scholarly journals Clinico-Laboratory Profile and Immediate Outcomes of Hyperbilirubinemic Babies Admitted in Kanti Children Hospital

1970 ◽  
Vol 30 (1) ◽  
pp. 31-36 ◽  
Author(s):  
Deepeshwara Nepal ◽  
Dinesh Banstola ◽  
Ajaya Kumar Khakal ◽  
Udbhabhat Mishra ◽  
Chandeshawar Maheseth
Keyword(s):  
Exchange Transfusion ◽  
Serum Bilirubin ◽  
Neonatal Period ◽  
Tertiary Care ◽  
Paediatric Hospital ◽  
Study Population ◽  
Laboratory Profile ◽  
Near Term ◽  
Key Words Hyperbilirubinemia ◽  
Rule Out

Introduction: Jaundice is an important problem in the neonatal period especially in the first week of life. Our objective of the study is to find out the immediate outcome of hyperbilirubinemic babies admitted in Kanti Children Hospital. Methodology: This is a retrospective study and carried out in tertiary care paediatric hospital. Results: Altogether 73 babies were enrolled in the study. Male babies outnumbered the female (72.6% vs. 27.4%).Only 2.4% babies were near-term. LBW babies constitute 19.2% of the study population.86.3% of babies also have clinical sepses as defined by WHO criteria. Almost half of the babies have mild hyperbilirubinemia (15-19.9 mg/dl). Most of the babies (94.5%) improved and the mortality was 5.5%. Conclusion: Healthy term babies with a serum bilirubin <17mg/dl should not be admitted for routinely as they do not need phototherapy. Phototherapy is effective in most of the time, but exchange transfusion should also be carried out when phototherapy fails. Causes of hyperbilirubinemia should be searched extensively especially to rule out haemolysis. Key words: hyperbilirubinemia, kernicterus, neonates, phototherapy DOI: 10.3126/jnps.v30i1.2457 Journal of Nepal Paediatric Society Vol.30(1) 2010 31-36

scholarly journals Neonatal hyperbilirubinaemia and its early outcome

1970 ◽  
Vol 31 (3) ◽  
pp. 17-20
Author(s):  
D. Nepal ◽  
D. Banstola ◽  
A. K. Dhakal ◽  
U. Mishra ◽  
C. Mahaseth
Keyword(s):  
Tertiary Care ◽  
Institute Of Medicine ◽  
Clinical Sepsis ◽  
Early Outcome ◽  
Paediatric Hospital ◽  
Study Results ◽  
Common Causes ◽  
Study Population ◽  
Near Term ◽  
Key Words Hyperbilirubinaemia

Introduction: Jaundice is an important cause of morbidity in the neonatal period, especially in the 1st week of life. our Objective of the study was to find out early outcome of babies admitted in Kanti Children Hospital with neonatal jaundice (NNJ) and its association with other co-morbidities. Methods: This is a retrospective study conducted in tertiary care paediatric hospital from 1st March to1st June 2009. Altogether 73 babies were included in the study. Results: Male babies outnumbered females (72.6% vs. 27.4%). Only 2.4% babies were near-term. Low birth weight (LBW) babies constituted 19.2% of the study population. Clinical sepsis as defined by WHO criteria was observed in 86.3% of babies. Nearly 50% of the babies had serum bilirubin of 15-19.9 mg/dl. Most of the babies (94.5%) improved with 5.5% of mortality. Conclusions: Hyperbilirubinaemia is one of the most common causes of hospital admission in our nursery and it is associated with various other clinical morbidities. Phototherapy is effective in most of the time, but exchange transfusion should also be carried out when phototherapy fails. Causes of hyperbilirubinaemia should be searched extensively especially to rule out haemolysis Key words: Hyperbilirubinaemia, kernicterus, neonates, phototherapy DOI: 10.3126/joim.v31i3.2990 Journal of Institute of Medicine, December, 2009; 31(3) 17-20

scholarly journals A prospective study on etiological factors and clinical indicators in term and near term neonates admitted with hyperbilirubinemia in nicu in a tertiary care hospital in Hyderabad, India

2021 ◽  
Vol 7 (2) ◽  
pp. 51-56
Author(s):  
C.V.S. Lakshmi ◽  
Syed Adnan Ali ◽  
Uppin Narayan Reddy ◽  
Farhana Nazneen ◽  
Muzammil
Keyword(s):  
Risk Factors ◽  
Blood Group ◽  
Exchange Transfusion ◽  
Serum Bilirubin ◽  
Tertiary Care ◽  
Neonatal Hyperbilirubinemia ◽  
Neurological Dysfunction ◽  
Safe Procedure ◽  
Care Hospital ◽  
Near Term

1.To study the etiology and risk factors of neonatal hyperbilirubinemia in term and near-term infants. 2. To study the clinical course of these infants during NICU stayThe present study was conducted at NICU, Department of Pediatrics, Princess Esra hospital, Deccan Medical College, Hyderabad, India, from October 2019 to October 2020. Term and late preterm infants admitted in NICU with Serum Bilirubin levels more than 12mg/dl were included in the study. The risk factors, etiology and clinical profile of these infants during NICU stay were studied. 210 neonates were admitted in NICU with hyperbilirubinemia (Serum Bilirubin &#62;12mg/dl) during the study period, out of which 118 were male (56.20%) and 92 were female (43.80%). Neonates were further distributed based on gestational age, in which 46 (21.90%) were late pre-terms i.e. between 34-37 weeks and 164 neonates (78.10%) were full term i.e. greater than 37 weeks. The neonates were also classified based on their birth weight, with neonates between 2500-3000 grams having the highest incidence (46.19%). Lastly, the etiological and risk factors were assessed and quantified, with physiological jaundice occurring as the major cause and late prematurity as the most common risk factor associated with neonatal hyperbilirubinemia. The average duration of phototherapy was 2.50 days and 3 babies required Double Volume Exchange Transfusion (DVET) for significant hyperbilirubinemia.None of the babies requiring DVET had clinical features of Bilirubin Induced Neurological Dysfunction (BIND) during NICU stay. 1. Most common cause of neonatal hyperbilirubinemia was found to be Physiological followed by Septicemia and Idiopathic etiologies. Blood group incompatibilities were less common causes. 2. Phototherapy is a cheap and effective way to reduce bilirubin levels in neonatal jaundice. 3. Exchange transfusion is a safe procedure and should be considered when indicated, to decrease the incidence of BIND. All cases requiring DVET were due to blood group incompatibility.

Outcome of neonatal thrombocytopenia in tertiary care NICU

2020 ◽  
Vol 10 (3) ◽  
pp. 92-96
Author(s):  
Deepak Madhavi ◽  
Shamama Subuhi ◽  
Mohammed Zubai
Keyword(s):  
Risk Factor ◽  
Neonatal Intensive Care ◽  
Neonatal Period ◽  
Tertiary Care ◽  
Neonatal Intensive Care Units ◽  
Severe Thrombocytopenia ◽  
Maternal Risk ◽  
Intracranial Bleed ◽  
Study Population ◽  
Neonatal Thrombocytopenia

Thrombocytopenia is one of the commonest haematological disorders in the neonatal period, affecting up to a third of those admitted to neonatal intensive care units. It is well recognized that many fetomaternal and neonatal conditions are associated with thrombocytopenia. The majority of episodes of neonatal thrombocytopenia are relatively mild, self-limiting and of short duration but it may cause severe morbidity & mortality due to severe complication like IVH. Methods & material: 140 Newborn admitted in tertiary care NICU were selected to find out outcome and etiology of neonatal thrombocytopenia. Detail maternal history and neonatal physical examination done and Neonates were followed for outcome, relevant investigation done according to cases. Result: Out of 140 neonates 63 neonates had thrombocytopenia (45%).42.8% neonates were premature out of which 63.3% had thrombocytopenia. Other neonatal risk factor for thrombocytopenia are sepsis 38 (74.5%), SGA/IUGR 28(80%) and NEC 9(100%). Maternal risk factor for thrombocytopenia are eclampsia81.8% and infection during pregnancy 72.72%. 95.5 % of all study population were discharged.4.5 % cases of whole study population didn’t survive. 4.54% of mild, 9.09% of moderate and 60 % of severe thrombocytopenic babies didn’t survive. Conclusion: Bleeding manifestations i.e. mucosal, cutaneous and intracranial bleed were significantly associated with severe thrombocytopenia. 60% of mortality was found in severe thrombocytopenic group. Thus, severe thrombocytopenia was found to be a predictor of poor outcome in sick neonates of NICU.

scholarly journals Adverse Events of Exchange Transfusion in Neonatal Hyperbilirubinemia

2014 ◽  
Vol 34 (1) ◽  
pp. 7-13 ◽  
Author(s):  
M Chitlangia ◽  
GS Shah ◽  
P Poudel ◽  
OP Mishra
Keyword(s):  
Adverse Events ◽  
Respiratory Distress ◽  
Exchange Transfusion ◽  
Serum Bilirubin ◽  
Tertiary Care ◽  
Neonatal Hyperbilirubinemia ◽  
Total Serum Bilirubin ◽  
Total Serum ◽  
Bilirubin Encephalopathy ◽  
The Common

Introduction: Jaundice is an important problem during neonatal period. When total serum bilirubin (TSB) level exceeds a critical limit, it crosses the blood brain barrier and results into bilirubin encephalopathy. The main aim of therapy for neonatal hyperbilirubinemia is prevention of bilirubin encephalopathy by phototherapy and/or exchange transfusion. The aims of this study were to evaluate the efficacy of exchange transfusion (ET) and observe the adverse events during and following three days of ET in neonates with hyperbilirubinemia. Materials and Method: Hospital based cross-sectional descriptive study. All neonates admitted to neonatal intensive care unit and /or paediatric wards of a tertiary- care centre between September 2010 to March 2012, requiring ET were enrolled. Results: A total of 139 ETs were performed in 120 neonates. The common causes were ABO incompatibility (30.8%), prematurity (30.8%), idiopathic (27.5%), Rh isoimmunization (6.7%) and cephalhematoma (4.2%). Mean pre- ET total serum bilirubin (TSB) was 24.2 mg% dL. There was 58% reduction in TSB in post ET and 31% net reduction in 6 hr post ET. Term and preterm neonates showed equal percentage of TSB reduction. Respiratory distress (10.8%) and bradycardia (6.7%) were the common adverse events during, and hypocalcemia (98.3%) and thrombocytopenia (34.2%) in 3 days following ET. The sick neonates had significantly higher incidence of thrombocytopenia (p= 0.031), respiratory distress (p=0.009), apnea (p<0.001) and cardiorespiratory arrest (p<0.001). Overall mortality was 4.2%, and non-survivors were mostly low birth weight, born outside the present hospital and had higher incidence of adverse events. Conclusion: Exchange transfusion is an effective intervention in reducing the serum bilirubin level. However, these neonates require monitoring of ionised calcium and thrombocytopenia. Sick neonates had higher incidence of adverse events than healthy and close clinical monitoring is needed to improve the outcome. DOI: http://dx.doi.org/10.3126/jnps.v34i1.9030   J Nepal Paediatr Soc 2014;34(1):7-13

scholarly journals REVIEW OF NEONATAL JAUNDICE AND ITS MANAGEMENT

2018 ◽  
Vol 6 (1) ◽  
pp. 172-176
Author(s):  
Pooja Pattanshetti ◽  
P. K. Dash
Keyword(s):  
Exchange Transfusion ◽  
Serum Bilirubin ◽  
Neonatal Period ◽  
Enterohepatic Circulation ◽  
Hepatic Clearance ◽  
Term Infant ◽  
Common Finding ◽  
Common Disease ◽  
High Dose ◽  
Therapeutic Modalities

Jaundice is the most common finding during neonatal period. It is observed during the 1st week of life in approximately 60% of term infant and 80% of preterm infants. Level of serum bilirubin is not raised that much so as to cause fatal brain damage. It is the most common disease during neonatal period occurring mostly due to increased hemolysis, decreased hepatic clearance, enterohepatic circulation, immaturity, blood group incompatibility and infections. Its management includes 1] Phototherepy 2] Exchange transfusion are two major effective therapeutic modalities available today. Additional options include Pharmacotherapy in the form of phenobarbital and high dose intravenous immunoglobulin.

....Beginning to See the Light

PEDIATRICS ◽  
1985 ◽  
Vol 75 (4) ◽  
pp. 792-795
Author(s):  
M. JEFFREY MAISELS
Keyword(s):  
Randomized Controlled Trial ◽  
Exchange Transfusion ◽  
Serum Bilirubin ◽  
Neonatal Period ◽  
Controlled Trial ◽  
Newborn Infants ◽  
Bilirubin Encephalopathy ◽  
Randomized Controlled ◽  
Prospective Randomized Controlled Trial ◽  
Postmortem Finding

In March 1952, Mollison and Walker1 reported the results of their prospective, randomized, controlled trial on the effect of exchange transfusion v simple transfusion in infants with severe erythroblastosis fetalis. They showed that exchange transfusion led to significantly lower mortality and a much lower incidence of fatal kernicterus. In the interim, numerous published studies have examined the relation between serum bilirubin levels in the neonatal period and the postmortem finding of kernicterus or the presence of later, clinical, bilirubin encephalopathy. With few exceptions, the design of these studies has made interpretation of their results hazardous, if not nugatory.2 We now have a study from the National Institute of Child Health and Human Development (NICHD)3 in which the population is sufficiently large and the study design sufficiently rigorous to permit actual, if tentative, conclusions concerning the effect of a different intervention (phototherapy) upon the immediate and later outcome of jaundiced newborn infants.

scholarly journals A prospective case control study on metabolic syndrome in lichen planus in a tertiary care centre

2017 ◽  
Vol 3 (3) ◽  
pp. 427
Author(s):  
Girlly Kurian ◽  
Krishnan S. ◽  
Shakthi P.
Keyword(s):  
Metabolic Syndrome ◽  
Lichen Planus ◽  
Case Control Study ◽  
Tertiary Care ◽  
Case Control ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Study Population ◽  
Control Study ◽  
Rule Out

<p class="abstract"><strong>Background:</strong> Lichen planus is an autoimmune, inflammatory papulosquamous disease affecting skin and mucous membrane with a possible association with the parameters of metabolic syndrome.</p><p class="abstract"><strong>Methods:</strong> We carried out a hospital based case control study among patients attending DVL OPD during a period of 1.5 years (January 2015 - May 2016). Study population included 40 cases of LP and 80 age and sex matched controls. Relevant history, clinical examination and blood investigations were done. Diagnosis of MS was made based on IDF criteria.<strong></strong></p><p class="abstract"><strong>Results:</strong> There was no significant association between metabolic syndrome and lichen planus (p=0.292). Although there was higher prevalence of hypertension (47.5% vs. 27.5%, p=0.029), triglyceride level (25% vs. 10%, p=0.030) and low HDLC levels (65% vs. 45%, p=0.039). We could not establish significant association between FBS and waist circumference with LP.</p><p><strong>Conclusions:</strong> Though metabolic syndrome was not significantly associated with LP, its components such as hypertension, triglycerides and low HDLC levels were significantly associated with LP as per the study. Therefore patients with LP need to be screened to rule out each of these parameters to avoid later complications.</p>

Neurodevelopmental outcome of healthy term newborn with serum bilirubin >15 mg/dl at one year

2020 ◽  
pp. 1-6
Author(s):  
P. Dubey ◽  
J. Shrivastava ◽  
B.P. Choubey ◽  
A. Agrawal ◽  
V. Thakur
Keyword(s):  
Serum Bilirubin ◽  
Tertiary Care ◽  
Neurodevelopmental Outcome ◽  
Significant Risk ◽  
Central India ◽  
Significant Risk Factor ◽  
Motor Domain ◽  
Medical Emergency ◽  
One Year ◽  
Group 1

BACKGROUND: Neonatal hyperbilirubinemia is a common medical emergency in early neonatal period. Unconjugated bilirubin is neurotoxic and can lead to lifelong neurological sequelae in survivors. OBJECTIVE: To find out the association between serum bilirubin and neurodevelopmental outcome at 1 year of age using Development Assessment Scale for Indian Infants (DASII). METHODS: A prospective cohort study was conducted in the Department of Pediatrics of a tertiary care institution of Central India between January 2018 and August 2019. Total 108 term healthy neonates, with at least one serum bilirubin value of >15 mg/dl, were included. Subjects were divided into three groups based on the serum bilirubin; group 1: (15–20 mg/dl) –85(78.7%) cases, group 2: (20–25 mg/dl) –17(15.7%), and group 3: (>25 mg/dl) –6(5.5%). Developmental assessment was done using DASII at 3, 6, 9, 12 months of age. RESULTS: Out of 108 cases, 101(93.5%) received phototherapy, and 7(6.5%) received double volume exchange transfusion. Severe delay was observed in 5(4.6%) and mild delay in 2(1.9%) cases in the motor domain of DASII at one year. Severe delay in the motor domain was associated with mean TSB of 27.940±2.89 mg/dl and mild delay with mean TSB of 22.75±1.76 mg/dl (p = 0.001). On cluster analysis, delay was observed in locomotion 1 score in 11(13%) cases (p = 0.003) and manipulation score in 6(7.1%) cases in group 1. CONCLUSION: Increased serum bilirubin was a significant risk factor for the delayed neurodevelopment in babies with neonatal jaundice. Even a moderate level of bilirubin significantly affects the developmental outcome.

Trend of Hospital Admission and Outcome Study of Patients Admitted in a Neurology Unit at a Tertiary Care Neuroscience Hospital in Bangladesh

2018 ◽  
Vol 4 (2) ◽  
pp. 69-74
Author(s):  
Md Tauhidul Islam Chowdhury ◽  
Mohammad Shah Jahirul Hoque Choudhury ◽  
KM Ahasan Ahmed ◽  
Mohammad Sadekur Rahman Sarkar ◽  
Md Abdullah Yusuf ◽  
...  
Keyword(s):  
Neurological Disorders ◽  
Neurological Diseases ◽  
Tertiary Care ◽  
Length Of Hospital Stay ◽  
Retrospective Chart Review ◽  
Total Death ◽  
Neurological Patients ◽  
Study Population ◽  
The Mean ◽  
Day By Day

Background: Neurological disorders is becoming a growing concern both for developed and developing countries. Magnitude of the problem is increasing day by day. Among all neurological disorders, stroke is the leading cause of morbidity and mortality globally.Objectives: The purpose of the study was to see the trend of admission of patients with neurological diseases and to study the outcome of patients at referral neurology hospital in Bangladesh.Methodology: This retrospective chart review was conducted in the blue unit of the Department of Neurology at National Institute of Neurosciences and Hospital, Dhaka, Bangladesh from 1st January to 31st December 2016 for a period of one (01) year. All the admitted patients with both sexes were selected as study population. The outcome was observed among the study population.Result: A total number of 1044 patients were admitted during the study period. Majority of the patients were in the age group of the 41 to 50 years which was 417(39.9%) cases. Both male and female were in highest number in the month of May which was 63 and 48 cases respectively. The total death of the study population was 146(14.0%) cases. The mean length of hospital stay was 8.4±2.31 days.Conclusion: Middle aged male is the main bulk of the neurological patients, admitted in a referral neurology hospital in Bangladesh. Highest admission and mortality was observed in stroke patients.Journal of National Institute of Neurosciences Bangladesh, 2018;4(2): 69-74

Sign in / Sign up

Export Citation Format

Share Document