scholarly journals Histoprotective effects of Curcumin on Bisphenol- A induced testicular toxicity in adult albino rats.

2019 ◽  
Vol 26 (12) ◽  
pp. 2206-2215
Author(s):  
Rabia Sajjad Toor ◽  
Faiza Irshad ◽  
Sania Asif
Keyword(s):  
Weight Gain ◽  
Basement Membrane ◽  
Bisphenol A ◽  
Corn Oil ◽  
Membrane Integrity ◽  
The Body ◽  
Albino Rats ◽  
Group A ◽  
Group B ◽  
Group D

Endocrine Disrupting chemicals including bisphenols have contaminated the environment significantly and is known to damage spermatogenesis via increase in oxidative stress. The anti-oxidant properties of naturally occurring substances like curcumin have been well established. Objectives: To evaluate the protective effects of curcumin against bisphenol-A induced testicular damage. Study Design: Experimental Study. Setting: Department of Anatomy, University of Health Sciences, Lahore. Period: From March 2015 to December 2015. Material & Methods: Thirty six rats were divided into four groups A, B, C and D of 9 animals each. Group A (control) was given 5ml/kg/day of corn oil orally for 10 days. Group B (Bisphenol-A) was given 100mg/kg/day of Bisphenol-A dissolved in corn oil orally for 10 days. Group C (recovery) was given 100mg/kg/day of BPA dissolved in corn oil orally for 10 days and left untreated for 10 days. Group D (Curcumin + BPA) was given 100mg/kg/day of BPA and 100mg/kg/day of Curcumin, dissolved in corn oil orally for 10 days. Rats of group A, B and D were sacrificed on day 11 and those of group C on day 21. After weighing the euthanized rats, testes were removed, processed and tissue sections were stained with H&E for Johnson scoring and with PAS stain for assessment of basement membrane integrity. Results: Bisphenol-A administration caused a significant decrease in weight of animals, a significantly low Johnson score of seminiferous tubules and high frequency of disrupted basement membranes of the tubules in Group B as compared to control. The weight gain of animals improved in the with-drawl group C while no self-recovery was observed in other parameters. Curcumin co-administration improved the body weight gain of animals, increased the Johnson scoring of tubules significantly and partially restored the basement membrane integrity in group D, comparable to the control group. Conclusion: The results of this study indicate that co-administration of a potent antioxidant curcumin causes a significant antagonism of the histo-toxicity of testis produced by Bisphenol-A in albino rats.

scholarly journals Optimal gestational weight gain for underweight pregnant women in Japan

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Ryosuke Shindo ◽  
Mihoko Aoki ◽  
Yuriko Yamamoto ◽  
Toshihiro Misumi ◽  
Etsuko Miyagi ◽  
...  
Keyword(s):  
Weight Gain ◽  
Gestational Weight Gain ◽  
Institute Of Medicine ◽  
Optimal Range ◽  
Birth Registry ◽  
Gestational Weight ◽  
Registry System ◽  
Group A ◽  
Group B ◽  
Group D

AbstractWe aimed to investigate the optimal range of gestational weight gain (GWG) for Japanese underweight (body mass index <18.5 kg/m2) women using the Japanese Birth Registry System. The study subjects included underweight women who were divided into groups according to the GWG recommendations of the Ministry of Health, Labour and Welfare (MHLW) (9–12 kg): <9.0 kg, group A; 9–12 kg, group B; and >12 kg, group C. The subjects were then classified according to the recommendations of the Institute of Medicine (IOM) (12.7–18.1 kg): <12.7 kg, group D; 12.7–18.1 kg, group E; and >18.1 kg, group F. In total, 148,135 cases were analysed. The frequencies of small for gestational age, preterm delivery, and caesarean delivery were as follows: 19.3%, 22.7%, and 28.5% for group A; 11.7%, 8.7%, and 22.8% for group B; 8.0%, 4.9%, and 21.5% for group C; 15.0%, 14.7%, and 25.2% for group D; 8.0%, 5.3%, and 21.5% for group E; and 7.0%, 5.5%, and 25.0% for group F, respectively. These results indicated that groups C and E had the best outcomes. Therefore, the IOM guidelines seem more appropriate than the MHLW guidelines. Therefore, the MHLW recommended GWG guidelines require revision.

scholarly journals Effects of growth promoter and multivitamin-mineral premix supplementation on body weight gain in broiler chickens

2013 ◽  
Vol 10 (2) ◽  
pp. 245-248 ◽  
Author(s):  
MA Rahman ◽  
MS Parvin ◽  
RR Sarker ◽  
MT Islam
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Broiler Chickens ◽  
Body Weight Gain ◽  
The Body ◽  
Growth Promoter ◽  
Commercial Feed ◽  
Significant Difference ◽  
Group A ◽  
Group B

An experiment was conducted at the Khanpura Poultry Farm, near to the Babugonj campus of Patuakhali Science and Technology University, Patuakhali during the period from August to September, 2011 to evaluate the effect of growth promoter and multivitamin-mineral premix on the body weight gain in broiler chickens. A total of 90 ‘Cobb 500’ day-old broiler chickens were randomly divided into three equal groups (n = 30), namely Groups A, B and C. Broiler birds in groups A and B were supplemented with growth promoter and multivitamin-mineral premix, respectively in addition to commercial feed from day 4 till day 25. The dose of both the growth promoter and multivitamin-mineral premix was 2.5 g/kg of feed. Chickens of group C served as control and supplemented with commercial feed only. Body weight was recorded at three times as on day 11, 18 and 25, respectively. The mean body weight was insignificantly (p > 0.05) higher in birds of groups A (992.5±139.6g) and B (978.3±147.0g) than those of group C (926.7±133.2g). The percent increase in body weight gain compare to control was increased in both the supplemented groups (5.8% in group A and 8.8% in group B) though there was no significant difference. Based on the results, it is suggested that supplementation of growth promoter and multivitamin-mineral premix in broilers even after feeding of commercial feed has positive effect on the growth of broilers.DOI: http://dx.doi.org/10.3329/jbau.v10i2.14914 J. Bangladesh Agril. Univ. 10(2): 245-248, 2012

Semen characteristics and sperm morphology of Pistia stratiotes Linn. (Araceae) protected male albino rats (Wistar strain) exposed to sodium arsenite

2016 ◽  
Vol 13 (3) ◽  
Author(s):  
Olufunke Ola-Davies ◽  
O. Samuel Ajani
Keyword(s):  
Sperm Motility ◽  
Sodium Arsenite ◽  
Mean Value ◽  
Pistia Stratiotes ◽  
Albino Rats ◽  
Protective Potential ◽  
Wistar Strain ◽  
Group A ◽  
Group B ◽  
Group D

Abstract: Sodium arsenite has been proven to be abundant in nature and released into the environment through human activities, including agricultural and industrial processes. The objective of our study was to investigate the sperm protective potential of: The sperm protective potential of: Group B had a significantly lower (p<0.05) percentage sperm motility (26.7±6.67 %) while group A had a significantly (p<0.05) higher mean value (63.3±3.33 %) when compared across the groups. The sperm motility of rats in group D was significantly higher (p<0.05) than groups B and C. This implies that: The study concluded that ethanol leaf extract of

scholarly journals Lower weight gain after vaping cessation than after smoking quitting

2019 ◽  
pp. 253-258
Author(s):  
Ewelina Wawryk-Gawda ◽  
Michał K. Zarobkiewicz ◽  
Patrycja Chylińska-Wrzos ◽  
Barbara Jodłowska-Jędrych
Keyword(s):  
Weight Gain ◽  
Electronic Cigarettes ◽  
Mass Gain ◽  
The Body ◽  
Control Group ◽  
Prior History ◽  
History Of ◽  
Group A ◽  
Lower Weight Gain ◽  
Group B

Background. Smoking is frequently a way to control appetite and weight. The data concerning the body mass gain after quitting among the users of electronic cigarettes who have no prior history of smoking traditional cigarettes is inconsistent. Objective. In our study we have compared smoking and vaping impact on weight gain and glycaemia. Material and methods. 3 groups of rats were used. The group A was exposed to vapour and group B were exposed to smoke. Rats in the group C constituted the control group without nicotine exposition. Results. During 6 weeks of experiment weight gain of rats in the A and B groups was comparable, while animals from group C had gained signifi0cantly more. During 2 weeks after cessation of exposition to nicotine animals from group B gained more weight than rats of A and C group. Blood glucose was higher in group B than in groups A and C 24 h after last exposure to nicotine and 2 weeks after nicotine exposure cessation. Conclusion. Effects of vaping on weight increase is similar to smoking, but after vaping cassation weight gain is lower and comparable with nicotine nonusers.

scholarly journals CELECOXIB

2018 ◽  
Vol 25 (01) ◽  
pp. 50-57
Author(s):  
Sadia Sundus ◽  
Nazia Qamar ◽  
Raheela Adil ◽  
Muhammad Faisal Fahim
Keyword(s):  
Body Weight ◽  
Relative Weight ◽  
Treated Group ◽  
Renal Tissue ◽  
The Body ◽  
Control Group ◽  
Albino Rats ◽  
Group A ◽  
Group B ◽  
General Architecture

Objective: To observe the absolute, relative weight of kidney and body weightof albino rats on celecoxib induced kidney with protection by lycopene. Study Design:Experimental study. Place and Duration of study: This study was conducted in BMSI (Anatomydepartment), JPMC, Karachi, from 4th May 2015 to 3rd June 2015. Materials and Methods: Fortyhealthy adult, male Albino rats, 90-120 days old, weighing 200-220gm was taken for the study.The rats were divided into 4 groups, Group A was control group, Group B receive Celecoxib 50mg/kg body weight orally, Group C receive Celecoxib 50 mg/kg body weight orally along withlycopene50 mg/kg body weight orally and Group D receive lycopene 50 mg/kg body weightorally for 30 days. At the end of study rats were sacrificed and renal tissue sections were stainedwith hematoxylin and eosin. Results: Markedly decreased weight was observed in rats takingcelecoxib. Slides which were stained with hematoxylin and eosinshowed general architecture ofrenal parenchyma, shape and arrangement of epithelial cells. Apoptosis, hemorrhage, necrosisand vacuolation seen in Celecoxib group, whereas renal architecture were ameliorated andreverted back in celecoxib along with lycopene receiving group. Conclusion: This studyconcludes that lycopene restored the body weight, absolute and relative kidney weight incelecoxib treated group.

scholarly journals PO-212 Effects of hypoxic endurance training on weight loss and Irisin expression in nutritional obese rats

2018 ◽  
Vol 1 (5) ◽  
Author(s):  
Zhigang Li ◽  
Wentao Lin
Keyword(s):  
Skeletal Muscle ◽  
Body Weight ◽  
Oxygen Concentration ◽  
Training Group ◽  
The Body ◽  
Hypoxia Exposure ◽  
Obese Rats ◽  
Group A ◽  
Group B ◽  
Group D

Objective Exercise can induce the release of various myokine such as Irisin, which promote browning of white fat, improve body metabolism, and loss weight. Appropriate hypoxic training plays a better role in weight loss than single exercise, but the effect of hypoxic training on muscle factors that promote browning of fat is rarely reported. Therefore, this study aims to observe different concentrations of hypoxia training on the PGC1α-Irisin-UCP1 signaling pathway in nutritional obese rats, and the role of weight loss. Methods Male Sprague-Dawley rats (n=140) of 6 weeks old were divided into normal diet feeding group (group N, n=20) and high-fat diet feeding group (group HFD, n=120). The HFD rats became obese after 8 weeks’ feeding, and they were further divided randomly into 8 groups. Including sedentary group(group A), training group (group AE), 16.3% hypoxia exposure group (group B), 16.3% hypoxia training group (group BE), and 13.3% hypoxia exposure group (group C), 13.3% hypoxia training group (group CE), 11.3% hypoxia exposure group (group D), 11.3% hypoxia training group (group DE), group B, group C and group D Rats were exposed to oxygen in concentrations of 16.3%, 13.3%, and 11.3% for 12 h/d, respectively. Rats in group BE, CE, and DE were subjected to animal treadmill training during hypoxic exposure with a slope of 0°, 20 m /min, 40min/d, 5d/w. After 8 weeks of intervention, blood, adipose tissue and skeletal muscle were collected and tested. Results (1) In group AE, the body weight of obese rats decreased in a short time, but bounced back later. The body weight of rats in group CE and group DE decreased continuously. Hypoxia exposure and hypoxia training can inhibit the food intake of obese rats in varying degrees, and group CE has the most obvious effect. Hypoxia, endurance training and hypoxia training all reduced the percentage of visceral fat to body weight, group C is significantly lower than group B and D group (p < 0.05), the effect of hypoxia training is more obvious than single hypoxia or exercise, and the lower oxygen concentration the more significant effect. Group C、group CE、group D and group DE significantly decreased the concentration of LDL-C, increased the content of HDL-C in serum than other groups (p < 0.05).(2) The concentration of serum Irisin in group AE, group BE, group CE and group DE rats was significantly higher than that in group A (p < 0.05), and the highest level was found in group CE and DE. The insulin resistance of obese rats in group CE and group DE was significantly better than that in group AE (p < 0.05). (3) Three different concentrations of hypoxia exposure and hypoxia training can significantly increase the skeletal muscle PGC-1 α and FNDC5 gene expression, showing that the lower the concentration of oxygen, the higher the expression, 13.3% and 16.3% hypoxia training can significantly promote the gene transcription of UCP1. The contents of PGC-1 α and FNDC5 protein in skeletal muscle of obese rats in group C, AE and DE were significantly higher than those in group A (p < 0. 05). The expression of UCP1 protein in skeletal muscle of rats in group C, CE and DE was significantly higher than that in group A (p < 0. 05). Conclusions 13.3% and 11.3% oxygen concentration combined with endurance training can effectively reduce the body weight and visceral fat of nutritional obese rats, enhance serum HDL-C and decrease LDL-C levels and insulin resistance. 13.3% and 11.3% oxygen concentration training can significantly improve the level of serum Irisin, 11.3% oxygen concentration training can significantly promote the expression of PGC1α-Irisin-UCP1 gene and protein in skeletal muscle.

scholarly journals Effects of bisphenol-A (BPA) on body weight, hematological parameters and histo-texture of kidney in swiss albino mice

2021 ◽  
Vol 6 (4) ◽  
pp. 635-640
Author(s):  
Emdadul Hoque ◽  
Khaled Mahmud Sujan ◽  
Md Suman Mia ◽  
Md Iqramul Haque ◽  
Afrina Mustari ◽  
...  
Keyword(s):  
Body Weight ◽  
Bisphenol A ◽  
Histopathological Examination ◽  
Hematological Parameters ◽  
Hemoglobin Concentration ◽  
The Body ◽  
High Dose ◽  
Daily Lives ◽  
Group A ◽  
Group B

Bisphenol-A (BPA) is one of the highest volume chemicals produced world-wide and used in the manufacture of plastics and epoxy resins that are pervasive in our environment and daily lives. The present research was carried out to investigate the effects of two different doses of Bisphenol-A (BPA) on the body weight, hematological parameters and patho-physiological changes of kidney in mice. For this study, fifteen mice, 6 to 8 weeks of age with an average bwt 27.10±0.5 gm, were randomly divided into three groups (n= 5). Group A (control) received only normal mouse pellet while group B and group C received pellet mixed with BPA @ 50 mg and 100 mg / kg bwt daily for 12 weeks, respectively. At the end of the experiment, blood and tissues were collected and processed for hematological and histopathological examination. Results showed that BPA- treated mice caused significant elevation (p<0.01) in weight gain even treated with low dose (50mg) of BPA. The mice exposed to high dose of BPA (100 mg) showed marked reduction (p<0.05) in total erythrocyte count (TEC), significant decreased (p<0.01) in hemoglobin concentration (Hb) and packed cell volume (PCV). Histopathological alterations were detected in the kidneys of BPA-treated mice. In conclusion, this study suggested that BPA exerts deleterious impacts on hematological parameters including association with renal injuries. Asian J. Med. Biol. Res. December 2020, 6(4): 635-640

scholarly journals Poverty alleviation of destitute women and poor farmers in Barisal district of Bangladesh through beef fattening

2016 ◽  
Vol 2 (1) ◽  
pp. 48-54
Author(s):  
Mohammad Rohul Amin ◽  
Mohammad Hafizur Rahman ◽  
Milton Talukder ◽  
Md Ali Asgar ◽  
Ashit Kumar Paul ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Poverty Alleviation ◽  
Body Weight Gain ◽  
The Body ◽  
Income Poverty ◽  
Animal Diseases ◽  
Group I ◽  
Group A ◽  
Group D

The cattle fattening programme was represents an important component of the agribusiness sector with great economic, income, poverty alleviation and social implications. The present study was performed at Barisal district in Bangladesh. Data were collected from 220 women and farmers on their household during the period June, 2013. Among them, 54 destitute women and poor farmers were identified and making groups of them for beef fattening. 54 cattle of each destitute women and poor farmers were randomly divided into nine groups (A, B, C, D, E, F, G, H and I), each consisting of six (6) cattle. Endex®, Aldazole® and Tetranid® were administered orally to the cattle of group A, B and C, respectively. Cattle of group D received subcutaneously Oxynil®. Cattle of group E received orally Peraclear® and Urea Molasses Straw (UMS). Cattle of group F received orally Endex® and lugols iodine intravenously. Cattle of group G were treated orally with Endex® and Metaphos® intramuscularly. Cattle of group H were treated orally with Endex® and A-Sol® intramuscularly. Cattle of group I was kept as control without giving any treatment. Body weight was examined before trials (day 0) and on 10th day, 20th day, 30th day, 40th day, 50th day, 60th day and 70th day. Out of the 220 women and farmers 56.36% were involved in agriculture, 10.45% in own business, 3.64% in shared business, 6.36% in govt. service and 23.18% in non-govt. service. 18.18% women and farmers had the knowledge of animals characteristics used for beef fattening. The knowledge of feed, animal diseases, veterinary drugs, animal vaccine, and drugs used for beef fattening was 18.64%, 47.73%, 25.45%, 25.45%, and 19.55%, respectively. About 7.73% respondents have training on cattle fattening. The body weight was increased significantly (p<0.01 and p<0.05) after Endex®, Aldazole®, Tetranid®, Oxynil®, Peraclear®+UMS, Endex®+loguls iodine, Endex®+Metaphos® and Endex®+A-Sol® treatment in group A, B, C, D, E, F, G and H, respectively. Highest percentages of body weight gain in Endex® + Metaphos® (19.79%) treated cattle followed by Endex®+A-Sol® (10.06%), Peraclear® +UMS (9.97%) and Endex®+loguls iodine (8.68%) treated cattle. The results of the present study will be helpful for farmers and researchers for beef fattening in Bangladesh.Asian J. Med. Biol. Res. March 2016, 2(1): 48-54

Effect of Dietary Probiotics(Saccharomyces cerevisae)Supplementation on Serum Biochemicals ofTrypanosoma brucei bruceiInfected Rats

2019 ◽  
Vol 15 (3) ◽  
pp. 337-342
Author(s):  
James I. Eze ◽  
Ubochioma E. Didacus
Keyword(s):  
Total Protein ◽  
Health Benefit ◽  
Vital Role ◽  
Albino Rats ◽  
Induce Lipid Peroxidation ◽  
Parasitaemia Level ◽  
Lower Protein ◽  
Group A ◽  
Group B ◽  
Group D

Background:Trypanosomosis is an important disease of both humans and animals commonly found in most parts of Africa and South America. Because of their activities, the parasites produce numerous changes in the cellular and biochemical constituents of blood. Also, trypanosomosis cause immunosuppression and also induce lipid peroxidation in the host. Probiotics confer beneficial health benefit to the host such as immune stimulation, protection against pathogens, metabolism, reduced oxidative stress, etc.Methods:Thirty (30) adult albino rats were assigned into 5 groups (A – E) of 6 rats each. Groups A, B and C rats were fed feed supplemented with probiotics at 0.08, 0.12 and 0.16 mg per kg respectively. On day 14 on the supplementation (OTS), groups A, B, C and D rats were infected with 1 x 106 trypanosomes intraperitonealy. Group E served as the not infected, not supplemented control.Results:The pre-infection supplementation did not vary the serum alanine transaminase (ALT), aspartrate transaminase (AST), urea, creatinine and total protein values of groups A, B and C. However, following infection, the ALT value of group D (infected, not supplemented) was significantly (p<0.05) higher than other groups on day 42 OTS. Also, the AST value of groups A and D were significantly (p<0.05) higher than group E but not with groups B and C on days 42 and 56 on the supplementation. On day 28 OTS, the urea level of group B was significantly (p<0.05) lower than group D whereas on days 42 and 56, group E and groups E and C were significantly (p<0.05) lower than other groups respectively. The serum creatinine level showed increase following infection with groups A and D being significantly (p<0.05) higher than other groups on days 42 and 56 OTS. On day 28 OTS, the total protein value of group A was significantly (p<0.05) lower than group C but not with other groups. By days 42 and 56 OTS, group D showed significantly (p<0.05) lower protein level when compared with other groups. The mean parasitaemia level of group D was significantly higher than other infected infected groups on days 28 and 42 on the supplementation. However, on day 56, the parasitaemia level of all infected groups did not vary (p>0.05).Conclusion:The ability of the supplementation to keep serum biochemical values before infection within range, and the subsequent maintenance of the value during most part of the infection were indication that probiotic was not toxic and may play a vital role in management of trypanosomosis.

scholarly journals Effects of calcium carbonate, potassium iodide and zinc sulphate in lead induced toxicities in rat model

1970 ◽  
Vol 4 (2) ◽  
pp. 123-127
Author(s):  
MM Haque ◽  
MA Awal ◽  
M Mostofa ◽  
MMH Sikder ◽  
MA Hossain
Keyword(s):  
Body Weight ◽  
Calcium Carbonate ◽  
Potassium Iodide ◽  
Zinc Sulphate ◽  
The Body ◽  
Postmortem Changes ◽  
Group A ◽  
Group B ◽  
Group D

A study was carried out to find out the effects of calcium carbonate, potassium iodide and zinc sulphate in lead induced toxicities in rat with the observation of toxic signs, postmortem changes and determination of lead quantity in different organs of the body. Twenty-five long Evans rats weighing between 202-305g were randomly divided into five groups keeping group A as untreated control. Rest four groups (B, C, D & E) were treated with lead acetate @ 20mg/kg body weight in addition, rats of groups C, D & E were given Calcium carbonate (50mg/kg body weight), potassium iodide (20mg/kg bwt) and zinc sulphate (10mg/kg bwt.) respectively. Treatments were continued for 42 consecutive days. Rats of group B showed reduction in fecal consumption, anxiety, indigestion, fatigue, muscle tremor, paralysis and ruffled hair coat. However, rats of group C were apparently normal but rats of group D and E showed mild toxic signs of similar nature. On postmortem examination, severe congestion and blackish discoloration with enlargement of the liver, kidney, spleen and inflammation of the gastric mucosa were observed in rats of group B. However, these changes were less severe in other groups. The significant reduction of lead in blood, liver, kidney and brain was observed in rats of group C, D and E in comparison to group B. In addition, significant reduction of lead content was observed in femur of group C only. The present findings revealed that during lead exposure administration of calcium carbonate may be effective in modifying and preventing lead deposition in tissues followed by zinc sulphate and potassium iodide in rat. Key words: Toxicity, lead, calcium carbonate, potassium iodide, zinc sulphate, rat DOI = 10.3329/bjvm.v4i2.1295 Bangl. J. Vet. Med. (2006). 4 (2): 123-127

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