Oncogenic Evaluation of 3,3′-Dimethoxybenzidine Dihydrochloride in BALB/c Mice

1990 ◽  
Vol 9 (1) ◽  
pp. 71-77 ◽  
Author(s):  
G. J. Schieferstein ◽  
W. G. Sheldon ◽  
R. R. Allen ◽  
D. L. Greenman ◽  
W. T. Allaben
Keyword(s):  
Drinking Water ◽  
Body Weight ◽  
Dose Level ◽  
Body Weight Gain ◽  
Inbred Mouse ◽  
Inbred Mouse Strain ◽  
Current Investigation ◽  
Related Effect ◽  
Male And Female ◽  
Males And Females

3,3′-Dimethoxybenzidine, a congener of the known carcinogen benzidine, is carcinogenic in the rat and possibly the hamster. This study was undertaken to assess carcinogenicity in an inbred mouse strain. Male and female (840 each) BALB/c mice were given 0, 20, 40, 80, 160, 315, or 630 ppm of 3,3′-dimethoxybenzidine dihydrochloride in their drinking water. At the serial sacrifices (13, 26, 39, 52, 78, or 112 weeks on dose), detailed necropsies and histopathologic examinations were performed. There was a decrease in water consumption at the 630 ppm dose level. Compared with controls, the 630 ppm dose produced a decrease in body weight gain of 10.7 and 13.3% in males and females, respectively, at 48 to 52 weeks on test. These weight decrements may be related to low water palatability at the 630 ppm dose level and may not reflect toxicity induced by 3,3′-dimethoxybenzidine itself. There was no treatment-related effect upon mortality or pathology. In summary, 3,3′-dimethoxybenzidine dihydrochloride was not carcinogenic in the mouse in the current investigation.

Short-Term Toxicity (1 and 10 Days) of Cadmium Chloride in Male and Female Rats: Gavage and Drinking Water

1989 ◽  
Vol 8 (2) ◽  
pp. 377-404 ◽  
Author(s):  
Joseph F. Borzelleca ◽  
Elizabeth C. Clarke ◽  
L. W. Condie
Keyword(s):  
Drinking Water ◽  
Body Weight ◽  
Weight Gain ◽  
Body Weight Gain ◽  
Female Rats ◽  
Testicular Atrophy ◽  
Dependent Manner ◽  
Male And Female ◽  
Males And Females ◽  
Dose Dependent

Male and female Sprague-Dawley-derived rats received CdCl2 by gavage at doses of 25, 51, 107, and 225 mg CdCl2 per kg body weight per day for 1 or 10 consecutive days or in drinking solutions at concentrations of 13–323 mg CdCl2 per liter for 10 consecutive days. There were appropriate controls. In the 1 day study in males only, an apparent treatment-related but not statistically significant decrease in body weight was reported; spleen weights and ratios were significantly lower and lung weights and ratios were significantly higher (in the highest dose only). Dose-dependent mortality was observed in the 10 day gavage study. Body weight gain was depressed in a dose-dependent manner in both males and females. Weights and/or ratios of brain, liver, spleen, lungs, thymus, kidneys, and testes of treated males were depressed in a dose-dependent manner. In females, weights and/or ratios of liver, spleen, thymus, and kidneys were depressed in a dose-dependent manner. Focal necrotic changes in renal tubular epithelium and tubular degeneration were reported in males and females. Testicular and hepatic histopathologic changes (testicular atrophy and necrosis and hepatic necrosis) were also reported in males. In the drinking water study, males demonstrated dose-dependent decreases in body weight gain and weight and/or ratios of liver, spleen, thymus, and kidneys. There were no significant compound-related effects in females, although liver weights and ratios were lower. There were no compound-related histopathologic effects.

scholarly journals Genetic parameters for body weight and different definitions of residual feed intake in broiler chickens

2019 ◽  
Vol 51 (1) ◽  
Author(s):  
Wossenie Mebratie ◽  
Per Madsen ◽  
Rachel Hawken ◽  
Hélène Romé ◽  
Danye Marois ◽  
...  
Keyword(s):  
Body Weight ◽  
Feed Intake ◽  
Broiler Chickens ◽  
Genetic Parameters ◽  
Body Weight Gain ◽  
Genetic Correlations ◽  
Residual Feed Intake ◽  
Nutrient Utilization ◽  
Male And Female ◽  
Males And Females

Abstract Background The objectives of this study were to (1) simultaneously estimate genetic parameters for BW, feed intake (FI), and body weight gain (Gain) during a FI test in broiler chickens using multi-trait Bayesian analysis; (2) derive phenotypic and genetic residual feed intake (RFI) and estimate genetic parameters of the resulting traits; and (3) compute a Bayesian measure of direct and correlated superiority of a group selected on phenotypic or genetic residual feed intake. A total of 56,649 male and female broiler chickens were measured at one of two ages ($${\text{t}}$$ t or $${\text{t}} - 6$$ t - 6 days). BW, FI, and Gain of males and females at the two ages were considered as separate traits, resulting in a 12-trait model. Phenotypic RFI ($${\text{RFI}}_{\text{P}}$$ RFI P ) and genetic RFI ($${\text{RFI}}_{\text{G}}$$ RFI G ) were estimated from a conditional distribution of FI given BW and Gain using partial phenotypic and partial genetic regression coefficients, respectively. Results Posterior means of heritability for BW, FI and Gain were moderately high and estimates were significantly different between males and females at the same age for all traits. In addition, the genetic correlations between male and female traits at the same age were significantly different from 1, which suggests a sex-by-genotype interaction. Genetic correlations between $${\text{RFI}}_{\text{P}}$$ RFI P and $${\text{RFI}}_{\text{G }}$$ RFI G were significantly different from 1 at an older age but not at a younger age. Conclusions The results of the multivariate Bayesian analyses in this study showed that genetic evaluation for production and feed efficiency traits should take sex and age differences into account to increase accuracy of selection and genetic gain. Moreover, for communicating with stakeholders, it is easier to explain results from selection on $${\text{RFI}}_{\text{G}}$$ RFI G than selection on $${\text{RFI}}_{\text{P}}$$ RFI P , since $${\text{RFI}}_{\text{G}}$$ RFI G is genetically independent of production traits and it explains the efficiency of birds in nutrient utilization independently of energy requirements for production and maintenance.

scholarly journals Effect of Adding Lycium barbarum L. Extract to Drinking Water on Some Productive Traits of Japanese Quail (Coturnix japonica)

2019 ◽  
Vol 32 (2) ◽  
pp. 208-212
Author(s):  
Arshad T.M. Sultan ◽  
Khalid C.K. Al-Salhie ◽  
Tarik F. Shawket
Keyword(s):  
Drinking Water ◽  
Body Weight ◽  
Japanese Quail ◽  
Body Weight Gain ◽  
The Other ◽  
Feed Consumption ◽  
Feed Conversion ◽  
Lycium Barbarum ◽  
Males And Females ◽  
Productive Traits

This study was conducted to investigate the effect of adding Lycium barbarum extract to drinking water on some productive traits of Japanese quail. A total of 270 one-week-old Japanese quails were used in this study. The birds were divided into six treatments (45 for each). Each litre of drinking water (RO) was treated with 400 mg of L. barbarum extract add from (leaves, fruits, stems, and roots) for T2, T3, T4, and T5 respectively. 400 mg of mixed extract from leaves, stems, fruits and roots of L. barbarum were added to drinking water (T6). The control treatment (T1) was free of L. barbarum drinking water. The results showed no significant differences in the body weight, body weight gain, feed consumption and feed conversion ratio. A significant decrease in the age of sexual puberty and sexual maturity for males and females were recorded in the second and third treatments compared to the other treatments. On the other hand, the results showed no significant differences between the experimental treatments for the weight at sexual puberty and maturity for males and females. It can be concluded that the leaves and fruits of L. barbarum extract decreased the sexual puberty age for males and females of Japanese quail. On the other hand, it has no effect on body weight, body weight gain, feed consumption and feed conversion ratios.

Studies on Eimeria grenieri in the guinea fowl (Numida meleagris)

Parasitology ◽  
1978 ◽  
Vol 76 (1) ◽  
pp. 1-9 ◽  
Author(s):  
P. L. Long ◽  
B. J. Millard
Keyword(s):  
Drinking Water ◽  
Body Weight ◽  
Small Intestine ◽  
Body Weight Gain ◽  
Chorioallantoic Membrane ◽  
Severe Depression ◽  
Guinea Fowl ◽  
Third Generation ◽  
Numida Meleagris ◽  
Pathogenic Effects

SummaryEimeria grenieri was isolated from intensively reared guinea fowl in Britain. The oocysts had average dimensions of 21·09 × 15·48 μm and a small micropyle. Three generations of schizonts were found in the small intestine. The first mature schizonts were found in the upper intestine 30 h after inoculation. Second-generation schizonts were seen 48–80 h and third-generation schizonts were present 80–96 h after inoculation. These schizonts were found in the middle and lower small intestine. It was confirmed that gametogony of this species occurs only in the caeca. The pre-patent time was 112 h and the reproductive index from a dose of 6 × 102 oocysts was 8 × 104. Doses of between 1 × 104 and 1 × 106 caused severe depression of body weight gain. Immunity to re-infection developed rapidly. Sulphaquinoxaline at a dose of 0·04% in the drinking water given after inoculation was effective in reducing the pathogenic effects of the disease. Robenidine given in the food at a concentration of 16·5 ppm (50% of the recommended concentration for chickens) was effective in preventing disease caused by E. grenieri.The endogenous life-cycle of E. grenieri was completed in the chorioallantoic membrane of developing chicken embryos.

scholarly journals PERFORMANCE OF QUAILS (Coturnix-coturnix japonica) GIVEN DRINK CONTAINING MORINGA LEAF SOLUTION IN THEIR GROWING PERIOD

2019 ◽  
Vol 4 (2) ◽  
pp. 75
Author(s):  
Fatkur Rohman ◽  
Ristika Handarini ◽  
Hanafi Nur
Keyword(s):  
Drinking Water ◽  
Body Weight ◽  
Egg Production ◽  
Body Weight Gain ◽  
Coturnix Japonica ◽  
Feed Conversion ◽  
Coturnix Coturnix ◽  
Growing Period ◽  
Randomized Design ◽  
Completely Randomized Design

Moringa leaves contain phytochemicals which can be used to improve the performance of quails in their growing period.  This study was aimed at assessing the effects of the inclusion of moringa leaf solution in drinking water on the performance of quails.  The study was conducted at Badrupuyuh Farm, Sukajaya Village RT 01/02, Ciomas, Bogor Regency from October to December 2017.  One-hundred quail birds aged 7 days with average initial body weight of 17.87±0.46 g were used.  The birds were fed starter and grower commercial rations.  Moringa leaf solution was given through drinking water.  A completely randomized design with 4 treatments and 5 replicates was used.   Treatments consisted of drinking water containing no moringa leaf solution (R0), drinking water containing 5% moringa leaf solution (R1), drinking water containing 10% moringa leaf solution (R2), drinking water containing 15% moringa leaf solution (R3).  Data were subjected to an analysis of variance and a Duncan test.  Measurements were taken on feed intake, body weight gain (BWG), feed conversion, and mortality rate.  Results showed that there were significant effects (P<0.05) of treatments on BWG in week 2 and 4 and feed conversion in week 2.  No mortality of quails was found.  It was concluded that the inclusion of 10% moringa leaf solution in drinking water could increase BWG in week 2 and 4, improve feed conversion, and maintain the life of quails.  It was recommended that further studies on the effects of moringa leaf solution inclusion in drinking water on egg production in laying period.  Key words: performance, quail, moringa leaf solution

scholarly journals The correlation between dimensional characteristics, live weight and fluff and feather level of obroshynska gray and obroshynska white natural groups geese

2017 ◽  
Vol 19 (74) ◽  
Author(s):  
V. S. Zaplatynsky
Keyword(s):  
Body Weight ◽  
Linear Growth ◽  
Correlation Coefficients ◽  
Live Weight ◽  
Natural Group ◽  
Male And Female ◽  
Body Sizes ◽  
Males And Females ◽  
Natural Groups

This article presents data on dynamics of linear growth and weight rates of obroshynska gray and obroshynska gray natural groups geese, factional fluff content, correlation coefficients between body weight and body sizes and amount of feathers. It has been found that male and female individuals of obroshynska gray natural group geese dominated by live weight of obroshynska white natural group geese. Particularly, this advantage in 90 days aged males was 549.4 (P < 0.05), in 120 days aged males – 635.6 (P < 0.01) and in 180 days aged males – 422.6 (P < 0.05) g, in females – 177.0, 461.8 (P < 0.01) and 401.8 g respectively. It has been also revealed the obroshynska gray natural group geese domination by researched body sizes in all geese ages, but it was only reliable in some cases. Geese of both sexes in both natural groups were characterized by high fluff and feather level. We investigated age, sex and interbreed differentiation on fluff and feather levels in studied geese groups. It should be noted that fluff and feather level was better in white geese indicating a better fluff and feather quality. The correlation coefficients between body weight and overall fluff and feather levels in females of obroshynska gray natural group geese dependent on ages and fluff and feather levels were between -0.30 – +0.63, in males – between -0.51 – +0.68 and in obroshynska white natural groups geese coefficients were between -0.29 – +0.70 and -0.30 до +0.82 respectively. It has been found the correlations between geese body sizes and fluff and feather levels. In males and females geese from abroshynska gray natural group depenent on ages, body sizes and fluff and feather levels coefficients were -0.49 – +0.81 and -0.76 – +0.88, and for obroshynska white natural group geese – -0.49 – +0.90 and -0.65 – +0.65.

Long-latency growth-promoting activity of EGF when administered to mice at the neonatal stage

1987 ◽  
Vol 253 (3) ◽  
pp. E251-E254
Author(s):  
O. Imada ◽  
N. Hayashi ◽  
K. Masamoto ◽  
S. Kasuga ◽  
T. Fuwa ◽  
...  
Keyword(s):  
Body Weight ◽  
Body Weight Gain ◽  
Daily Administration ◽  
Long Latency ◽  
Neonatal Stage ◽  
Epidermal Growth ◽  
Males And Females ◽  
Accelerated Growth ◽  
Dose Dependent Increase ◽  
Dose Dependent

The effect of biosynthetic human epidermal growth factor (Bh-EGF) as well as mouse EGF on postnatal development of mice of ICR strain was examined. Daily administration of Bh-EGF (0.01, 0.1, and 1.0 microgram X g body wt-1 X day-1) for 30 consecutive days postpartum caused a clearly dose-dependent increase in their body weight. Furthermore, in addition to the well-known premature eyelid opening and early tooth eruption, we have also observed precocious opening of the vagina among treated females. As far as the accelerated growth rate as reflected in their body weight gain was concerned, daily administration for only five consecutive days postpartum was just as effective as the above noted 30 consecutive daily injections. As to the precocious vaginal opening, however, the susceptible 5-day-period was found to be 14-18 days after the parturition. Some of those treated females also entered the estrous cycle precociously, a few days after the precocious opening of their vagina. The microscopic examination of various organs from treated males and females revealed no apparent pathological changes. As far as the above noted effects of EGF were concerned, Bh-EGF, which is xenogenic to mice, was as potent as mouse EGF.

scholarly journals Effect of chronic infusion of olanzapine and clozapine on food intake and body weight gain in male and female rats

Life Sciences ◽  
2007 ◽  
Vol 81 (12) ◽  
pp. 1024-1030 ◽  
Author(s):  
SuJean Choi ◽  
Briana DiSilvio ◽  
JayLynn Unangst ◽  
John D. Fernstrom
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Food Intake ◽  
Body Weight Gain ◽  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats ◽  
Chronic Infusion

The reproductive cycle of the newt Triturus italicus

1992 ◽  
Vol 13 (2) ◽  
pp. 121-133 ◽  
Author(s):  
Fabio M. Guarino ◽  
Vincenzo Caputo ◽  
Francesco Angelini
Keyword(s):  
Body Weight ◽  
Reproductive Cycle ◽  
Annual Variation ◽  
Southern Italy ◽  
Fat Body ◽  
Reproductive Activity ◽  
Male And Female ◽  
Egg Deposition ◽  
Males And Females ◽  
Mountain Population

AbstractThis paper describes the reproductive cycle in male and female newts Triturus italicus (Peracca, 1898) from a mountain population living in southern Italy. The male shows a well-defined seasonal testicular cycle: spermatogenesis almost stops from November to March, resuming in April-May; the maturative stage of spermatogenesis occurs in summer and spermiohistogenesis is completed by late October. Spermiation starts in late autumn and culminates in the next spring. The female shows a seasonal ovarian cycle. Vitellogenesis starts in September; ovulation and egg deposition occur between late January and early June. Thus potentially long reproductive activity is demonstrated in both males and females of T italicus. Testicular and ovarian weights seem to be reliable indices of the reproductive status of an animal. Annual variation in gonadal weight appears unrelated to annual variation in fat body weight in both sexes.

Testicular and spermatotoxic effect of nitrate in mice

2002 ◽  
Vol 21 (1) ◽  
pp. 37-41 ◽  
Author(s):  
N Pant ◽  
SP Srivastava
Keyword(s):  
Drinking Water ◽  
Body Weight ◽  
Dose Level ◽  
Sperm Count ◽  
Cell Types ◽  
Potassium Nitrate ◽  
The Body ◽  
Specific Cell ◽  
Human Beings ◽  
Dose Levels

A study was conducted with nitrate to assess the testicular and spermatotoxic effects in mice at doses to which human beings are exposed as well as at higher dose levels in the drinking water. Potassium nitrate was administered to mice at dose levels 90, 200, 500, 700 and 900 ppm for 35 days. There was no difference in the uptake of water in control and treated animals. The amount of nitrate intake// mouse///day calculated on the basis of water intake in the different groups ranged from 22.5 to 27, 50 to 60, 125 to 150, 175 to 210 and 225 to 270 mg///kg body weight. No changes were evident in the body weight, testicular, epididymal and accessory organ weight at all the dose levels tested, although a decline in sperm count and sperm motility along with an increase in abnormal sperm was noticed at 900 ppm. The activity of marker testicular enzymes, mainly 17-β hydroxysteroid dehydrogenase (17-β HSD) and figlutamyl transpeptidase (fi-GT), associated with specific cell types were altered. Histopathological changes including atrophy and disturbed spermatogenesis were observed only at the 900-ppm dose level. In conclusion, we can say that the testicular and spermatotoxic effects are observed only at the highest dose level, which is not likely to be encountered in the drinking water.

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