scholarly journals COVID 19, Pathophysiology and Prospects for Early Detection in Patients with Mild Symptoms of The Controversial Virus in Underdeveloped Countries

2020 ◽  
Vol 4 (2) ◽  
pp. 91-98
Author(s):  
Miguel Angel Garcés Villalá ◽  
José Andrés Nollen ◽  
Sergio David Rico ◽  
Gustavo Aníbal Cortez Quiroga ◽  
JOSE LUIS CALVO GUIRADO ◽  
...  
Keyword(s):  
General Population ◽  
Early Detection ◽  
Health Personnel ◽  
Signs And Symptoms ◽  
Screening Tests ◽  
Mild Symptom ◽  
Underdeveloped Countries ◽  
Professional Societies ◽  
Bibliographic Search ◽  
Google Search

COVID 19 has spread uniformly across the planet without distinction of hemispheres, borders, or climates. However, underdeveloped countries lack sufficient means to effectively detect and cope with the pandemic. The catastrophic economic situation forces indefinite quarantines to avoid health collapse. The scarcity of massive detection tests has led health personnel, the general population and their rulers to ignorance of the true epidemiological magnitude of SARS-CoV-2. Method: A computerized bibliographic search was performed using the Google search engine of original and review articles indexed by Scopus and WOS, in the PubMed / Medline and Cochrane databases to identify all relevant manuscripts and preprints, notices from professional societies and comments from Experts published from the start of the current epidemic related to mild COVID 19 symptoms. Tools, massive methods for detecting the disease and their low availability in underdeveloped countries were analyzed. Inexpensive and easily accessible methods for testing for the disease were discussed. Result: According to the indexed publications on the incidence of hypoxemia as a symptom and parameter of the evolution of the disease, oxygen saturation of less than 93% was determined as the limit to consider the patient suspected of COVID 19. In addition, it was determined after the analysis of published studies show an average prevalence of anosmia-hyposmia as a mild symptom in 69% of patients infected with COVID 19. Conclusion: Suspected cases of COVID 19 infection could be detected by the presence of its prevalent signs and symptoms. More studies are needed to standardize and validate the postulated screening tests.

Update of the last 2 years on the impact of the internet and social networks on the management of type 2 diabetes mellitus: simple review. (Preprint)

2020 ◽  
Author(s):  
Mayli Lañas-Navarro ◽  
Jose Ipanaque-Calderon Sr ◽  
Fiorela E Solano
Keyword(s):  
Social Networks ◽  
Mobile Applications ◽  
Health Personnel ◽  
Online Courses ◽  
The Internet ◽  
Diabetic Patients ◽  
Bibliographic Search ◽  
Use Of The Internet ◽  
And Control ◽  
The Impact

BACKGROUND Research on the use of the Internet in the medical field is experiencing many advances, including mobile applications, social networks, telemedicine. Its implementation in medical care and comprehensive patient management is a much discussed topic at present. OBJECTIVE This narrative review aims to understand the impact of the internet and social networks on the management of diabetes, both for patients and medical staff. METHODS The bibliographic search was carried out in the databases Pubmed, Virtual Health Library (VHL) and Lilacs between 2018 to 2020. RESULTS Multiple mobile applications have been created for the help and control of diabetic patients, as well as the implementation of online courses, improving the knowledge of health personnel applying them in the field of telemedicine. CONCLUSIONS The use of the Internet and social networks brings many benefits for both the diabetic patient and the health personnel, offering advantages for both.

scholarly journals Google search volume trends for cancer screening terms during the COVID-19 pandemic

2021 ◽  
pp. 096914132199942
Author(s):  
Austin Snyder ◽  
Sean Jang ◽  
Ilana S Nazari ◽  
Avik Som ◽  
Efren J Flores ◽  
...  
Keyword(s):  
Cancer Screening ◽  
Cancer Diagnosis ◽  
Pap Smear ◽  
Marked Decrease ◽  
Lung Cancer Screening ◽  
Screening Tests ◽  
Public Attention ◽  
Search Volume ◽  
Cancer Screening Tests ◽  
Google Search

The COVID-19 pandemic has led to delays in cancer diagnosis, in part due to postponement of cancer screening. We used Google Trends data to assess public attention to cancer screening during the first peak of the COVID-19 pandemic. Search volume for terms related to established cancer screening tests (“colonoscopy,” “mammogram,” “lung cancer screening,” and “pap smear”) showed a marked decrease of up to 76% compared to the pre-pandemic period, a significantly greater drop than for search volume for terms denoting common chronic diseases. Maintaining awareness of cancer screening during future public health crises may decrease delays in cancer diagnosis.

scholarly journals Screening tests for endometrial cancer in the general population

2021 ◽  
Author(s):  
Kelechi Njoku ◽  
Helena O'Flynn ◽  
Eleanor Jones ◽  
Neal C Ramchander ◽  
Helen White ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
General Population ◽  
Screening Tests

Cardiovascular Oncology: The Need for a Multidisciplinary Approach

2021 ◽  
Author(s):  
Rodrigo Ortega Pérez ◽  
Ana Pardo Sanz ◽  
Valentín García Gutiérrez ◽  
José Luis Zamorano Gómez
Keyword(s):  
Atrial Fibrillation ◽  
Clinical Practice ◽  
General Population ◽  
Early Detection ◽  
Multidisciplinary Approach ◽  
Ventricular Dysfunction ◽  
Care Process ◽  
Scientific Journals ◽  
Raising Awareness ◽  
Low Rate

AbstractImproved cancer survivorship has led to an increase in cardiovascular (CV) complications in the oncologic population, mainly associated with therapeutic regimens. Hence, cardio-oncology has grown toward unifying the cancer care process in which the best prevention, early detection, treatment, and CV surveillance are offered to patients. This multidisciplinary approach allows us to optimize and agree upon clinical decisions to enhance clinical outcomes. Atrial fibrillation is one of the hot topics in the field because it is still challenging in cancer patients. The optimal antithrombotic therapy remains unclear. Nevertheless, evidence supports that specific recommendations are needed due to a hemorrhagic/thrombotic disbalance present within this subgroup of patients and a low rate of anticoagulation treatments compared with the general population. Further, cardiotoxicity management is currently transforming. Increasingly, early detection of subclinical alterations is raising awareness. When medical therapy is initiated early, fewer patients progress to ventricular dysfunction and the rate of patients completing cancer therapy gradually increases. New approaches are demonstrating better outcomes and these strategies will expectedly be established in clinical practice. Cardio-oncology enables us to find the best balance between cancer treatment and CV health protection. Nowadays, more and more physicians are being instructed in this discipline, which gradually exhibits a greater presence in conferences and scientific journals. However, given the need for physicians thoroughly trained in cardio-oncology, this subspecialty must be promoted further.

scholarly journals Risk Factors for Hepatitis C Infection Among Sexually Transmitted Disease-Infected, Inner City Obstetric Patients

2003 ◽  
Vol 11 (4) ◽  
pp. 191-198 ◽  
Author(s):  
Youyin Choy ◽  
Lisa Gittens-Williams ◽  
Joseph Apuzzio ◽  
Joan Skurnick ◽  
Carl Zollicoffer ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hepatitis C ◽  
High Risk ◽  
General Population ◽  
Inner City ◽  
Multiple Logistic Regression Analysis ◽  
Transmitted Disease ◽  
Screening Tests ◽  
Hepatitis C Infection ◽  
Sexually Transmitted

Objective:To test the hypothesis that our inner city obstetric patients who have been infected with sexually transmitted diseases (STDs) will have a higher prevalence of hepatitis C virus infection than the general population and to identify specific risk factors and high-risk groups.Methods:All patients in our prenatal clinic (July 1997–April 1999) who tested positive for one or more STDs were asked to return for hepatitis C antibody testing. Medical charts of all patients who returned for hepatitis C testing were reviewed.Results:A total of 106 patients with STDs were tested for hepatitis C. Positive screening tests for anti-hepatitis C antibody were found in 6.6% (7/106) of the patients (95% CI = 2.7–13.1%). This frequency is significantly higher than the hepatitis C prevalence (1.8%) in the general United States population (p= 0.006). Multiple logistic regression analysis confirmed only older age (p= 0.016) and positive HIV status (p= 0.023) to be significant predictors of hepatitis C infection.Conclusions:Inner city STD-infected obstetric patients are at high risk for hepatitis C infection compared with the general population. Increasing age and HIV-positive status are risk factors which are significantly associated with hepatitis C infection.

scholarly journals Detection of Hydroxychloroquine Retinal Toxicity by Automated Perimetry in 60 Rheumatoid Arthritis Patients with Normal Fundoscopic Findings

2015 ◽  
Vol 8 (3) ◽  
pp. 59 ◽  
Author(s):  
Qader Motarjemizadeh ◽  
Naser Samadi Aidenloo ◽  
Mohammad Abbaszadeh
Keyword(s):  
Rheumatoid Arthritis ◽  
Early Detection ◽  
Anterior Segment ◽  
Field Testing ◽  
Retinal Toxicity ◽  
Screening Tests ◽  
Automated Perimetry ◽  
Cross Sectional ◽  
Dry Eyes ◽  
Significant Difference

<p>Hydroxychloroquine (HCQ) is an antimalarial drug used extensively in treatment of autoimmune diseases such as rheumatoid arthritis. Retinal toxicity is the most important side effects of this drug. Even after the drug is discontinued, retinal degeneration from HCQ can continue to progress. Consequently, multiple ophthalmic screening tests have been developed to detect early retinopathy. The aim of the current study was to evaluate the value of central 2-10 perimetry method in early detection of retinal toxicity. This prospective cross-sectional investigation was carried out on 60 rheumatoid arthritis patients, who had been receiving HCQ for at least 6 months and still were on their medication (HCQ intake) at the time of enrollment. An ophthalmologist examined participants using direct and indirect ophthalmoscopy. Visual field testing with automated perimetry technique (central 2-10 perimetry with red target) was performed on all included subjects twice in 6 months interval: The first one at the time of enrollment and the second one 6 months later. Males and females did not show any significant difference in terms of age, duration of therapy, daily and cumulative HCQ dose, anterior or posterior segment abnormalities, hypertension, body mass index, and best corrected visual acuity. Anterior segment was abnormal in 9 individuals including 3 subjects with macular pigmentary changes, 4 individuals with cataract and 2 cases with dry eyes. Moreover, 12 subjects had retinal pigmented epithelium (RPE) in their posterior segments. After 6 months, depressive changes appeared in 12 subjects. Additionally, HCQ therapy worsened significantly the perimetric results of 5 (55.6%) patients with abnormal anterior segment. A same trend was observed in perimetric results of 6 (50.0%) subjects with abnormal posterior segments (P=0.009). The daily dose of HCQ (P=0.035) as well as the cumulative dose of hydroxychloroquine (P=0.021) displayed statistically significant associations with perimetric results. Central 2-10 perimetry is a useful method for early detection of HCQ retinal toxicity, but more comprehensive studies, with larger sample size, longer-term follow-up and more precise techniques are mandatory to confirm HCQ retinal toxicity.</p>

scholarly journals Multianalyte Tests for the Early Detection of Cancer: Speedbumps and Barriers

2007 ◽  
Vol 2 ◽  
pp. 117727190700200 ◽  
Author(s):  
Michael A. Tainsky ◽  
Madhumita Chatterjee ◽  
Nancy K. Levin ◽  
Sorin Draghici ◽  
Judith Abrams
Keyword(s):  
Early Detection ◽  
Tumor Antigens ◽  
Early Stage ◽  
False Negative ◽  
Clinical Intervention ◽  
Screening Tests ◽  
Molecular Event ◽  
Non Invasive ◽  
In Vitro Diagnostic

It has become very clear that a single molecular event is inadequate to accurately predict the biology (or pathophysiology) of cancer. Furthermore, using any single molecular event as a biomarker for the early detection of malignancy may not comprehensively identify the majority of individuals with that disease. Therefore, the fact that technologies have arisen that can simultaneously detect several, possibly hundreds, of biomarkers has propelled the field towards the development of multianalyte-based in vitro diagnostic early detection tests for cancer using body fluids such as serum, plasma, sputum, saliva, or urine. These multianalyte tests may be based on the detection of serum autoantibodies to tumor antigens, the presence of cancer-related proteins in serum, or the presence of tumor-specific genomic changes that appear in plasma as free DNA. The implementation of non-invasive diagnostic approaches to detect early stage cancer may provide the physician with evidence of cancer, but the question arises as to how the information will affect the pathway of clinical intervention. The confirmation of a positive result from an in vitro diagnostic cancer test may involve relatively invasive procedures to establish a true cancer diagnosis. If in vitro diagnostic tests are proven to be both specific, i.e. rarely produce false positive results due to unrelated conditions, and sufficiently sensitive, i.e. rarely produce false negative results, then such screening tests offer the potential for early detection and personalized therapeutics using multiple disease-related targets with convenient and non-invasive means. Here we discuss the technical and regulatory barriers inherent in development of clinical multianalyte biomarker assays.

Sign in / Sign up

Export Citation Format

Share Document