Traumatic Ulcerative Granuloma with Stromal Eosinophilia: Sinister Appearing Innocuous Lesion

Trauma within the oral cavity is one of the common incidence of occurrence which can be an inducer as well as propagator for wide range of oral lesion of diverse course. A unique combination of formation of granulomatous lesion with reactive eosinophilic stromal infiltration in response of trauma is “traumatic ulcerative granuloma with stromal eosinophilia (TUGSE)”. It is a reactive, infrequent, self-limiting condition of oral mucosa. The commonly involved site and the clinical presentation might click to suspect it as a lesion of oral cancer. Clinical history and examination guide through the diagnosis whereas histopathology forms the basis of the diagnosis.

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Oral premalignant lesions: a clinicopathological study

International Surgery Journal ◽

10.18203/2349-2902.isj20174520 ◽

2017 ◽

Vol 4 (10) ◽

pp. 3477

Author(s):

Sunil Vitthalrao Jagtap ◽

Pranita Warhate ◽

Neerav Saini ◽

Swati S. Jagtap ◽

P. G. Chougule

Keyword(s):

Oral Cancer ◽

Buccal Mucosa ◽

Clinical Presentation ◽

Oral Submucous Fibrosis ◽

Premalignant Lesions ◽

Histopathological Study ◽

Female Ratio ◽

Male Predominance ◽

The Common ◽

Tobacco Chewing

Background: A significant number of oral cancer cases present initially with precursor lesions. If detected earlier in disease course it will reduce the morbidity and mortality. The objective of this study was to evaluate the clinical presentation and various histopathological types of premalignant lesions.Methods: This is descriptive, observational, analytical type of study of five-year duration. The detail clinical presentation, relevant investigation and histopathological study on biopsy tissue stain with H and E was done and the data is analysed.Results: During study period, 173 cases having oral lesions were observed. Among these 38 cases showed oral premalignant lesions. The most common age group affected was in between 50 to 59 years. The male predominance was noted. Male to female ratio was 1.9:1. The location of the lesions were buccal mucosa (55.26%), tongue (26.31%), gingiva (7.90%), alveolus (5.26%), lip (2.6%), retromolar area (2.63%) was noted. The common etiological factor observed was tobacco chewing. On histopathological features, cases were of leukoplakia 68.41%, oral lichen planus 13.16%, oral submucous fibrosis 7.90%, actinic cheilitis-7.9%, and oral erythroplakia 2.6%.Conclusions: In this study, various oral premalignant lesions were observed. Their clinical and histopathological evaluation was done. Oral leukoplakia was most common lesion in the present study. Buccal mucosa was the most common site. Tobacco chewing habit was the common risk factor observed. Early detection of premalignant oral lesion is of utmost importance to prevent further morbidity as these lesions further progress to oral cancer.

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Angio-Architectural Features of High-Grade Intracranial Dural Arteriovenous Fistulas: Correlation With Aggressive Clinical Presentation and Hemorrhagic Risk

Neurosurgery ◽

10.1093/neuros/nyw175 ◽

2017 ◽

Vol 81 (2) ◽

pp. 315-330 ◽

Cited By ~ 16

Author(s):

Giuseppe Maria Della Pepa ◽

Paolo Parente ◽

Francesco D’Argento ◽

Alessandro Pedicelli ◽

Carmelo Lucio Sturiale ◽

...

Keyword(s):

Clinical Presentation ◽

Venous Drainage ◽

Clinical History ◽

Venous Hypertension ◽

High Grade ◽

Arteriovenous Fistulas ◽

Clinical Risk ◽

Architectural Features ◽

Wide Range ◽

Dural Arteriovenous Fistulas

Abstract BACKGROUND: High-grade dural arteriovenous fistulas (dAVFs) can present shunts with very different angio-architectural characteristics. Specific hemodynamic factors may affect clinical history and determine very different clinical courses. OBJECTIVES: To evaluate the relationship between some venous angio-architectural features in high-grade dAVFs and clinical presentation. Specific indicators of moderate or severe venous hypertension were analyzed, such as altered configurations of the dural sinuses (by a single or a dual thrombosis), or overload of cortical vessels (restrictions of outflow, pseudophlebitic cortical vessels, and venous aneurysms). METHODS: The institutional series was retrospectively reviewed (49 cases), and the pattern of venous drainage was analyzed in relationship with clinical presentation (benign/aggressive/hemorrhage). RESULTS: Thirty-five of 49 cases displayed cortical reflux (high-grade dAVFs). This subgroup displayed a benign presentation in 31.42% of cases, an aggressive in 31.42%, and hemorrhage in 37.14%. CONCLUSIONS: Our data confirm that within high-grade dAVFs, 2 distinct subpopulations exist according to severity of clinical presentation. Some indicators we examined showed correlation with aggressive nonhemorrhagic manifestations (outflow restriction and pseudophlebitic cortical vessels), while other showed a correlation with hemorrhage (dual thrombosis and venous aneurysms). Current classifications appear insufficient to identify a wide range of conditions that ultimately determine the organization of the cortical venous drainage. Intermediate degrees of venous congestion correlate better with the clinical risk than the simple definition of cortical reflux. The angiographic aspects of venous drainage presented in this study may prove useful to assess dAVF hemodynamic characteristics and identify conditions at higher clinical risk.

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An Overview of Dementias

Perspectives on Swallowing and Swallowing Disorders (Dysphagia) ◽

10.1044/sasd21.3.75 ◽

2012 ◽

Vol 21 (3) ◽

pp. 75-84

Author(s):

Venkata Vijaya K. Dalai ◽

Jason E. Childress ◽

Paul E Schulz

Keyword(s):

Clinical Presentation ◽

Treatment Options ◽

Current Treatment ◽

Great Variability ◽

Health Concern ◽

Public Health Concern ◽

Life Threatening ◽

The Common ◽

Neurodegenerative Dementias ◽

Made In

Dementia is a major public health concern that afflicts an estimated 24.3 million people worldwide. Great strides are being made in order to better diagnose, prevent, and treat these disorders. Dementia is associated with multiple complications, some of which can be life-threatening, such as dysphagia. There is great variability between dementias in terms of when dysphagia and other swallowing disorders occur. In order to prepare the reader for the other articles in this publication discussing swallowing issues in depth, the authors of this article will provide a brief overview of the prevalence, risk factors, pathogenesis, clinical presentation, diagnosis, current treatment options, and implications for eating for the common forms of neurodegenerative dementias.

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COPPER ALLOY No. 268

Alloy Digest ◽

10.31399/asm.ad.cu0306 ◽

1976 ◽

Vol 25 (2) ◽

Keyword(s):

Corrosion Resistance ◽

Copper Alloy ◽

Cold Working ◽

Heat Treating ◽

Zinc Alloy ◽

Good Resistance ◽

Wide Range ◽

Copper Zinc ◽

The Common ◽

Cold Worked

Abstract Copper Alloy No. 268 is a copper-zinc alloy with excellent cold-working properties and good resistance to corrosion. It can be cold worked by all the common fabrication processes and has a wide range of applications. This datasheet provides information on composition, physical properties, hardness, elasticity, tensile properties, and shear strength as well as fatigue. It also includes information on corrosion resistance as well as forming, heat treating, machining, and joining. Filing Code: Cu-306. Producer or source: Brass mills.

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Conclusion

10.1093/oso/9780198759973.003.0007 ◽

2018 ◽

Author(s):

Matthew S. Seligmann

Keyword(s):

Corporal Punishment ◽

Social Reform ◽

Alcohol Intake ◽

Religious Practice ◽

Royal Navy ◽

The Poor ◽

Wide Range ◽

The Everyday ◽

Push Forward ◽

The Common

As this book has shown the common conception that ‘Churchill’s “radical phase” was cast to the winds’ when he was put in charge of the Navy in October 1911, although well established in the literature, is not, in fact, accurate.1 The radical President of the Board of Trade, eager to improve the lives of the poor, became the radical Home Secretary, no less enthusiastic for social reform, who then became the radical First Lord of the Admiralty, imbued with both a desire and, perhaps more importantly, a will to intervene in order to better conditions for those who served in the Royal Navy. Accordingly, he embarked upon a major programme of improvement across a wide range of different areas all of which affected the everyday life of sailors. Alcohol intake, sexual behaviour, religious practice, corporal punishment, as well as pay and equality of progression, all came under the spotlight while Churchill was First Lord. Of course, not all of the new measures were successful and not all were progressive in the modern understanding of the term, but all of them represented significant attempts to push forward a radical agenda for change....

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Punk as Folk: Continuities and Tensions in the UK and Beyond

The Oxford Handbook of Punk Rock ◽

10.1093/oxfordhb/9780190859565.013.4 ◽

2020 ◽

Author(s):

Pete Dale

Keyword(s):

Folk Music ◽

Music Making ◽

Collective Creativity ◽

Living Tradition ◽

Wide Range ◽

The Us ◽

The Common ◽

The Individual ◽

The Uk

Numerous claims have been made by a wide range of commentators that punk is somehow “a folk music” of some kind. Doubtless there are several continuities. Indeed, both tend to encourage amateur music-making, both often have affiliations with the Left, and both emerge at least partly from a collective/anti-competitive approach to music-making. However, there are also significant tensions between punk and folk as ideas/ideals and as applied in practice. Most obviously, punk makes claims to a “year zero” creativity (despite inevitably offering re-presentation of at least some existing elements in every instance), whereas folk music is supposed to carry forward a tradition (which, thankfully, is more recognized in recent decades as a subject-to-change “living tradition” than was the case in folk’s more purist periods). Politically, meanwhile, postwar folk has tended more toward a socialist and/or Marxist orientation, both in the US and UK, whereas punk has at least rhetorically claimed to be in favor of “anarchy” (in the UK, in particular). Collective creativity and competitive tendencies also differ between the two (perceived) genre areas. Although the folk scene’s “floor singer” tradition offers a dispersal of expressive opportunity comparable in some ways to the “anyone can do it” idea that gets associated with punk, the creative expectation of the individual within the group differs between the two. Punk has some similarities to folk, then, but there are tensions, too, and these are well worth examining if one is serious about testing out the common claim, in both folk and punk, that “anyone can do it.”

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Endoscopic Study of the Oral and Pharyngeal Cavities in the Common Dolphin, Striped Dolphin, Risso’s Dolphin, Harbour Porpoise and Pilot Whale: Reinforced with Other Diagnostic and Anatomic Techniques

Animals ◽

10.3390/ani11061507 ◽

2021 ◽

Vol 11 (6) ◽

pp. 1507

Author(s):

Álvaro García de los Ríos y Loshuertos ◽

Marta Soler Laguía ◽

Alberto Arencibia Espinosa ◽

Francisco Martínez Gomariz ◽

Cayetano Sánchez Collado ◽

...

Keyword(s):

Oral Cavity ◽

Common Dolphin ◽

Resonance Imaging ◽

Pilot Whale ◽

Anatomical Structures ◽

Vascular Plexus ◽

Endoscopic Study ◽

Main Technique ◽

The Common ◽

Magnetic Resonance Imaging Mri

In this work, the fetal and newborn anatomical structures of the dolphin oropharyngeal cavities were studied. The main technique used was endoscopy, as these cavities are narrow tubular spaces and the oral cavity is difficult to photograph without moving the specimen. The endoscope was used to study the mucosal features of the oral and pharyngeal cavities. Two pharyngeal diverticula of the auditory tubes were discovered on either side of the choanae and larynx. These spaces begin close to the musculotubaric channel of the middle ear, are linked to the pterygopalatine recesses (pterygoid sinus) and they extend to the maxillopalatine fossa. Magnetic Resonance Imaging (MRI), osteological analysis, sectional anatomy, dissections, and histology were also used to better understand the function of the pharyngeal diverticula of the auditory tubes. These data were then compared with the horse’s pharyngeal diverticula of the auditory tubes. The histology revealed that a vascular plexus inside these diverticula could help to expel the air from this space to the nasopharynx. In the oral cavity, teeth remain inside the alveolus and covered by gums. The marginal papillae of the tongue differ in extension depending on the fetal specimen studied. The histology reveals that the incisive papilla is vestigial and contain abundant innervation. No ducts were observed inside lateral sublingual folds in the oral cavity proper and caruncles were not seen in the prefrenular space.

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Zebrafish Models to Study New Pathways in Tauopathies

International Journal of Molecular Sciences ◽

10.3390/ijms22094626 ◽

2021 ◽

Vol 22 (9) ◽

pp. 4626

Author(s):

Clément Barbereau ◽

Nicolas Cubedo ◽

Tangui Maurice ◽

Mireille Rossel

Keyword(s):

Cognitive Deficits ◽

Tau Protein ◽

Common Point ◽

Transgenic Models ◽

Synaptic Loss ◽

Wide Range ◽

Transgenic Lines ◽

Functional Consequences ◽

The Common

Tauopathies represent a vast family of neurodegenerative diseases, the most well-known of which is Alzheimer’s disease. The symptoms observed in patients include cognitive deficits and locomotor problems and can lead ultimately to dementia. The common point found in all these pathologies is the accumulation in neural and/or glial cells of abnormal forms of Tau protein, leading to its aggregation and neurofibrillary tangles. Zebrafish transgenic models have been generated with different overexpression strategies of human Tau protein. These transgenic lines have made it possible to highlight Tau interacting factors or factors which may limit the neurotoxicity induced by mutations and hyperphosphorylation of the Tau protein in neurons. Several studies have tested neuroprotective pharmacological approaches. On few-days-old larvae, modulation of various signaling or degradation pathways reversed the deleterious effects of Tau mutations, mainly hTauP301L and hTauA152T. Live imaging and live tracking techniques as well as behavioral follow-up enable the analysis of the wide range of Tau-related phenotypes from synaptic loss to cognitive functional consequences.

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Cyclotide host-defense tailored for species and environments in violets from the Canary Islands

Scientific Reports ◽

10.1038/s41598-021-91555-y ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Blazej Slazak ◽

Klara Kaltenböck ◽

Karin Steffen ◽

Martyna Rogala ◽

Priscila Rodríguez-Rodríguez ◽

...

Keyword(s):

Host Defense ◽

Canary Islands ◽

Cyclic Peptides ◽

Fusarium Culmorum ◽

Host Defense Peptides ◽

Biological Assays ◽

Minimal Inhibitory Concentrations ◽

Wide Range ◽

The Common ◽

Teide Volcano

AbstractCyclotides are cyclic peptides produced by plants. Due to their insecticidal properties, they are thought to be involved in host defense. Violets produce complex mixtures of cyclotides, that are characteristic for each species and variable in different environments. Herein, we utilized mass spectrometry (LC–MS, MALDI-MS), transcriptomics and biological assays to investigate the diversity, differences in cyclotide expression based on species and different environment, and antimicrobial activity of cyclotides found in violets from the Canary Islands. A wide range of different habitats can be found on these islands, from subtropical forests to dry volcano peaks at high altitudes. The islands are inhabited by the endemic Viola palmensis, V. cheiranthifolia, V. anagae and the common V. odorata. The number of cyclotides produced by a given species varied in plants from different environments. The highest diversity was noted in V. anagae which resides in subtropical forest and the lowest in V. cheiranthifolia from the Teide volcano. Transcriptome sequencing and LC–MS were used to identify 23 cyclotide sequences from V. anagae. Cyclotide extracts exhibited antifungal activities with the lowest minimal inhibitory concentrations noted for V. anagae (15.62 μg/ml against Fusarium culmorum). The analysis of the relative abundance of 30 selected cyclotides revealed patterns characteristic to both species and populations, which can be the result of genetic variability or environmental conditions in different habitats. The current study exemplifies how plants tailor their host defense peptides for various habitats, and the usefulness of cyclotides as markers for chemosystematics.

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Detection and characterization of Leptospira spp. in dogs diagnosed with kidney and/or liver disease in Selangor, Malaysia

Journal of Veterinary Diagnostic Investigation ◽

10.1177/10406387211024575 ◽

2021 ◽

pp. 104063872110245

Author(s):

Sabri A. Rahman ◽

Kuan H. Khor ◽

Siti Khairani-Bejo ◽

Seng F. Lau ◽

Mazlina Mazlan ◽

...

Keyword(s):

Liver Disease ◽

Mortality Rate ◽

Direct Detection ◽

Bacterial Disease ◽

Pathogenic Leptospira ◽

Wide Range ◽

Leptospira Spp ◽

Rrna Sequencing ◽

The Common

Leptospirosis is a serious bacterial disease that affects both humans and animals. A wide range of symptoms have been described in humans; the disease in dogs is commonly associated with kidney and/or liver disease. In Malaysia, information about the common serovars infecting dogs is limited. Therefore, we investigated the occurrences of leptospirosis in 124 pet dogs diagnosed with kidney and/or liver disease. Blood, urine, abdominal effusion, and/or kidney and liver were collected from the dogs. Based on microscopic agglutination testing, 53 of 124 (42.7%) dogs were seropositive for leptospiral exposure. Sera were frequently positive to serovars Bataviae ( n = 12), Javanica ( n = 10), and Icterohaemorrhagiae ( n = 10). Direct detection using PCR showed that 42 of 124 (33.9%) of the whole blood and 36 of 113 (31.9%) urine samples were positive for pathogenic Leptospira spp. By PCR, 2 of 23 (9.1%) kidney and 2 of 23 (9.1%) liver were positive for pathogenic Leptospira spp. Abdominal effusion from 4 dogs were PCR-positive for pathogenic Leptospira spp. The species detected were L. interrogans, L. borgpetersenii, L. kirschneri, and L. kmetyi by partial 16S rRNA sequencing. We further identified and characterized 11 Leptospira spp. isolates from 8 dogs as serovars Bataviae, Javanica, and Australis. The mortality rate of the Leptospira-infected dogs was high (18 of 53; 34%).

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