The relationship between pruritus and the clinical signs of psoriasis in patients receiving tofacitinib

The findings of clinical nutrition surveys of 3351 children aged 8–15 years and of 3326 adults, of both sexes, were analysed statistically to ascertain the relationship existing between nutritional grade (good, fair and poor) and the incidence of a variety of clinical signs (pityriasis, folliculosis, gingivitis, etc.) observed at the time of the medical examination but not taken into account in grading the subjects according to their state of nutrition.The analysis showed negligible correlations between the clinical signs singly and collectively and the clinician's nutritional grade. Further, when we compared the incidence of each clinical sign and the nutritional state as a combination of all the clinical signs (i.e. the general nutritional factor), there was negligible agreement as shown by the low general factor saturation coefficients, thus suggesting that the presence of these signs is not a dependable expression of the general state of nutrition.A special clinical survey of 1067 children was carried out to provide data which would throw light on the relationship between the criteria (posture, muscular development, etc.) which the clinician consciously takes into account but does not as a rule record in deciding the nutritional grade, and the nutritional grade itself. The grading criteria in the survey were separately assessed and recorded and so also were the usual clinical signs (pityriasis, gingivitis, etc.).For the grading criteria there was a high degree of correlation between each one and the nutritional grade and also between each one and the combined pool of all the criteria. The clinical signs showed only negligible correlations with each other, with the nutritional grade or with any of the grading criteria.It would seem, therefore, that nutritional assessment as at present understood is determined mainly by the value placed on the grading criteria (posture, muscular development, etc.), and to a negligible extent or not at all by the presence or absence of clinical signs (pityriasis, folliculosis, gingivitis, etc.).

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The relationship between clinical signs and brain herniation associated with rostrotentorial mass lesions in the dog

The Veterinary Journal ◽

10.1016/j.tvjl.2005.05.012 ◽

2006 ◽

Vol 172 (2) ◽

pp. 258-264 ◽

Cited By ~ 15

Author(s):

G.L. Walmsley ◽

M.E. Herrtage ◽

R. Dennis ◽

S.R. Platt ◽

N.D. Jeffery

Keyword(s):

Clinical Signs ◽

Brain Herniation ◽

Mass Lesions ◽

The Relationship

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Relationships between cardiovascular signs and neurological signs in asphyxiated neonates in Ilorin, North Central Nigeria

African Health Sciences ◽

10.4314/ahs.v21i2.33 ◽

2021 ◽

Vol 21 (2) ◽

pp. 743-752

Author(s):

Amudalat Issa ◽

Mohammed Baba Abdulkadir ◽

Omotayo Olukemi Adesiyun ◽

Bilkis Owolabi ◽

Habibat Suberu ◽

...

Keyword(s):

Perinatal Asphyxia ◽

Clinical Signs ◽

Cross Sectional Study ◽

Multiple Organ ◽

Cross Sectional ◽

North Central ◽

Neurological Outcomes ◽

The Relationship ◽

Volume Pulse ◽

Organ Dysfunctions

Background: Perinatal asphyxia is a condition associated with multiple organ dysfunctions inclusive of cardiovascular dys- function. Neurologic predictors of survival have been studied, but little has been reported regarding cardiovascular signs and their role in determining outcome in asphyxia. Objective: The study aimed to determine the relationship between cardiovascular signs and outcomes in asphyxiated new- borns with hypoxic ischaemic encephalopathy. Methods: This was a cross sectional study involving asphyxiated new-born babies recruited within the first 24 hours of life. Hypoxic ischaemic encephalopathy staging was done using Sarnat and Sarnat staging. All patients had a detailed cardi- ovascular examination on admission, after initial resuscitation (30 – 60 minutes) into admission, and were followed till final outcome: discharge or death. Results: Eighty-five asphyxiated new-borns with HIE were studied over seven months. Abnormal cardiovascular-related signs identified in the patients included respiratory distress (64.7%), small volume pulse (57.6%), hypotension (52.9%), hy- poxemia (48.2%) and shock (32.9%). Five babies died. None of the clinical signs had a significant relationship with mortality. Conclusion: Abnormal cardiovascular signs increased with the progression of HIE staging but had no relationship with mortality. Keywords: Cardiovascular signs; Neurological outcomes; Mortality; Perinatal asphyxia.

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Cerebrospinal Fluid Mitochondrial DNA in Rapid and Slow Progressive Forms of Alzheimer’s Disease

International Journal of Molecular Sciences ◽

10.3390/ijms21176298 ◽

2020 ◽

Vol 21 (17) ◽

pp. 6298

Author(s):

Petar Podlesniy ◽

Franc Llorens ◽

Margalida Puigròs ◽

Nuria Serra ◽

Diego Sepúlveda-Falla ◽

...

Keyword(s):

Cerebrospinal Fluid ◽

Mitochondrial Dna ◽

Clinical Diagnosis ◽

Neuronal Damage ◽

Clinical Signs ◽

Amyloid Peptide ◽

Slow Progression ◽

Csf Levels ◽

T Tau ◽

The Relationship

Alzheimer’s type dementia (AD) exhibits clinical heterogeneity, as well as differences in disease progression, as a subset of patients with a clinical diagnosis of AD progresses more rapidly (rpAD) than the typical AD of slow progression (spAD). Previous findings indicate that low cerebrospinal fluid (CSF) content of cell-free mitochondrial DNA (cf-mtDNA) precedes clinical signs of AD. We have now investigated the relationship between cf-mtDNA and other biomarkers of AD to determine whether a particular biomarker profile underlies the different rates of AD progression. We measured the content of cf-mtDNA, beta-amyloid peptide 1–42 (Aβ), total tau protein (t-tau) and phosphorylated tau (p-tau) in the CSF from a cohort of 95 subjects consisting of 49 controls with a neurologic disorder without dementia, 30 patients with a clinical diagnosis of spAD and 16 patients with rpAD. We found that 37% of controls met at least one AD biomarker criteria, while 53% and 44% of subjects with spAD and rpAD, respectively, did not fulfill the two core AD biomarker criteria: high t-tau and low Aβ in CSF. In the whole cohort, patients with spAD, but not with rpAD, showed a statistically significant 44% decrease of cf-mtDNA in CSF compared to control. When the cohort included only subjects selected by Aβ and t-tau biomarker criteria, the spAD group showed a larger decrease of cf-mtDNA (69%), whereas in the rpAD group cf-mtDNA levels remained unaltered. In the whole cohort, the CSF levels of cf-mtDNA correlated positively with Aβ and negatively with p-tau. Moreover, the ratio between cf-mtDNA and p-tau increased the sensitivity and specificity of spAD diagnosis up to 93% and 94%, respectively, in the biomarker-selected cohort. These results show that the content of cf-mtDNA in CSF correlates with the earliest pathological markers of the disease, Aβ and p-tau, but not with the marker of neuronal damage t-tau. Moreover, these findings confirm that low CSF content of cf-mtDNA is a biomarker for the early detection of AD and support the hypothesis that low cf-mtDNA, together with low Aβ and high p-tau, constitute a distinctive CSF biomarker profile that differentiates spAD from other neurological disorders.

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Provocative Sensory Testing in Carpal Tunnel Syndrome

Journal of Hand Surgery (European Volume) ◽

10.1016/0266-7681(92)90090-o ◽

1992 ◽

Vol 17 (2) ◽

pp. 204-208 ◽

Cited By ~ 39

Author(s):

C. B. NOVAK ◽

S. E. MACKINNON ◽

R. BROWNLEE ◽

L. KELLY

Keyword(s):

Carpal Tunnel Syndrome ◽

Carpal Tunnel ◽

Clinical Signs ◽

Nerve Compression ◽

Positive Pressure ◽

Sensory Testing ◽

Clinical Tests ◽

Provocative Test ◽

Tunnel Syndrome ◽

The Relationship

This study reports the relationship between three clinical tests in the diagnosis of carpal tunnel syndrome and the stages of nerve compression. Assessments of 158 patients with carpal tunnel syndrome were reviewed retrospectively. 77% of patients had at least one of the clinical signs present. The incidence of positive pressure-provocative and Phalen’s tests were similar and more likely to occur in combination than separately. Tinel’s sign was more likely to be positive in the later stages of nerve compression. Our results suggest that the presence or absence of a provocative test is dependent upon the severity of the nerve compression.

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Linkage and Association Studies of Joint Morbidity from Rheumatoid Arthritis

The Journal of Rheumatology ◽

10.3899/jrheum.090526 ◽

2009 ◽

Vol 37 (2) ◽

pp. 291-295 ◽

Cited By ~ 2

Author(s):

JIN-YOUNG MIN ◽

KYOUNG-BOK MIN ◽

JOOHON SUNG ◽

SUNG-IL CHO

Keyword(s):

Rheumatoid Arthritis ◽

Association Studies ◽

Clinical Signs ◽

Joint Damage ◽

Genetic Variations ◽

Nucleotide Polymorphisms ◽

Sibling Pairs ◽

Rf Values ◽

Family Based ◽

The Relationship

Objective. To investigate the relationship between genetic variations of rheumatoid arthritis (RA) susceptibility in terms of joint morbidity.Methods. We used data from Genetic Analysis Workshop 15. The Illumina linkage panel IV included 5858 single-nucleotide polymorphisms (SNP), with 5744 SNP passing quality control filters. The phenotypic variables analyzed were the level of rheumatoid factor (RF) and score on the Joint Alignment and Motion (JAM) scale. We modified the scale, dividing by RF values relevant to disease severity. Linkage analysis for affected sibling pairs was done using the MERLIN program, and family-based association tests were carried out using PLINK and FBAT software.Results. We found a high peak (LOD = 3.29; NPL Z = 4.07) near the HLA-DRB1 region on chromosome 6. The linkage at 6p24 at rs1410766 [LOD = 2.66; nonparametric linkage (NPL) Z = 3.23] was statistically significant. Two other regions also showed possible linkage peaks: chromosome 7q30 at rs322812 (LOD = 2.47; NPL Z = 3.39) and chromosome 15p34 at rs347117 (LOD = 1.95; NPL Z = 2.80). For the family-based association study, 7 SNP related to clinical RA severity were detected.Conclusion. Genetic variations may lead to an enhanced risk of joint damage and increased levels of RF. Further studies are needed to elucidate the roles of other genes involved in RA and to explore whether the clinical signs of RA are associated with particular genetic variations.

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Age and gender features of clinical course COVID-19

Shidnoevropejskij zurnal vnutrisnoi ta simejnoi medicini ◽

10.15407/internalmed2021.02.004 ◽

2021 ◽

Vol 2021 (2) ◽

pp. 4-9

Author(s):

OM Kovalyova ◽

Keyword(s):

Clinical Signs ◽

Scientific Data ◽

Age And Gender ◽

Gender And Age ◽

Different Populations ◽

And Gender ◽

Definition Of ◽

The Impact ◽

The Relationship ◽

Gender Features

The article presents the review of modern publications devoted the assessment the impact of age and gender on susceptibility, clinical manifestation and outcome of COVID-19 infection. Statistical data on rate of COVID-19 in relation to age categories and adverse clinical signs of disease in different populations are shown. Old and older ages are the predictors of severe coronavirus course and mortality are emphasized. Gender features of coronavirus infection have been described according to gender cardiology with taken in account the disproportion of hypertension and coronary heart disease in male and female. Due to the scientific research the gender and age peculiarities of immune response to virus infection is considered. The definition of hypothesis “immunosenescence” underlying adverse outcome due to COVID-19 in older patients is taken. Gender peculiarities of COVID-19 are presented by evident scientific data according to the relationship between sex hormone and immune inflammation factors

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Surgical treatment of Chiari malformation with and without syringomyelia: experience with 177 adult patients

Journal of Neurosurgery ◽

10.3171/2012.10.jns12305 ◽

2013 ◽

Vol 118 (2) ◽

pp. 232-242 ◽

Cited By ~ 53

Author(s):

Ulrich Batzdorf ◽

David L. McArthur ◽

John R. Bentson

Keyword(s):

Clinical Outcome ◽

Posterior Fossa ◽

Chiari Malformation ◽

Clinical Signs ◽

Signs And Symptoms ◽

Surgical Decompression ◽

Imaging Studies ◽

Clinical Signs And Symptoms ◽

The Relationship ◽

Cerebellar Tonsils

Object This study aims to show the relationship between clinical outcome in patients who underwent surgical decompression for Chiari malformation (CM) and postoperative imaging studies, with particular emphasis on the subarachnoid cisterns of the posterior fossa. Methods One hundred seventy-seven patients with CM, including 97 with syringomyelia, underwent posterior fossa decompressive surgery. Both the dura and arachnoid were opened in 150 of these patients, and 135 underwent reduction of the cerebellar tonsils. The patients' clinical signs and symptoms were evaluated at 2 time points after surgery. Their imaging studies were analyzed specifically for the size of the retrotonsillar and subtonsillar cisterns and the syringomyelic cavities. The authors evaluated the relationship between these imaging findings and clinical parameters. Results Clinical improvement correlated strongly with enlargement of the subarachnoid cisterns, and enlargement of the cisterns also correlated with reduction in size of the syrinx cavities. Symptoms related to syringomyelia responded to reduction in size of the syrinx cavities. Conclusions Surgical decompression of the posterior fossa should aim to create relatively large subarachnoid cisterns and reduce the size of the syrinx cavity. Reduction of the cerebellar tonsils by surgical means, together with duraplasty, achieves this goal and thereby improves the clinical outcome for patients with CM. An incidental observation of the study is that obesity increases the likelihood of headache in patients with CM.

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