scholarly journals Chagas Disease: seroprevalence and effectiveness of antiparasitic treatment

2021 ◽  
Vol 9 (17) ◽  
pp. 60-68
Author(s):  
Jorge Alberto Monroy-Vargas ◽  
Eduardo Bustos-Vázquez ◽  
Gisela Galindo-Juárez

INTRODUCTION: Chagas disease is considered the most serious parasitosis in America, forgotten and neglected in the world, with a characteristic that has its maximum expression in the difficulties and limitations for its diagnosis and treatment. OBJECTIVE: To assess the status of seropositivity of Chagas disease in Mexico, in addition to monitoring the effectiveness of treatment in infected patients. MATERIAL AND METHODS: Systematic reviews were conducted, with searches in Crossref, Google Scholar, Scielo, PubMed and the inclusion of guides and manuals of related health programs was evaluated based on their titles, news and relevance. RESULTS: for seropositivity, the data coincide with 100% in the characterization of the risk factors, as well as in the evaluations in the Blood Transfusion Centers of the country, finding captive cases in each state that explain the persistence of the disease . When monitoring treatments and evidence of effectiveness, the following difficulties arise: prolonged duration and side effects, adding the lack of reliable healing criteria, with an effectiveness of 60-75% in acute cases and in 100% of acute congenital cases, and in chronic cases a variation of between 15 and 30 years was found. CONCLUSIONS: Although the achievements have been commendable in reducing rates, the territory has factors that allow the redistribution of the infection, the evidence on the effectiveness is scarce, there is no evidence of epidemiological follow-up of cases in Mexico with respect to healing indicator.

1995 ◽  
Vol 113 (2) ◽  
pp. 821-825 ◽  
Author(s):  
Maria de Lourdes Higuchi

Endomyocardial biopsy procedure has been performed in many centers around the world, allowing a better treatment and follow up of the patients with myocardial disease. In Chagas' disease, it has been performed in São Paulo Heart Institute since 1978 and has brought important contributions to the understanding of the disease and consequently of the patient's clinical stage. In the present work we summarize the principal findings regarding the pathogenesis of Chagas' disease obtained mainly from the studies using endomyocardial biopsy specimens. Nowadays we do not have doubts that the inflammatory infiltrate aggressing myocardial fibers has fundamental role in the progression of the myocardial damage in Chagas' disease what culminates in chronic heart failure. The parasite seems to have active participation in the maintenance of such myocardial inflammation.


Author(s):  
Jane Howarth

Phenomenology is not a unified doctrine. Its main proponents – Husserl, Heidegger, Sartre and Merleau-Ponty – interpret it differently. However, it is possible to present a broad characterization of what they share. Phenomenology is a method of philosophical investigation which results in a radical ontological revision of Cartesian Dualism. It has implications for epistemology: the claim is that, when the foundations of empirical knowledge in perception and action are properly characterized, traditional forms of scepticism and standard attempts to justify knowledge are undermined. Phenomenological method purports to be descriptive and presuppositionless. First one adopts a reflective attitude towards one’s experience of the world by putting aside assumptions about the world’s existence and character. Second, one seeks to describe particular, concrete phenomena. Phenomena are not contents of the mind; they all involve an experiencing subject and an experienced object. Phenomenological description aims to make explicit essential features implicit in the ‘lived-world’ – the world as we act in it prior to any theorizing about it. The phenomenological method reveals that practical knowledge is prior to propositional knowledge – knowing that arises from knowing how. The key thesis of phenomenology, drawn from Brentano, is that consciousness is intentional, that is, directed onto objects. Phenomenologists interpret this to mean that subjects and objects are essentially interrelated, a fact which any adequate account of subjects and objects must preserve. Phenomenological accounts of subjects emphasize action and the body; accounts of objects emphasize the significance they have for us. The aim to be presuppositionless involves scrutinizing scientific and philosophical theories (Galileo, Locke and Kant are especially challenged). Phenomenology launches a radical critique of modern philosophy as overinfluenced by the findings of the natural sciences. In particular, epistemology has adopted from science its characterization of the basic data of experience. The influence of phenomenology on the analytic tradition has been negligible. The influence on the Continental tradition has been greater. The phenomenological critique of modern science and philosophy has influenced postmodern thought which interprets the modernist worldview as having the status of master narrative rather than truth. Postmodern thought also criticizes the positive phenomenological claim that there are essential features of the lived-world.


2010 ◽  
Vol 30 (2) ◽  
pp. 115-120 ◽  
Author(s):  
João Paulo da E. Pascon ◽  
Gláucia B. Pereira Neto ◽  
Marlos G. Sousa ◽  
Daniel Paulino Júnior ◽  
Aparecido A. Camacho

On the American continent, almost 15 million people are affected by Chagas disease, resulting in important economic and social damages. Dogs are considered to be an excellent experimental model to study Chagas' disease; as a result, in this research, the characterization of cardiovascular abnormalities was performed in dogs experimentally infected with Trypanosoma cruzi (the Colombian strain) that were at chronic stage. Thirteen adult female dogs were evaluated by electrocardiographic, echocardiographic, hematological and biochemical analyses in the chronic phase. For the electrocardiographic studies, respiratory sinus arrhythmia was the predominant rhythm during the entire research period (49.55% to 67%), with a low prevalence of right bundle branch block (0-13%) and first-degree atrioventricular block (0-14%). The spectral Doppler echocardio-graphy showed E and A mitral wave reversal (0.71±0.17), confirming the diastolic dysfunction present in all dogs. An increase in the enzymes activities was detected in the serum analysis, indicating myocardial injury by the infection. Six dogs died during the follow-up. In this way, the clinical characterization of experimentally infected dogs, as described here, increases the knowledge and allows for recognition of the behavioural modifications present in Chagas' disease in affected dogs.


2015 ◽  
Vol 3 (3) ◽  
pp. 5
Author(s):  
Dr. Neha Sharma

Language being a potent vehicle of transmitting cultural values, norms and beliefs remains a central factor in determining the status of any nation. India is a multilingual country which tends to encourage people to use English at national and international level. Basically English in India owes its presence to the British but its subsequent rise is not fully attributable to the British. It has now become the language of wider communication which is now spoken by large number of people all over the world. It is influenced by many factors such as class, society, developments in science and technology etc. However the major influence on English language is and has been the media.


Author(s):  
Vu Kha Thap

Entering the XXI century and especially in the period of the industrial revolution has entered the era of IT with the knowledge economy in the trend of globalization. The 4.0 mankind development of ICT, especially the Internet has had a strong impact and make changes to all activities profound social life of every country in the world. Through surveys in six high School, interviewed 85 managers and teachers on the status of the management of information technology application in teaching, author of the article used the SWOT method to distribute surface strength, weaknesses, opportunities and challenges from which to export 7 management measures consistent with reality. 7 measures have been conducting trials and the results showed that 07 measures of necessary and feasible.


2020 ◽  
Vol 1 (3) ◽  
pp. 49-56
Author(s):  
Feruza Mamatova ◽  

The present paper aims to compare the principles of choosing a marriage partner and analyse the status of being in the marrriage in the frame of family traditions that are totally inherent to the both of the nations: English and Uzbek. It is known that interconnection and cross-cultural communication between the countries of these two nationalities have been recently developed. The purpose to give an idea about these types of family traditions and prevent any misunderstanding that might occur in the communications makes our investigation topical one. The research used phraseological units as an object and the marriage aspects as the subject


2014 ◽  
Vol 6 (01) ◽  
Author(s):  
JAVED ALAM SHEIKH

Almost 50 per cent of the world population is constituted by the women and they have been making substantial contribution to socio-economic development. But, unfortunately their tremendous contribution remains unrecognized and unnoticed in most of the developing and least developed countries causing the problem of poverty among them. Empowering women has become the key element in the development of an economy. With women moving forward, the family moves, the village moves and the nation moves. Hence, improving the status of women by way of their economic empowerment is highly called for. Entrepreneurship is a key tool for the economic empowerment of women around the world for alleviating poverty. Entrepreneurship is now widely recognized as a tool of economic development in India also. In this paper I have tried to discuss the reasons and role of Women Entrepreneurship with the help of Push and Pull factors. In the last I have also discussed the problems and the road map of Women Entrepreneurs development in India.


Author(s):  
Tetyana Jezhyzhanska

In the information society the status of information is changing: this main value of global civilization becomes an important resource of socio- economic, technological and cultural development. The rapid development of virtual technologies and the growing number of Internet users in Ukraine and in the world causes the new challenges to communication of each organization. The book publishers are also obliged to respond to these processes. However, the works devoted directly to publishers’ communication in the modern media space are still lacking in Ukraine. The objective of the article is to clarify peculiarities and conditions of the activities of Ukrainian book publishers in today’s media space which is an important issue today. It is analyzed the literature and sources on this issue and it is ascertained the theoretical and practical possibilities to take into account the trends in the world of modern media in the PR-activity of book publishers. Also the prospects for further scientific study and practical use of PR-communications in the activity of publishers are determined. The analysis of current changes in the modern information space allows us to trace the general tendencies: the new subject and object areas are formed; the number of subjects is expanded; the new formats of interaction within the system of communications of the organization and in society as a whole are created. That means that publishing house’s PR-communications are complicated by the emergence of new elements, such as active audience, social networks as communication channels, promotions on the Internet and others. PR communication in the Internet space is the most effective and inexpensive tool for interaction of publishers with active audiences. Thus, the activation of PR communication in the modern media space is associated with the emergence of the latest information technologies, online media as well as development of Internet. The use of online channels of Internet for communication with the target audience of publishing organizations has certain advantages over traditional media. At the same time, it is necessary to take into account the information saturation of media space, which complicates the way of PR-messages of book publishers to the reader.


2020 ◽  
Vol 3 (3) ◽  
Author(s):  
Jiawen Fu

Since the birth of 5G, it has attracted much attention from all countries in the world. The development of 5G industry is particularly important for domestic economic development. 4G changes life, 5G changes society. 5G will not only accelerate the speed of people surfing the Internet, but also bring revolutionary changes to all aspects of social life, making people's lives, work and entertainment more convenient and diverse. The economic impact of the development of the 5G industry on China cannot be underestimated. Nowadays, information and communication technology has increasingly become a new driving force for economic development. 5G technology has already become a key technology pursuit for countries to compete for the status of world power, and it has also become an indispensable part of contemporary economic and social development. We should give full play to the government's guiding role, and work with network giants to build a new platform for cooperation, promote coordinated industrial development, achieve win-win results, and promote economic and social prosperity and development.


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