scholarly journals Potential of medicinal plants in management of diabetes: An updates

2021 ◽  
Vol 8 (1) ◽  
pp. 149-169
Author(s):  
Lochana L. Malode ◽  
Jagdish V. Manwar ◽  
Wrushali A. Panchale ◽  
Shivam A. Bartere ◽  
Ravindra L. Bakal

Phytochemical means plant derived chemicals they are defined as bioactive nutrient present in plant in fruits, vegetables, grains, and other part of plants that may provide advantageous health benefits across basic nourishment. Medicinal plants are used in the treatment of various illness due to the presence of therapeutically important phytochemicals. Sometimes in patients with diabetes mellitus, the levels of antioxidant parameters are found to decrease, hence in many studies phytochemicals are suggested to improve the insulin sensitivity. Some phytocompounds such as flavonoids, prophenyl phenols, are also found effective in the complications of diabetes. The major challenging issue in diabetes management is the obstruction of various complications that remain the main cause of diabetes-related mortality. This review mainly focuses on the relationship between diabetes mellitus and preventive roles of various phytochemicals on diabetes.

2020 ◽  
Vol 12 ◽  
pp. 1759720X2098121
Author(s):  
Gustavo Constantino de Campos ◽  
Raman Mundi ◽  
Craig Whittington ◽  
Marie-Josée Toutounji ◽  
Wilson Ngai ◽  
...  

Aims: The objective of this review was to examine the relationship between osteoarthritis (OA) and mobility-related comorbidities, specifically diabetes mellitus (DM) and cardiovascular disease (CVD). It also investigated the relationship between OA and mortality. Methods: An overview of meta-analyses was conducted by performing two targeted searches from inception to June 2020. The association between OA and (i) DM or CVD ( via PubMed and Embase); and (ii) mortality ( via PubMed) was investigated. Meta-analyses were selected if they included studies that examined adults with OA at any site and reported associations between OA and DM, CVD, or mortality. Evidence was synthesized qualitatively. Results: Six meta-analyses met inclusion criteria. One meta-analysis of 20 studies demonstrated a statistically significant association between OA and DM, with pooled odds ratio of 1.41 (95% confidence interval: 1.21, 1.65; n = 1,040,175 patients). One meta-analysis of 15 studies demonstrated significantly increased risk of CVD among OA patients, with a pooled risk ratio of 1.24 (1.12, 1.37, n = 358,944 patients). Stratified by type of CVD, OA was shown to be associated with increased heart failure (HF) and ischemic heart disease (IHD) and reduced transient ischemic attack (TIA). There was no association reported for stroke or myocardial infarction (MI). Three meta-analyses did not find a significant association between OA (any site) and all-cause mortality. However, OA was found to be significantly associated with cardiovascular-related death across two meta-analyses. Conclusion: The identified meta-analyses reported significantly increased risk of both DM and CVD (particularly, HF and IHD) among OA patients. It was not possible to confirm consistent directional or causal relationships. OA was found to be associated with increased mortality, but mostly in relation to CVD-related mortality, suggesting that further study is warranted in this area.


Author(s):  
P. Amulya Reddy ◽  
K. Saravanan ◽  
A. Madhukar

Aim: The aim of the study was to evaluate the QOL of patients with Diabetes Mellitus. Study Design: This was a prospective, observational study. Duration of Study: The study was conducted from August 2019 to January 2021 in Yashoda Hospital, Hyderabad. Methodology: Patients of either sex with ≥1year history of diabetes willing to give the consent were included in the study. Patients of either sex with <1year history of DM, Pregnant/lactating women and patients not willing to give the consent were excluded from the study. Data on Blood glucose levels (FBS, PPBS) and HbA1C was also obtained and assessed. QOLID questionnaire was administered to the patients and assessed which consisted of a set of 34 items representing 8 domains such as Role limitation due to the physical health, Physical endurance, General health, Treatment satisfaction, Symptom botherness, Financial worries, Mental health, and Diet satisfaction). Results: A total of 200 patients were analysed in the study,108(54%) were males and 92(46%) were females. The average age of the patients was 58.5 years with majority being 51-70years (73.5%) of age. Patients with higher age and females had poor QOL compared to others. The correlation between various categorical variables with that of scores of QOL in various domains was assessed, Age of the patients influenced QOL score in various domains like RLPH (p value-0.038), PE (p value-0.0183), and SB (p value-0.0002), Gender has influenced QOL score in domains like RLPH (p value-0.0008), PE (p value-0.0106), TS (p value-0.0005) and Educational Qualification has influenced QOL score in RLPH (p value-0.0008), GH (p value-<0.0001), TS (p value-<0.0001), E/MH (p value-<0.0001). Conclusion: The results concluded that overall QOL was noticeably low in Diabetic patients especially in Women and elderly thus indicating that Diabetes management is not restricted to treatment but also requires attention on QOL of patients.


2019 ◽  
Author(s):  
aura widad al addawiyah hamzah

Diabetes mellitus is a chronic metabolic disorder characterized by an increase in blood glucose (hyperglycemia). Physical activity has an impact on insulin action in people at risk for diabetes mellitus.Lack of activity is one of the contributing factors that causes insulin resistance in type II diabetes mellitus and diet is the behavior of humans or a group of humans in meeting their dietary needs which include food attitudes, beliefs and choices. The purpose of this study was to analyze the relationship between patterns of physical activity and diet with blood sugar levels in patients with diabetes melitustipe II. The research method used is a qualitative method. The results of the study showed that there was a relationship between patterns of physical activity and diet with blood sugar levels. Conclusions there is a relationship between patterns of physical activity and diet with blood sugar levels in patients with diabetes melitustipe II


Author(s):  
Andrew P. Hall ◽  
Melanie J. Davies

Diabetes mellitus is a common condition in the general population, and particularly so among hospital inpatients. Complications associated with diabetes mellitus further increase its incidence in surgical patients, particularly those requiring vascular, renal, or ophthalmic procedures. Patients with diabetes have a higher rate of morbidity and mortality associated with surgery. This includes cardiovascular and renal complications, infection, and impaired wound healing. The process of surgery, a controlled form of trauma, provokes a metabolic response due to the release of cytokines and stress-associated hormones. These agents promote a catabolic state that includes increased insulin resistance. The resulting hyperglycaemia leads to overflow of substrates in the mitochondria and the generation of excess free oxygen radicals, which can be toxic to the cell. It should, therefore, be possible to reduce these effects by avoiding or attenuating the stress response and/or counteracting its metabolic effects. The stress response is proportional to the degree of tissue trauma. Insulin administration and normoglycaemia have been shown to reverse catabolic changes and improve wound healing and skin grafting, and also to reduce the incidence of infective complications. Additionally, the stress response may be, in part, attenuated by the choice of anaesthetic technique. Neuraxial (spinal and epidural local anaesthetic) analgesia can reduce sympathetic nervous system tone and adrenal output. Additionally, much ophthalmic surgery is now performed with local anaesthesia techniques. Such approaches avoid the more prolonged starvation and cardiorespiratory risks associated with general anaesthesia.


2020 ◽  
Vol 9 (3) ◽  
pp. e000982
Author(s):  
Adeel Ahmad Khan ◽  
Aamir Shahzad ◽  
Samman Rose ◽  
Dabia Hamad S H Al Mohanadi ◽  
Muhammad Zahid

A significant number of patients admitted to the medical floor have type 2 diabetes mellitus (DM). Lack of a standardised inpatient hyperglycaemia management protocol leads to improper glycaemic control adding to morbidity in such patients. American Diabetes Association, in its 2019 guidelines, recommends initiation of a regimen consisting of basal insulin (long-acting insulin) or basal plus correctional insulin for non-critically ill hospitalised patients with poor or no oral intake. A combination of basal insulin, bolus (short-acting premeal or prandial) insulin and correctional scale insulin is recommended for inpatient hyperglycaemia management in non-critical patients with type 2 DM who have proper oral intake. Baseline data of 100 patients with diabetes admitted to Hamad General Hospital Doha, Qatar, showed that although insulin was used in the majority of patients, there was lack of uniformity in the initiation of insulin regimen. Adequate glycaemic control (7.8–10 mmol/L) was achieved in 45% of patients. Using Plan–Do–Study–Act (PDSA) model of improvement, a quality improvement project was initiated with the introduction of a standardised inpatient hyperglycaemia management protocol aiming to achieve 50% compliance to protocol and improvement in inpatient glycaemic control from baseline of 45% to 70%. Interventions for change included development of a standardised inpatient hyperglycaemia management protocol and its provision to medical trainees, teaching sessions for trainees and nurses, active involvement of medical consultants for supervision of trainees to address the fear of hypoglycaemia, regular reminders/feedbacks to trainees and nurses about glycaemic control of their patients and education about goals of diabetes management during hospitalisation for patients with diabetes. Overall, glycaemic control improved significantly with target glycaemic control of 70% achieved in 4 of the 10 PDSA cycles without an increase in the number of hypoglycaemic episodes. We conclude that development of a standardised inpatient insulin prescribing protocol, educational sessions for medical trainees and nurses about goals of diabetes management during hospitalisation, regular reminders to healthcare professionals and patient education are some of the measures that can improve glycaemic control of patients with type 2 DM during inpatient stay.


2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Mario C Rivera Bernuy ◽  
Kollipara Usha ◽  
Jessica Burks ◽  
Jason Fish ◽  
Sadia Ali

Abstract DMAIC: Define, Measure, Analyze, Improve, Control. LSL: Lower specified limit. USL: Upper specified limit. Lean Six Sigma DMAIC is quality improvement methodology used for strategic business management. Frequent applications of this methodology in healthcare include improvement of patient satisfaction, reduction of emergency department waiting times, prescription error reduction and monetary recovery by reducing waste. Patients with a HgbA1c testing frequency of &gt;6 months have poorer glycemic control. The American Diabetes Association recommends HgbA1c test quarterly in patients whose therapy has changed or who are not meeting glycemic goals and at least two times a year in patients who are meeting treatment goals. We hypothesized that the Lean Six-Sigma DMAIC tools can be used in the outpatient clinic setting to improve frequency of HgbA1c testing in patients with diabetes mellitus. At baseline, 19% of our patients with diabetes mellitus had HgbA1c tested infrequently, defined as more than 6 months. This high percentage is a concern as it could lead to poor diabetes control. The aim was to increase percentage of patients having an HgbA1c tested between 3 to 6 months before an appointment in our clinic, to a goal of 90%. Target population included all patients with diabetes mellitus seen in outpatient endocrinology clinic. A baseline analysis of existing processes was done through brainstorming with the clinic staff using a fish bone diagram. Lack of follow up and HgbA1c testing orders were some of the modifiable factors identified. The new processes implemented include nurse driven standing medical orders for HgbA1c testing and pre-visit planning. Control phase included regular audits to sustain the improvements. The percentage of patients with a HgbA1c testing within 3-6 months of appointment improved from a baseline of 76.7% (LSL:70%, USL:94%) to 92.2% (LSL:88%, USL:93.7%). The improvement was noticeable within 1 month of new process implementation and continues to sustain. The mean had an absolute improvement of 15.5%. The variation from the mean decreased from 25% at baseline to 6% at the end of the control phase. The reduction in variation made our future results more predictable. The use of Lean Six-Sigma DMAIC quality improvement tools are an effective method to improve quality of care in the outpatient setting. These strategies can be replicated for other clinical quality outcomes.


Author(s):  
Ismail Baloglu ◽  
Kultigin Turkmen ◽  
Nedim Selcuk ◽  
Halil Tonbul ◽  
Adalet Ozcicek ◽  
...  

Abstract Introduction and aim Cardiovascular diseases remain the most common cause of morbidity and mortality in patients with diabetes. Epicardial adipose tissue (EAT), visceral fat depot of the heart, was found to be associated with coronary artery disease in cardiac and non-cardiac patients. Increased visceral adiposity is associated with proinflammatory activity, impaired insulin sensitivity, increased risk of atherosclerosis and high mortality. In the present study we aimed to investigate the relationship between EAT and visceral adiposity index (VAI) in patients with diabetes. Methods This was a cross-sectional study involving 128 patients with type 2 diabetes mellitus (73 females, 55 males; mean age, 54.09+±+9.17 years) and 32 control subjects (23 females, 9 males; mean age, 50.09+±+7.81 years). EAT was measured by using a trans-thoracic echocardiograph. Parameters such as waist circumference (WC), body mass index (BMI), triglyceride and high density lipoprotein (HDL) cholesterol were used to calculate VAI. Result EAT and VAI measurements were significantly higher in patients with diabetes when compared to control subjects. In the bivariate correlation analysis, VAI was positively correlated with uric acid level (r=0.214, p=0.015), white blood cell count (r= 0.262, p=0.003), platelet count (r=0.223, p=0.011) and total cholesterol levels (r= 0.363, p<0.001). Also, VAI was found to be the independent predictor of EAT. Conclusion Simple calculation of VAI was found to be associated with increased EAT in patients with type 2 diabetes.


Author(s):  
Asirotul Marifah Marifah

There are still many of our people who have never heard or even seen the shape of the Japanese ants, so sometimes people consume Japanese ants with different doses between people with each other and even some who consume Japanese ants are not appropriate doses because they want to get well soon. The purpose of research to know the relationship between consumption patterns of Japanese ants and blood sugar levels of people with diabetes mellitus. The design of this study is correlational analytic with crossectional approach. Variables of this research there are two that is the pattern of consumption of Japanese ants as an independent variable and blood sugar levels as the dependent variable. The population of this study was all patients with diabetes Mellitus who had suffered > 5 years who consumed Japanese ants in Grinting Village Karangjeruk Village Jatirejo Subdistrict Mojokerto regency as many as 10 respondents. in the sampling of researchers using total sampling technique. Data collection with an observation sheet of Japanese ant consumption and blood sugar level. The result of the research showed that most of the respondents consume Japanese ants regularly as much as 6 respondents (60%) and most respondents have blood sugar level in the normal category that is between 100-125 mg/dl as many as 6 respondents (60%). Consumption Japanese ants can routinely lower blood sugar levels of people with diabetes mellitus because ants contain enzymes that can keep blood sugar levels diabetics.


Author(s):  
Bengur Taskiran ◽  
Guven Baris Cansu

Background: Diabetes education, as an essential component of diabetes management, improves various aspects of diabetes mellitus including lowering Haemoglobin A1c. There is a number of surveys evaluating diabetes knowledge.Methods: The purpose of this study to measure diabetes knowledge of patients with diabetes mellitus after a structured group education programme named as diabetes school. This study is an observational study and the design is a cohort study. The study took place in 2017-2018. The duration of follow-up is 4 weeks. Fifty-four patients aged over 18 with a previous diagnosis of diabetes mellitus, who attended to the diabetes school education programme, were included to the study. Twenty-three patients participated in the true-false version of the revised Michigan diabetes knowledge questionnaire before and after the programme.Results: Twenty female and 3 male patients were aged 60.43±9.97 years. The scores improved significantly after the education programme (7.61±4.59 vs 12.39±3.35, p<0.0001). The number of patients correctly identifying more than half of the statements showed a steep increase after the programme (n=6, 26.0% vs n=17, 73.9%). Before education programme 13 had poor knowledge, 9 had moderate, and 1 had good knowledge. After completion 6 had poor knowledge, 11 had moderate, and 5 had good knowledge.Conclusions: Diabetes school is effective in improving diabetes knowledge in patients with diabetes mellitus. Revised Michigan Diabetes Knowledge Questionnaire can be used to evaluated diabetes knowledge. It may aid to detect the subgroup of patients who are lack knowledge of various aspects of diabetes mellitus.


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