharmacokinetic (PK) and pharmacodynamic (PD) data; to phase 2, proof of concept for efficacy with safety and PK/PD data; and phase 3, designed to demonstrate definitive efficacy and safety to support regulatory approval. Important aspects of RCT designs include selection of patient population, sample size estimations, treatment allocation, rescue, blinding, and statistical analyses of prespecified endpoints to preserve trial integrity. Over the past 20 years, significant progress has been made in the design of RCTs in rheumatoid arthritis (RA). Similarly, development and validation of composite outcome measures in psoriatic arthritis (PsA), axial spondyloarthritis (axSpA), gout, and osteoarthritis (OA) have furthered trial design and treatment approvals. RCTs in systemic lupus erythematosus (SLE), systemic sclerosis (SSc), vasculitis and other multisystem, heterogeneous diseases pose more challenges. Trial design will continue to evolve as promising therapies are introduced into the clinic and more therapies are approved for each indication.

scholarly journals RELEVANT ISSUES OF LEGAL REGULATION OF THE INSTITUTE OF HEADMAN IN UKRAINE: THEORY AND PRACTICE

2021 ◽  
pp. 14-20
Author(s):  
M.M. Voronov
Keyword(s):  
Social Relations ◽  
Legal Status ◽  
Legal Regulation ◽  
Theory And Practice ◽  
Local Elections ◽  
Checks And Balances ◽  
Local Council ◽  
Definition Of ◽  
Two Stages ◽  
Selection Of

The article highlights the conceptual vision of the role and place of the headman in the system of local self-government in Ukraine, provides a comprehensive description of its formal and material criteria. The idea of ​​allocating two stages of legislative regulation of this institute is substantiated. The first stage: February 2015 - July 2020. The second stage: July 2020 - to the present. It is emphasized that in the current municipal legislation of Ukraine there are low legal gaps that do not allow to establish a transparent procedure for selection of candidates for the post of mayor, as well as a clear procedure for approval of the mayor at the session of the council. Attention is drawn to the fact that during this period the procedure for appointment to the position of headman has changed significantly - from direct elections to local elections to approval at a session of the local council on the proposals of the relevant chairman. Some dynamics of legal regulation of social relations of the institute of headmеn is due to attempts to find the optimal format of such an institution in the system of checks and balances in the quadrangle: villagers, settlements - council - the corresponding chairman - the headman. It is noted that the headman should be a true representative of the interests of residents in relations with the relevant chairman and representative body of local government. At the same time, among the topical issues of the legal status of the head should be the definition of his place in the structure of executive bodies of local self-government (I believe that it is necessary to leave a guaranteed place in the executive committee of the local council). Attention is drawn to the need to establish a clear and transparent procedure for selecting candidates for the post of headman. Clear criteria must be developed and approved for the objective selection of candidates and their public discussion before approval. Proposals are made that qualitative and quantitative criteria for the formation of headmеn`s districts should be enshrined in the current legislation of Ukraine. It is noted that special attention should be paid to the professional and personal qualities of headman, the process of its training and retraining, advanced training of headman as an effective representative of the interests of residents. Addressing such issues will contribute to the formation of a balanced system of local self-government in the village, town and city.

PSIII-42 Diet selection and trade-offs between condensed tannins and nutrients in parasitized sheep

2019 ◽  
Vol 97 (Supplement_3) ◽  
pp. 184-185
Author(s):  
Morgane Costes-Thiré ◽  
Pauline Laurent ◽  
Cécile Ginane ◽  
Juan J Villalba
Keyword(s):  
Condensed Tannins ◽  
Phase 1 ◽  
Parasitic Infection ◽  
High Energy ◽  
Repeated Measure ◽  
Phase 2 ◽  
Phase 3 ◽  
Foraging Preferences ◽  
Trade Offs ◽  
Selection Of

Abstract We determined how parasitized sheep prioritize selection of crude protein, energy and a medicinal plant secondary compound (quebracho tannins-QT). Foraging preferences were tested in 40 lambs before experiencing a parasitic infection (Phase 1), during an infection (Phase 2; 10,000 L3 Haemonchus contortus per lamb) and after chemotherapy (Phase 3). Lambs were assigned to four groups (10 lambs/group) such that animals in Group 1 (Control) could choose between rations of high energy (HE) or high protein (HP) density. The other groups received the same choice, but QT were added (4%) to HE (Group 2), to HP (Group 3) or to both HE and HP (Group 4). Intake and preference indexes were analyzed as a split-plot design with lambs nested within group and day as the repeated measure. All groups increased their preference for HE when parasitized relative to Phase 1 (0.66 and 0.44 ± 0.042, respectively; P < 0.05). As a result, lambs increased their intake of digestible energy during Phase 2 (0.126 ± 0.007 Mcal/kg BW) relative to Phase 1 (0.106 ± 0.007 Mcal/kg BW; P < 0.05). These patterns remained during Phase 3. Only lambs receiving QT in the HE increased their intake of condensed tannins from Phase 1 to Phase 2 (P < 0.05). Fecal egg counts (FEC) and blood parameters revealed a parasitic infection (P < 0.05) in Phase 2 that subsided in Phase 3, although no differences were detected among groups (P > 0.05). The importance of protein nutrition on parasitized animals has been highlighted before, but these results suggest that parasitized lambs prioritized the ingestion of energy-dense over protein-dense foods or medicinal condensed tannins. Nevertheless, intake of tannins increased when these compounds were present in the energy-dense food, suggesting that selection of condensed tannins was influenced by the nutritional composition of the foods during testing.

Development of a Rating Scale for Determining Competence in Basketball Referees: Implications for Sport Psychology

1995 ◽  
Vol 9 (1) ◽  
pp. 4-28 ◽  
Author(s):  
Mark H. Anshel
Keyword(s):  
Sport Psychology ◽  
External Validity ◽  
Rating Scale ◽  
Phase 1 ◽  
External Validation ◽  
Sports Psychology ◽  
Phase 2 ◽  
Performance Effectiveness ◽  
Two Stages ◽  
Performance Competencies

The purpose of this article is to describe the construction (Phase 1) and external validation (Phase 2) of a behaviorally anchored rating scale (BARS) for identifying and measuring competencies for basketball referees (BARS-BR). In Phase 1, BARS-BR was developed by deriving a consensus of two panels of individuals (N = 20), with varying degrees of knowledge and experience in basketball officiating, about the proper competencies of basketball referees. The panels generated 13 performance categories (or competencies), each including at least three behavioral examples (or “anchors”). Phase 2 consisted of two stages: (a) obtaining external validity of BARS-BR by 212 practicing skilled basketball referees by indicating their support for the performance categories and behavioral examples, and (b) assessing performance effectiveness of high-skilled and novice referees on each of the 13 BARS performance competencies. The results lent support to the validation of the BARS-BR for assessing competence in basketball officiating. Implications for using the BARS technique in sports psychology are discussed.

scholarly journals PRODUKSI ENZIM SELULASE TERMOSTABIL DARI BAKTERI NG2 MENGGUNAKAN BERBAGAI SUMBER SELULOSA ASAL LIMBAH PERTANIAN DAN PERKEBUNAN (Production of Thermostable Cellulase Enzyme by NG2 Bacteria Using Various Cellulose Sources from the Agriculture Waste)

2020 ◽  
Vol 8 (2) ◽  
pp. 64-72
Author(s):  
Rahmad Fani Ramadhan ◽  
M. Montesqrit ◽  
Yetti Marlida
Keyword(s):  
Specific Activity ◽  
Thermophilic Bacteria ◽  
Phase 1 ◽  
Phase 2 ◽  
Agriculture Waste ◽  
Cellulase Enzyme ◽  
Corn Cobs ◽  
Randomized Design ◽  
Thermostable Cellulase ◽  
Two Stages

This experiment aimed to determine the best cellulose sources from the agricultural by product on the production of the thermostable cellulase enzymes by thermophilic bacteria (NG2) and also to find out the best concentration level of the selected sources of cellulose. The experiment was conducted in two stages using a completely randomized design (CRD). In phase 1, four cellulose sources were used, namely A: corn cobs, B: rice straw, C: coconut fiber, and D: oil palm trunk, in which the replication for each source was five. In phase 2,  the best sources of cellulose from the phase 1 was used at four different levels of concentration, i.e., A: 2%, B: 3%, C: 4%, and D: 5%, in which replication for each concentration was five. The result of phase 1 showed that the corn cobs was the best cellulose source  in producing cellulase enzyme. This was indicated by the activity of 0.329 U/ml, the enzyme protein of 0.0328 mg/ml, and the specific activity of 10.165 U/mg, which were significantly higher (P<0.01) than those of other cellulose sources. The results of phase 2 showed that the concentration of 4% (w/v) had the highest (P<0.01) specific activity of 44.002 U/mg  compared with those of the other concentrations. In conclusion, the highest production of cellulase enzyme using thermophilic bacteria (NG2) was obtained at the concentration of 4% (w/v) using the corn cobs as the cellulose source.

O1-12-06: PHASE 1 MULTIPLE ASCENDING DOSE (MAD) STUDY OF PHOSPHODIESTERASE-9 INHIBITOR E2027: CONFIRMATION OF TARGET ENGAGEMENT AND SELECTION OF PHASE 2 DOSE IN DEMENTIA WITH LEWY BODIES

2006 ◽  
Vol 14 (7S_Part_4) ◽  
pp. P251-P251
Author(s):  
Ishani Landry ◽  
Robert YK. Lai ◽  
Peter Boyd ◽  
Jagadeesh Aluri ◽  
Min-Kun Chang ◽  
...  
Keyword(s):  
Dementia With Lewy Bodies ◽  
Phase 1 ◽  
Lewy Bodies ◽  
Phase 2 ◽  
Target Engagement ◽  
Selection Of

Rationalization and internalization

2001 ◽  
Vol 60 (4) ◽  
pp. 215-230 ◽  
Author(s):  
Jean-Léon Beauvois
Keyword(s):  
Phase 1 ◽  
Facilitatory Effect ◽  
Phase 2 ◽  
Causal Explanations ◽  
Reduction Effect ◽  
Dissonance Reduction

After having been told they were free to accept or refuse, pupils aged 6–7 and 10–11 (tested individually) were led to agree to taste a soup that looked disgusting (phase 1: initial counter-motivational obligation). Before tasting the soup, they had to state what they thought about it. A week later, they were asked whether they wanted to try out some new needles that had supposedly been invented to make vaccinations less painful. Agreement or refusal to try was noted, along with the size of the needle chosen in case of agreement (phase 2: act generalization). The main findings included (1) a strong dissonance reduction effect in phase 1, especially for the younger children (rationalization), (2) a generalization effect in phase 2 (foot-in-the-door effect), and (3) a facilitatory effect on generalization of internal causal explanations about the initial agreement. The results are discussed in relation to the distinction between rationalization and internalization.

PENERAPAN MODEL QUANTUM LEARNING UNTUK MENINGKATKAN HASIL BELAJAR AUTOCAD SISWA KELAS X TEKNIK PEMESINAN SMK NEGERI 1 STABAT

2013 ◽  
Vol 5 (1) ◽  
Author(s):  
Abdul Hasan Saragih
Keyword(s):  
Positive Response ◽  
Phase 1 ◽  
First Grade ◽  
Learning Model ◽  
Second Phase ◽  
Phase 2 ◽  
Phase 3 ◽  
The Third ◽  
Third Phase ◽  
Quantum Learning

This classroom research was conducted on the autocad instructions to the first grade of mechinary class of SMK Negeri 1 Stabat aiming at : (1) improving the student’ archievementon autocad instructional to the student of mechinary architecture class of SMK Negeri 1 Stabat, (2) applying Quantum Learning Model to the students of mechinary class of SMK Negeri 1 Stabat, arising the positive response to autocad subject by applying Quantum Learning Model of the students of mechinary class of SMK Negeri 1 Stabat. The result shows that (1) by applying quantum learning model, the students’ achievement improves significantly. The improvement ofthe achievement of the 34 students is very satisfactory; on the first phase, 27 students passed (70.59%), 10 students failed (29.41%). On the second phase 27 students (79.41%) passed and 7 students (20.59%) failed. On the third phase 30 students (88.24%) passed and 4 students (11.76%) failed. The application of quantum learning model in SMK Negeri 1 Stabat proved satisfying. This was visible from the activeness of the students from phase 1 to 3. The activeness average of the students was 74.31% on phase 1,81.35% on phase 2, and 83.63% on phase 3. (3) The application of the quantum learning model on teaching autocad was very positively welcome by the students of mechinary class of SMK Negeri 1 Stabat. On phase 1 the improvement was 81.53% . It improved to 86.15% on phase 3. Therefore, The improvement ofstudent’ response can be categorized good.

In situ deteriorating patient simulation in general practice

2020 ◽  
Vol 70 (suppl 1) ◽  
pp. bjgp20X711425
Author(s):  
Joanna Lawrence ◽  
Petronelle Eastwick-Field ◽  
Anne Maloney ◽  
Helen Higham
Keyword(s):  
Life Support ◽  
Early Recognition ◽  
Phase 1 ◽  
Patient Simulation ◽  
Medical Emergency ◽  
Phase 2 ◽  
Action Plans ◽  
Integrated Simulation ◽  
Deteriorating Patient

BackgroundGP practices have limited access to medical emergency training and basic life support is often taught out of context as a skills-based event.AimTo develop and evaluate a whole team integrated simulation-based education, to enhance learning, change behaviours and provide safer care.MethodPhase 1: 10 practices piloted a 3-hour programme delivering 40 minutes BLS and AED skills and 2-hour deteriorating patient simulation. Three scenarios where developed: adult chest pain, child anaphylaxis and baby bronchiolitis. An adult simulation patient and relative were used and a child and baby manikin. Two facilitators trained in coaching and debriefing used the 3D debriefing model. Phase 2: 12 new practices undertook identical training derived from Phase 1, with pre- and post-course questionnaires. Teams were scored on: team working, communication, early recognition and systematic approach. The team developed action plans derived from their learning to inform future response. Ten of the 12 practices from Phase 2 received an emergency drill within 6 months of the original session. Three to four members of the whole team integrated training, attended the drill, but were unaware of the nature of the scenario before. Scoring was repeated and action plans were revisited to determine behaviour changes.ResultsEvery emergency drill demonstrated improved scoring in skills and behaviour.ConclusionA combination of: in situ GP simulation, appropriately qualified facilitators in simulation and debriefing, and action plans developed by the whole team suggests safer care for patients experiencing a medical emergency.

Clinical Drug Development for the Treatment of Pulmonary Arterial Hypertension: Collaboration With the Pharmaceutical Industry and Regulatory Agencies

2010 ◽  
Vol 9 (4) ◽  
pp. 214-219
Author(s):  
Robyn J. Barst
Keyword(s):  
Clinical Trials ◽  
Pulmonary Arterial Hypertension ◽  
Drug Development ◽  
Phase 1 ◽  
Preclinical Studies ◽  
Phase 2 ◽  
Phase 3 ◽  
Preclinical Testing ◽  
New Drug ◽  
Pulmonary Arterial

Drug development is the entire process of introducing a new drug to the market. It involves drug discovery, screening, preclinical testing, an Investigational New Drug (IND) application in the US or a Clinical Trial Application (CTA) in the EU, phase 1–3 clinical trials, a New Drug Application (NDA), Food and Drug Administration (FDA) review and approval, and postapproval studies required for continuing safety evaluation. Preclinical testing assesses safety and biologic activity, phase 1 determines safety and dosage, phase 2 evaluates efficacy and side effects, and phase 3 confirms efficacy and monitors adverse effects in a larger number of patients. Postapproval studies provide additional postmarketing data. On average, it takes 15 years from preclinical studies to regulatory approval by the FDA: about 3.5–6.5 years for preclinical, 1–1.5 years for phase 1, 2 years for phase 2, 3–3.5 years for phase 3, and 1.5–2.5 years for filing the NDA and completing the FDA review process. Of approximately 5000 compounds evaluated in preclinical studies, about 5 compounds enter clinical trials, and 1 compound is approved (Tufts Center for the Study of Drug Development, 2011). Most drug development programs include approximately 35–40 phase 1 studies, 15 phase 2 studies, and 3–5 pivotal trials with more than 5000 patients enrolled. Thus, to produce safe and effective drugs in a regulated environment is a highly complex process. Against this backdrop, what is the best way to develop drugs for pulmonary arterial hypertension (PAH), an orphan disease often rapidly fatal within several years of diagnosis and in which spontaneous regression does not occur?

Sign in / Sign up

Export Citation Format

Share Document