scholarly journals Design and Implement an Exoskeleton Arm for Reinforcement the Human Muscles after Stroke

2019 ◽  
Vol 22 (4) ◽  
pp. 252-258
Author(s):  
Duha Qais Abd-ul-Amir ◽  
Auns Qusai Hashim ◽  
Abdulnasir Hussin Ameer
Keyword(s):  
Stroke Rehabilitation ◽  
Elbow Flexion ◽  
Mobility Limitations ◽  
Basic Principles ◽  
Robotic Exoskeleton ◽  
Human Muscles ◽  
Negative Impacts ◽  
Exoskeleton Device ◽  
Flexion And Extension

Mobility limitations in stroke survivors yield negative impacts on the quality of life for such individuals. Rehabilitation is needed to help them recover and regain mobility. Accordingly, this study aims to design and validate a “Robotic Exoskeleton” intended for stroke rehabilitation. The basic principles of this robotic exoskeleton device are its dependence on electromyography signal and electronic microcontroller to provide an efficient physiotherapy exercises system.The robotic exoskeleton is a one degree of freedom which performs the flexion and extension of the elbow joint. After the design was completed, 19 subjects participated in this study: 4 healthy subjects, and 15 post-stroke patients.The results showed the benefit of robotic exoskeleton in increasing the elbow range of motion, where angle of elbow flexion was raised from the first physiotherapy session to maximum elbow flexion in the last session.

scholarly journals The Heavy Metals in Agrosystems and Impact on Health and Quality of Life

2015 ◽  
Vol 3 (2) ◽  
pp. 345-355 ◽  
Author(s):  
Adnan Tutic ◽  
Srecko Novakovic ◽  
Mitar Lutovac ◽  
Rade Biocanin ◽  
Sonja Ketin ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Animal Health ◽  
Toxic Effects ◽  
Basic Principles ◽  
Essential Trace Elements ◽  
Ionic Bonds ◽  
Negative Impacts ◽  
Surface And Groundwater ◽  
Quality Surface

The metal is a chemical element that conducts electricity well and heat, and the nonferrous metals builds cations and ionic bonds. Heavy metals include metals whose density is higher than 5 g/cm3. The whole range of the metal is in the form of essential trace elements, essential for a number of functions in the human body, and its deficiency results in a lack of occurrence of a serious symptom. The best examples are anemia lack of iron, lack of chromium in diabetes, growth problems in lack of nickel. Other elements such as lead, cadmium, mercury, arsenic and molybdenum have been shown to exhibit large quantities of toxic effects. The paper examines the problem of heavy metals originating from agriculture on agroecosystems. This group of pollutants is considered the most important cause of degradation of soil quality, surface and groundwater and direct causal adverse effects on human and animal health. In order to complete the environmental monitoring of pollutants, these main categories, origins, and possible negative impacts of the basic principles of preventing their toxic effects were examined.

scholarly journals Asciminib Mitigates DNA Damage Stress Signaling Induced by Cyclophosphamide in the Ovary

2021 ◽  
Vol 22 (3) ◽  
pp. 1395
Author(s):  
Luca Mattiello ◽  
Giulia Pucci ◽  
Francesco Marchetti ◽  
Marc Diederich ◽  
Stefania Gonfloni
Keyword(s):  
Ovarian Reserve ◽  
Kinase Inhibitor ◽  
Concomitant Administration ◽  
Cancer Therapies ◽  
Cancer Treatments ◽  
Abl Tyrosine Kinase ◽  
Negative Impacts ◽  
Abl Tyrosine Kinase Inhibitor

Cancer treatments can often adversely affect the quality of life of young women. One of the most relevant negative impacts is the loss of fertility. Cyclophosphamide is one of the most detrimental chemotherapeutic drugs for the ovary. Cyclophosphamide may induce the destruction of dormant follicles while promoting follicle activation and growth. Herein, we demonstrate the in vivo protective effect of the allosteric Bcr-Abl tyrosine kinase inhibitor Asciminib on signaling pathways activated by cyclophosphamide in mouse ovaries. We also provide evidence that Asciminib does not interfere with the cytotoxic effect of cyclophosphamide in Michigan Cancer Foundation (MCF)7 breast cancer cells. Our data indicate that concomitant administration of Asciminib mitigates the cyclophosphamide-induced ovarian reserve loss without affecting the anticancer potential of cyclophosphamide. Taken together, these observations are relevant for the development of effective ferto-protective adjuvants to preserve the ovarian reserve from the damaging effects of cancer therapies.

scholarly journals Faecal bacteria in Perna perna (Linnaeus, 1758) (Mollusca: Bivalvia) for biomonitoring coastal waters and seafood quality

2010 ◽  
Vol 58 (spe3) ◽  
pp. 29-35 ◽  
Author(s):  
Diego Igawa Martinez ◽  
Ana Júlia Fernandes Cardoso de Oliveira
Keyword(s):  
Coastal Waters ◽  
Microbiological Quality ◽  
Perna Perna ◽  
Clearance Rates ◽  
Bacterial Concentration ◽  
Allometric Relations ◽  
The Mean ◽  
Negative Impacts ◽  
Faecal Bacteria

Urban development in coastal areas is intense and leads to the increase of sewage outfall and other negative impacts as consequences. Thus, stringent regulations establishing limits to the microbiological contamination of water and seafood are needed. The objective of this study is to evaluate the usefulness of Enterococci and Thermotolerant Coliform densities in the flesh of mussels Perna perna as an alternative tool for monitoring the microbiological quality of coastal waters. The study also considers allometric relations applied to clearance rates to understand rates of bacterial concentration. Bacterial loads obtained in mussels' flesh were from 50 to 4,300 times greater than in the water sampled in the vicinity of the mussels and some were considered inappropriate for consumption even when the water presented no restrictions. The mean clearance rate obtained for Enterococci retention was 317.7 ml h-1 and this rate (CR) is related to the mussels' size (L) by the equation CR = 28.3229L1.6421. The results showed that bacterial densities in the mussels' tissues may reflect chronic contamination of the environment and that clearance rates are important for taking the best decision in situations where, for example, it is desired to introduce mussels for aquaculture and the evaluation of the water concerned is required.

Optimizing patient adherence to stroke rehabilitation: A mixed method telerehabilitation trial (Preprint)

2021 ◽  
Author(s):  
Isabelle Gaboury ◽  
Michel Tousignant ◽  
Hélène Corriveau ◽  
Matthew Menear ◽  
Guylaine Le Dorze ◽  
...  
Keyword(s):  
Decision Making ◽  
Shared Decision Making ◽  
Stroke Rehabilitation ◽  
Patient Adherence ◽  
Interprofessional Collaboration ◽  
Interdisciplinary Collaboration ◽  
Control Group ◽  
Shared Decision ◽  
The Impact

BACKGROUND Strong evidence supports beginning stroke rehabilitation as soon as the patient’s medical status has stabilized and continuing following discharge from acute care. However, adherence to rehabilitation treatments over the rehabilitation phase has been shown to be suboptimal. OBJECTIVE Objective: The aim of this study is to assess the impact of a telerehabilitation platform on stroke patients’ adherence to a rehabilitation plan and on their level of reintegration to normal social activities, in comparison with usual care. The primary outcome is patient adherence to stroke rehabilitation (up to 12 weeks), which is hypothesized to influence reintegration to normal living. Secondary outcomes for patients include functional recovery and independence, depression, adverse events related to telerehabilitation, use of services (up to 6 months), perception of interprofessional shared decision making, and quality of services received. Interprofessional collaboration as well as quality of interprofessional shared decision making will be measured on clinicians. METHODS In this interrupted time series with a convergent qualitative component, rehabilitation teams will be trained to develop rehabilitation treatment plans that engage the patient and family, while taking advantage of a telerehabilitation platform to deliver the treatment. The intervention will entail 220 patients to receive stroke telerehabilitation with an interdisciplinary group of clinicians (telerehabilitation) versus face-to-face, standard of care (n = 110 patients). RESULTS Results: Our Research Ethics Board has approved the study in June 2020. Data collection for the control group is underway, with another year planned before we begin the intervention phase. CONCLUSIONS This study will contribute to minimize both knowledge and practice gaps, while producing robust, in-depth data on the factors related to the effectiveness of telerehabilitation in a stroke rehabilitation continuum. Findings will inform best practices guidelines regarding telecare services and the provision of telerehabilitation, including recommendations regarding effective interdisciplinary collaboration regarding stroke rehabilitation. CLINICALTRIAL ClinicalTrials.gov NCT04440215

Excitotoxic acid lesions of the primate subthalamic nucleus result in reduced pallidal neuronal activity during active holding

1992 ◽  
Vol 68 (5) ◽  
pp. 1859-1866 ◽  
Author(s):  
I. Hamada ◽  
M. R. DeLong
Keyword(s):  
Subthalamic Nucleus ◽  
Neuronal Activity ◽  
Elbow Flexion ◽  
Ibotenic Acid ◽  
Excitatory Input ◽  
Behavioral Task ◽  
Discharge Rates ◽  
Before And After ◽  
The Mean ◽  
Flexion And Extension

1. To gain a better understanding of the pathophysiology of hemiballismus in primates, and to test directly the hypothesis that the subthalamopallidal projection is excitatory, we studied the effects of lesions of the subthalamic nucleus (STN) on neuronal activity in the globus pallidus (GP) of monkeys during performance of a motor behavioral task. 2. Animals were trained to position and hold a manipulandum to which torque pulses were applied, producing elbow flexion and extension. The activity of neurons in the external (GPe) and internal (GPi) segments of GP was recorded in two monkeys during task performance before and after STN lesions. The STN was lesioned by the fiber-sparing neurotoxins ibotenic acid and/or kainic acid. 3. After lesioning, the firing rate of neurons in both segments of GP, which was measured during the period of holding before torque application, was significantly decreased in both animals. The mean of discharge rates of GPi neurons decreased (P < 0.001) from 69.8 (n = 169, SD = 21.6) to 47.4 spikes/s (n = 180, SD = 22.6) after lesioning. The mean of discharge rates of GPe neurons decreased from 63.6 spikes/s (n = 218, SD = 25.1) before lesions to 41.0 spikes/s (n = 208, SD = 18.1) after lesioning. 4. These results provide further evidence that STN gives rise to a major excitatory input to both segments of the GP and support the hypothesis that dyskinesias result from decreased GPi output.

Visual Impairment is Not Blindness

1971 ◽  
Vol 65 (10) ◽  
pp. 334-336
Author(s):  
Benjamin Wolf
Keyword(s):  
Visual Impairment ◽  
Visually Impaired ◽  
Essential Difference ◽  
Basic Principles ◽  
Functional Potential ◽  
Blind Persons ◽  
Partially Sighted ◽  
Visually Impaired Persons

□ Visual impairment is not necessarily blindness and the requirements of visually impaired persons are in many ways significantly different from those of blind persons. All too often agencies for the blind have not distinguished between these different requirements in providing services. The essential difference is that blind persons must rely on their other senses in order to function, while partially sighted persons must be helped to use whatever vision they have in coordination with their other senses. In providing services to partially sighted persons, the following basic principles should be considered: 1) Full service requires the cooperation of medical, physical, and behavioral specialists; 2) Services for partially sighted clients should be individualized on the basis of their differences in degree and quality of sight; 3) Whatever vision the client has should be augmented or strengthened through either mechanical or physical means; and 4) Clients should be helped to enhance their perception to its maximum functional potential.

scholarly journals A Pilot Study of Individual Muscle Force Prediction during Elbow Flexion and Extension in the Neurorehabilitation Field

Sensors ◽  
2016 ◽  
Vol 16 (12) ◽  
pp. 2018 ◽  
Author(s):  
Jiateng Hou ◽  
Yingfei Sun ◽  
Lixin Sun ◽  
Bingyu Pan ◽  
Zhipei Huang ◽  
...  
Keyword(s):  
Pilot Study ◽  
Muscle Force ◽  
Elbow Flexion ◽  
Force Prediction ◽  
Individual Muscle ◽  
Flexion And Extension

scholarly journals Myofascial Massage for Chronic Pain and Decreased Upper Extremity Mobility After Breast Cancer Surgery

2018 ◽  
Vol 11 (3) ◽  
pp. 4-9 ◽  
Author(s):  
Jeanne Massingill, LMT, MLD, CST, KT, NMT ◽  
Cara Jorgensen, LMT ◽  
Jacqueline Dolata, MBA ◽  
Ashwini R. Sehgal, MD
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Chronic Pain ◽  
Upper Extremity ◽  
Outcome Measures ◽  
Cancer Surgery ◽  
Breast Cancer Surgery ◽  
Mobility Limitations ◽  
And Control

Background: Chronic localized pain and decreased upper extremity mobility commonly occur following breast cancer surgery and may persist despite use of pain medication and physical therapy.Purpose: We sought to determine the value of myofascial massage to address these pain and mobility limitations.Setting: The study took place at a clinical massage spa in the U.S. Midwest. The research was overseen by MetroHealth Medical Center’s Institutional Review Board and Case Center for Reducing Health Disparities research staff.Participants: 21 women with persistent pain and mobility limitations 3–18 months following breast surgery.Research Design: We conducted a pilot randomized controlled trial where intervention patients received myofascial massages and control patients received relaxation massages.Intervention: Intervention participants received 16 myofascial massage sessions over eight weeks that focused on the affected breast, chest, and shoulder areas. Control participants received 16 relaxation massage sessions over eight weeks that avoided the affected breast, chest, and shoulder areas. Participants completed a validated questionnaire at the beginning and end of the study that asked about pain, mobility, and quality of life.Main Outcome Measures: Outcome measures include change in self-reported pain, self-reported mobility, and three quality-of-life questions.Results: At baseline, intervention and control participants were similar in demographic and medical characteristics, pain and mobility ratings, and quality of life. Compared to control participants, intervention participants had more favorable changes in pain (-10.7 vs. +0.4, p < .001), mobility (-14.5 vs. -0.8, p < .001), and general health (+29.5 vs. -2.5, p = .002) after eight weeks. All intervention and control participants reported that receiving massage treatments was a positive experience.Conclusions: Myofascial massage is a promising treatment to address chronic pain and mobility limitations following breast cancer surgery. Further work in several areas is needed to confirm and expand on our study findings.

scholarly journals Peran Penyuluh Agama dalam Kehidupan Beragama guna Meningkatkan Keluarga Sakinah (Studi Kasus pada Majelis Ta'lim Al-Muhajirin Sukarame II Bandar Lampung)

2019 ◽  
Vol 1 (1) ◽  
pp. 92-108
Author(s):  
Rahmat Hidayat
Keyword(s):  
Religious Language ◽  
Community Leaders ◽  
Religious Leaders ◽  
Government Program ◽  
New Family ◽  
Strategic Role ◽  
The Government ◽  
Negative Impacts

ABSTRACT  Islamic Religious Instructor has a quite strategic role in the midst of society. besides he is a preacher of Islam, also the Islamic Religious Instructor, according to his function as a guide, illuminator, and community builder with religious language. The role of religious counselors in addition to functioning as an impetus for the community to actively participate in development also plays a role in overcoming obstacles that build the course of development, particularly overcoming negative impacts. Religious instructors as religious leaders always guide, nurture, and move the community to do good and stay away from prohibited acts, inviting something that is needed by the community in fostering its territory both for the purposes of social facilities and worship. The Religious Instructor is a place to ask questions and a place to complain for his community to solve and resolve with his advice. Religious Instructors as community leaders act as priests in matters of religion and social problems as well as in matters of state by an effort to succeed the government program. The role of religious instructors in improving and creating the quality of sakinah families in the Muhajirin AL Muhajirin voluntary II Ta'lim Assembly group in Teluk Betung Barat Subdistrict, Bandar Lampung City, it can be concluded that religious counselors play an important role in improving the quality of sakinah families, one of which is in terms of worship , and also able to improve the quality of a new family and has long become a sakinah family.

scholarly journals A Comparative Study between Pre-construction and Construction Phases of Champhai-Zokhawthar Road Construction, Mizoram: Air Quality and Noise Quality Assessments

2019 ◽  
Vol 7 (1) ◽  
pp. 47-53
Author(s):  
Lalven tluanga ◽  
◽  
H. Lalramnghinglova
Keyword(s):  
Economic Growth ◽  
Particulate Matter ◽  
Air Quality ◽  
Comparative Study ◽  
Noise Level ◽  
Road Construction ◽  
Suspended Particulate ◽  
The Mean ◽  
Negative Impacts

In recent years, Mizoram has made immense progress in various sectors and initiated developmental programmes for its economic growth. An important contributing factor to this development and growth is the transport connectivity projects. Although connectivity projects can boost economic growth, its negative effects cannot be neglected. In view of this, the present research studies the impacts of Champhai – Zokhawthar road construction on the air quality and noise quality of the region. This comparative study of the impact on the quality of air and noise pollution in the pre-construction phase and construction phase provide a clear-cut example of the negative impacts caused by road construction and provide a fresh outlook for formulation of improved management plans. Air quality assessment was carried out using High Volume Air Sampler and the following parameters were monitored – suspended particulate matter (SPM), respirable suspended particulate matter (RSPM), nitrogen dioxide (NO2) and sulphur dioxide (SO2). The results indicate that mean SPM concentration was increased by 22.82 µg/m3; RSPM concentration by 14.67 µg/m3; NO2 concentration by 4.08 µg/m3; and SO2 concentration was increased by 0.06 µg/m3 from the pre-construction phase to construction phase. Noise quality assessment was carried out at three sites – Zotlang, Melbuk and Zokhawthar by using Lutron SL-4001 Sound Level Meter and Leq, Lmax and Lmin were recorded and calculated. The mean noise level at Zotlang wasincreased by 8.72 dB (A) and at Melbuk the mean noise level was increased by 9.35 dB (A). However, at Zokhawthar, there was a decrease in mean noise level by 0.13 dB (A). From the present study, it is evident that road construction poses a threat to the air quality and noise quality of the study area and improved measuresneed to betaken to curb its negative impacts

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