scholarly journals New types of bakery products for pregnant and lactating women

2021 ◽  
Vol 11 (225) ◽  
Author(s):  
Natalia Laptenok ◽  
◽  
Svetlana Pashuk ◽  
Elena Tumar ◽  
Elena Shafranovskaya ◽  
...  

The results of studies of the effect of new types of baked goods on the body of pregnant and non-pregnant rats. The study of hematological and biochemical parameters showed the quality and safety levels of the products used.

2021 ◽  
Vol 2021 ◽  
pp. 1-14
Author(s):  
Micheli Zanetti ◽  
Mikaela Scatolin ◽  
Amanda Rebonatto Oltramari ◽  
Maria Luiza Lima da Costa Lopes ◽  
Rubieli Carla Frezza Zeferino ◽  
...  

In the present study, the antifungal activity and toxicity of the geranyl cinnamate ester (GCE) were investigated. The GCE showed antifungal activity at a minimum concentration of 0.16 μL/mL against Candida albicans and at concentrations greater than 2.5 μL/mL against Aspergillus niger. In acute toxicity studies, the administration of GCE (2.000 mg/kg) affected the body weight gain and food intake but did not induce the mortality of the animals studied. After the investigation of repeated-dose toxicity of GCE at 2 and 4 mg/kg, the hematological and biochemical parameters were changed. In addition, the adrenal weight of male mice treated with GCE at 4 mg/kg was affected. In conclusion, according to the Organization for Economic Cooperation and Development (OECD) acute toxicity parameters, the geranyl cinnamate ester can be classified into safety category number 5. The results of this study suggested that the geranyl cinnamate ester may be a source of natural antifungals.


Author(s):  
M.I. Burmistrova ◽  
F.I. Vasilevich ◽  
A.A. Deltsov

The effect of the drug Delcid 7.5 ® on the clinical, hematological and biochemical parameters of rabbits of the New Zealand breed, 6 months of age, when used in doses of 2 ml or 4 ml. Three times with a cutaneous application along the vertebral column from the head to the tail. The conducted studies allow us to conclude that after applying the drug in these doses for 3 days, there were no external signs of intoxication in rabbits. All the animals of the experimental groups were active. The reaction to external stimuli is preserved. Hematological parameters of peripheral blood (number of erythrocytes, leukocytes, hemoglobin, color index, the average hemoglobin content of PG in erythrocytes, mean corpuscular volume, the exponent of anisocytosis of red blood cells, etc.) of the experimental group after treatment in 5, 15, 25 days had no significant differences from those in the control group, this suggests that the applied drug to the skin along the spine from the withers to the rump at a dose of 2 and 4 ml has no Toxicological effect on peripheral blood. The leukogram of the peripheral blood of rabbits when using the drug did not differ from the control parameters. The analysis of biochemical parameters (activity of aminotransferase, alkaline phosphatase, lactate dehydrogenase, creatinine, urea, glucose, total protein, bilirubin, etc.) of the blood of the experimental groups when applying the drug Delcid 7.5 ® along the spinal column at the maximum therapeutic dose did not reveal statistically significant differences from the control, which indicates that the drug does not have a genotoxic effect, does not interfere with the kidneys and metabolism in the body of rabbits. The results of the conducted studies show that the insecticide-acaricide drug Delcid 7.5® for veterinary use, developed by NVC Agrovetzashchita LLC, is safe for rabbits, and therefore it can be recommended for studying the effectiveness of acarosis in rabbits and other animal species.


MedPharmRes ◽  
2020 ◽  
Vol 4 (1) ◽  
pp. 1-6
Author(s):  
Mai Nguyen Ngoc Trac ◽  
Pham Thu Ha ◽  
Do Thi Hong Tuoi

The tubers of Hydnophytum formicarum Jack. have been used for the treatment of rheumatism, liver and intestinal diseases in the traditional medicine of Vietnam. The 50% ethanolic extract of H. formicarum (EEHF) has been proved anti-inflammatory and analgesic effects as well as hepatoprotective activity at the oral doses of 100 and 200 mg/kg in Swiss albino mice. The aim of this work was to study on the subacute oral toxicity of the EEHF at the doses of 100 and 200 mg/kg for 30 and 60 consecutive days in both sexes of mice. The observations were undertaken on the mortality, the body weights, the toxic signs, hematological and biochemical parameters. At the end of the experiment, the histopathology of liver and kidneys was studied. The results showed that the 100 mg/kg of EEHF did not cause any toxic signs in mice. There was no significant difference of hematological and biochemical parameters between the treated animals and the controls. Histopathological examinations of livers and kidneys showed no significant difference suggesting no morphological disturbances in treated mice. In conclusion, the results indicated that the EEHF did not cause any subacute toxicity in mice at the dose of 100 mg/kg, providing the evidence of the safety of health products from this medicinal plant.


Author(s):  
Gajendra Pratap Choudhary ◽  
Ashutosh Pal Jain

Sphaeranthus indicus is one of the extremely precious herbs in the Indigenous System of Medicine. The present study was carried out to acute, subacute and LD50 values of methanolic extract of S. indicus leaves in Swiss mice of both sexes. The acute toxicity studies were conducted oral administration of 1.75, 5.5, 17.5, 55, 175, 550, 2000mg/kg body weight SIME used. Observations were recorded systemically up to 24 h after dose administration for behavior related to nervous system response or autonomic functions. Food and water intake, body weight variations, hematological and biochemical parameters were assessed. In sub acute toxicity treatment there were no significant variation in the body weights and haematological parameters except dose-dependent increase in lymphocyte count was noted in both sexes supported immunostimulant activity. Pathologically, significant protective effect on hepatic, renal functions and decreased cholesterol, triglyceride levels. The results did not show any treatment related abnormalities in terms of hematological and biochemical parameters in sub-acute toxicity. After acute administration, no mortality was recorded in mice treated with the SIME orally at a dose of 1000mg/kg. The LD50 values were determined using graphical method; we found a broad therapeutic window and a high therapeutic index value showed that the LD50 of the extract is 2480mg/kg. The results suggest that the plant seems to be high margin of drug safety in mice.


2008 ◽  
Vol 117 (1) ◽  
pp. 28-33 ◽  
Author(s):  
Simone Reschke Mendes Grance ◽  
Maria Araújo Teixeira ◽  
Roseana Silveira Leite ◽  
Eurípedes Batista Guimarães ◽  
João Máximo de Siqueira ◽  
...  

2019 ◽  
pp. 44-46
Author(s):  
A.V. Timakov ◽  
T.K. Timakova

Ревматоидный миокардит у коров протекает остро и характеризуется быстрым развитием клинических симптомов, поражает соединительную ткань сердечнососудистой системы (эндокард, миокард, реже перикард) и крупные суставы. Проявляется как осложнение при инфекционных и гемоспоридиозных болезнях, интоксикациях химическими и медикаментозными ядами, а также при аутоинтоксикациях вследствие поражения кишечника, почек. Воспалительный процесс развивается под воздействием токсинов основного заболевания. Всё это ведёт к нарушению портального кровообращения, развитию застоя крови в печени, кишечнике, легких. Как следствие возникает одышка, цианоз, отёки (начинаются на нижних частях тела), резкие нарушения ритма. Общее состояние больного животного резко ухудшается, и на фоне токсикоаллергических состояний могут возникать артриты. У коров могут быть послеродовые осложнения. В крови отмечают несоответствие гематологических и биохимических показателей. Своевременная диагностика и комплексное лечение коров с использованием средств патогенетической и симптоматической терапии позволяют восстановить нарушенные функции организма и продуктивность животных.Rheumatoid myocarditis in cows follows acute and is characterized by the rapid development of clinical symptoms, affects the connective tissue of the cardiovascular system (endocardium, myocardium, less often the pericardium) and major joints. It is come out as a complication of infectious and hemosporidial diseases, intoxication with chemical and drug poisons as well as during autointoxication due to bowel and kidney damage. The inflammatory process develops under the influence of toxins of the underlying disease. All this leads to a violation of the portal circulation, the development of blood stagnation in the liver, bowel, lungs. As a result, apnoea, cyanosis, edema (start on the lower parts of the body), sharp rhythm disturbances occur. The general condition of the sick animal is deteriorating dramatically and arthritides can occur in the course of toxicoallergic conditions. Cows can have postpartum complications. There is a discrepancy between hematological and biochemical parameters in the blood. Timely diagnosis and complex treatment of cows with the use of pathogenetic and symptomatic therapy can restore impaired body functions and animal productivity.


Author(s):  
R. A. Maksimova ◽  
◽  
E. M. Ermolova ◽  
V. I. Kosilov ◽  
Yu. A. Karmatskikh ◽  
...  

Increasing the milk productivity of cows is the main task facing the livestock industry of our country. The study of some hematological and biochemical blood parameters in dairy cows when different feed additives are included in their rations is an urgent research task. The purpose of the investigations was to study the hematological and biochemical parameters of the blood of lactating cows when using different feed additives in the ration. During the investigations, the influence of feed additives such as Zaslon 2+ (at a dose of 20 g/head/day to the main ration), Diatomite (100 g/head/day to the main ration) and Monosporin (70 g/head/day to the main ration) on the hematological and biochemical blood parameters of lactating cows has been observed. The studied feed additives are used for the adsorption of mycotoxins in feed, normalization of digestive processes, and improvement of the livability and productivity of farm animals. In order to study the influence of the tested feed additives on the hematological parameters of the blood of lactating cows under the conditions of the Troitsky area in the Chelyabinsk region, on four groups of cows selected according to the principle of analogues (age, live weight, productivity, breed, physiological condition) the scientific and economic experiment has been carried out. As the result of the investigations, data have been obtained indicating that the feed additive Zaslon 2+ at the dose of 20 g/head/day has the greatest effect on the metabolism in the body of lactating cows.


Author(s):  
R. V. Hunchak ◽  
H. M. Sedilo

The article presents the results of experimental studies on the determination of the influence of iodine citrate on hematological and biochemical parameters of blood of sucking piglets. It was established that hemopoiesis and metabolic reactions in pigs depend on the level of Iodine in the sows, and in the later period (the 10th day) and from the receipt of the biometal as part of the prestarter. Iodine, in nanocitate form, at the expense of high bioavailability and chemical activity, provided the need for thyroid gland in it in much less quantities than the amounts recommended for pregnant and lactating sows in the form of potassium iodide. It has been established that at the admission to the body of a sow 0.095–0.19 mg/kg of feeding of iodine in a nanocyte form (1/4–1/2 of the recommended amount of iodine in the form of CI), its positive effect on hemopoiesis and metabolic processes in newborn piglets is peculiar (increased number of red blood cells, hemoglobin content, high percentage of lymphocytes, increases in the concentration of total protein and in particular albumin, against the backdrop of growth in blood plasma levels of CSF, the concentration of hormones T3 and T4 is quite stable. A higher dose in the premix of iodine citrate (1 : 1) is irrational and most likely undesirable, since against the background of inhibition of this group of erythropoiesis, eosinophilia and lymphopenia, the protein synthesis function decreases and the activity of AlAT, AsAT increases. Hematological and biochemical parameters of blood of piglets obtained from sows, which received a minimum amount of iodine in the form of citrate (0.1 : 1) with premix, did not undergo significant changes, were within the limits of physiological values, although in comparison with the animals of the control group, and particularly, the piglets of the group D2 and D3 tended to decrease (growth). Consequently, iodine citrate as a source of iodine for pregnant and subsistence sows can be recommended in the amounts: 0.095–0.19 mg/kg and 0.125–0.25 mg/kg feed.


Author(s):  
M Amirul Islam ◽  
Sefaly Khatun ◽  
MA Bakr

Malic acid-phthalic acid-propane 1,2-diol copolyester (MPPC) was administered intraperitoneally to the rats at a dose of 300 μg rat-1day-1 for 21 consecutive days to find out its harmful effect on rats. The gross general observations such as changes of body weight, hematological profiles, biochemical parameters of blood and the histopathology of liver, kidney, heart, lungs and spleen were investigated in control and experimental rats. The body weights of the rats were slightly increased. The changes of hematological and biochemical parameters were statistically insignificant. No abnormalities were found in the histopathology of the liver, kidney, heart, lung and spleen in the experimental group of rats when compared with control group of rats. From this study, it was inferred that malic acid- phthalic acid-propane 1,2-diol copolyester would be used as a matrix for controlled and sustained release of drugs. Key words: Malic acid-phthalic acid-propane 1,2-diol copolyester, sub-acute toxicity, haematological parameter, biochemical parameter, histopathology. DOI = 10.3329/jard.v5i1.1472 J Agric Rural Dev 5(1&2), 150-156, June 2007


2021 ◽  
Vol 3 (11 (111)) ◽  
pp. 57-69
Author(s):  
Ulbala Tungyshbayeva ◽  
Saverio Mannino ◽  
Raushangul Uazhanova ◽  
Mamyrbek Alibekovich Adilbekov ◽  
Madina Asatullaevna Yakiyayeva ◽  
...  

This study was conducted to determine the impact of the HACCP management system on the safety of final products in baked goods production. The object of the study is two critical control points of the production of bakery products, which in turn affect the indicator of microbiological quality and safety of finished products. Using a mathematical model, the critical limits of critical control points (CCP) were determined – in the baking and cooling processes of baked goods. For the two CCPs, measures for continuous monitoring have been defined and critical limits have been developed. For CCT 1, a theoretical calculation using a mathematical model is given: the critical limit of the baking process (95.2–99.1 °C in the center of the crumb), by controlling this process, the company controls the biohazard factor, for CCP 2 the critical limit of cooling the finished product to a temperature of 22.84 °C in the center of the crumb for safe packing. The presentation of the results of the development of critical control limits and critical points of the production of bakery products using the construction of mathematical modeling is the theoretical beginning of further research. When compiling the model, the physical parameters of a specific dough with a certain geometric shape were used, from which the bakery product is baked. The use of a mathematical model allows predetermining the baking parameters for the dough of any initial concentration. The results can be used in the production of baked goods to better ensure the quality and safety of the final product


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