Prevention of complications of pregnancy and childbirth of patients with a burdensome gynecological anamnesis

The objective: determination of the effectiveness of prevention and medicinal correction of placental dysfunction in pregnant women with chronic salpingo-oophoritis.Materials and methods. The study included 100 pregnant women (basic group) with chronic salpingo-oophoritis, of these, I group (50 women) included patients who received proposed treatment and prevention approach, II group (50 women) received a common set of treatment and prevention measures. The proposed treatment-and-prophylactic approach included prophylactic administration to pregnant women with chronic salpingo-oophoritis from the 8th to the 10th and from the 16th to the 18th week inclusive of natural micronized progesterone at a dose of 100 mg intravaginally twice a day for two weeks. Venotonik and angioprotector were prescribed prophylactically at dose 600 mg from 18 weeks to 37-38 weeks of pregnancy. For therapeutic purposes (blood flow disorders in the uterine arteries and vessels of the umbilical cord that are determined by Doppler), the drug was prescribed at dose 600 mg twice a day for 3–4 weeks.Results. A lower frequency of obstetric and perinatal complications was found in the women in I group than in the patients in the II group. Thus, the rate of placental dysfunction was 6.0±3.36% vs. 34.0±6.7%, respectively, oligohydramnios – 6.0±3.36% and 12.0±4.59%, polyhydramnios – 10.0±4.24% and 22.0±5.86%, fetal distress during childbirth – 6.0±3.36% and 14.0±4.91%, cesarean section – 12.0±4.6% and 24.0±4.27%. In the group of patients with treatment-and-prophylactic approach, the mean of the body weight of newborns was 3486.7±312.71 g, and in women who received a common set of treatment-and-prophylactic measures – 3099.8±295.69 g. The mean of the assessment of the condition of newborns by the Apgar scale at the 1st minute – 7.92±1.54 and 6.81±1.16 points, respectively.Conclusions. The use of micronized natural progesterone and the drug diosmin 600 mg in pregnant women with a history of chronic salpingo-oophoritis reduces the rate of obstetric and perinatal complications during pregnancy.

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PERINATAL ASPECTS OF PREGNANCY AND CHILDBIRTH ON THE BACKGROUND OF VITAMIN D LACK IN PREGNANT WOMEN

Wiadomości Lekarskie ◽

10.36740/wlek202110210 ◽

2021 ◽

Vol 74 (10) ◽

pp. 2585-2587

Author(s):

Vitaliy V. Maliar

Keyword(s):

Vitamin D ◽

Blood Serum ◽

Pregnant Women ◽

Perinatal Outcomes ◽

Fetal Distress ◽

Test System ◽

Perinatal Complications ◽

Pregnancy And Childbirth ◽

Wide Range ◽

Pregnancy And Delivery

The aim: To study the features of the course of gestation and perinatal outcomes of delivery in women with vitamin D lack. Materials and methods: The article presents the results of studies of the characteristics of the course of pregnancy and delivery outcomes in 50 patients with vitamin D lack compared with a group of 50 somatically healthy pregnant women with normal level of 25 (OH) D. In order to establish a lack of vitamin D in pregnant women in the 10-12, 20-22, 30-32 weeks of gestation electrochemiluminiscence method by using a test system EURIMMUN (Germany) in the blood serum level of 25-hydroxycalciferol (25 (OH) D) in pregnant women. Results: When analyzing the structure of complications in women with vitamin D lack during pregnancy and childbirth we found out that risk of premature birth and premature births dominated among all the complications, respectively (58.0% and 36.0%) against (12.0% and 16.0%), p <0.05. Vitamin D lack in pregnant women is often associated with a wide range of obstetric and perinatal complications, namely: preeclampsia, gestational diabetes, bacterial vaginosis , premature rupture of membranes, placental abruption, abnormal labor activity, fetal distress that required delivery by Caesarean section. Conclusions: An analysis of the course of pregnancy and childbirth in women of thematic groups proved the expediency of an individual approach to the therapy of obstetric pathology among women with vitamin D lack. Despite the level of 25 (OH) D in the blood serum of a pregnant woman of 30 ng / ml and below, it is advisable to prescribe vitamin D for prophylaxes and treatment of Vitamin D deficiency in mother and fetus.

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Pregnancy after influenza in the first trimester

HEALTH OF WOMAN ◽

10.15574/hw.2020.153.14 ◽

2018 ◽

pp. 14-18

Author(s):

V.V. Kaminskyi ◽

◽

O.I. Zhdanovich ◽

T.V. Kolomiychenko ◽

A.D. Derkach ◽

...

Keyword(s):

Pregnant Women ◽

High Frequency ◽

Clinical Manifestations ◽

Birth Asphyxia ◽

Fetal Distress ◽

First Trimester ◽

Placental Insufficiency ◽

Perinatal Complications ◽

Placental Dysfunction ◽

First Trimester Of Pregnancy

The endpoint of the negative impact of adverse processes in the mother’s body with influenza is the formation of placental insufficiency, the basis of which is a violation of the uteroplacental blood flow. The objective: to study the features of the course of pregnancy, the state of the fetus and the newborn after the influenza in the first trimester of pregnancy. Materials and methods. 120 women who had the influenza in the first trimester of pregnancy were examined. In 68 (56.7%) pregnant women signs of feto-placental dysfunction were observed, 2 groups were distinguished: the main group - 68 patients with feto-placental dysfunction, the comparison group – 52 pregnant women without signs of feto-placental insufficiency. Results. 3 times more often than women without manifestations of placental insufficiency (42.6% versus 15.4%; p<0.05) a severe course of influenza was observed, it accompanied by a high frequency of clinical manifestations, including in almost all patients (95.6% versus 67.3%; p<0.05), body temperature rose to 38 °C and higher, and in 61.7% of women it stayed for 4–6 days (versus 11.5%; p<0.05). Among the complications of influenza: bronchitis (25.0% versus 9.3%; p<0.05), pneumonia (17.6% versus 5.7%; p<0.05), sinusitis (17.6% versus 7.7%; p<0.05). The threat of abortion was noted in 57.4% of cases, the threat of preterm birth was observed in 39.7% of women. Most often, placental dysfunction was associated with fetal distress (76.5% versus 13.5%; p<0.05) and growth retardation (54.4% versus 3.8%; p<0.05). 32.4% versus 13.5% of women had preeclampsia (p<0.05). The frequency of both polyhydramnios (17.6%) and low water (10.3%) is significantly higher. By cesarean section, 35.3% women were delivered (versus 15.4%, (p<0.05). Delivery was preterm in 17.6% of women versus 7.7% (p<0.05). Premature discharge of amniotic fluid (17.6%) and pathological blood loss during childbirth (16.2%), fetal distress during childbirth (48.5% versus 9.6%; p<0.05) were noted. Maternal placental dysfunction, fetal distress, prematurity (17.6%) and malnutrition (22.1%) led to a high incidence of birth asphyxia (46.5% versus 19.2%, p <0.05). Half (51.5%) of children had disadaptation syndromes, most often neurological disorders (32.4% versus 11.5%; p<0.05) and respiratory disorders (27.9% versus 7.7%; p<0.05). Conclusion. Influenza in early pregnancy with a severe course and a high frequency of complications is associated with a high frequency of feto-placental dysfunction and other obstetric and perinatal complications, which requires a more detailed study to determine risk factors and develop tactics for managing this category of pregnant women. Keywords: pregnancy, influenza, feto-placental dysfunction, obstetric and perinatal complications, newborn.

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КОМПЛЕКС ПРОФІЛАКТИЧНИХ ЗАХОДІВ ДЛЯ ВАГІТНИХ ПІСЛЯ ДРТ З ВИСОКИМ РИЗИКОМ ПРЕЕКЛАМПСІЇ

World Science ◽

10.31435/rsglobal_ws/30122020/7279 ◽

2020 ◽

pp. 1-6

Author(s):

Камінський В’ячеслав Володимирович ◽

Коломійченко Тетяна Василівна ◽

Жданович Олексій Ігоревич ◽

Рогава Ірина Володимирівна

Keyword(s):

Pregnant Women ◽

Perinatal Outcomes ◽

Fetal Distress ◽

Pregnancy And Childbirth ◽

System Reduction ◽

Vascular Regulation ◽

Prophylactic Measures ◽

Neonatal Adaptation ◽

Gynecological Care

The purpose of the study: to evaluate the effectiveness of the proposed set of preventive measures for pregnant women after ART with a high risk of preeclampsia. Material and methods. To test the effectiveness of the proposed set of prophylactic measures, 60 pregnant women after ART were selected, which were randomly divided into 2 groups: 30 women who received the recommended complex (main group) and 30 women (comparison group), whose preeclampsia was prevented by order of the Ministry of Health. № 417 "Guidelines for the provision of outpatient obstetric and gynecological care." Results. The use of the recommended measures improves lipid metabolism (significant reduction of triglycerides and low density cholesterol), eliminates vitamin D deficiency, balances the cytokine profile (reduction of proinflammatory focus), reduces the prothrombotic potential of the hemostasis system (reduction of D-dimer and background marker damage). Improving the general condition and the use of psychotherapy can reduce the manifestations of vegetative-vascular dystonia, anxiety and improve quality of life. Such changes provide a more favorable background for the development of gestation. The incidence of preeclampsia decreased by 43.8% (from 26.7 to 15.0%), and mainly due to early preeclampsia, the incidence of which decreased by 78%, no cases of severe preeclampsia were reported. The frequency of placental insufficiency, fetal distress and growth retardation is reduced. The frequency of birth of children in a state of asphyxia is reduced by 2 times (up to 20.0 vs. 46.7%), severe asphyxia is not observed. Significantly lower and the frequency of violations of the period of neonatal adaptation (30.0 vs. 53.3%). Conclusions. The use of treatment and prophylactic complex to prevent preeclampsia in pregnant women after ART can improve a woman's homeostasis, balance vegetative-vascular regulation, reduce the incidence of preeclampsia by 43.8% (from 26.7 to 15.0%) and other complications of pregnancy and childbirth, improve perinatal outcomes. Proven medical, social and economic efficiency of the developed complex allows to recommend it for implementation in medical practice.

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Великі акушерські синдроми – сучасні можливості профілактики

HEALTH OF WOMAN ◽

10.15574/hw.2018.132.67 ◽

2018 ◽

pp. 67-72

Author(s):

T.G. Romanenko ◽

◽

O.M. Sulimenko ◽

Keyword(s):

Statistical Analysis ◽

High Risk ◽

Pregnant Women ◽

Fetal Distress ◽

Placental Insufficiency ◽

Control Group ◽

Fetal Growth Retardation ◽

Prophylactic Measures ◽

Pathological Pregnancy ◽

Micronized Progesterone

The objective: was to reduce the incidence and severity of the development of «Great Obstetrical Syndromes»: miscarriage of pregnancy, placental insufficiency, fetal growth retardation and / or fetal distress, preeclampsia, premature detachment of a normally located placenta, premature delivery, by developing an algorithm for prophylaxis during pregnancy in women at high risk for their development. Materials and methods. Clinical and statistical analysis of pregnancy in 88 pregnant women with high risk of decompensation of placental insufficiency was conducted. Depending on the method of preventing complications, 2 groups were formed. The I group included 58 pregnant women who were offered the following algorithm: micronized progesterone 200 mg PV from 6 to 20 weeks of gestation; from 21 to 26 weeks of gestation and from 31 to 36 weeks; phleboprotector with ultra-micronized fractions of bioflavonoids (Flego) 15 ml per os; with subsequent appointment from 21 to 26 weeks of gestation; and from 31 to 36 weeks. Group II included 30 pregnant women who had abandoned any proposed prophylactic measures. The control group consisted of 30 healthy pregnant women. Clinical and statistical analysis of pregnancy in the study groups was conducted. During statistical processing, personal computer and software Microsoft Excel XP and Statistica 6.0 Windows, methods of descriptive statistics, correlation analysis were used. The reliability of the difference between the indicators is estimated by the Student-Fisher criterion. Results. The method of prophylaxis of «Great Obstetrical Syndromes» by sequential administration from the early stages of pregnancy of micronized progesterone with the following appointment – from the second trimester of pregnancy – showed a high efficacy of the phleboprotector, which is manifested in a significantly lower number of cases of preeclampsia in the main group of 3.5% (2) versus 50% (15) in the control group, placental insufficiency was 13.8% (8) versus 100% (30); fetal growth retardation was 5.2% (3) versus 56.7% (17); fetal distress was 3.5% (2) versus 43 , 3% (13), preterm labor 1.7% (1) versus 13.3% (4) and in the absence of premature detachment normal but located on the placenta, severe forms of preeclampsia and placental insufficiency. Conclusions. Pregnant of «Great Obstetrical Syndromes» risk groups need timely prophylactic measures to reduce the likelihood of a pathological pregnancy and improve perinatal outcomes. The proposed prophylaxis scheme significantly lowered the incidence of large obstetric syndromes and improved neonatal outcomes. Key words: great obstetrical syndromes, pathological pregnancy, placental dysfunction, phleboprotector.

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Influence of pregnancy on iron and copper exchange rates in women with normal body weight and women with obesity

Russian Clinical Laboratory Diagnostics ◽

10.51620/0869-2084-2021-66-4-205-209 ◽

2021 ◽

Vol 66 (4) ◽

pp. 205-209

Author(s):

E. L. Makarova ◽

N. A. Terekhina

Keyword(s):

Body Weight ◽

Blood Serum ◽

Pregnant Women ◽

Copper Metabolism ◽

The Body ◽

Reproductive Age ◽

Perinatal Complications ◽

Effective Prevention ◽

Normal Body ◽

Normal Body Weight

The number of obese pregnant women increases annually and reaches 20-30%. The metabolism of hormones and minerals changes in the presence of a large amount of adipose tissue in the body of a pregnant woman, which leads to a number of obstetric and perinatal problems. The aim of the work is to study and compare the influence of the gestational process on the indicators of iron and copper metabolism in the blood serum of women with normal body weight and women with obesity. In the blood serum of 125 women of reproductive age, the content of hemoglobin, iron, transferrin, ferritin, copper and ceruloplasmin was determined. The influence of pregnancy on the indicators of iron and copper metabolism in the blood serum of women was revealed. Pregnancy in women with normal body weight increases the content of transferrin and ceruloplasmin. Correlation of ceruloplasmin and ferritin content with body mass index of obese pregnant women was revealed. In pregnancy with concomitant obesity, hyperferritinemia is formed with a reduced content of hemoglobin and serum iron. Knowledge of the indicators of iron and copper metabolism is necessary to optimize the observation of pregnant women, effective prevention and prediction of obstetric and perinatal complications.

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Specific Characteristics of Bioelectric Activity of the Brain in Women with Placental Dysfunction Considering the Type of Psychological Component of Gestation Dominant

Archive of Clinical Medicine ◽

10.21802/acm.2018.2.2 ◽

2018 ◽

Vol 24 (2) ◽

Author(s):

Nataliya Henyk ◽

Nataliya Yakumchuk

Keyword(s):

Pregnant Women ◽

Comparison Group ◽

Clinical Symptoms ◽

Gestational Hypertension ◽

Fetal Distress ◽

Main Group ◽

Software Complex ◽

Placental Dysfunction ◽

Psychological Component ◽

Attitude Test

The study of the influence of the autonomic nervous system on the course of pregnancy, childbirth and fetal state remains relevant. Changes in the parameters of electroencephalography may be detected long before the onset of clinical symptoms in the complicated course of pregnancy. The objective of the research was to evaluate electroencephalography in women with placental dysfunction and gestational complications taking into account the type of psychological component of gestation dominant. Materials and methods. Electroencephalography was performed in 60 pregnant women at the age of 19 to 45 years with gestational hypertension and fetal distress during pregnancy. The main group included 40 patients, who were stratified according to the type of psychological component of gestation dominant: 10 patients with euphoric type, 20 pregnant women with anxious and depressive type, 10 patients with hypogestognostic type. The comparison group comprised 20 patients with optimal type of psychological component of gestation dominant and normal course of the first half of pregnancy. The assessment of psychological component of gestation dominant was carried out according to the method proposed by Dobriakov I.V. - "Pregnant woman attitude test". Registrations, spectral and coherent analysis of electroencephalography were performed using BrainTest-24 hardware and software complex. \textbf{Results and discussion. }Electroencephalography of the patients of the comparison group was in line with current concepts regarding the physiological norm. In the main group, there were the following changes in electroencephalography: non-sinusoidal forms of alpha-oscillations (77.5%), high index of fast rhythms, flashes of spike waves under load, disturbances of the frontal occipital gradient with the focus on the anterior sections of the hemispheres. Conclusions. The use of electroencephalography in women with different types of psychological component of gestation dominant in case of progressive placental dysfunction and preeclampsia on its background allows identifying characteristic changes, modifying the program of therapeutic measures, differentiating obstetric tactics and terms of delivery.

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Morphological identification of Nematodirus spathiger nematodes (Nematoda, Molineidae) obtained from the small intestine of sheep

Regulatory Mechanisms in Biosystems ◽

10.15421/022119 ◽

2021 ◽

Vol 12 (1) ◽

pp. 121-127

Author(s):

V. Melnychuk ◽

V. Yevstafieva ◽

M. Pishchalenko ◽

O. Reshetylo ◽

A. Antipov

Keyword(s):

Small Intestine ◽

Experimental Studies ◽

The Body ◽

Economic Losses ◽

Domestic Sheep ◽

Morphological Identification ◽

Prevention Measures ◽

Morphometric Characters ◽

Treatment And Prevention ◽

Delayed Growth

Strongyloidiases are caused by nematodes of the suborder Strongylida and are the most widely prevalent group of gastrointestinal helminthiases of sheep in many regions of the world. Among gastrointestinal strongylids, the helminths of the genus Nematodirus are represented by the largest number of species and highest infection rates in sheep. Nematodirosis causes significant economic losses in the sheep industry through decreased sheep productivity, delayed growth and development of young animals, and a reduced resistance to other diseases. Timely and accurate diagnosis of nematodirosis and identification of the pathogen will effectively prevent the disease and help to carry out treatment and prevention measures. Therefore, the aim of the work was to study the definitive morphometric characters of mature males and females of Nematodirus spathiger Railliet, 1896, obtained from the small intestine of domestic sheep. The results of experimental studies showed that nematodes of this species morphologically are characterized by a thin filiform body, a vesicle at the head end and a chitinous tooth in a short oral capsule. The differential morphological features of male nematodes of N. spathiger include specifics of the structure of spicules, their distal end and the shape and location of the rays of the caudal bursa; in females, those are the features of the structure of the vulva and tail end. In identification of male nematodes of N. spathiger, it is proposed to use 40 metric parameters, of which 11 characterize the overall size of the body, esophagus and vesicles, 24 refer to the size of the tail bursa, 5 to the size of the spicules and the enveloping membrane. To help identify the females of N. spathiger, 25 parameters are chosen, of which 14 also characterize the overall size of the body, esophagus and head vesicle, 6 refer to the size of the cuticular formations of the vulva and its location, and 5 to the size of the tail end, the location of the anus and the size of the tail spike.

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Characteristics of early pregnancy and prevention of gestational and perinatal complications in women with metabolic syndrome

Obesity and metabolism ◽

10.14341/omet2017457-66 ◽

2017 ◽

Vol 14 (4) ◽

pp. 57-66

Author(s):

Igor' S. Lipatov ◽

Yurii V. Tezikov ◽

Andrei D. Protasov ◽

Nadezhda V. Martynova ◽

Anna A. Bukreeva ◽

...

Keyword(s):

Metabolic Syndrome ◽

Pregnant Women ◽

Early Pregnancy ◽

Perinatal Outcomes ◽

Preventive Treatment ◽

Number Needed To Treat ◽

Perinatal Complications ◽

Group Iii ◽

Placental Dysfunction ◽

Group I

Introduction. Based on the knowledge of early gestational disorders related to metabolic syndrome (MS), pathogenetically relevant preventive treatment meeting the requirements of perinatal pharmacology can be developed. Aim. To reveal clinical and laboratory characteristics of early pregnancy and develop pathogenetically relevant preventive monotherapy for unfavorable gestational and perinatal outcomes in women with metabolic syndrome. Material and methods. A total of 230 women were investigated and divided into four groups: Group I consisted of 68 pregnant women with MS who refused any preventive measures; Group II comprised 97 women with MS who received periconceptional preventive monotherapy with dydrogesterone, a progestagen; Group III consisted of 35 healthy primigravidas women with physiological course of gestation; Group IV comprised 30 healthy non-pregnant women. Laboratory testing during IIII trimesters allowed to assess the dynamics demonstrated by markers of lipid spectrum, endothelial dysfunction, apoptosis, decidualization, energy metabolism, and immunomodulation. Results. A balance between factors of physiological damage and gestational adaptation in the course of physiological pregnancy has been shown to be of primary significance. In women with MS, embryo-placental dysfunction develops during early pregnancy, and this stage is preceding for major obstetric syndromes. Preventive administration of dydrogesterone in women with MS appeared highly effective: NNT (number needed to treat) was 1.33 (95% CI 0.91.8); OR 5.2 (95% CI 4.65.7). Conclusion. Pregestational changes and atherogenic profile of gestational process determine the course of early pregnancy in women with MS with the development of embryo-placental dysfunction and major obstetric syndromes. High efficacy in the prevention of unfavorable gestational and perinatal outcomes was shown by preventive dydrogesterone monotherapy.

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Modern views on the prevention of obstetric and perinatal complications in healthy pregnant women (Literature review)

Reproductive health of woman ◽

10.30841/2708-8731.1.2021.229715 ◽

2021 ◽

Vol 1 ◽

pp. 49-53

Author(s):

Y.V. Nevyshnа

Keyword(s):

Pregnant Women ◽

Birth Asphyxia ◽

Obstetric Care ◽

Married Couples ◽

Positive Influence ◽

Partner Support ◽

Perinatal Complications ◽

Preparation Methods ◽

Pregnancy And Childbirth

This review article provides information on the role of different methods for pregnant women to prepare for childbirth according to the data regarding both foreign and domestic practices in obstetrics. The article highlights the issue of partner support starting from when pregnancy is established and gestation, through to childbirth and the postpartum period. According to the research, it is clear that the physiological course of the pregnancy directly depends on the psycho-emotional state of a pregnant woman, which impacts not only the course of pregnancy and childbirth, but also the condition of the fetus and newborn.The results of the research show that the method of psychophysiological preparation and partner support undoubtedly has a positive influence on the consequent childbirth: the duration of childbirth and the frequency of anomalies during maternity activity are reduced; surgery is performed less; the frequency of cervical and perineum ruptures, as well as the amount of blood loss, are decreased; intrauterine hypoxia and birth asphyxia are less common; and the manifestation of obstetric aggression decreases. Furthermore, the technologies of prenatal preparation are aimed at the demedicalization of childbirth and the minimization of the use of pharmacological drugs which have an ambiguous influence on a parturient, a fetus and a newborn.Therefore, the data mentioned above reveal the role of prenatal preparation methods of married couples for childbirth not only in the reduction of obstetric and perinatal complications in relatively healthy, pregnant women, but also in the choice of anesthesia methods, taking safety and efficiency into account.Unfortunately, the decreased interest toward psychophysiological preparation for childbirth by pregnant women and their partners, as well as medical institutions in general, was revealed while studying the issue of preparation for childbirth.Consequently, prenatal preparation of married couples must be obligatory in the system of obstetric care in Ukraine at all medical levels.

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Placental dysfunction as a basic pathology of perinatal complications

Reproductive Endocrinology ◽

10.18370/2309-4117.2021.58.107-112 ◽

2021 ◽

pp. 107-112

Author(s):

О.V. Kravchenko

Keyword(s):

Pregnant Women ◽

Genital Tract ◽

Pregnancy Termination ◽

Perinatal Complications ◽

Placental Dysfunction ◽

Group I ◽

Genital Tract Infections ◽

Group Ii ◽

Tract Infections ◽

Micronized Progesterone

Research aim was to study the features of perinatal complications depending on the nature and timing of therapy in pregnant women with primary placental dysfunction.Materials and methods. 82 pregnant women with verified placental dysfunction (chorionic hypoplasia at 12–13 weeks) against the background of the threat of pregnancy termination and genital tract infections were included. All examined were divided into 2 groups: group I consisted of 42 pregnant women who started treatment before 16 weeks of gestation, group II consisted of 40 pregnant women whose treatment was started after 16 weeks of gestation. Women in group I received micronized progesterone, venotonic Normoven, Magnicum and Artihol. Antibacterial sanitation was carried out before 16 weeks of gestation. Group II also received micronized progesterone only. Antibacterial sanitation in this group was carried out after 16 weeks of gestation.Research results. After antibiotic therapy in group I monoinfections value decreased from 26.8 to 9.5%, mixed infections value decreased from 56.1 to 20.7%, while in group II the effectiveness of antibacterial therapy after 16 weeks was significantly lower. Statistically significant differences in weight, volume and area of the placenta in patients of studied groups were obtained. Assessing perinatal complications showed that the frequency of gestosis, premature birth, intrauterine growth retardation and intrauterine infection of the fetus were almost 2 times less frequent in group I than in group II.Conclusions. Placental dysfunction, which developed in the first trimester against the background of the threat of pregnancy termination and genital tract infections, is the basic pathology for complications of the perinatal period. A timely prescribed set of medical supplies, including micronized progesterone, venotonic Normoven, Artihol and Magnicum, was as an effective method of preventing perinatal complications in pregnant women with primary placental dysfunction. Antibiotic therapy up to 16 weeks of gestation does not fully prevent the development of perinatal complications, but it can significantly reduce the level of severe gestational pathology.

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