scholarly journals RETROSPECTIVE ANALYSIS OF CERVICAL CYTOPATHOLOGICAL EXAMS PERFORMEDAT AT THE LABORATORY OF PATHOLOGICAL ANATOMY AND CYTOPATHOLOGY OF THE HOSPITAL ESCOLA ÁLVARO ALVIM

2021 ◽  
Vol 16 (2) ◽  
pp. 07-12
Author(s):  
Lorena Ferreira Portugal ◽  
Letícia Ribeiro Escocard da Fonseca ◽  
Alessandra Oliveira Ferrari Gomes ◽  
Maria Auxiliadora Peixoto Peçanha ◽  
Luisa Aguirre Buexm
Keyword(s):  
Cervical Cancer ◽  
Early Diagnosis ◽  
Malignant Neoplasm ◽  
Malignant Neoplasms ◽  
Pathological Anatomy ◽  
The North ◽  
Intraepithelial Lesion ◽  
Cytological Characteristics ◽  
Over 40 Years ◽  
Cell Atypia

Each year about 272,610 new cases of cancer are diagnosed in Brazil, being cervical cancer the third most incident among women. Our country is among those that have made the most progress in consolidating the integrated cancer tracking and surveillance system. This article aims to collect sociodemographic and clinicopathological data from patients who underwent cervical cytopathological examinations at the Laboratory of Pathological Anatomy and Cytopathology at the Hospital Escola Álvaro Alvim (HEAA) from 2014 to 2018, considering a retrospective and longitudinal observation of the data. Sociodemographic and clinicopathological data were collected from 121,044 patients, and it was observed that women from Campos dos Goytacazes (84.7%) over 40 years old (56.8%) were the most prevalent at the service. The following cytological characteristics that predominated in these patients were: absence of atrophy (83.6%) or metaplasia (92.6%) of the uterine epithelium, presence of microorganisms (96.4%) and inflammation (97.2%). The presence of cell atypia (6.5%), squamous intraepithelial lesion (2%) and malignant neoplasm (0.1%) was also observed. Therefore, it becomes possible to highlight the importance of cytological examination in the process of diagnosis of malignant neoplasms of the uterine cervix, being essential for a better control and adequate screening, implementing an effective early diagnosis. It also demonstrates the profile of the patients examined at the Pathological Anatomy and Cytopathology Laboratory of HEAA, as well as the scope of this service for early diagnosis of cervical cancer in the North and Northwest Fluminense.

scholarly journals Cervical cancer mortality trends in Brazil, 1981-2006

2010 ◽  
Vol 26 (12) ◽  
pp. 2399-2407 ◽  
Author(s):  
Gulnar Azevedo e Silva ◽  
Vania Reis Girianelli ◽  
Carmen Justina Gamarra ◽  
Maria Teresa Bustamante-Teixeira
Keyword(s):  
Cervical Cancer ◽  
Cancer Mortality ◽  
Malignant Neoplasm ◽  
The State ◽  
Downward Trend ◽  
Mortality Trends ◽  
Female Population ◽  
The North ◽  
Cervical Cancer Mortality ◽  
Screening Coverage

The aim of this study was to describe cervical cancer mortality trends in Brazil for the period 1981-2006. Cervical cancer mortality was corrected on the basis of proportional redistribution of the deaths from "malignant neoplasm of uterus, part unspecified". Time trends were evaluated by means of simple linear regression. After correction, cervical cancer ranked second among the leading causes of death from cancer in the female population up to 2005, with a downward trend for the country as a whole, a decline in the State capitals, and a stable trend in the municipalities in the interior. A downward trend was confirmed in the State capitals in all geographic regions of the country. In the municipalities in the interior, there was an increase in the North and Northeast regions, a decline in the Southeast and South, and a stable trend in the Central-West. Although uneven, the decline began to take consistent shape in the country. Even better results could be achieved by investing in the expansion of screening coverage, especially among the populations at greatest risk.

scholarly journals Oral Carcinoma of Squamous Cells with Early Diagnosis: Case Report and Literature Review

2017 ◽  
Vol 19 (1) ◽  
pp. 43
Author(s):  
Yadira V. Boza Oreamuno DDS, MSc
Keyword(s):  
Cancer Screening ◽  
Oral Cancer ◽  
Early Diagnosis ◽  
Relevant Literature ◽  
Malignant Neoplasm ◽  
Mortality And Morbidity ◽  
Squamous Cells ◽  
Oral Cancer Screening ◽  
Over 40 Years ◽  
Frequent Localization

Oral squamous cell carcinoma (OSCC) is the most common malignant neoplasm of epithelial origin in the oral cavity, usually affecting men over 40 years of age. The most frequent localization sites are the tongue and the floor of the mouth. The etiology is multifactorial being tobacco and alcohol the most important risk factors. The clinical presentation is variable and although it is preceded by visible changes in the oral mucosa, the diagnosis is usually made late. An early diagnosis is critically important to improve survival and treatment outcomes. Oral cancer screening is effective in reducing the mortality and morbidity of oral cancer. The purpose of this study was to present a case of OSCC and to highlight the importance of an early diagnosis using oral cancer screening, and the review of the relevant literature as for this pathology.

scholarly journals Oral Carcinoma of Squamous Cells with Early Diagnosis: Case Report and Literature Review

2017 ◽  
Vol 19 (1) ◽  
pp. 43
Author(s):  
Yadira V. Boza Oreamuno DDS, MSc
Keyword(s):  
Cancer Screening ◽  
Oral Cancer ◽  
Early Diagnosis ◽  
Relevant Literature ◽  
Malignant Neoplasm ◽  
Mortality And Morbidity ◽  
Squamous Cells ◽  
Oral Cancer Screening ◽  
Over 40 Years ◽  
Frequent Localization

Oral squamous cell carcinoma (OSCC) is the most common malignant neoplasm of epithelial origin in the oral cavity, usually affecting men over 40 years of age. The most frequent localization sites are the tongue and the floor of the mouth. The etiology is multifactorial being tobacco and alcohol the most important risk factors. The clinical presentation is variable and although it is preceded by visible changes in the oral mucosa, the diagnosis is usually made late. An early diagnosis is critically important to improve survival and treatment outcomes. Oral cancer screening is effective in reducing the mortality and morbidity of oral cancer. The purpose of this study was to present a case of OSCC and to highlight the importance of an early diagnosis using oral cancer screening, and the review of the relevant literature as for this pathology.

scholarly journals Proteomic Analysis of Zeb1 Interactome in Breast Carcinoma Cells

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3143
Author(s):  
Sergey E. Parfenyev ◽  
Sergey V. Shabelnikov ◽  
Danila Y. Pozdnyakov ◽  
Olga O. Gnedina ◽  
Leonid S. Adonin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Epithelial To Mesenchymal Transition ◽  
Critical Role ◽  
Malignant Neoplasm ◽  
Malignant Neoplasms ◽  
Breast Cancer Patients ◽  
Survival Prognosis ◽  
Mesenchymal Transition ◽  
Wide Range

Breast cancer is the most frequently diagnosed malignant neoplasm and the second leading cause of cancer death among women. Epithelial-to-mesenchymal Transition (EMT) plays a critical role in the organism development, providing cell migration and tissue formation. However, its erroneous activation in malignancies can serve as the basis for the dissemination of cancer cells and metastasis. The Zeb1 transcription factor, which regulates the EMT activation, has been shown to play an essential role in malignant transformation. This factor is involved in many signaling pathways that influence a wide range of cellular functions via interacting with many proteins that affect its transcriptional functions. Importantly, the interactome of Zeb1 depends on the cellular context. Here, using the inducible expression of Zeb1 in epithelial breast cancer cells, we identified a substantial list of novel potential Zeb1 interaction partners, including proteins involved in the formation of malignant neoplasms, such as ATP-dependent RNA helicase DDX17and a component of the NURD repressor complex, CTBP2. We confirmed the presence of the selected interactors by immunoblotting with specific antibodies. Further, we demonstrated that co-expression of Zeb1 and CTBP2 in breast cancer patients correlated with the poor survival prognosis, thus signifying the functionality of the Zeb1–CTBP2 interaction.

Impact of human papillomavirus coinfections on the risk of high-grade squamous intraepithelial lesion and cervical cancer

2014 ◽  
Vol 134 (3) ◽  
pp. 534-539 ◽  
Author(s):  
Adela Carrillo-García ◽  
Sergio Ponce-de-León-Rosales ◽  
David Cantú-de-León ◽  
Verónica Fragoso-Ontiveros ◽  
Imelda Martínez-Ramírez ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
High Grade ◽  
Squamous Intraepithelial Lesion ◽  
Intraepithelial Lesion

scholarly journals Risk of Late Mortality and Second Malignant Neoplasms among 5-Year Survivors of Young Adult Cancer: A Report of the Childhood, Adolescent, and Young Adult Cancer Survivors Research Program

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Yang Zhang ◽  
Karen Goddard ◽  
John J. Spinelli ◽  
Carolyn Gotay ◽  
Mary L. McBride
Keyword(s):  
Young Adult ◽  
Proportional Hazards Model ◽  
Malignant Neoplasm ◽  
Cox Proportional Hazards Model ◽  
Adolescent And Young Adult ◽  
Malignant Neoplasms ◽  
Risk Of Death ◽  
Young Adult Cancer Survivors ◽  
Adult Cancer Survivors ◽  
Young Adult Cancer

We conducted a population-based retrospective study to assess the long-term risks of overall and cause-specific mortality and second malignant neoplasm (SMN) among survivors of young adult cancer compared to the risk in British Columbia (BC) population and to evaluate the effects of demographic and clinical factors on risk. 1248 5-year survivors of young adult cancer diagnosed 1970–1995 between 20 and 24 years of age were identified from the BC Cancer Registry and followed to the end of 2007. Standardized mortality ratios (SMRs) and standardized incidence ratios (SIRs) were calculated. The Cox proportional hazards model was used to estimate the effects of different demographic and disease-related characteristics on the risk of death and SMN. A total of 138 deaths and 62 SMNs were observed during follow-up. The overall SMR was 5.9 (95% CI 4.9–6.9) and the absolute excess risk was 5.3 per 1,000 person-years. The overall SIR was 3.0 (95% CI 2.3–3.8). Treatment with radiation resulted in increased risks of death and SMN. These observed increased risks emphasize the importance of prevention, surveillance, and treatment of late effects in survivors of young adult cancers.

scholarly journals High-risk HPV genotypes and cervical lesions association in postmenopausal women

2021 ◽  
Vol 31 (Supplement_2) ◽  
Author(s):  
Ana Rita Fernandes Miranda da Costa ◽  
Cláudia Sousa ◽  
Erica Isidoro ◽  
Regina Silva ◽  
Cristiana Mourato
Keyword(s):  
Cervical Cancer ◽  
High Risk ◽  
Postmenopausal Women ◽  
Age Groups ◽  
Low Grade ◽  
High Grade ◽  
Cervical Lesions ◽  
Intraepithelial Lesion ◽  
The Bethesda System ◽  
High Risk Hpv

Abstract Background Persistent infection by high-risk Human Papillomavirus (hrHPV) are the major cause of cervical cancer. Studies report disparities in the incidence of infection and the various genotypes of this virus in different age groups, suggesting a higher frequency of hrHPV in young women and low-risk subtypes being predominant in older women. This study aimed to investigate the incidence and distribution of hrHPV genotypes in postmenopausal women as well as the correlation with the cytological findings. Methods 16 859 women, aged 50–64 years, performed cervical cancer screening test in Friuri Venezia Giulia region, Italy. The infection was evaluated by the Polymerase Chain Reaction methodology and the positive samples were evaluated by Liquid Based Cytology according to the Bethesda System from 2014. A statistical analysis was performed to study the molecular and cytological data of this population. Results hrHPV infection were found in 5.8% of the women and 78.3% of these were caused by hrHPV other than HPV16 and HPV18 (). Also, 65.7% of the positive samples were negative for intraepithelial lesion or malignancy while low grade squamous intraepithelial lesion was the most frequent (22.4%). There was an increase in the number of high-grade intraepithelial lesions in the presence of HPV16 compared to that recorded when this genotype was absent (20.8% vs. 8.5%). No cervical cancers were detected. Conclusions Infection with hrHPV is uncommon in postmenopausal women and it is mostly caused by subtypes less associated with the development of cervical cancer. Yet, HPV16 infection triggers the development of high-grade lesions.

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