scholarly journals Biochemical Markers in Perinatal Asphyxia

2011 ◽  
Vol 31 (2) ◽  
pp. 151-156 ◽  
Author(s):  
Manisha Naithani ◽  
Ashish Kumar Simalti
Keyword(s):  
Creatine Kinase ◽  
Uric Acid ◽  
Biochemical Markers ◽  
Perinatal Asphyxia ◽  
Elevated Serum ◽  
Neuron Specific Enolase ◽  
Protein S ◽  
Cerebral Injury ◽  
Early Assessment ◽  
Therapeutic Decisions

Early assessment of the severity of an acute cerebral lesion secondary to hypoxia-ischemia or other pathologic conditions may provide a very useful basis for preventive or therapeutic decisions in pediatric patients. In the present review, we discuss the diagnostic and prognostic value of a series of biochemical parameters, with special reference to the diagnosis of neonatal HIE. Currently many specific biochemical markers of brain injury are being investigated to assess regional brain damage after perinatal asphyxia in neonates of which serum protein S-100β, brain-specific creatine kinase, neuron-specific enolase, IL6 and urinary uric acid levels appear promising in identifying patients with a risk of developing hypoxic-ischemic encephalopathy. Whether detection of elevated serum concentrations of these proteins reflects long-term neurodevelopmental impairment remains to be investigated. Key words: S-100; Brain specific creatine kinase; neuron specific enolase; IL6; urinary uric acid; hypoxic ischaemic cerebral injury. DOI: 10.3126/jnps.v31i2.4155 J Nep Paedtr Soc 2010;31(2):151-156

scholarly journals Study of urinary uric acid and creatinine ratio as a marker of neonatal asphyxia for babies born in a tertiary care hospital

2017 ◽  
Vol 5 (12) ◽  
pp. 5418 ◽  
Author(s):  
Elango Krishnana ◽  
Venmugil Ponnusamy ◽  
Sathiya Priya Sekar
Keyword(s):  
Uric Acid ◽  
Perinatal Asphyxia ◽  
Tertiary Care ◽  
Neonatal Morbidity ◽  
Cerebral Injury ◽  
Care Hospital ◽  
Creatinine Ratio ◽  
Spot Urine ◽  
Medical College ◽  
Non Invasive

Background: Perinatal asphyxia is a common neonatal problem and there is significant contribution to neonatal morbidity and mortality. It is regarded as an important and common cause of preventable cerebral injury. The prediction of perinatal asphyxial outcome is important but formidable. There is only a limited role for the Apgar score for predicting the immediate outcome, such as HIE and the long-term neurological sequelae observational error can happen in APGAR. But biochemical parameters can be truly relied upon. This study was to evaluate the utility of urinary uric acid to creatinine ratio (UA/CR ratio) as non-invasive, easy, cheap and at the same time early biochemical means of asphyxia diagnosis.Methods: In this prospective case control study conducted in KAPV Government medical college between Feb 2017 to Sept 2017, 100 asphyxiated and 100 non-asphyxiated newborns were included. Detailed history and assessment were for all the enrolled newborns. Spot urine samples were sent for uric acid and creatinine estimation. Results were recorded, and statistical analysis was done.Results: The mean Uric acid/Creatinine ratio in the cases and controls groups were 2.58±1.09 and 0.86±0.17 respectively. The ratio also correlated well with the stage of HIE.Conclusions: The ratio of UA/Cr enables early and rapid recognition of asphyxial injury and also the assessment of its severity and the potential for short term morbidity or death.

scholarly journals Cardiopulmonary bypass strategy without donor blood components as a method for preventing brain damage in children

2021 ◽  
Vol 10 (2) ◽  
pp. 21-26
Author(s):  
A. A. Ivkin ◽  
D. V. Borisenko ◽  
E. V. Grigoriev
Keyword(s):  
Cardiopulmonary Bypass ◽  
Interleukin 1 ◽  
Neuron Specific Enolase ◽  
Protein S ◽  
Clinical Analysis ◽  
Cerebral Injury ◽  
Blood Components ◽  
Donor Blood ◽  
Surgical Interventions ◽  
S 100

Aim. To establish the role of donor blood components which are used in the intraoperative period in children with septal congenital heart disease (CHD) who need surgical interventions with cardiopulmonary bypass (CPB) for the prevention of cerebral injury in the postoperative period.Methods. 40 children of 14 months old on average and 8.8 kg of weight were under the study. All patients underwent radical correction of the septal CHD with the use of CPB. The patients were divided into 2 groups according to the donated blood components used. Cerebral damage was assessed with the help of three specific markers: protein S-100-ß, neuron-specific enolase (NSE) and glial fibrillar acidic protein (GFAP). The severity of the systemic inflammatory response was defined by the level of the following markers: interleukin 1, 6 and 10 in serum before operations, after the completion of IC and 16 hours after surgery. The clinical analysis of cerebral injury was performed via the Cornell Assessment for Pediatric Delirium.Results. Statistically the concentration of all three markers of cerebral injury was significantly higher in the transfusion group after the end of CPB. Similar dynamics was observed in the concentrations of interleukins. In addition, the values for GFAP were higher in the transfusion group and 16 hours after surgery.Conclusion. The safety and effectiveness of the strategy on refusal of intraoperative transfusion in order to prevent cerebral injury in children during the correction of septal CHD has been demonstrated. 

scholarly journals Urinary uric acid or urinary creatinine ratio as a non-invasive marker for perinatal asphyxia

2020 ◽  
Vol 7 (6) ◽  
pp. 1378
Author(s):  
Siddharth . ◽  
Preeti Lata Rai ◽  
P. L. Prasad
Keyword(s):  
Uric Acid ◽  
Early Recognition ◽  
Perinatal Asphyxia ◽  
Birth Asphyxia ◽  
Neonatal Morbidity ◽  
Cerebral Injury ◽  
Creatinine Ratio ◽  
Urinary Creatinine ◽  
Spot Urine ◽  
Non Invasive

Background: Perinatal asphyxia is amongst the common problem of neonates and there exists a significant contribution to the neonatal morbidity and mortality. It is observed as a common and a vital cause of the preventable cerebral injury. The prediction of the perinatal asphyxial outcome is very important but dreadful. There is a limited role for APGAR score to predict the immediate outcome, like HIE and the long-term neurological sequelae observational error may happen in APGAR. But the biochemical parameters can truly be relied upon. This study was done to assess urinary uric acid/urinary creatinine ratio (UA/Cr) as a non-invasive marker for perinatal asphyxia and co-relate its absolute value to the degree of the perinatal asphyxia.Methods: In this prospective case control study conducted in the Pediatrics Department of Shri Ram Murti Smarak Institute of Medical Sciences between Nov 2017 to May 2019, 42 asphyxiated and 42 non-asphyxiated newborns were included. Detailed history and assessment were for all the enrolled newborns. Spot urine samples were sent for the uric acid and creatinine estimation. Results were documented, and statistical analysis was performed.Results: Urinary uric acid to creatinine ratio used as additional non-invasive, early and easy biochemical marker of the birth asphyxia that biochemically supports severity grading and clinical diagnosis of the asphyxia by APGAR score.Conclusions: The ratio of the urinary uric acid and creatinine enables rapid and early recognition of asphyxial injury and also the evaluation of its severity and potential for short-term morbidity or death.

Perinatal Asphyxia in Preterm Neonates Leads to Serum Changes in Protein S-100 and Neuron Specific Enolase

2009 ◽  
Vol 6 (2) ◽  
pp. 110-116 ◽  
Author(s):  
Distefano Giuseppe ◽  
Curreri Sergio ◽  
Betta Pasqua ◽  
Li Giovanni ◽  
Cilauro Salvatore ◽  
...  
Keyword(s):  
Perinatal Asphyxia ◽  
Neuron Specific Enolase ◽  
Protein S ◽  
Preterm Neonates ◽  
S 100

scholarly journals Study of urinary uric acid and creatinine ratio as a marker for perinatal asphyxia

2020 ◽  
Vol 7 (5) ◽  
pp. 993
Author(s):  
Trinadh Gubbala ◽  
Shree Krishna G. N.
Keyword(s):  
Uric Acid ◽  
Perinatal Asphyxia ◽  
Full Term ◽  
Control Group ◽  
Case Group ◽  
Creatinine Ratio ◽  
Early Assessment ◽  
Female Ratio ◽  
Arterial Blood ◽  
Significant Difference

Background: Perinatal asphyxia refers to an impairment of the normal oxygenation during parturition and the ensuing adverse effects on the fetus/neonate.  In India, due to birth asphyxia, between 250,000 to 350,000 infants die each year, mostly within the first three days of life. Low APGAR score is commonly used to as a indicator of asphyxia in infants, but it may often be not available and may be reduced in premature infants. In present study we evaluated urinary uric acid and creatinine ratio as a marker for perinatal asphyxia, at our tertiary care hospital.Methods: Present study was a observational, case-control study, conducted in department of paediatrics, in case group consisted of 40 full-term neonates who were hospitalized with the diagnosis of perinatal asphyxia. The control group consisted of 40 healthy full-term newborns.Results: Male to female ratio was 1.5:1 in case group as compared to 1.22:1 in control group. Mean gestational age in case group was 286±10.32 days, while in control group it was 274±7.310 days. Mean birth weight was 2.72±0.51 kg & 2.88±0.49 kg in case & control group respectively. In 52.5 % neonates from case group, signs of intrapartum fetal distress were noted. A statistically significant difference (p<0.005) was noted in Apgar 5 min, Arterial blood pH, pO2 (mm Hg), pCO2 (mm Hg), Urinary uric acid (mg/dl) and Urinary uric acid/ creatinine ratio. Authors did not noted any significant difference in Urinary creatinine (mg/dl) values of cases and control group. Urinary UA/CR ratio is significantly higher in case group when compared with control group with t=11.19; P<0.001.Conclusions: The ratio of urinary uric acid to creatinine helps in rapidly recognizing asphyxia and assessing its severity, so it can be a good, simple screening test for early assessment of neonatal asphyxia.

scholarly journals Serum S100B Protein Levels Are Correlated with Subclinical Neurocognitive Declines after Carotid Endarterectomy

Neurosurgery ◽  
2001 ◽  
Vol 49 (5) ◽  
pp. 1076-1083 ◽  
Author(s):  
E. Sander Connolly ◽  
Christopher J. Winfree ◽  
Anita Rampersad ◽  
Ruchey Sharma ◽  
William J. Mack ◽  
...  
Keyword(s):  
Carotid Endarterectomy ◽  
Test Performance ◽  
Biochemical Markers ◽  
Effective Means ◽  
Neuron Specific Enolase ◽  
Serum Levels ◽  
Cerebral Injury ◽  
S100b Protein ◽  
Serum S100b ◽  
Injured Patients

ABSTRACT OBJECTIVE Carotid endarterectomy (CEA) is an effective means of stroke prevention among appropriately selected patients; however, neuropsychometric testing has revealed subtle cognitive injuries in the early postoperative period. The purpose of this study was to establish whether serum levels of two biochemical markers of cerebral injury were correlated with postoperative declines in neuropsychometric test performance after CEA. METHODS Fifty-five consecutive patients underwent a battery of neuropsychometric tests 24 hours before and 24 hours after elective CEA. Two patients were excluded because of postoperative strokes. The pre- and postoperative serum levels of S100B protein and neuron-specific enolase for injured patients, defined as those who exhibited significant declines in neuropsychometric test performance (n = 12), were compared with the levels for uninjured patients (n = 41). RESULTS There were no significant differences in the baseline S100B levels for the two groups. Injured patients exhibited significantly higher S100B levels, compared with uninjured patients, at 24, 48, and 72 hours after surgery (P &lt; 0.05). There were no significant differences in neuron-specific enolase levels for injured and uninjured patients at any time point. CONCLUSION These data suggest that subtle cerebral injuries after CEA, even in the absence of overt strokes, are associated with significant increases in serum S100B but not neuron-specific enolase levels. Analyses of earlier time points in future studies of subtle cognitive injuries and biochemical markers of cerebral injury after CEA may be revealing.

Chlorogenic acid supplementation ameliorates hyperuricemia, relieves renal inflammation, and modulates intestinal homeostasis

2021 ◽  
Author(s):  
Xiaofei Zhou ◽  
Bowei Zhang ◽  
Xiuli Zhao ◽  
Yongxi Lin ◽  
Jin Wang ◽  
...  
Keyword(s):  
Uric Acid ◽  
Chlorogenic Acid ◽  
Serum Uric Acid ◽  
Inflammatory Responses ◽  
Elevated Serum ◽  
Purine Metabolism ◽  
Intestinal Homeostasis ◽  
Renal Inflammation ◽  
Acid Supplementation

Hyperuricemia (HUA) is induced by abnormal purine metabolism and elevated serum uric acid (UA) concentrations, and it is often accompanied by inflammatory responses and intestinal disorders. This study aims to...

Elevated Serum Creatine Kinase Level in Rotavirus Gastroenteritis

2005 ◽  
Vol 8 (2) ◽  
pp. 117 ◽  
Author(s):  
Won Tae Bae ◽  
Jae Hui Kim ◽  
Eun Sil Park ◽  
Ji Hyun Seo ◽  
Jae Young Lim ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Creatine Kinase Level ◽  
Elevated Serum ◽  
Serum Creatine Kinase ◽  
Rotavirus Gastroenteritis ◽  
Serum Creatine Kinase Level

scholarly journals Interference of ascorbic acid with chemical analytes

2005 ◽  
Vol 42 (6) ◽  
pp. 475-477 ◽  
Author(s):  
Qing H Meng ◽  
William C Irwin ◽  
Jennifer Fesser ◽  
K Lorne Massey
Keyword(s):  
Ascorbic Acid ◽  
Creatine Kinase ◽  
Uric Acid ◽  
Total Cholesterol ◽  
Acid Concentration ◽  
Total Bilirubin ◽  
Binding Capacity ◽  
Ascorbic Acid Concentration ◽  
Sodium Potassium ◽  
Creatine Kinase Mb

Background: Ascorbic acid can interfere with methodologies involving redox reactions, while comprehensive studies on main chemistry analysers have not been reported. We therefore attempted to determine the interference of ascorbic acid with analytes on the Beckman Synchron LX20®. Methods: Various concentrations of ascorbic acid were added to serum, and the serum analytes were measured on the LX20. Results: With a serum ascorbic acid concentration of 12.0 mmol/L, the values for sodium, potassium, calcium and creatinine increased by 43%, 58%, 103% and 26%, respectively ( P<0.01). With a serum ascorbic acid concentration of 12.0 mmol/L, the values for chloride, total bilirubin and uric acid decreased by 33%, 62% and 83%, respectively ( P<0.01), and were undetectable for total cholesterol, triglyceride, ammonia and lactate. There was no definite influence of ascorbic acid on analytical values for total CO2, urea, glucose, phosphate, total protein, albumin, amylase, creatine kinase, creatine kinase-MB, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, total iron, unbound iron-binding capacity or magnesium. Conclusions: Ascorbic acid causes a false increase in sodium, potassium, calcium and creatinine results and a false decrease in chloride, total bilirubin, uric acid, total cholesterol, triglyceride, ammonia and lactate results.

Serum uric acid levels and risk of prehypertension: a meta-analysis

2017 ◽  
Vol 55 (3) ◽  
Author(s):  
Menglin Jiang ◽  
Dandan Gong ◽  
Yu Fan
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Meta Analysis ◽  
Elevated Serum ◽  
China National Knowledge Infrastructure ◽  
Cross Sectional ◽  
Knowledge Infrastructure ◽  
Increased Risk ◽  
Cross Sectional Studies ◽  
The Relationship

AbstractElevated serum uric acid (SUA) levels may increase the risk of prehypertension. However, the findings from these studies remain conflicting. The objective of this study was to determine the relationship between SUA levels and risk of prehypertension by conducting a meta-analysis. We conducted a comprehensive literature search of PubMed, Embase, China National Knowledge Infrastructure, VIP, and the Wangfang database without language restrictions through May 2015. Observational studies assessing the relationship between SUA levels and prevalence of prehypertension were included. Pooled adjust odds ratio (OR) and corresponding 95% confidence intervals (CI) of prehypertension were calculated for the highest vs. lowest SUA levels. Prehypertension was defined as systolic blood pressure (BP) ranging from 120 to 139 mmHg or diastolic BP ranging from 80 to 89 mmHg. Eight cross-sectional studies with a total of 21,832 prehypertensive individuals were included. Meta-analysis showed that elevated SUA levels were associated with increased risk of prehypertension (OR: 1.84; 95% CI: 1.42–2.38) comparing the highest vs. lowest level of SUA levels. Subgroup analyses showed that elevated SUA levels significantly increased the risk of prehypertension among men (OR: 1.60; 95% CI: 1.12–2.21) and women (OR: 1.59; 95% CI: 1.17–2.16). Elevated SUA levels are positively associated with the risk of prehypertension in the general population. However, more well-designed longitudinal studies are needed before a definitive conclusion can be drawn due to the cross-sectional studies included are susceptible to bias.

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