scholarly journals Higher venom-specific IgE levels differentiate children with previous local large reactions from children with previous systemic reactions of different severity

2021 ◽  
Vol 5 (1) ◽  
pp. 017-021
Author(s):  
Elide Anna Pastorello ◽  
Linda Borgonovo ◽  
Marta Piantanida ◽  
Jan Walter Schroeder ◽  
Valerio Pravettoni ◽  
...  
Keyword(s):  
Risk Factors ◽  
Honey Bees ◽  
Pediatric Population ◽  
Adult Population ◽  
Specific Ige ◽  
Systemic Reactions ◽  
History Of ◽  
Grade Ii ◽  
Local Reactions ◽  
Large Local Reactions

Introduction: Risk factors for systemic reactions (SRs) from hymenoptera venom (HV) allergy are well known in the adult population but they have been little studied in the pediatric one. Method: The aim of our study was to identify risk factors for SRs in a population of children allergic to HV, comparing a series of clinical (age, gender, atopy, asthma) and laboratory (total IgE, tryptase, venom-specific IgE levels) variables between patients with at least two large local reactions (LLRs) and patients with SRs of different severity for the identified insect. We selected a population of HV allergic children aged <15 years with LLRs or SRs stratified according to Mueller grades after stinging. Results: The population included 80 children, 35 with at least 2 LLRs and 45 with SRs. The level of specific IgE for vespid (Polistes dominula, Vespula species) venoms was significantly higher (p = 0.0321) in children with SRs (Mueller grade II+III+IV) than in those with LLRs and the same significance was also found for specific IgE for Apis mellifera, considering SRs group (Mueller grade I+II+III+IV) in respect with LLRs group (p = 0.0001). Conclusion: The main difference in our pediatric population was the highest level of specific IgE in children with a history of SRs compared to those with a history of LLRs for both vespids and honey bees. These results, once confirmed on a larger population, could suggest the opportunity to follow the behavior of venom specific IgE in children with LLRs to reveal a risk to develop future more serious reactions.

scholarly journals Incidence of diabetes mellitus and associated risk factors in the adult population of the Basque country, Spain

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Inés Urrutia ◽  
◽  
Alicia Martín-Nieto ◽  
Rosa Martínez ◽  
J Oriol Casanovas-Marsal ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Family History ◽  
Basque Country ◽  
Adult Population ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Family History Of Diabetes ◽  
History Of ◽  
Incident Cases

AbstractThe aim of this study was to estimate the incidence of diabetes mellitus in the Basque Country and the risk factors involved in the disease by reassessing an adult population after 7 years of follow-up. In the previous prevalence study, 847 people older than 18 years were randomly selected from all over the Basque Country and were invited to answer a medical questionnaire, followed by a physical examination and an oral glucose tolerance test. In the reassessment, the same variables were collected and the resulting cohort comprised 517 individuals of whom 43 had diabetes at baseline. The cumulative incidence of diabetes was 4.64% in 7 years and the raw incidence rate was 6.56 cases/1000 person-years (95%CI: 4.11–9.93). Among the incident cases, 59% were undiagnosed. The most strongly associated markers by univariate analyses were age > 60 years, dyslipidaemia, prediabetes and insulin resistance. We also found association with hypertension, obesity, family history of diabetes and low education level. Multivariate analysis adjusted for age and sex showed that a set of risk factors assessed together (dyslipidaemia, waist-to-hip-ratio and family history of diabetes) had great predictive value (AUC-ROC = 0.899, 95%CI: 0.846–0.953, p = 0.942), which suggests the need for early intervention before the onset of prediabetes.

scholarly journals Epidemiological and Clinical-Pathological Aspects of Helicobacter pylori Infection in Brazilian Children and Adults

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Evelyn Pedroso Toscano ◽  
Fernanda Fernandes Madeira ◽  
Mayra Pinheiro Dutra-Rulli ◽  
Luiz Otavio Maia Gonçalves ◽  
Marcela Alcântara Proença ◽  
...  
Keyword(s):  
Risk Factors ◽  
Pediatric Population ◽  
Adult Population ◽  
Developed Countries ◽  
Upper Gastrointestinal Endoscopy ◽  
Only Children ◽  
Screening Programs ◽  
Adolescents And Adults ◽  
H Pylori ◽  
Over 40 Years

Aim. To evaluate the prevalence and risk factors of H. pylori infection in the pediatric and adult population seen at a public hospital in São José do Rio Preto, SP, Brazil. Methods. This is a retrospective study that evaluated 2406 medical records of children, adolescents, and adults with dyspeptic symptoms who underwent upper gastrointestinal endoscopy. H. pylori diagnosis and demographic and clinical-pathological features were recorded. Results. A total of 852 subjects were H. pylori positive, with an overall prevalence of infection of 35.4%, occurring mainly in adults over 40 years of age, and a 24.7% prevalence considering only children and adolescents. No association was observed between H. pylori infection and risk factors. However, the H. pylori positive individuals showed a higher frequency of pangastritis (p<0.01), severe lesions (p=<0.001), and erosive lesions (p=0.04). The bacterium was eradicated in 83.5% (127) of the patients who received the standard therapy. Conclusions. The prevalence of H. pylori detected in a public service in São José do Rio Preto, SP, Brazil, is as expected for developed countries, showing growing rates with increasing age. As H. pylori infection occurs during childhood, screening programs for detection and prevention in the pediatric population are important to reduce the prevalence of this infection in adults.

Natural history of systemic reactions and risk factors in children and adults with Hymenoptera venom allergy

2020 ◽  
Vol 29 (2) ◽  
pp. 26-33
Author(s):  
Darío Antolín-Amérigo ◽  
Berta Ruiz-León ◽  
A. Vega-Castro ◽  
Belén de la Hoz Caballer
Keyword(s):  
Risk Factors ◽  
Natural History ◽  
Hymenoptera Venom ◽  
Venom Allergy ◽  
Hymenoptera Venom Allergy ◽  
Systemic Reactions ◽  
History Of

scholarly journals Risk factors of recurrence after an arthroscopic stabilisation procedure performed for traumatic anterior shoulder instability in pediatric population

2017 ◽  
Vol 5 (2_suppl2) ◽  
pp. 2325967117S0006 ◽  
Author(s):  
Mustafa Özer ◽  
Tacettin Ayanoğlu ◽  
Muhammet Baybars Ataoğlu ◽  
Mehmet Çetinkaya ◽  
Ulunay Kanatlı
Keyword(s):  
Risk Factors ◽  
Recurrence Rate ◽  
Shoulder Instability ◽  
Pediatric Population ◽  
Anterior Shoulder Instability ◽  
Sports History ◽  
Contact Sports ◽  
Pediatric Age Group ◽  
Arthroscopic Stabilisation ◽  
History Of

Arthroscopic stabilisation of traumatic anterior shoulder instability is being performed also in pediatric age group, and reports associated with risks of recurrent instability have been presented. The aim of the current study was determining the risk factors of recurrence after the arthroscopic anatomic repair preformed in pediatric age group. 46 patients who underwent arthroscopic Bankart repair for traumatic anterior shoulder instability with the mean age of 17 ±0.8 (15-18) were included in this study. After an average follow-up time of 40.4± 22.7(24-155) months age, gender, dominant side, number of dislocations before surgery, participation in contact sports, Rowe and Oxford shoulder scores, labral lesion type, number of anchor used, and capsular laxity were assessed, and their correlation with recurrence were investigated. Recurrence was encountered in 9 (19,5%) patients, on average, 16.1 ±13.43 months after surgery. The only risk factor of recurrence was found to be the history of five or more times of dislocation before surgery (p=0,006). Although statistically insignificant, when evaluated separately, it was found that patients with contact sports history had double times of recurrence rate if they had ALPSA or SLAP lesion and triple times of recurrence rate if they had capsular laxity. The recurrence rate was found to be 38,4% when accompained by capsular laxity, 50% when accompained by both capsular laxity and ALPSA lesion, and 100% when accompanied by all capsular laxity, ALPSA lesion and contact sports history. Arthroscopic stabilisation of traumatic anterior shoulder instability in pediatric population is an appropriate technique, especially in those with less than five times of dislocation because of the low recurrence rate (3.4%). Surgical procedures that are non-anotomic, such as coracoid transfer or anterior glenoid bone block, should be considered in patients with high risk of recurrence rate after an arthroscopic anatomic repair because of the risk factors like history of five or more times of dislocation, being accompanied by an ALPSA, SLAP lesion, or a capsular laxity and participation in contact sports.

scholarly journals Depression-anxiety in Adult Population of Qatar during the First Year of COVID-19

2021 ◽  
Author(s):  
Salma Mawfek Khaled ◽  
Iman Amro ◽  
Lina Bader ◽  
Tarek Bellaj ◽  
Yousri Marzouki ◽  
...  
Keyword(s):  
Risk Factors ◽  
Online Survey ◽  
Adult Population ◽  
First Year ◽  
Cross Sectional ◽  
Never Married ◽  
Potential Risk Factors ◽  
History Of ◽  
Adjusted Model ◽  
Arabic Speaking

There is limited data from Arabic-speaking countries on risk factors for depression and anxiety during the COVID-19 pandemic. Country-specific data is necessary given differences in culture, demographics, and COVID-19 infection and mortality rates. This study intended to identify the factors associated with symptoms of depression-anxiety in the adult population of Qatar during the first year of the COVID-19 pandemic. We conducted a cross-sectional online survey in Qatar between July and December 2020 after Qatar’s first COVID-19 wave and before the beginning of the second wave. Depression-anxiety was defined as a cut-off of 20 or higher on the PHQ-ADS scale. Of 1138 participants, 71.05% were female, 69.0% Arabs, and 70.0% Non-Qataris. 77 % were < 40 years (the median age in Qatar is 32 years). In a fully-adjusted model, six variables were significantly associated with PHQ-ADS; Arab ethnicity (OR=1.67, p=0.026), never married (OR=1.69, p < 0.015), prior psychiatric history (OR=1.80, p=0.009), Social Media induced worries (OR=1.72, p=0.003), history of COVID-19 (OR=1.76, p=0.039), loneliness (OR=1.91, p < 0.001), and lower levels of religiosity (OR=0.96, p=0.039). The potential risk factors identified may assist with anxiety and depression prevention in future COVID-19 waves, similar national events and assist with early intervention to treat sufferers.

scholarly journals Factors Associated with Depression and Anxiety in the Adult Population of Qatar in the First Year of the COVID-19 pandemic: Results from an Online Survey

2021 ◽  
Author(s):  
Salma M. Khaled ◽  
Iman Amro ◽  
Lina Bader ◽  
Peter Woodruff ◽  
Majid A Alabdulla ◽  
...  
Keyword(s):  
Risk Factors ◽  
Online Survey ◽  
Adult Population ◽  
Prior History ◽  
First Year ◽  
Depression And Anxiety ◽  
Cross Sectional ◽  
Factors Associated ◽  
Potential Risk Factors ◽  
History Of

Abstract Background: There is limited data from Arabic-speaking countries on risk factors for depression and anxiety during the COVID-19 pandemic. Country-specific data is necessary given differences in culture, demographics, COVID-19 infection and mortality rates.Aim: To identify factors associated with symptoms of depression-anxiety in the adult population of Qatar during the first year of the COVID-19 pandemic.Method: We conducted a cross-sectional online survey in Qatar between July and December 2020 after the first COVID-19 wave and before the beginning of the second wave. Depression-anxiety was defined as a cut-off of 20 or higher on the PHQ-ADS scale. Results: Of 1138 participants, 71.05% were female, 69.0% Arabs, and 70.0% Non-Qataris. 77% were < 40 years (the median age in Qatar is 32 years). In a fully-adjusted model, six variables were significantly associated with PHQ-ADS; Arab ethnicity (OR=1.67, p=0.026), never married (OR=2.04, p < 0.001 (versus married), prior history of psychiatric disorder (versus no history) (OR=1.76, p=0.039), increased worries due to social media use for COVID-related news/updates (OR=1.72, p=0.003), those with a history of COVID-19 (OR=1.76, p=0.039), loneliness (OR=1.91, p < 0.001), and lower levels of religiosity (OR=0.96, p=0.039). These associations also pertained in the reduced model, with exception of religiosity which was only marginally statistically significant (OR=0.97, p=0.055).Conclusions: The potential risk factors identified may assist with anxiety and depression prevention in future COVID-19 waves, and similar crises, and assist with early intervention to treat sufferers.

scholarly journals DEPRESSION

2018 ◽  
Vol 25 (08) ◽  
pp. 1229-1234
Author(s):  
Muhammad Ishtiaq ◽  
Muhammad Imtiaz Afridi ◽  
Imranullah - ◽  
Said Akbar Khan
Keyword(s):  
Risk Factors ◽  
Sleep Problems ◽  
Adult Population ◽  
Sampling Technique ◽  
Mental Illnesses ◽  
Cross Sectional ◽  
Medical College ◽  
Prevalence Of Depression ◽  
History Of ◽  
Microsoft Office

Prevalence & risk factors of depression among adult population of districtPeshawar. Background: Depression is one of the most common major mental illnesses andaffects 5% to 20% of the adult population and is related to many determinants. Objectives:To estimate the prevalence and risk factors of depression among the adult population. StudyDesign: A cross sectional descriptive study. Setting & Study Duration: The department ofcommunity medicine, Khyber medical college, Peshawar; among the adult population of districtPeshawar; from November 2016 to May 2017. Materials & Methods: A total of 410 adults, bothmale and female, of ages 18 and above years were selected from the District Peshawar; onthe basis of multistage probability sampling technique. A structured questionnaire was usedto collect data regarding the prevalence and risk factors of depression along with importantvariables. Data was analysed by Microsoft Office and SPSS, and results were presented intables. Results: Results showed that the prevalence of depression was 85.85%. Out of thetotal depression, 24.88% had positive medical history; 57.8% had tobacco smoking; 29.02 %had history of abuse or neglect; 60.24% had sleep problems; and 18.29% & 10.49% wereaffected by terrorism and flood respectively. Conclusions: It was concluded that the prevalenceof depression among the adult population of district Peshawar was high and shows strongassociation with predisposing determinants. Moreover, whole population needs to be screento estimate the accurate prevalence and to treat high burden of mental illnesses among thecommunity.

scholarly journals Physical activity profile of the Iranian population: STEPS survey, 2016

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Farnam Mohebi ◽  
Bahram Mohajer ◽  
Moein Yoosefi ◽  
Ali Sheidaei ◽  
Hossein Zokaei ◽  
...  
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Urban Areas ◽  
Vegetable Consumption ◽  
Adult Population ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
Life Years ◽  
Insufficient Physical Activity ◽  
History Of

Abstract Background Insufficient physical activity (IPA) is one of the leading causes of premature mortality through the increased burden of non-communicable diseases. From 1990 to 2017, the percentage of low physical activity attributable disability-adjusted life years (DALY) increased globally by 1.5 times and 2-fold in Iran, causing more than 1.2 million deaths worldwide and 18,000 deaths in Iran in 2017. Reports suggest that Iran, a developing middle-income country, suffers from a high level of IPA. Socioeconomic and cultural alterations along with the country’s developments expose the population to IPA risk. We aimed to describe IPA prevalence in Iran’s adult population, categorized by demographics, geographical region, and activity domains to assess the present pattern of physical inactivity and its domains in the country. Methods In 2016, in order to represent Iran’s adult population, adult participants (n: 30541) from 30 provinces were selected using systematic proportional to size cluster sampling. Physical activity (PA) was assessed via the Global Physical Activity Questionnaire, calculating the Metabolic Equivalent of Task (MET) value in minutes per week for work, recreation, and transport domains. Insufficient physical activity (IPA) was defined according to WHO’s recommendation (less than 600 METs per week). Adjusted odds ratios of IPA associates for sociodemographic, lifestyle related variables, and metabolic risk factors were reported. Results A high prevalence of IPA was seen in the total population (54.7%, 95%CI: 54.0–55.3) with a considerable difference between the two genders (males: 45.3% (95%CI: 44.3–46.3); females: 61.9% (95%CI: 61.0–62.7)). Work-related activity was the domain with the greatest percentage of total PA, whereas, both genders lacked recreational activities. In our findings, being female, a housekeeper, younger and living in urban areas were significantly associated with higher levels of IPA. Moreover, insufficient fruit and vegetable consumption, lack of alcohol consumption, having a personal vehicle, and finally, having a medical history of diabetes were significantly associated with the presence of IPA in our population. Among the study population, 33.6% (95%CI: 33.0–34.2) had at least 4 h of sedentary behavior in a typical day. Conclusions Widespread IPA among the Iranian adult population is of major concern. In our findings, we observed a considerable gap in the prevalence and pattern of IPA between the two genders. Additionally, IPA was associated with living in urban areas, unhealthy lifestyle habits and a history of other metabolic risk factors. Thus, a prompt initiative for population-specific actions should be taken.

Incidence and characteristics of cancer-associated thrombosis in a racially diverse population: A population-based study.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e13088-e13088
Author(s):  
Gary E. Raskob ◽  
Aaron M. Wendelboe ◽  
John Grady Heller ◽  
Kai Ding ◽  
Nimia L. Reyes ◽  
...  
Keyword(s):  
Risk Factors ◽  
Adult Population ◽  
Tertiary Care ◽  
Population Based ◽  
Incidence Rates ◽  
Diverse Population ◽  
Racially Diverse ◽  
Imaging Results ◽  
History Of ◽  
History Of Cancer

e13088 Background: Venous thromboembolism (VTE) is a common complication in cancer patients, but contemporary data on the incidence and characteristics of cancer-associated VTE in different racial populations is limited. We sought to measure the incidence rate and characteristics of cancer-associated VTE in a racially diverse population. Methods: We performed a prospective, population–based cohort study of VTE in Oklahoma County, OK during April 1, 2012–March 31, 2014. Surveillance staff regularly visited all tertiary care and relevant outpatient facilities in the county and reviewed the text from all imaging results of chest computed tomography or magnetic resonance imaging, lung perfusion scans, and ultrasound of the extremities to identify cases of VTE. Data on patient characteristics were collected from the electronic medical record. VTE was considered cancer-associated if the patient had a history of cancer other than basal or squamous cell skin cancer. Cancer was defined as “active” if metastatic or diagnosed within 6 months prior to VTE. Associations and incidence were calculated using the chi-square test and Poisson regression, respectively. Results: Of 3,255 patients with ≥1 VTE event (deep-vein thrombosis and/or pulmonary embolism), 732 (23%) had a history of cancer, of whom 309 had active cancer. The types of cancer varied widely. The age-adjusted incidence of cancer-associated VTE was 648 per 100,000 adult population (age ≥ 18). Incidence increased with each decade of age. The racial/ethnic-specific incidence rates were as follows (each per 100,000): Whites non-hispanic (607), Blacks non-Hispanic (557), Native Americans (128), Asian/Pacific Islanders (113) and Hispanics (70). Risk factors for VTE among the 732 with cancer-associated VTE included previous VTE (19%), hospitalization (37%), surgery (33%), and central venous catheter (22%). Of those with a history of cancer ≥ 6 months previously, 32% had no other identifiable VTE risk factor. Conclusions: Cancer-associated VTE comprised about 20-25% of the total population burden of VTE. The incidence varied substantially by race/ethnicity. An appreciable proportion of those with a history of cancer ≥ 6 months previously subsequently developed VTE in the absence of other risk factors.

Advances in the Diagnosis and Treatment of Stinging Insect Allergy

PEDIATRICS ◽  
1981 ◽  
Vol 67 (3) ◽  
pp. 325-328
Author(s):  
John W. Yunginger
Keyword(s):  
Mast Cells ◽  
Systemic Reaction ◽  
Signs And Symptoms ◽  
The United States ◽  
Specific Ige ◽  
Allergic Reactions ◽  
Short Period ◽  
Local Reactions ◽  
Large Local Reactions ◽  
Stinging Insect

Allergic reactions to insect stings occur in approximately 0.4% of the general population.1,2 Severe anaphylactic reactions may occur in sensitive patients, and estimates suggest that 40 persons die during such reactions each year in the United States.3 From the standpoint of allergy the Hymenoptera order of insects is the most important; this order includes the bees (honeybees and bumblebees), vespids (wasps, yellow jackets, and hornets), and fire ants. CLASSIFICATION OF STING REACTIONS Insect sting reactions may be grouped into immediate (within two hours) or delayed (more than two hours) categories. Immediate reactions can be subdivided into local, large local, or systemic reactions, depending on the severity and extent of the reaction. Local reactions are normal reactions—a sting will cause transient pain, redness, and swelling at the sting site. In large local reactions the reaction is much more extensive, although all signs and/or symptoms produced are contiguous with the sting site. For example, a sting on the finger may produce swelling of the entire forearm or extremity. In a systemic reaction signs and/or symptoms occur at sites remote from the sting site. For example, a sting on the finger may produce angioedema of the eyelids or generalized urticaria. Toxic reactions are nonimmunologic reactions produced when an individual is stung by multiple insects within a short period of time; signs and symptoms are those of a systemic allergic reaction, but are due to the physiologic effects of vasoactive materials in the venom. Systemic allergic reactions are immunologic reactions produced by vasoactive materials released from the blood basophils or tissue mast cells as a result of interaction between venom components and specific IgE antibodies fixed to the basophils or mast cells.

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