scholarly journals BIOCHEMICAL ANALYSIS OF FLOWERS OF Vinca major, A MEDICINAL WEED PLANT OF HILLY AREAS OF PAKISTAN

2021 ◽  
Vol 27 (4) ◽  
pp. 537-546
Author(s):  
Arshad Javaid ◽  
Malik F. H. Ferdosi ◽  
Iqra Haider Khan ◽  
Amna Shoaib ◽  
Hafiz M. Saeed ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Biochemical Analysis ◽  
Biological Properties ◽  
Hexadecanoic Acid ◽  
Perennial Weed ◽  
Khyber Pakhtunkhwa ◽  
Weed Plant ◽  
Vinca Major ◽  
Anti Inflammatory ◽  
Pure Methanol

Vinca major L. is an evergreen perennial weed of family Apocynaceae, growing naturally in hilly areas of Hazara region of Khyber Pakhtunkhwa, Pakistan. Flowers of this weed were collected from Khanspur, Ayubia during June 2021, shade dried and extracted in pure methanol for two weeks. After filtration, the extract was analyzed by GC-MS for identification of possible bioactive compounds. α-Amyrin was the major compounds (32.49%) followed by lup-20(29)-en-3-ol, acetate, (3β)- (25.72%). Moderately abundant compounds included γ-sitosterol (8.78%), β-amyrone (7.25%), cyclohexane, 1,3,5-triphenyl- (7.01%), olean-12-en-3-ol, acetate, (3β)- (5.68%), and n-hexadecanoic acid (3.18%). Some of the identified compounds have various important biological properties including anti-inflammatory, antimicrobial, anticancer, antimalarial, antioxidant, antidiabetic, antitumor etc.

scholarly journals GCMS Profile of Bioactive Compounds with Therapeutic Potential in Beta vulgaris (L.) Ethanolic Leaf Extracts

2021 ◽  
pp. 354-360
Author(s):  
J. Harine Sargunam ◽  
S. Thilakavathy
Keyword(s):  
Beta Vulgaris ◽  
Bioactive Compounds ◽  
Therapeutic Potential ◽  
Antioxidant Properties ◽  
Octadecenoic Acid ◽  
Acid Methyl Ester ◽  
World Health ◽  
Gas Chromatography Mass Spectrometry ◽  
Hexadecanoic Acid ◽  
Anti Inflammatory

Plants, animals, and microorganisms have all been shown to have health benefits for humans. According to World Health Organization, plant medicines continue to be used by 80 percent of the world’s population in developing countries. Plant-derived secondary metabolites are macromolecules that are biosynthesized in plants and have a variety of biological properties that are beneficial to humans, including antiallergic, anti-inflammatory, anti-diabetic, and antioxidant properties. Therefore, the present investigation was done to determine the bioactive compounds present in Beta vulgaris (L.) leaves powder using Perkin-Elmer Gas Chromatography-Mass Spectrometry, while the mass spectra of the compounds found in the extract matched the National Institute of Standards and Technology (NIST) library. GC-MS analysis of an ethanolic extract of Beta vulgaris (L.) revealed the presence of 25 bioactive compounds with different area percentages and structural details. The major bioactive compounds are 1,3,5,7- Tetroxane (73.1%), Decane (83.1%), Azulene (73.8%), 4-Hepten-2-one, 5-ethyl-3,3,4-trimethyl-(71.1%), 6-Amino-1,3,5-triazine-2,4 (1H, 3H)-dione(65.1%), Phthalic acid, 4-bromophenyl ethyl ester(83.7%), Neophtadiene(93.1%), Neophytadiene (88.2%)Hexadecanoic acid, methyl ester(84.8%), n-Hexadecanoic acid(84.3%), Phytol(86.0%), 9- octadecenoic acid, (E)(88.6%), 2-Hexadecen-1-ol,3,7,11,15-tetramethyl-acetate,[R-[R*,R*-(E)]]-(64.0%), 1-Tricosene(72.3%) and 17-Pentatriacontene(65.6%). Most identified compounds have bioactivities such as Antimalaria, Anti-inflammatory, Antibacterial, Antifungal, Antiviral, Antidiabetic, Antioxidant, Anticancer, Analgesic, Anti-hyperlipidemic, Hypocholesterolemic, Hepatoprotective, and Anti-androgenic, so that they can be recommended as a plant of phytopharmaceutical importance. Therefore ethanol extract of Beta vulgaris (L.) leaves proves as a potential source of bioactive compounds of pharmacological importance.

scholarly journals BIOACTIVE COMPONENTS IN METHANOLIC FLOWER EXTRACT OF Ageratum conyzoides

2021 ◽  
Vol 27 (2) ◽  
pp. 181-190
Author(s):  
Malik Fiaz Hussain Ferdosi ◽  
Arshad Javaid ◽  
Iqra Haider Khan ◽  
Muhammad F. A. Ferdosi ◽  
Ayesha Munir
Keyword(s):  
Bioactive Compounds ◽  
Biological Properties ◽  
Literature Survey ◽  
Bioactive Components ◽  
Ageratum Conyzoides ◽  
Flower Extract ◽  
Precocene Ii ◽  
The Family ◽  
Anti Inflammatory

In order to find out various bioactive compounds in flowers of Ageratum conyzoides, a weed of the family Asteraceae, the dried powdered flowers were extracted in analytical grade methanol and the extract was examined by GC-MS. In total, eight constituents were identified. The predominant compound in the extract was precocene II (59.50%). Three moderately abundant compounds included ethanone, 1-(7-hydroxy-5-methoxy-2,2-dimethyl-2H-1-benzopyran-6-yl)- (9.77%), precocene I (8.61%) and caryophyllene (7.60%). Three compounds namely (E)-β-famesene (4.23%), β-cubebene (4.19%) and 1-nonadecene (4.07%) were categorized as less abundant. The eighth compounds phytol was the least abundant one with peak are of 1.99%. The literature survey showed that most of the identified compounds possessed various biological properties such as aphid repellant, antioxidant, anticancer, antimicrobial and/or anti-inflammatory.

Pharmacologically potentials of different substituted coumarin derivatives

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Benzene Ring ◽  
Bioactive Compounds ◽  
Biological Activities ◽  
Pharmacological Properties ◽  
Coumarin Derivatives ◽  
Wide Range ◽  
Anti Oxidant ◽  
Anti Inflammatory ◽  
Coumarin Compounds

Coumarin and its derivatives are widely spread in nature. Coumarin goes to agroup as benzopyrones, which consists of a benzene ring connected to a pyronemoiety. Coumarins displayed a broad range of pharmacologically useful profile.Coumarins are considered as a promising group of bioactive compounds thatexhibited a wide range of biological activities like anti-microbial, anti-viral,antiparasitic, anti-helmintic, analgesic, anti-inflammatory, anti-diabetic, anticancer,anti-oxidant, anti-proliferative, anti-convulsant, and antihypertensiveactivities etc. The coumarin compounds have immense interest due to theirdiverse pharmacological properties. In particular, these biological activities makecoumarin compounds more attractive and testing as novel therapeuticcompounds.

Diverse chemical and biological potentials of various pyridazine and pyridazinone derivatives

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Heterocyclic Compounds ◽  
Biological Activities ◽  
Wide Spectrum ◽  
Biological Properties ◽  
Industrial Chemical ◽  
Anti Inflammatory ◽  
Pyridazinone Derivatives

A series of heterocyclic compounds incorporating pyridazine moiety were for diverse biological activities. Pyridazines and pyridazinones derivatives showed wide spectrum of biological activities such as vasodialator, cardiotonic, anticonvulsant, antihypertensive, antimicrobial, anti-inflammatory, analgesic, anti-feedant, herbicidal, and various other biological, agrochemical and industrial chemical activities. The results illustrated that the synthesized pyridazine/pyridazine compounds have diverse and significant biological activities. Mechanistic insights into the biological properties of pyridazinone derivatives and various synthetic techniques used for their synthesis are also described.

The Molecular Diversity Scope of Urazole in the Synthesis of Organic Compounds

2019 ◽  
Vol 16 (7) ◽  
pp. 953-967 ◽  
Author(s):  
Ghodsi M. Ziarani ◽  
Fatemeh Mohajer ◽  
Razieh Moradi ◽  
Parisa Mofatehnia
Keyword(s):  
Biological Activities ◽  
Biological Properties ◽  
Biologically Active ◽  
Microtubule Assembly ◽  
Heterocyclic Molecules ◽  
Biological Perspective ◽  
Highly Active ◽  
Anti Inflammatory ◽  
High Yields ◽  
Short Time

Background: As a matter of fact, nitrogen as a hetero atom among other atoms has had an important role in active biological compounds. Since heterocyclic molecules with nitrogen are highly demanded due to biological properties, 4-phenylurazole as a compound containing nitrogen might be important in the multicomponent reaction used in agrochemicals, and pharmaceuticals. Considering the case of fused derivatives “pyrazolourazoles” which are highly applicable because of their application for analgesic, antibacterial, anti-inflammatory and antidiabetic activities as HSP-72 induction inhibitors (I and III) and novel microtubule assembly inhibitors. It should be mentioned that spiro-pyrazole also has biological activities like cytotoxic, antimicrobial, anticonvulsant, antifungal, anticancer, anti-inflammatory, and cardiotonic activities. Objective: Urazole has been used in many heterocyclic compounds which are valuable in organic syntheses. This review disclosed the advances in the use of urazole as the starting material in the synthesis of various biologically active molecules from 2006 to 2019. Conclusion: Compounds of urazole (1,2,4-triazolidine-3,5-dione) are the most important molecules which are highly active from the biological perspective in the pharmaceuticals as well as polymers. In summary, many protocols for preparations of the urazole derivatives from various substrates in multi-component reactions have been reported from different aromatic and aliphatic groups which have had carbonyl groups in their structures. It is noted that several catalysts have been synthesized to afford applicable molecules with urazole scaffolds. In some papers, being environmentally friendly, short time reactions and high yields are highlighted in the protocols. There is a room to synthesize new catalysts and perform new reactions by manipulating urazole to produce biologically active compounds, even producing chiral urazole component as many groups of chiral urazole compounds are important from biological perspective.

scholarly journals Bioactive Compounds Obtained from Polish “Marynka” Hop Variety Using Efficient Two-Step Supercritical Fluid Extraction and Comparison of Their Antibacterial, Cytotoxic, and Anti-Proliferative Activities In Vitro

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2366
Author(s):  
Katarzyna Klimek ◽  
Katarzyna Tyśkiewicz ◽  
Malgorzata Miazga-Karska ◽  
Agnieszka Dębczak ◽  
Edward Rój ◽  
...  
Keyword(s):  
Supercritical Fluid Extraction ◽  
Supercritical Fluid ◽  
Bioactive Compounds ◽  
Crude Extract ◽  
Normal Skin ◽  
Extraction Methods ◽  
Biological Properties ◽  
Added Value ◽  
Fluid Extraction

Given the health-beneficial properties of compounds from hop, there is still a growing trend towards developing successful extraction methods with the highest yield and also receiving the products with high added value. The aim of this study was to develop efficient extraction method for isolation of bioactive compounds from the Polish “Marynka” hop variety. The modified two-step supercritical fluid extraction allowed to obtain two hop samples, namely crude extract (E1), composed of α-acids, β-acids, and terpene derivatives, as well as pure xanthohumol with higher yield than that of other available methods. The post-extraction residues (R1) were re-extracted in order to obtain extract E2 enriched in xanthohumol. Then, both samples were subjected to investigation of their antibacterial (anti-acne, anti-caries), cytotoxic, and anti-proliferative activities in vitro. It was demonstrated that extract (E1) possessed more beneficial biological properties than xanthohumol. It exhibited not only better antibacterial activity against Gram-positive bacteria strains (MIC, MBC) but also possessed a higher synergistic effect with commercial antibiotics when compared to xanthohumol. Moreover, cell culture experiments revealed that crude extract neither inhibited viability nor divisions of normal skin fibroblasts as strongly as xanthohumol. In turn, calculated selectivity indexes showed that the crude extract had from slightly to significantly better selective anti-proliferative activity towards cancer cells in comparison with xanthohumol.

scholarly journals Phytochemicals and Biological Activity of Desert Date (Balanites aegyptiaca (L.) Delile)

Plants ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 32
Author(s):  
Hosakatte Niranjana Murthy ◽  
Guggalada Govardhana Yadav ◽  
Yaser Hassan Dewir ◽  
Abdullah Ibrahim
Keyword(s):  
Biological Activity ◽  
Middle East ◽  
Bioactive Compounds ◽  
Phenolic Acids ◽  
Tree Species ◽  
Indian Subcontinent ◽  
Therapeutic Agents ◽  
Root Bark ◽  
Balanites Aegyptiaca ◽  
Anti Inflammatory

Many underutilized tree species are good sources of food, fodder and possible therapeutic agents. Balanites aegyptiaca (L.) Delile belongs to the Zygophyllaceae family and is popularly known as “desert date”, reflecting its edible fruits. This tree grows naturally in Africa, the Middle East and the Indian subcontinent. Local inhabitants use fruits, leaves, roots, stem and root bark of the species for the treatment of various ailments. Several research studies demonstrate that extracts and phytochemicals isolated from desert date display antioxidant, anticancer, antidiabetic, anti-inflammatory, antimicrobial, hepatoprotective and molluscicidal activities. Mesocarp of fruits, seeds, leaves, stem and root bark are rich sources of saponins. These tissues are also rich in phenolic acids, flavonoids, coumarins, alkaloids and polysterols. Some constituents show antioxidant, anticancer and antidiabetic properties. The objective of this review is to summarize studies on diverse bioactive compounds and the beneficial properties of B. aegyptiaca.

scholarly journals Formation of Amphiphilic Molecules from the Most Common Marine Polysaccharides, toward a Sustainable Alternative?

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4445
Author(s):  
Tiphaine Wong ◽  
Lorette Brault ◽  
Eric Gasparotto ◽  
Romuald Vallée ◽  
Pierre-Yves Morvan ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Carboxylic Acid ◽  
Bioactive Compounds ◽  
Biological Properties ◽  
Cross Linking ◽  
Structural Modifications ◽  
Chemical Structures ◽  
Amphiphilic Molecules

Marine polysaccharides are part of the huge seaweeds resources and present many applications for several industries. In order to widen their potential as additives or bioactive compounds, some structural modifications have been studied. Among them, simple hydrophobization reactions have been developed in order to yield to grafted polysaccharides bearing acyl-, aryl-, alkyl-, and alkenyl-groups or fatty acid chains. The resulting polymers are able to present modified physicochemical and/or biological properties of interest in the current pharmaceutical, cosmetics, or food fields. This review covers the chemical structures of the main marine polysaccharides, and then focuses on their structural modifications, and especially on hydrophobization reactions mainly esterification, acylation, alkylation, amidation, or even cross-linking reaction on native hydroxyl-, amine, or carboxylic acid functions. Finally, the question of the necessary requirement for more sustainable processes around these structural modulations of marine polysaccharides is addressed, considering the development of greener technologies applied to traditional polysaccharides.

scholarly journals Pharmacological Insights into Halophyte Bioactive Extract Action on Anti-Inflammatory, Pain Relief and Antibiotics-Type Mechanisms

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3140
Author(s):  
Rocco Giordano ◽  
Zeinab Saii ◽  
Malthe Fredsgaard ◽  
Laura Sini Sofia Hulkko ◽  
Thomas Bouet Guldbæk Poulsen ◽  
...  
Keyword(s):  
Pain Relief ◽  
Bioactive Compounds ◽  
Biomedical Applications ◽  
Medicinal Products ◽  
Salt Tolerant ◽  
Salicornia Europaea ◽  
Pharmacological Activities ◽  
Sustainable Resources ◽  
Anti Inflammatory ◽  
Significant Attention

The pharmacological activities in bioactive plant extracts play an increasing role in sustainable resources for valorization and biomedical applications. Bioactive phytochemicals, including natural compounds, secondary metabolites and their derivatives, have attracted significant attention for use in both medicinal products and cosmetic products. Our review highlights the pharmacological mode-of-action and current biomedical applications of key bioactive compounds applied as anti-inflammatory, bactericidal with antibiotics effects, and pain relief purposes in controlled clinical studies or preclinical studies. In this systematic review, the availability of bioactive compounds from several salt-tolerant plant species, mainly focusing on the three promising species Aster tripolium, Crithmum maritimum and Salicornia europaea, are summarized and discussed. All three of them have been widely used in natural folk medicines and are now in the focus for future nutraceutical and pharmacological applications.

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