scholarly journals Overproduction of gastric mucus as a mechanism of stomach’s mucosa protection during energy drinks consumption in Wistar rats

2018 ◽  
Vol 72 ◽  
pp. 376-380
Author(s):  
Ruby Maini ◽  
Ewelina Wawryk-Gawda ◽  
Mirosław Sławiński ◽  
Paweł Halczuk ◽  
Beata Cichacz-Kwiatkowska ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Energy Drinks ◽  
Energy Drink ◽  
The Body ◽  
Gastric Mucus ◽  
Gastric Glands ◽  
Mucus Production ◽  
The Impact ◽  
Stimulation Of

Aim: Energy drinks are the most consumed, socially accepted stimulants in the world. They are drunk by drivers and students, and more often also by adolescents and children. It has been noted that some adverse events are due to the stimulation of the sympathetic nervous system and include palpitations, hypertension, diuresis, nausea, vomiting, and convulsions. The health consequences of long-term consumption of energy drinks are not known, but we suppose that continuous stimulation of the body can lead to irreparable changes of tissues. In our study we investigated the impact of long-term energy drink consumption on gastric mucus production. Material/Methods: Ten male young Wistar rats of of 190 grams +/- 64 grams of weight were positioned in two groups: A (experimental) and C (control). The animals of A group received energy drink for 8 weeks. The animals of C group drank just water. After this time the rats of both groups were decapitated and the stomach was taken for histological analysis. The slides were stained with H&E and PAS method and analyzed with Cell^D software. Results: H&E staining indicated an increase in the thickness of the lamina propria of the glandular stomach. PAS staining indicated an increased area of mucus in the gastric glands of the stomach of the experimental group of rats. Conclusions: Regular consumption of energy drinks can lead to changes in the mucosal lining of the stomach, which activate mucus secretion.

Effects of long-term consumption of energy drinks on the body and brain weights of adult Wistar rats

2014 ◽  
Vol 13 (1) ◽  
pp. 17
Author(s):  
JosiahObaghwarhievwo Adjene ◽  
Victor Emojevwe ◽  
DavidEseoghene Idiapho
Keyword(s):  
Wistar Rats ◽  
Energy Drinks ◽  
The Body

Influence of DAFS-25+polizon composition on blood and functional state of liver of steers at fattening

2020 ◽  
pp. 15-18
Author(s):  
Inna R. Kilmetova ◽  
◽  
Igor A. Rodin ◽  
Nazira I. Khayrullina ◽  
Nikolay G. Fenchenko ◽  
...  
Keyword(s):  
Functional State ◽  
White Blood Cells ◽  
Live Weight ◽  
The Body ◽  
Farm Animals ◽  
Control Group ◽  
Standard Diet ◽  
The Impact ◽  
Experimental Group ◽  
Stimulation Of

Summary. The disbalanced feeding and the uneven distribution of micro- and macroelements in the environment leads to a trace element, in particular hypomelanosis. To accelerate the growth and preservation of young farm animals include in the diet of various biological additives and drugs, which include selenium. For stimulation of weight gain in the livestock industry, as well as for the prevention and treatment of pathological processes in addition to micro - and macrouse amino acids, primarily methionine. The aim of this work was to study the influence of composition of DAFS-25+Polizon on morpho-biochemical parameters of blood and functional state of the liver in fattening bulls of black-motley breed in the conditions of the Republic of Bashkortostan. Experiments using were conducted on bull-calves of black-motley breed of the properties in the properties age from 6 to 15 months. The first experimental group during the experiment was additionally given the composition of DAFS-25+Polizon at a dose of 2 mg/kg, the animals of the control group received a standard diet. To assess the impact of the composition DAFS-25+Polizon on metabolism cattle studied morphological and biochemical indicators of blood and conducted histological examination of the liver. It is established that the use of the composition of DAFS-25+Polizon at a dose of 2 mg/kg increases the number of erythrocytes and hemoglobin in the experimental group and reduces the amount of white blood cells. The serum content of total protein, phosphorus and calcium increases in the group of experimental animals. Microscopic examination of the liver revealed no changes in the structure of the organ and hepatocytes in the experimental group, whereas in the control group hemodynamic disorders and dystrophic changes in liver cells were observed. Thus, the use of the composition DAFS-25+Polizon at a dose of 2 mg/kg of live weight in fattening bulls black-and-white breed contributes to the increase of redox processes in the body, stimulation of metabolism, prevent the development of liver disorders of cellular mechanisms of metabolism, optimizes the structure of the liver, which generally provides higher productivity.

Comparative assessment of morphological mechanisms of maintaining structural liver homeostasis in the dynamics of exposure to coal-rock dust and sodium fluoride on the body

2020 ◽  
pp. 189-194
Author(s):  
M. S. Bugaeva ◽  
O. I. Bondarev ◽  
N. N. Mikhailova ◽  
L. G. Gorokhova
Keyword(s):  
Sodium Fluoride ◽  
Morphological Changes ◽  
The Body ◽  
System Level ◽  
Production Factor ◽  
Coal Rock ◽  
The Impact ◽  
Structural Homeostasis ◽  
Rock Dust

Introduction. The impact on the body of such factors of the production environment as coal-rock dust and fluorine compounds leads to certain shift s in strict indicators of homeostasis at the system level. Maintaining the relative constancy of the internal environment of the body is provided by the functional consistency of all organs and systems, the leading of which is the liver. Organ repair plays a crucial role in restoring the structure of genetic material and maintaining normal cell viability. When this mechanism is damaged, the compensatory capabilities of the organ are disrupted, homeostasis is disrupted at the cellular and organizational levels, and the development of the main pathological processes is noted.The aim of the study is to compare the morphological mechanisms of maintaining structural homeostasis of the liver in the dynamics of the impact on the body of coal-rock dust and sodium fluoride.Materials and methods. Experimental studies were conducted on adult white male laboratory rats. Features of morphological mechanisms for maintaining structural homeostasis of the liver in the dynamics of exposure to coal-rock dust and sodium fluoride were studied on experimental models of pneumoconiosis and fluoride intoxication. For histological examination in experimental animals, liver sampling was performed after 1, 3, 6, 9, 12 weeks of the experiment.Results. The specificity of morphological changes in the liver depending on the harmful production factor was revealed. It is shown that chronic exposure to coal-rock dust and sodium fluoride is characterized by the development of similar morphological changes in the liver and its vessels from the predominance of the initial compensatory-adaptive to pronounced violations of the stromal and parenchymal components. Long-term inhalation of coal-rock dust at 1–3 weeks of seeding triggers adaptive mechanisms in the liver in the form of increased functional activity of cells, formation of double-core hepatocytes, activation of immunocompetent cells and endotheliocytes, ensuring the preservation of the parenchyma and the general morphostructure of the organ until the 12th week of the experiment. Exposure to sodium fluoride leads to early disruption of liver compensatory mechanisms and the development of dystrophic changes in the parenchyma with the formation of necrosis foci as early as the 6th week of the experiment.Conclusions. The study of mechanisms for compensating the liver structure in conditions of long-term exposure to coal-rock dust and sodium fluoride, as well as processes that indicate their failure, and the timing of their occurrence, is of theoretical and practical importance for developing recommendations for the timely prevention and correction of pathological conditions developing in employees of the aluminum and coal industry.The authors declare no conflict of interests.

scholarly journals Lalabet Financial Analysis: Study of Islamic Economics at Micro Level

2021 ◽  
Vol 4 (1) ◽  
pp. 233-244
Author(s):  
Ainorrofiqie Ainorrofiqie ◽  
Umrotul Khasanah ◽  
Akhmad Djalaluddin
Keyword(s):  
Financial Management ◽  
Financial Analysis ◽  
Financial Statements ◽  
The Body ◽  
Short Term ◽  
The Family ◽  
Micro Level ◽  
The Impact ◽  
The Village

This research aims to explore the model of financial management tradition Lalabet in the village of Babbalan District Batuan Sumenep. This study is based on the fact that occurred in the community about the implementation of traditions carried out by the heirs to family members who died. Interpretative qualitative research is used and an in-depth understanding of a problem that occurs is emphasized more. Based on the results of this study, the financial management tradition Lalabet can be done based on accounting equations. The accounts contained in the accounting equation is not used in its entirety and are reported as are generally financial statements. In this case, the source of funds in carrying out Lalabet tradition is sourced from personal money, money and donations from the family, money from Muslimat, debt, and money or goods from Lalabet's proceeds. The impact is the onset of debt both short-term and long-term. While the expenditure is in the form of costs in taking care of the body, costs for tahlilan (petto'arean), pa'polo, nyatos, nyataon, nyaebu, mangaji, ngin-tangin, nyalenin mayyid, and ajege makam (kep-sekep).

Artificial Intelligence In Oncology Socio-Economic Incentives As A Factor In Eliminating The Shortage Of Medical Personnel In Rural Health Care

2020 ◽  
pp. 41-52
Author(s):  
Olga Doshchannikova ◽  
Keyword(s):  
Rural Health ◽  
Rural Areas ◽  
Medical Personnel ◽  
Economic Incentives ◽  
Active Involvement ◽  
Medical Institutions ◽  
Economic Support ◽  
The Impact ◽  
Stimulation Of

The study determines the impact of regional measures of socio-economic stimulation of medical personnel on the process of employment in medical institutions in rural areas. The analysis of Federal and regional legislation regulating the process of encouraging doctors to find employment in the rural health system is carried out. It was found that measures of socio-economic support for the provision of ready-made housing in the framework of regional events, contributed to a more active involvement and long-term consolidation of medical personnel in rural areas.

scholarly journals Characterization of a Coproduct from the Sea Cucumber Cucumaria frondosa and Its Effects on Visceral Adipocyte Size in Male Wistar Rats

Marine Drugs ◽  
2020 ◽  
Vol 18 (11) ◽  
pp. 530
Author(s):  
Alan Ramalho ◽  
Nadine Leblanc ◽  
Marie-Gil Fortin ◽  
André Marette ◽  
André Tchernof ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Sea Cucumber ◽  
The Body ◽  
Cardiometabolic Health ◽  
Potential Health ◽  
Triterpenoid Saponins ◽  
Saponin Content ◽  
Male Wistar Rats ◽  
Cucumaria Frondosa ◽  
The Impact

Sea cucumbers have been shown to have potential health benefits and are a rich source of several bioactive compounds, particularly triterpenoid saponins. However, most studies concentrate on the body wall, and little is known about the health effects of the coproducts. The objectives of this study were to determine the nutritional composition of a coproduct from the sea cucumber Cucumaria frondosa and the effects of the dietary consumption of this coproduct on cardiometabolic health in rats. Chemical, biochemical, and nutritional analyses were performed to characterize this coproduct. Forty (40) male Wistar rats were then equally divided into four groups and fed a purified control diet or a diet enriched with 0.5%, 1.5%, or 2.5% (by protein) of coproduct. After 28 days of feeding, the rats were sacrificed. Body and tissue weight, body composition, epididymal adipocyte diameter, plasma and hepatic lipids, glycemia, and insulinemia were measured at the end of the 28-day experiment. Analysis of the coproduct revealed high levels of protein, omega-3 fatty acids, minerals, and saponins. The 1.5% group had significantly smaller epididymal adipocytes vs. the control. We conclude that dietary administration of this sea cucumber coproduct at 1.5% doses decreases visceral adiposity, potentially decreasing the risk of cardiometabolic dysfunction. The coproduct’s saponin content may contribute to the observed effects, but the impact of other components cannot be ruled out.

Transplacental Toxicity and Carcinogenesis Studies in Rats with Hexamethylenetetramine

1970 ◽  
Vol 56 (6) ◽  
pp. 325-334 ◽  
Author(s):  
Giuseppe Della Porta ◽  
José R. Cabral ◽  
Giorgio Parmiani
Keyword(s):  
Drinking Water ◽  
Body Weight ◽  
Wistar Rats ◽  
The Body ◽  
Carcinogenic Activity ◽  
Long Term Experiments ◽  
Pregnancy And Lactation ◽  
Successive Generations ◽  
And Control

In a previous paper (Fd Cosmet. Toxicol., 6: 707–715, 1968) it was reported that hexamethylenetetramine (HMT) had no carcinogenic activity in long-term experiments in mice and rats. In the present study, 12 ♀ and 6 ♂ Wistar rats were given 1% HMT in the drinking water starting 2 weeks before mating. The females were kept under treatment during pregnancy and lactation. A similar untreated group of 12 ♀ and 6 ♂ served as control. Twelve treated females and eleven controls became pregnant and gave birth to 124 and 118 babies respectively; no malformations were noted. From these animals, 24 for each sex were continued on the 1% HMT up to the 20th week of age or were kept untreated. The body weight of treated animals was significantly lower than that of controls one, only up to the 9th week of age for the males and up to the 13th week for the females. At the end of the treatment both groups were sacrificed; the weight of organs was identical in the treated and control animals; there were no gross or histological pathology. In a second experiment, rats were given 1% HMT in the drinking water for 3 successive generations, up to the age of 40 weeks in the F1 and F2 groups and of 20 weeks for F3. The three groups were composed of 13 ♂ and 7 ♀, 15 ♂ and 11 ♀, 12 ♂ and 12 ♂, respectively. In addition, a group of 16 ♂ and 16 ♀ descendants of 2% HMT treated parents, were given 2% HMT for 50 weeks. A group of 48 ♂ and 48 ♀ served as untreated controls. All groups were kept under observation for over 2 years of age. No evidence of carcinogenicity was found in any of the HMT-treated groups.

Dams: Effects of Hydrological Infrastructure on Development

2019 ◽  
Vol 11 (1) ◽  
pp. 125-148
Author(s):  
Andrew Dillon ◽  
Ram Fishman
Keyword(s):  
Economic Development ◽  
Flood Control ◽  
The Body ◽  
Future Research ◽  
Emerging Issues ◽  
Potential Benefits ◽  
The Impact ◽  
Benefits And Costs ◽  
Distributional Impacts

Hydrological investments, particularly irrigation dams, have multiple potential benefits for economic development. Dams also have financial, environmental, and distributional impacts that can affect their benefits and costs. This article reviews the evidence on the impact of dams on economic development, focusing on the levels and variability of agricultural productivity, and its effect on poverty, health, electricity generation, and flood control. We also review the evidence on irrigation efficiency and collective action of dam maintenance. Throughout the discussion, we highlight the empirical challenges that restrict the body of causally interpretable impact estimates and areas in which the evidence is particularly thin. We conclude with a discussion of emerging issues pertaining to the long-term sustainability of dams’ impacts and suggest directions for future research.

The Different Impacts on the Long-Term Survival of Tunneled Internal Jugular Hemodialysis Catheters Based on Tip Position and Laterality

2017 ◽  
Vol 43 (4) ◽  
pp. 315-320 ◽  
Author(s):  
Vedran Premuzic ◽  
Drazen Perkov ◽  
Ranko Smiljanic ◽  
Bruna Brunetta Gavranic ◽  
Bojan Jelakovic
Keyword(s):  
Superior Vena ◽  
Vena Cava ◽  
The Body ◽  
Term Survival ◽  
Catheter Tip ◽  
Tip Position ◽  
The Impact

Background/Aims: The aim of this study was to examine the impact of different catheter tip positions on the life of the catheter, dysfunction, infection, and quality of hemodialysis and possible differences between the access site laterality in jugular-tunneled hemodialysis catheters. Methods: Catheters were evaluated for the following parameters: place of insertion, time of insertion, duration of use, and reason for removal. In all patients, the catheter tip position was checked using an X-ray. Results: The mean duration of implanted catheters with the tip placed in the cavo-atrial junction and right atrium was significantly longer. There were no differences in catheter functionality at follow-up or complications based on catheter laterality for each catheter tip position. Conclusion: According to our results, the localization of the catheter tip in superior vena cava still remains the least preferable method. Our results showed that the main factor responsible for better catheter functionality was not laterality but the depth to which the catheter tip is inserted into the body.

scholarly journals Impact des extraits éthyliques des feuilles de Hexalobus Monopétalus sur lemétabolisme protéiques des rats Wistar

2018 ◽  
Vol 6 (01) ◽  
Author(s):  
Akotegnon Rodrigue ◽  
Michodjehoun Loetitia ◽  
Behanzin Justin ◽  
Houeze Elisabeth ◽  
Sezan Alphonse
Keyword(s):  
Uric Acid ◽  
Total Protein ◽  
Wistar Rats ◽  
Polyphenolic Compounds ◽  
Blood Levels ◽  
Phytochemical Screening ◽  
Duration Of Treatment ◽  
Anthracene Derivatives ◽  
The Impact

The aim of this study was to evaluate the impact of the ethyl extract of dried leaves of Hexalobus monopetalus on protein metabolism in Wistar rats. After a phytochemical screening of extracts, total protein, urea, uric acid and creatinine were measured spectrophotometrically at six (06) sets of three (03) Wistar rats each. Batches 2 to 6 were given with orally administered respectively the daily doses of: 0.25 mg / kg, 0.5mg / kg, 1mg / kg, 1.5mg / kg and 2.5mg kg body weight of the extracts (for 14 days). The lot1 witness received distilled water instead of the extract. The results of the phytochemical screening revealed the presence polyphenolic compounds (gallic tannins, catechin tannin or condensed, anthocyanins, and leuco anthocyanins), flavonoids, mucilages reducing compounds, alkaloids, certain anthracene derivatives ( free anthracene, the O-glycosides), Steroids, and quinone derivatives. It was observed a significant increase (p ˂ 0.05) blood levels of total protein and uric acid and a significant (p ˂ 0.05) blood urea and creatinine levels in treated plots to extracts. These observed variations did not depend on the administered dose of the extracts but were depending on the duration of treatment; they were outstanding from the 7th day of treatment. The long term use of ethyl extract of dried leaves of Hexalobus monopetalus could compromise the liver function and the kidneys and may inhibit apoptosis in Wistar rats.

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