scholarly journals Нelicobacter pylori as etiological factor of acute pancreatitis and marker of its purulent-septic complications development

2020 ◽  
Vol 87 (7-8) ◽  
pp. 15-19
Author(s):  
І. V. Коlosovych ◽  
І. V. Hanol ◽  
К. О. Lebedieva
Keyword(s):  
Acute Pancreatitis ◽  
Positive Result ◽  
Biological Material ◽  
Etiological Factor ◽  
Control Group ◽  
Septic Complications ◽  
Group A ◽  
Bacteriological Investigation ◽  
Positive Results

Objective. Studying of role of Нelicobacter pylori as etiological factor of acute pancreatitis and marker of development of its purulent-septic complications. Маterials and methods. Screening investigation was performed in all 124 patients, suffering acute pancreatitis and admitted to hospital; then a screening investigation of Нelicobacter pylori in feces and the blood serological investigation was conducted. In 39 (31.5%) patients bacteriological investigation of biological material for revealing of Нelicobacter pylori was conducted. The patients were distributed into two groups: the main - 66 patients with severe and with a middle severity course of acute pancreatitis and a control one - 58 patients with light course of acute pancreatitis. Results. Positive results of fecal express-test were obtained in 105 (84.7%) patients. In accordance to the blood serological investigations results in 24 h from the admittance to hospital moment in a control group a positive result was obtained in 8 (13.8%) patients, and in the main - in 23 (34.8%); while in 7 days - in 9 (15.5%) and 42 (63.6%) patients, accordingly. Аntibiotics, which are applied for therapy in purulent-septic complications of acute pancreatitis, guarantee the efficacy of eradication of Нelicobacter pylori in 94.9% patients. Conclusion. The enhancement of quantity of the blood positive serological investigations by 28.8% (р < 0.001) in patients of the main group in 7 days from the admittance to the hospital date trusts, that Нelicobacter pylori constitutes not the only one etiological factor in acute pancreatitis, but a possible marker of development of its purulent-septic complications as well.

scholarly journals Meaning Of Respiratory Mycoplasma Infection In Children With Bronchial Asthma

2020 ◽  
Vol 02 (12) ◽  
pp. 47-54
Author(s):  
Gulnoza Aloevna Toshmatova ◽  
◽  
Maftuna Shukhrat Qizi Shakarova ◽  
Keyword(s):  
Positive Result ◽  
Bronchial Asthma ◽  
Control Group ◽  
Mycoplasma Infection ◽  
Positive Results

Meaning and role of mycoplasma infection for children with bronchial asthma small studied. By us was inspected 39 children with BA in age from 2 to 14, from them 27 (69,2%) boys and 12 (30,8) girls. Obtained data from PChR testing is shown: among the children of patients with BA for 33,3% (13/39) patients found out M. pneumoniae.; for 66,7% (26/39) patients and for all children of control group M. pneumoniae. it is not discovered (table.№1). For children in a range 2-5, the more than half (53,8%) of children-asthmatics was got positive results of PChR; among the investigated children in age 6-14, only at 46,2% patients had M. pneumonia. Except it, among patients with BA, for 69,2% boys and 31% girls made the positive result of PChR, and correlation of sexes was made by 2,2: 1.

scholarly journals PURULENT SEPTIC COMPLICATIONS OF ACUTE PANCREATITIS AND THEIR PATHOGENETIC RELATIONSHIP WITH HELICOBACTER PYLORI

2021 ◽  
Vol 29 (5) ◽  
pp. 542-548
Author(s):  
I.V. Kolosovych ◽  
◽  
I.V. Hanol ◽  
Keyword(s):  
Acute Pancreatitis ◽  
Helicobacter Pylori ◽  
Antibiotic Therapy ◽  
Positive Result ◽  
Comparison Group ◽  
Main Group ◽  
Immunoglobulin M ◽  
Septic Complications ◽  
Bacteriological Study

Objective. To study of the role of Helicobacter pylori as an etiological factor of acute pancreatitis and a marker of the development of its purulent-septic complications. Мethods. The study was conducted in the period of 2015-2020; patients with acute pancreatitis (n=124) were divided into 2 groups: the main group (66 patients with moderate severity and severe course) and the comparison group (58 patients with a mild form). All patients underwent a screening study of Helicobacter pylori in feces and serological blood test to detect antibodies, namely immunoglobulin M to Helicobacter pylori (determination of the phase of the disease - acute or chronic). In 39 (31.5%) patients of the main group, a bacteriological study of biological and biopsyspecimensof antral mucous membrane were taken and examined histologically for organisms. The selection of antibiotics for treatment was carried out taking into account the infection of patients with Helicobacter pylori and was performed using the author’s method, the effectiveness of treatment was controlled microbiologically. Results. The positive result of the express test was in 66 (100%) patients of the main group and in 39 (67.2%) patients in the comparison group. During serological examination, a positive result was obtained: 24 hours after hospitalization - in 8 (13.8%) patients in the comparison group, in 23 (34.8%) patients in the main group; after 7 days - in 9 (15.5%) patients and 42 (63.3%) patients, respectively. Helicobacter pylori is sensitive to the majority of antibiotics used to treat purulent-septic complications of acute pancreatitis; after finishing the course of antibiotic therapy, eradication was achieved in 37 (94.9%) patients of the main group. Conclusion. Positive results of a serological study of Нelicobacter pylori after 7 days from the moment of hospitalization were more common in patients of the main group (63.3%) in relation to the comparison group (15.5%) (χ<sup>2</sup>=28.9, p<0.001), which gives grounds to consider bacteria, as one of the markers of the development of purulent-septic complications of acute pancreatitis. What this paper adds The role of Helicobacter pylori (HP) in the pathogenesis of acute pancreatitis has been studied for the first time and its value as a marker for septic complications development of acute pancreatitis is shown. It allowed optimizing the etiotropic antibiotic therapy for this disease.

scholarly journals A STUDY ON ROLE OF OCTREOTIDE ON OUTCOME OF PATIENTS WITH ACUTE PANCREATITIS

2020 ◽  
pp. 22-24
Author(s):  
Vishal Lodha ◽  
Rajesh Sonsale ◽  
Sandip Jadhav
Keyword(s):  
Acute Pancreatitis ◽  
Hospital Stay ◽  
Case Control Study ◽  
Case Control ◽  
Control Group ◽  
Care Hospital ◽  
Group A ◽  
Group B ◽  
Control Study

Introduction: Mild pancreatitis is a self limiting disease, while morbidity and mortality is considerably high in cases of severe necrotizing pancreatitis. Octreotide reduces secretion, release and activation of exocrine hormones; there is collection of pancreatic hormones in duct which in return causes irreversible destruction of the exocrine and endocrine pancreatic parenchyma leading to mal-digestion and diabetes. There are lot of controversies in the treatment of acute pancreatitis, so through this study we tried to evaluate whether there is a beneficial role of octreotide or not. Materials and Method: This case control study was done on patients admitted for the treatment of acute pancreatitis at a tertiary care hospital in Central India. This is retrospective study. The data of inpatient records were taken from the medical records department (MRD) of the hospital. The diagnosis of patients was established on basis of biochemical and radiological investigations. The patients were divided into two groups; cases and control, cases had received octreotide along with fluids (group A) controls received fluids without octreotide (group B). Symptomatic treatment was given in both the groups. Ages of the cases and controls were matched (±3 years). The statistical analysis of data was done and results were obtained. Results: In this retrospective case control study the records of fifty two patients were selected. The mean age in Group A was 35 ±16.45 years and in Group B 40±17.51 years in Group B (tA/B1.061; p ˂0.294). There were 22 males and 4 females in group A, while 20 males and 6 females in group B. Both the groups were comparable. All the patients in octreotide group survived while there were three deaths in control group. As far as mean hospital stay is was 10 days ± 7.10 in group A while it was 7 days ±3.65 in group B. All the p values for the criteria of study are non-significant. But when we talk about percentage, 11.53% patient died in control group. Conclusion: In our study we found that octreotide does not affect the final outcome of patients with acute pancreatitis. There is no effect on hospital stay and reduced need of analgesics in patients with acute pancreatitis. Keywords: Acute Pancreatitis; Octreotide; Hospital Stay; Mortality

scholarly journals Occurrence of urogenital mycoplasmas in men with the common genitourinary diseases

2021 ◽  
Author(s):  
Dominika Smolec ◽  
Alicja Ekiel ◽  
Piotr Kłuciński ◽  
Jan Kawecki
Keyword(s):  
Infectious Complications ◽  
Prostatic Hyperplasia ◽  
Control Group ◽  
Study Group ◽  
Immunocompromised Patients ◽  
Healthy Men ◽  
The Common ◽  
Estimate Prevalence ◽  
Positive Results

Abstract Many serious and fatal infections with urogenital mycoplasmas in immunocompromised patients have been reported. M. genitalium is recognized as a cause of male urethritis and other common genitourinary diseases. The aim of the study was to estimate prevalence of urogenital mycoplasmas which can cause complications in men with common genitourinary diseases. Study included 85 men with genitourinary tract carcinoma (n = 35), urolithiasis (n = 36), and BPH (benign prostatic hyperplasia) (n = 14). The control group consisted of 50 healthy men. FVU (first void urine) samples were examined by PCR for the presence of urogenital mycoplasmas DNA. Occurrence of urogenital mycoplasmas was significantly more common in study group compared with control 24/85 (28.2%) and 7/50 (14%), respectively (p = 0.05). In men with urolithiasis, positive results for mycoplasmas DNA were significantly more frequent than in control: 33.3% vs. 14% (p < 0.05). In patients with urolithiasis DNA of U. urealyticum was most often found, while in the genitourinary carcinoma and BPH groups, U. parvum was more frequent. Incidence of M. fermentans was also significantly higher in the urolithiasis group vs. control (p = 0.03). A higher percentage of positive results for urogenital mycoplasma DNA in study group has been found. Further studies are required to confirm the role of urogenital mycoplasmas in the development of infectious complications among patients with urolithiasis, genitourinary carcinoma, and BPH.

scholarly journals The role of brief intervention in achieving and maintaining abstinence in patients with alcoholic liver disease

2020 ◽  
pp. 182-188
Author(s):  
V. D. Lunkov ◽  
M. V. Maevskaya ◽  
V. T. Ivashkin
Keyword(s):  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
Psychological Intervention ◽  
Decompensated Cirrhosis ◽  
Control Group ◽  
Factors Associated ◽  
Entire Observation Period ◽  
Group A ◽  
Observation Period

Objective of the study. prove the effectiveness of brief psychological intervention (BPI) conducted by an internist in achieving and maintaining abstinence in patients with alcoholic liver disease (ALD).Materials and methods. A total of 65 patients were included in the study: 29 patients in the BPI group and 36 in the historical control group. A comparative analysis of the frequency of achievement and maintenance of abstinence and analysis of factors associated with these parameters were conducted.Results of the study. The frequency of achieving abstinence was significantly higher in the BPI group compared with the control group after 6, 9, 12 and 24 months from the date of inclusion in the study (p <0.001, p = 0.002, p = 0.001, p = 0.017, respectively; criterion χ2). The frequency of failures to achieve abstinence in the CPC group was significantly lower than in the control group after 6 months and in general for the entire observation period (p = 0.004, p = 0.005, respectively; criterion χ2). Provision of BPIs for 12 months after alcohol-induced decompensation serves as a factor that is reliably associated with achieving total abstinence within 24 months (p = 0.001, criterion χ2). Decompensated cirrhosis of the liver serves as factors independently associated with failures to achieve abstinence within 24 months after alcohol-induced illness (OS: 10.72 [95% CI 2.17–52.81]; p = 0.004) and the absence of BPI after discharge from the hospital (OSH BPI: 0.80 [95% CI 0.14–0.479]; p = 0.006)Conclusion. BPIs provided by an internist to the patients with ABD for 12 months after alcohol-induced decompensation leads to a higher rate of achieving total abstinence and decrease in the frequency of failures to achieve abstinence within 24 months after discharge from the hospital.

scholarly journals The Role of Post-Ingestive Feedback in the Development of an Enhanced Appetite for the Orosensory Properties of Glucose over Fructose in Rats

Nutrients ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 807 ◽  
Author(s):  
Kevin P. Myers ◽  
Megan Y. Summers ◽  
Elizabeth Geyer-Roberts ◽  
Lindsey A. Schier
Keyword(s):  
Taste Receptor ◽  
Glucose Consumption ◽  
Sweet Taste ◽  
Taste Quality ◽  
Sensory Properties ◽  
Control Group ◽  
Sensory Property ◽  
Matched Group ◽  
Group A

The simple sugars glucose and fructose share a common “sweet” taste quality mediated by the T1R2+T1R3 taste receptor. However, when given the opportunity to consume each sugar, rats learn to affectively discriminate between glucose and fructose on the basis of cephalic chemosensory cues. It has been proposed that glucose has a unique sensory property that becomes more hedonically positive through learning about the relatively more rewarding post-ingestive effects that are associated with glucose as compared to fructose. We tested this theory using intragastric (IG) infusions to manipulate the post-ingestive consequences of glucose and fructose consumption. Food-deprived rats with IG catheters repeatedly consumed multiple concentrations of glucose and fructose in separate sessions. For rats in the “Matched” group, each sugar was accompanied by IG infusion of the same sugar. For the “Mismatched” group, glucose consumption was accompanied by IG fructose, and vice versa. This condition gave rats orosensory experience with each sugar but precluded the differential post-ingestive consequences. Following training, avidity for each sugar was assessed in brief access and licking microstructure tests. The Matched group displayed more positive evaluation of glucose relative to fructose than the Mismatched group. A second experiment used a different concentration range and compared responses of the Matched and Mismatched groups to a control group kept naïve to the orosensory properties of sugar. Consistent with results from the first experiment, the Matched group, but not the Mismatched or Control group, displayed elevated licking responses to glucose. These experiments yield additional evidence that glucose and fructose have discriminable sensory properties and directly demonstrate that their different post-ingestive effects are responsible for the experience-dependent changes in the motivation for glucose versus fructose.

Renal function in the laboratory rat: a student exercise.

1995 ◽  
Vol 268 (6) ◽  
pp. S49 ◽  
Author(s):  
R L Walker ◽  
M E Olson
Keyword(s):  
Renal Function ◽  
Fluid Intake ◽  
Tap Water ◽  
Extracellular Fluid ◽  
Control Group ◽  
Blood Samples ◽  
Treatment Groups ◽  
Laboratory Rats ◽  
Group A

Because of the increased concern over use of human body fluids in physiology teaching laboratories, we developed an exercise in renal function that utilizes laboratory rats. The purpose is to demonstrate the role of the kidneys in the homeostatic control of extracellular fluid volume, plasma ionic concentrations, and osmolarity. Three treatment groups are utilized: a volume-expanded (access to 1 g/100 ml sucrose) group, a volume-expanded and salt-loaded (access to 0.9 g/100 ml NaCl) group, and a volume-depleted (water-deprived) group. A normovolemic control group (access to tap water) is also included. Rats are housed individually in metabolic cages that allow accurate measurement of fluid intake and urine output. Blood samples are removed via cardiac puncture. The animals recover from this procedure and can be reutilized within 2-3 wk. When class data are pooled, clear trends are seen that demonstrate the volume-, osmo-, and ionoregulatory abilities of the kidneys.

High-Dose Chemotherapy in Small Cell Neuroendocrine Carcinoma: Favorable Long-Term Outcome for Extrapulmonary Primary Localization.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 3075-3075
Author(s):  
Antonia M.S. Mueller ◽  
Alex Kuehnemund ◽  
Monika Engelhardt
Keyword(s):  
High Dose Chemotherapy ◽  
Small Cell ◽  
Primary Site ◽  
Disease Stage ◽  
Control Group ◽  
High Dose ◽  
Group A ◽  
Group B ◽  
Primary Localization

Abstract Small cell neuroendocrine carcinomas (SCNC) are composed of round to spindle-shaped cells with features of both neuroendocrine and epithelial neoplasms. SCNC can be found in basically all epitheloid organs; however, the vast majority arises in the lung, while extrapulmonary (EP) localization is rare. Small cell lung cancer (SCLC) and EP SCNC are considered one histological entity and are treated similarly. Despite the high initial response to chemo- and radiotherapy, most patients relapse after short remission, and overall prognosis is dismal. Clinical trials employing high-dose chemotherapy (HDCT) followed by autologous stem cell transplantation (auto-SCT) neither demonstrated a clear benefit nor clarified its significance in SCLC. The role of intensified treatment in EP SCNC has not been specifically addressed in detail. Conversely to SCLC, some subgroup analyses indicated that patients with EP SCNC might benefit from intensive treatment. We analyzed a total of 22 patients: 8 with EP SCNC (group A; m:f 3:5; median age 36 years (y) [range 22–56]) and 14 patients with SCLC (group B; m:f 10:4; median age 55 y [40–63]), all undergoing HDCT with auto-SCT at our single center from 07/90–01/05. A control group C consisted of 30 patients with EP SCNC (m:f 21:9, median age 66 years [32–81], who received different standard treatments without auto-SCT. All group A patients had stage IV disease (liver n=5, lymph nodes n=4, pancreas n=1, orbita n=1, bone n=1, kidney n=1). Two of these patients received additional local radiotherapy. In group B, 7 patients had limited and 7 patients extensive disease, (stage I (n=1), II (n=2), III (n=10), IV (n=1). HDCT with VIC (etoposide, ifosfamide, carboplatin; n=21), or CCT (carboplatin, cyclophosphamide, thiotepa; n=1) was followed by infusion of a median 3.2x10^6 CD34+ cells. Prophylactic radiotherapy was performed in 12 patients (mediastinum n=11; brain n=10). With a median follow-up (FU) of 48 months (7–152) for group A and 85 months (0–170) for group B, 5/8 (63%) of patients with EP SCNC (group A) are alive and in complete remission (CR), compared to 5/14 (36%) SCLC patients (group B). Best response ever achieved after HDCT was a CR in 5/8 (63%), a partial remission (PR) in 2/8 (25%) and stable disease (SD) in 1/8 (12%) in group A. In group B, a CR was attained in 11/14 (79%), a PR and a SD in 1/14 (7%) patients, respectively. In the conventionally treated control group C, a transient PR was achieved in 5/30 (16%), and after a median FU of 9.7 months, only 2/30 (6.7%) EP SCNC patients are alive. Our analysis suggests that selected SCNC patients may benefit from HDCT, particularly when integrated into multimodal treatment concepts. The remarkably favorable outcome in patients with EP primary site, even when HDCT was implemented as salvage treatment warrants further studies on the role of HDCT in SCNC. Careful attention will have to be paid to prognostic clinical features, such as primary site and/or histological parameters including neuroendocrine marker profiles and mitotic indices. These may help to predict which patients will benefit from intensified treatment. In addition, further histological studies should address the identification of markers specific for lung- vs. extrapulmonary primary localization. For this purpose all available tumor tissue from our study is currently under histological re-analysis, assessing the expression of the novel tumor testis antigens.

scholarly journals Convergence, Accommodation, Fusion, and Stereopsis: What Keeps the Eyes Aligned in Intermittent Exotropia?

Scientifica ◽  
2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Costantino Schiavi ◽  
Valentina Di Croce ◽  
Laura Primavera ◽  
Filippo Tassi
Keyword(s):  
Patient Group ◽  
Control Group ◽  
Intermittent Exotropia ◽  
Myopic Shift ◽  
Infrared Video ◽  
Group A ◽  
Angle Of Deviation ◽  
Convergence And Divergence ◽  
Group B

Purpose. To investigate the relationships between angle of deviation, fusional convergence and divergence amplitude, AC/A ratio, near point of convergence (NPC), and myopia-phoria in intermittent exotropia (IXT). Methods. 93 patients with IXT, divided into two groups, were recruited in the study. In Group A (73 patients), fusional convergence and divergence amplitudes, NPC, and AC/A ratio were studied and compared with a control group. In Group B (in 20 patients), myopia-phoria while switching from monocular to binocular view was studied with an infrared video retinoscopy and compared with a control group. Results. In Group A, positive fusional amplitudes, NPC, and AC/A ratio of IXT patients did not differ from those of normals. Negative fusional amplitudes were significantly higher in the patient group than in the control group. In Group B, myopic shift was statistically significantly higher in the patient group and there was a statistically significant positive correlation between myopic shift and angle of strabismus. Conclusions. Apart from the role of fusional convergence which accounts for myopia-phoria, that of the other binocular functions in the control at near of IXT and conversely their specific role in the pathogenesis of IXT remain unclear and the cause of divergent infantile strabismus is still unknown.

scholarly journals To assess the role of lingual flap for the removal of lower wisdom tooth.

2020 ◽  
Vol 27 (08) ◽  
pp. 1656-1663
Author(s):  
Noman Ahmed ◽  
Almas Rahoojo ◽  
Syed Zafar Abbas ◽  
Syed Ghazanfar Hassan ◽  
Zunair Memon
Keyword(s):  
Nerve Injury ◽  
Maxillofacial Surgery ◽  
Sensory Nerve ◽  
Lingual Nerve ◽  
Control Group ◽  
Wisdom Tooth ◽  
Significant Difference ◽  
Group A ◽  
Group B

Objectives: To assess the role of lingual flap in encountering lingual nerve injury during the surgical elimination of lower wisdom tooth. Study Design: Cross Sectional Case Control study. Setting: Department of Oral & Maxillofacial Surgery, Institute of Dentistry, Liaquat University of Medical & Health Sciences Jamshoro / Hyderabad. Period: January 2016 to September 2016. Material & Methods: Subjects were categorized into two categories: Group-A (lingual flap) & group-B (control group) each having 52 patients by Lottery method. In group A an envelope mucoperiosteal flap followed by lingual flap elevation carried out and in group B only envelope flap was carried out. All patients were reviewed on the first postoperative day and again 1 and 3rd week after surgery. At each postoperative visit, patient was examined for sensory nerve impairment of the lingual nerve by same observer. Results: Total 104 cases were studied, all the cases categorized among two groups 52 in each group. In group-A 34 were males and 18 were females, while in group-B 44 were male and 8 were females. There was no significant difference among both groups according to the pre-operative assessment. According to objective findings, lingual nerve paresthesia was found among 2 cases of group A on 1st visit, while no any case was found with nerve injury in group B. Out of 2 cases, one case was improved and only one had presented with complain at 2nd visit and 3rd visit, no significant difference among both groups, p-values were quite insignificant. Conclusion: It was concluded that lingual nerve injury (LNI) occurred among few cases of lingual flap group which was insignificantly higher as compare to control group, but the nature of injury was temporary.

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