scholarly journals Nanoemulsion: A Review on Novel Profusion in Advanced Drug Delivery

2014 ◽  
Vol 2 (01) ◽  
pp. 122-127 ◽  
Author(s):  
Rohit Rajendra Bhosale ◽  
Riyaz Ali Osmani ◽  
Prasanna Prasad Ghodake ◽  
Sabir Majjid Shaikh ◽  
Sarika Raghunath Chavan
Keyword(s):  
Drug Delivery ◽  
Single Phase ◽  
Droplet Diameter ◽  
Drug Carriers ◽  
Therapeutic Agents ◽  
Immiscible Liquid ◽  
Great Promise ◽  
Extensive Investigation ◽  
Systemic Delivery ◽  
Micron Size

Nanoemulsions are submicron sized emulsion that is under extensive investigation as drug carriers for improving the delivery of therapeutic agents. These are by far the most advanced nanoparticle systems for the systemic delivery of active pharmaceutical for controlled drug delivery and targeting. These are the thermodynamically stable isotropic system in which two immiscible liquid (water and oil) are mixed to form a single phase by means of an appropriate surfactants or it mixes with a droplet diameter approximately in the range of 0.5-100 μm. Nanoemulsion droplet size falls typically in the range of 20-200 nm and shows a narrow size distribution. Nanoemulsion show great promise for the future of cosmetics, diagnostics, drug therapies and biotechnologies. Thus the aim of this review is focused on nanoemulsion advantage and disadvantage, various methods of preparation, characterization techniques and the various applications of sub micron size emulsion in different areas such as various route of administration, in chemotherapy, in cosmetic, etc.

scholarly journals A REVIEW ON NANOEMULSIONS: FORMULATION, COMPOSITION, AND APPLICATIONS

2021 ◽  
pp. 22-28
Author(s):  
KHAN MOHAMMAD HAMID ◽  
MOHAMMAD WAIS ◽  
GAURANG SAWANT
Keyword(s):  
Drug Delivery ◽  
Droplet Diameter ◽  
Controlled Drug Delivery ◽  
Drug Carriers ◽  
Therapeutic Agents ◽  
Potential Drug ◽  
Systemic Delivery ◽  
Routes Of Administration ◽  
Detailed Assessment ◽  
Nanoparticulate Systems

Nanoemulsions are sub-micron sized emulsions that are undergoing detailed assessment as potential drug carriers for enhancing the delivery of therapeutic agents. These are to date the most developed nanoparticulate systems for the systemic delivery of active pharmaceutical for controlled drug delivery as well as targeting. These are the thermodynamically durable isotropic system, in which two incompatible liquids (water and oil) are blended to form a single homogenous phase by utilizing a required quantity of surfactants to achieve mixing with a droplet diameter approaching roughly in the range of 0.5–100 μm. They find applications in various fields such as cosmetics as well as are adopted in various routes of administration.

scholarly journals LIPOSOMES: A NOVEL DRUG DELIVERY SYSTEM

2017 ◽  
Author(s):  
Ayesha Naeem
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Size Range ◽  
Drug Carriers ◽  
Therapeutic Agents ◽  
Extensive Investigation ◽  
System P ◽  
Novel Drug Delivery System ◽  
Novel Drug ◽  
Aqueous Volume

Liposomes derived from two Greek words:Lipo(FAT) and soma(BODY).It is so named because of its composition is primarily of phopholipid.Liposomes are microparticulate lipoidal vesicales which are under extensive investigation as drug carriers for improving the drug delivery of therapeutic agents,relatively composed of biocompatible and bio degradable materials,and they consists of an aqueous volume entrapped by one or more bilayers of natural or synthetic lipids.A liposome is a spherical veicle having at least one lipid bilayer.the liposomes can be used as a vehicle for administration of nutrients and pharmaceutical drugs.liposomes can be prepared by disrupting biological membranes(such as by sonication).Size range:25-5000nm.

Liposome: A Powerful Approach Festinates Drug Delivery System

2010 ◽  
Vol 3 (1) ◽  
Author(s):  
Pawar Vinita ◽  
Mishra Shiv ◽  
Yadav Mahavir ◽  
Tiwari Archana
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Tumor Targeting ◽  
Drug Carriers ◽  
Therapeutic Agents ◽  
Extensive Investigation ◽  
Drug Molecules ◽  
Powerful Approach ◽  
Sites Of Action

Drug delivery systems have become important tools for the specific delivery of a large Number of drug molecules. Liposomes are microparticulate lipoidal vesicles which are under extensive investigation as drug carriers for improving the delivery of therapeutic agents. Initially they were used to study biomembrane behavior but later on developed into a drug delivery system for targeting specific sites of action like the tumor targeting, gene and antisense therapy, genetic vaccination, immunomodulation, topical, cytosolic, and respiratory various infections etc.

scholarly journals Plant/Bacterial Virus-Based Drug Discovery, Drug Delivery, and Therapeutics

Pharmaceutics ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 211 ◽  
Author(s):  
Esen Sokullu ◽  
Hoda Soleymani Abyaneh ◽  
Marc A. Gauthier
Keyword(s):  
Drug Delivery ◽  
Drug Discovery ◽  
Genetic Material ◽  
Drug Carriers ◽  
Plant Viruses ◽  
Therapeutic Agents ◽  
Biotechnological Applications ◽  
Challenges And Opportunities ◽  
Therapeutic Peptides ◽  
Organ Targeting

Viruses have recently emerged as promising nanomaterials for biotechnological applications. One of the most important applications of viruses is phage display, which has already been employed to identify a broad range of potential therapeutic peptides and antibodies, as well as other biotechnologically relevant polypeptides (including protease inhibitors, minimizing proteins, and cell/organ targeting peptides). Additionally, their high stability, easily modifiable surface, and enormous diversity in shape and size, distinguish viruses from synthetic nanocarriers used for drug delivery. Indeed, several plant and bacterial viruses (e.g., phages) have been investigated and applied as drug carriers. The ability to remove the genetic material within the capsids of some plant viruses and phages produces empty viral-like particles that are replication-deficient and can be loaded with therapeutic agents. This review summarizes the current applications of plant viruses and phages in drug discovery and as drug delivery systems and includes a discussion of the present status of virus-based materials in clinical research, alongside the observed challenges and opportunities.

scholarly journals Improving Curcumin Bioavailability: Current Strategies and Future Perspectives

Pharmaceutics ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 1715
Author(s):  
Rita Tabanelli ◽  
Simone Brogi ◽  
Vincenzo Calderone
Keyword(s):  
Drug Delivery ◽  
Therapeutic Agents ◽  
Future Perspective ◽  
Great Promise ◽  
Delivery Methods ◽  
Curcumin Nanoparticles ◽  
Advanced Technologies ◽  
Problematic Drug ◽  
Clinical Trial Results ◽  
Poor Absorption

Curcumin possesses a plethora of interesting pharmacological effects. Unfortunately, it is also characterized by problematic drug delivery and scarce bioavailability, representing the main problem related to the use of this compound. Poor absorption, fast metabolism, and rapid systemic clearance are the most important factors contributing to low curcumin levels in plasma and tissues. Accordingly, to overcome these issues, numerous strategies have been proposed and are investigated in this article. Due to advances in the drug delivery field, we describe here the most promising strategies for increasing curcumin bioavailability, including the use of adjuvant, complexed/encapsulated curcumin, specific curcumin formulations, and curcumin nanoparticles. We analyze current strategies, already available in the market, and the most advanced technologies that can offer a future perspective for effective curcumin formulations. We focus the attention on the effectiveness of curcumin-based formulations in clinical trials, providing a comprehensive summary. Clinical trial results, employing various delivery methods for curcumin, showed that improved bioavailability corresponds to increased therapeutic efficacy. Furthermore, advances in the field of nanoparticles hold great promise for developing curcumin-based complexes as effective therapeutic agents. Summarizing, suitable delivery methods for this polyphenol will ensure the possibility of using curcumin-derived formulations in clinical practice as preventive and disease-modifying therapeutics.

scholarly journals Cellular Uptake and Intracellular Cargo Release From Dextran Based Nanogel Drug Carriers

2013 ◽  
Vol 4 (1) ◽  
Author(s):  
M. Carme Coll Ferrer ◽  
Peter Sobolewski ◽  
Russell J. Composto ◽  
David M. Eckmann
Keyword(s):  
Drug Delivery ◽  
Drug Carriers ◽  
Mononuclear Phagocyte ◽  
Epifluorescence Microscopy ◽  
Great Promise ◽  
Target Cells ◽  
Human Umbilical Cord ◽  
Target Tissue ◽  
Delivery Platform

Nanogels (NG) hold great promise as a drug delivery platform. In this work, we examine the potential of lysozyme-dextran nanogels (LDNG) as drug carriers in vitro using two cell lines: a model target tissue, human umbilical cord vein endothelial cells (HUVEC) and a model of the mononuclear phagocyte system (phorbol 12-myristate 13-acetate (PMA)-stimulated THP-1 cells). The LDNG (∼100 nm) were prepared with rhodamine-label dextran (LRDNG) via Maillard reaction followed by heat-gelation reaction and were loaded with a fluorescent probe, 5-hexadecanoylaminofluorescein (HAF), as a mock drug. Epifluorescence microscopy confirmed rapid uptake of LRDNG by HUVEC. Although LysoTracker Green staining indicated a lysosomal fate for LRDNG, the mock drug cargo (HAF) diffused extensively inside the cell within 15 min. Flow cytometry and confocal microscopy indicated slow uptake of LRDNG in PMA-stimulated THP-1 cells, with only 41% of cells containing LRDNG after 24 h exposure. Finally, 24 h exposure to LRDNG did not affect the viability of either cell type at the dose studied (20 μg/ml). At a higher dose (200 μg/ml), LRDNG resulted in a marked loss of viability of HUVEC and THP-1, measuring 30% and 38%, respectively. Collectively, our results demonstrate the great potential of LRDNG as a drug delivery platform, combining simple production, rapid uptake and cargo release in target cells with “stealth” properties and low cytotoxicity.

The Role of Nano-ophthalmology in Treating Dry Eye Disease

2020 ◽  
Vol 8 (4) ◽  
pp. 258-289
Author(s):  
Subramanian Natesan ◽  
Sai H.S. Boddu ◽  
Venkateshwaran Krishnaswami ◽  
Moyad Shahwan
Keyword(s):  
Drug Delivery ◽  
Dry Eye ◽  
Therapeutic Agents ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Great Promise ◽  
Sustained Delivery ◽  
Multifactorial Disease ◽  
Site Specific ◽  
Preclinical And Clinical Studies

: Dry eye disease (DED) is a common multifactorial disease linked to the tears/ocular surface leading to eye discomfort, ocular surface damage, and visual disturbance. Antiinflammatory agents (steroids and cyclosporine A), hormonal therapy, antibiotics, nerve growth factors, essential fatty acids are used as treatment options of DED. Current therapies attempt to reduce the ocular discomfort by producing lubrication and stimulating gland/nerve(s) associated with tear production, without providing a permanent cure for dry eye. Nanocarrier systems show a great promise to revolutionize drug delivery in DED, offering many advantages such as site specific and sustained delivery of therapeutic agents. This review presents an overview, pathophysiology, prevalence and etiology of DED, with an emphasis on preclinical and clinical studies involving the use of nanocarrier systems in treating DED. Lay Summary: Lay Summary: Dry eye disease (DED) is a multifactorial disease associated with tear deficiency or excessive tear evaporation. There are several review articles that summarize DED, disease symptoms, causes and treatment approaches. Nanocarrier systems show a great promise to revolutionize drug delivery in DED, offering many advantages such as site specific and sustained delivery of therapeutic agents. Very few review articles summarize the findings on the use of nanotherapeutics in DED. In this review, we have exclusively discussed the preclinical and clinical studies of nanotherapeutics in DED therapy. This information will be attractive to both academic and pharmaceutical industry researchers working in DED therapeutics.

Nanoemulsion as Oral Drug Delivery - A Review

2020 ◽  
Vol 12 (1) ◽  
pp. 4-15 ◽  
Author(s):  
Khaleel Basha Sabjan ◽  
Syed Muzammil Munawar ◽  
Dhandayuthabani Rajendiran ◽  
Sugantha Kumari Vinoji ◽  
Kaviyarasu Kasinathan
Keyword(s):  
Drug Delivery ◽  
Oral Drug Delivery ◽  
Drug Stability ◽  
Drug Carriers ◽  
Therapeutic Agents ◽  
Oral Drug ◽  
Advantages And Disadvantages ◽  
Insoluble Drugs ◽  
The Stability ◽  
Near Future

Background: Objective:: The stability and delivery of drugs remain one of the key hurdles in the present situation. The present study depends on the design of a novel nanoemulsion drugdelivery system that would encapsulate a drug and to improve drug stability. The charisma of nanotechnology is majorly due to the smallest particle size at the nanoscale. Methods: Nanoemulsions attention is focused on emphasizing formulation aspect, method of preparation characterization techniques, evaluation parameters and various application of the nanoemulsions, several techniques to be used for the preparation of nanoemulsions like microfluidization, high-pressure homogenization, low energy emulsification and solvent evaporation method and their parameters to be characterized. Results: The design of effective formulations for drugs is being applied to enhance the solubility and bioavailability of water-insoluble drugs. The nanosized droplets have led to considerable attraction for this formulation, for the delivery of hydrophilic as well as hydrophobic drugs as drug carriers because of their improved drug solubilization capacity, long shelf life, ease of preparation and improvement of bioavailability of drugs. Conclusion: The application of these nanoformulation preparations, limitations, their advantages and disadvantages as nanoemulsions will solve the various problems that current therapeutic agents face and has opened a new scenario to formulate nanoemulsions with various therapeutic agents with heightened competence along with oral drug delivery to treat diseases in the near future.

Antithrombotic Therapy for DVT/PE

1997 ◽  
Vol 17 (03) ◽  
pp. 161-162
Author(s):  
Thomas Hyers
Keyword(s):  
Molecular Weight ◽  
Low Molecular Weight Heparin ◽  
Oral Anticoagulants ◽  
Cost Effective ◽  
Therapeutic Agents ◽  
Great Promise ◽  
Term Therapy ◽  
Low Molecular Weight ◽  
Long Term Therapy

SummaryProblems with unfractionated heparin as an antithrombotic have led to the development of new therapeutic agents. Of these, low molecular weight heparin shows great promise and has led to out-patient therapy of DVT/PE in selected patients. Oral anticoagulants remain the choice for long-term therapy. More cost-effective ways to give oral anticoagulants are needed.

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