Comparative assessment of morphological mechanisms of maintaining structural liver homeostasis in the dynamics of exposure to coal-rock dust and sodium fluoride on the body

2020 ◽  
pp. 189-194
Author(s):  
M. S. Bugaeva ◽  
O. I. Bondarev ◽  
N. N. Mikhailova ◽  
L. G. Gorokhova
Keyword(s):  
Sodium Fluoride ◽  
Morphological Changes ◽  
The Body ◽  
System Level ◽  
Production Factor ◽  
Coal Rock ◽  
The Impact ◽  
Structural Homeostasis ◽  
Rock Dust

Introduction. The impact on the body of such factors of the production environment as coal-rock dust and fluorine compounds leads to certain shift s in strict indicators of homeostasis at the system level. Maintaining the relative constancy of the internal environment of the body is provided by the functional consistency of all organs and systems, the leading of which is the liver. Organ repair plays a crucial role in restoring the structure of genetic material and maintaining normal cell viability. When this mechanism is damaged, the compensatory capabilities of the organ are disrupted, homeostasis is disrupted at the cellular and organizational levels, and the development of the main pathological processes is noted.The aim of the study is to compare the morphological mechanisms of maintaining structural homeostasis of the liver in the dynamics of the impact on the body of coal-rock dust and sodium fluoride.Materials and methods. Experimental studies were conducted on adult white male laboratory rats. Features of morphological mechanisms for maintaining structural homeostasis of the liver in the dynamics of exposure to coal-rock dust and sodium fluoride were studied on experimental models of pneumoconiosis and fluoride intoxication. For histological examination in experimental animals, liver sampling was performed after 1, 3, 6, 9, 12 weeks of the experiment.Results. The specificity of morphological changes in the liver depending on the harmful production factor was revealed. It is shown that chronic exposure to coal-rock dust and sodium fluoride is characterized by the development of similar morphological changes in the liver and its vessels from the predominance of the initial compensatory-adaptive to pronounced violations of the stromal and parenchymal components. Long-term inhalation of coal-rock dust at 1–3 weeks of seeding triggers adaptive mechanisms in the liver in the form of increased functional activity of cells, formation of double-core hepatocytes, activation of immunocompetent cells and endotheliocytes, ensuring the preservation of the parenchyma and the general morphostructure of the organ until the 12th week of the experiment. Exposure to sodium fluoride leads to early disruption of liver compensatory mechanisms and the development of dystrophic changes in the parenchyma with the formation of necrosis foci as early as the 6th week of the experiment.Conclusions. The study of mechanisms for compensating the liver structure in conditions of long-term exposure to coal-rock dust and sodium fluoride, as well as processes that indicate their failure, and the timing of their occurrence, is of theoretical and practical importance for developing recommendations for the timely prevention and correction of pathological conditions developing in employees of the aluminum and coal industry.The authors declare no conflict of interests.

Infl uence of coal-rock dust on the risk of developing morphological disorders of the cardiovascular system

2020 ◽  
pp. 415-420
Author(s):  
M. S. Bugaeva ◽  
L. G. Gorokhova ◽  
O. I. Bondarev ◽  
N. N. Mikhailova
Keyword(s):  
Cardiovascular System ◽  
Blood Vessels ◽  
Heart Muscle ◽  
The Body ◽  
Male Rats ◽  
Production Factor ◽  
Pathological Changes ◽  
Coal Rock ◽  
The Moment ◽  
Rock Dust

Cardiovascular pathology prevails in the structure of somatic diseases of miners. As a complication of pneumoconiosis, the development of a chronic pulmonary heart in workers against the background of pulmonary hypertension and congestive heart failure is considered. Data from clinical studies also indicate remodeling of the blood vessel wall, the formation of atherosclerosis, endothelial dysfunction and others. There are practically no in-depth comprehensive studies on the contribution of industrial dust to the development and course of this pathology. To implement this task, the simulation of occupational diseases in animals helps to trace the dynamics of the pathological process from the moment of exposure to the body of the production factor.The aim of the study is to study the infl uence of coal-rock dust on the risk of developing morphological disorders of the cardiovascular system in an experiment.Experiments were conducted on white non-linear male rats that were exposed to inhaled coal-rock dust of the “gas-fat” brand. For histological study in animals aft er 1, 3, 6, 9 and 12 weeks of exposure to the damaging factor, fragments of the brain, lungs, heart, liver and kidneys were taken. The quantitative content of matrix metalloproteinases, their inhibitor and vascular endothelial growth factor in blood plasma was studied using enzyme immunoassay.Morphological changes in the heart muscle and blood vessels are a systemic response of the body to prolonged inhalation of coal-rock dust. Violations develop from the moment of exposure to the damaging factor, so they can be considered as one of the manifestations of pneumoconiosis, and not its late complication. In the early stages of the experiment (1-3 weeks), the development of diff use protein dystrophy of cardiomyocytes with pronounced thickening of some fi bers due to cell hypertrophy is noted in the heart muscle of experimental animals. Increasing the timing of seed leads to the progression of  pathological changes, increased apoptotic activity of cells and the accumulation of lipofuscin granules in the perinuclear zone, as well as the formation of atrophic damage in muscle tissue. By the 12th week of the experiment, diff use cardiosclerosis and pronounced dystrophy of cardiomyocytes with fragmentation and myocytolysis of individual sections of muscle fi bers develop in the heart muscle. Long-term inhalation of coal-rock dust causes progressive development in the wall of blood vessels, regardless of their organ affi  liation, of the same type of pathological changes in the form of endotheliosis, diff use hypertrophy of the smooth muscle component of the medial layer and perivascular fi brosis against the background of pronounced microcirculatory disorders.The obtained results indicate the need for pre-nosological diagnostics of cardiovascular diseases and their prevention among miners working in harmful working conditions. 

scholarly journals A Statistical Modeling Methodology for Long-Term Wind Generation and Power Ramp Simulations in New Generation Locations

Energies ◽  
2018 ◽  
Vol 11 (9) ◽  
pp. 2442 ◽  
Author(s):  
Jussi Ekström ◽  
Matti Koivisto ◽  
Ilkka Mellin ◽  
Robert Millar ◽  
Matti Lehtonen
Keyword(s):  
Power Generation ◽  
Wind Power ◽  
Statistical Modeling ◽  
Renewable Energy Sources ◽  
Measurement Data ◽  
Wind Power Generation ◽  
System Level ◽  
Wind Generation ◽  
The Impact

In future power systems, a large share of the energy will be generated with wind power plants (WPPs) and other renewable energy sources. With the increasing wind power penetration, the variability of the net generation in the system increases. Consequently, it is imperative to be able to assess and model the behavior of the WPP generation in detail. This paper presents an improved methodology for the detailed statistical modeling of wind power generation from multiple new WPPs without measurement data. A vector autoregressive based methodology, which can be applied to long-term Monte Carlo simulations of existing and new WPPs, is proposed. The proposed model improves the performance of the existing methodology and can more accurately analyze the temporal correlation structure of aggregated wind generation at the system level. This enables the model to assess the impact of new WPPs on the wind power ramp rates in a power system. To evaluate the performance of the proposed methodology, it is verified against hourly wind speed measurements from six locations in Finland and the aggregated wind power generation from Finland in 2015. Furthermore, a case study analyzing the impact of the geographical distribution of WPPs on wind power ramps is included.

scholarly journals Lalabet Financial Analysis: Study of Islamic Economics at Micro Level

2021 ◽  
Vol 4 (1) ◽  
pp. 233-244
Author(s):  
Ainorrofiqie Ainorrofiqie ◽  
Umrotul Khasanah ◽  
Akhmad Djalaluddin
Keyword(s):  
Financial Management ◽  
Financial Analysis ◽  
Financial Statements ◽  
The Body ◽  
Short Term ◽  
The Family ◽  
Micro Level ◽  
The Impact ◽  
The Village

This research aims to explore the model of financial management tradition Lalabet in the village of Babbalan District Batuan Sumenep. This study is based on the fact that occurred in the community about the implementation of traditions carried out by the heirs to family members who died. Interpretative qualitative research is used and an in-depth understanding of a problem that occurs is emphasized more. Based on the results of this study, the financial management tradition Lalabet can be done based on accounting equations. The accounts contained in the accounting equation is not used in its entirety and are reported as are generally financial statements. In this case, the source of funds in carrying out Lalabet tradition is sourced from personal money, money and donations from the family, money from Muslimat, debt, and money or goods from Lalabet's proceeds. The impact is the onset of debt both short-term and long-term. While the expenditure is in the form of costs in taking care of the body, costs for tahlilan (petto'arean), pa'polo, nyatos, nyataon, nyaebu, mangaji, ngin-tangin, nyalenin mayyid, and ajege makam (kep-sekep).

Dams: Effects of Hydrological Infrastructure on Development

2019 ◽  
Vol 11 (1) ◽  
pp. 125-148
Author(s):  
Andrew Dillon ◽  
Ram Fishman
Keyword(s):  
Economic Development ◽  
Flood Control ◽  
The Body ◽  
Future Research ◽  
Emerging Issues ◽  
Potential Benefits ◽  
The Impact ◽  
Benefits And Costs ◽  
Distributional Impacts

Hydrological investments, particularly irrigation dams, have multiple potential benefits for economic development. Dams also have financial, environmental, and distributional impacts that can affect their benefits and costs. This article reviews the evidence on the impact of dams on economic development, focusing on the levels and variability of agricultural productivity, and its effect on poverty, health, electricity generation, and flood control. We also review the evidence on irrigation efficiency and collective action of dam maintenance. Throughout the discussion, we highlight the empirical challenges that restrict the body of causally interpretable impact estimates and areas in which the evidence is particularly thin. We conclude with a discussion of emerging issues pertaining to the long-term sustainability of dams’ impacts and suggest directions for future research.

The Different Impacts on the Long-Term Survival of Tunneled Internal Jugular Hemodialysis Catheters Based on Tip Position and Laterality

2017 ◽  
Vol 43 (4) ◽  
pp. 315-320 ◽  
Author(s):  
Vedran Premuzic ◽  
Drazen Perkov ◽  
Ranko Smiljanic ◽  
Bruna Brunetta Gavranic ◽  
Bojan Jelakovic
Keyword(s):  
Superior Vena ◽  
Vena Cava ◽  
The Body ◽  
Term Survival ◽  
Catheter Tip ◽  
Tip Position ◽  
The Impact

Background/Aims: The aim of this study was to examine the impact of different catheter tip positions on the life of the catheter, dysfunction, infection, and quality of hemodialysis and possible differences between the access site laterality in jugular-tunneled hemodialysis catheters. Methods: Catheters were evaluated for the following parameters: place of insertion, time of insertion, duration of use, and reason for removal. In all patients, the catheter tip position was checked using an X-ray. Results: The mean duration of implanted catheters with the tip placed in the cavo-atrial junction and right atrium was significantly longer. There were no differences in catheter functionality at follow-up or complications based on catheter laterality for each catheter tip position. Conclusion: According to our results, the localization of the catheter tip in superior vena cava still remains the least preferable method. Our results showed that the main factor responsible for better catheter functionality was not laterality but the depth to which the catheter tip is inserted into the body.

scholarly journals How predation shaped fish: the impact of fin spines on body form evolution across teleosts

2015 ◽  
Vol 282 (1819) ◽  
pp. 20151428 ◽  
Author(s):  
S. A. Price ◽  
S. T. Friedman ◽  
P. C. Wainwright
Keyword(s):  
Evolutionary Dynamics ◽  
Morphological Changes ◽  
Evolutionary Relationship ◽  
Vertical Plane ◽  
The Body ◽  
Body Dimension ◽  
Body Depth ◽  
Body Dimensions ◽  
The Impact ◽  
Fin Spines

It is well known that predators can induce morphological changes in some fish: individuals exposed to predation cues increase body depth and the length of spines. We hypothesize that these structures may evolve synergistically, as together, these traits will further enlarge the body dimensions of the fish that gape-limited predators must overcome. We therefore expect that the orientation of the spines will predict which body dimension increases in the presence of predators. Using phylogenetic comparative methods, we tested this prediction on the macroevolutionary scale across 347 teleost families, which display considerable variation in fin spines, body depth and width. Consistent with our predictions, we demonstrate that fin spines on the vertical plane (dorsal and anal fins) are associated with a deeper-bodied optimum. Lineages with spines on the horizontal plane (pectoral fins) are associated with a wider-bodied optimum. Optimal body dimensions across lineages without spines paralleling the body dimension match the allometric expectation. Additionally, lineages with longer spines have deeper and wider body dimensions. This evolutionary relationship between fin spines and body dimensions across teleosts reveals functional synergy between these two traits and a potential macroevolutionary signature of predation on the evolutionary dynamics of body shape.

scholarly journals Overproduction of gastric mucus as a mechanism of stomach’s mucosa protection during energy drinks consumption in Wistar rats

2018 ◽  
Vol 72 ◽  
pp. 376-380
Author(s):  
Ruby Maini ◽  
Ewelina Wawryk-Gawda ◽  
Mirosław Sławiński ◽  
Paweł Halczuk ◽  
Beata Cichacz-Kwiatkowska ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Energy Drinks ◽  
Energy Drink ◽  
The Body ◽  
Gastric Mucus ◽  
Gastric Glands ◽  
Mucus Production ◽  
The Impact ◽  
Stimulation Of

Aim: Energy drinks are the most consumed, socially accepted stimulants in the world. They are drunk by drivers and students, and more often also by adolescents and children. It has been noted that some adverse events are due to the stimulation of the sympathetic nervous system and include palpitations, hypertension, diuresis, nausea, vomiting, and convulsions. The health consequences of long-term consumption of energy drinks are not known, but we suppose that continuous stimulation of the body can lead to irreparable changes of tissues. In our study we investigated the impact of long-term energy drink consumption on gastric mucus production. Material/Methods: Ten male young Wistar rats of of 190 grams +/- 64 grams of weight were positioned in two groups: A (experimental) and C (control). The animals of A group received energy drink for 8 weeks. The animals of C group drank just water. After this time the rats of both groups were decapitated and the stomach was taken for histological analysis. The slides were stained with H&E and PAS method and analyzed with Cell^D software. Results: H&E staining indicated an increase in the thickness of the lamina propria of the glandular stomach. PAS staining indicated an increased area of mucus in the gastric glands of the stomach of the experimental group of rats. Conclusions: Regular consumption of energy drinks can lead to changes in the mucosal lining of the stomach, which activate mucus secretion.

scholarly journals PAMK Relieves LPS-Induced Enteritis and Improves Intestinal Flora Disorder in Goslings

2021 ◽  
Vol 2021 ◽  
pp. 1-16
Author(s):  
Wanyan Li ◽  
Xuelian Xiang ◽  
Bingxin Li ◽  
Yifei Wang ◽  
Long Qian ◽  
...  
Keyword(s):  
Small Intestine ◽  
Morphological Changes ◽  
Intestinal Flora ◽  
The Body ◽  
Biologically Active ◽  
Rdna Sequencing ◽  
Positive Rate ◽  
Atractylodes Macrocephala ◽  
Serum Crp ◽  
The Impact

Polysaccharide of Atractylodes macrocephala Koidz (PAMK) is a biologically active component of Atractylodes macrocephala, which has the effect of maintaining the immune homeostasis of the body. Therefore, this study constructed a model of PAMK to relieve LPS-induced gosling enteritis and observed the morphological changes of the small intestine after HE staining. ELISA was used to detect serum CRP, IL-1β, IL-6, and TNF-α levels; immunohistochemistry was used to detect the positive rate of IgA in the small intestine; TLR4, occludin, ZO-1, cytokines, and immunoglobulin mRNA expression in the small intestine were detected by qPCR; and intestinal flora of gosling excrement was analyzed by 16S rDNA sequencing to analyze the protective effect of PAMK on goslings enteritis and the impact on intestinal flora. The results showed that PAMK relieves LPS-induced gosling enteritis by maintaining the small intestine morphology, cytokine, tight junctions, and immunoglobulin relatively stable and improving the disorder of intestinal flora.

scholarly journals Human impacts reduce morphological diversity in an insular species of lizard

2017 ◽  
Vol 284 (1857) ◽  
pp. 20170921 ◽  
Author(s):  
Corentin Bochaton ◽  
Salvador Bailon ◽  
Anthony Herrel ◽  
Sandrine Grouard ◽  
Ivan Ineich ◽  
...  
Keyword(s):  
Late Pleistocene ◽  
Human Impacts ◽  
Morphological Changes ◽  
Morphological Evolution ◽  
Morphological Diversity ◽  
Apparent Size ◽  
Climatic Transition ◽  
Long Term Impact ◽  
The Impact

Fossil remains provide useful insights into the long-term impact of anthropogenic phenomena on faunas and are often used to reveal the local (extirpations) or global (extinctions) losses of populations or species. However, other phenomena such as minor morphological changes can remain inconspicuous in the fossil record depending on the methodology used. In this study, we used the anole of Marie-Galante Island ( Anolis ferreus ) in Guadeloupe (French, West Indies) as a model to demonstrate how the morphological evolution of an insular lizard can be tracked through the Pleistocene/Holocene climatic transition and the recent anthropization of the island. We used a fossil assemblage of nearly 30 000 remains and a combination of anatomical description, traditional morphometry and geometric morphometrics. These fossils are attributed to a single taxon, most likely to be A. ferreus on the basis of morphological and morphometric arguments. Our results show the disappearance of a distinct (sub)population of large specimens that were about 25% larger than the modern representatives of A. ferreus . We also demonstrate an apparent size stability of the main fossil population of this species since the Late Pleistocene but with the possible occurrence of a reduction in morphological diversity during the Late Holocene. These results highlight the impact of anthropic disturbances on a lizard whose morphology otherwise remained stable since the Late Pleistocene.

scholarly journals SARS-CoV-2 (COVID-19) and the Endocrine System

2020 ◽  
Vol 4 (11) ◽  
Author(s):  
Michelle D Lundholm ◽  
Caroline Poku ◽  
Nicholas Emanuele ◽  
Mary Ann Emanuele ◽  
Norma Lopez
Keyword(s):  
Severe Disease ◽  
Clinical Manifestations ◽  
Endocrine System ◽  
The Body ◽  
Active Area ◽  
Gonadal Function ◽  
Long Term Effects ◽  
The World ◽  
The Impact

Abstract As SARS-CoV-2 (COVID-19) overtakes the world, causing moderate to severe disease in about 15% of infected patients, COVID-19 is also found to have widespread effects throughout the body with a myriad of clinical manifestations including the endocrine system. This manuscript reviews what is known about the impact of COVID-19 on the pathophysiology and management of diabetes (both outpatient and inpatient) as well as pituitary, adrenal, thyroid, bone, and gonadal function. Findings in this area are evolving, and long-term effects of infection remain an active area of further research.

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