scholarly journals Synthesis of Mutual Prodrugs of Secnidazole and Ciprofloxacin and study Their Physicochemical Properties

2021 ◽  
Vol 30 (1) ◽  
pp. 133-143
Author(s):  
Marwah W. Khalid ◽  
Leaqaa Abd ◽  
Ahmed N. Abood
Keyword(s):  
Physicochemical Properties ◽  
Aqueous Solubility ◽  
Fold Increase ◽  
Antibacterial Activities ◽  
Log P ◽  
Klebsiella Pneumonia ◽  
Bacterial Strains ◽  
Structural Modifications ◽  
Chemical Hydrolysis ◽  
Ft Ir

  Secnidazole was linked with ciprofloxacin as mutual prodrugs to get antibiotics with broader spectrum of activity, improved physicochemical properties and given by single dose to improve patient’s compliance. Furthermore, they provide structural modifications to overcome bacterial adaptation. The structures of the synthesized compounds were confirmed using FT-IR, mass spectrometry, elemental microanalysis (CHNO) and some physiochemical properties. This modification was led to an increase in Log P values for Mutual I (Log P 1.114) and Mutual II (Log P 1.97) compared with its values for Secnidazole (Log P -0.373) and ciprofloxacin (Log P -0.832). The solubility of prodrugs had been determined in different media, Mutual II showed 144-fold increase in aqueous solubility compared to ciprofloxacin. Taste evaluation by panel method showed palatable taste in prodrugs compared to the parent drugs. The synthesized compounds were screened for their antimicrobial activity against different bacterial strains which are, Staphylococcus aureus, Pseudomonas aeruginosa, E. coli and Klebsiella pneumonia. The prodrugs have revealed excellent antibacterial activities compared with the parent compounds. Chemical hydrolysis study at pH (1.2 and 7.4) has indicated that these compounds may pass unhydrolyzed through the stomach and produce enough stability to be absorbed from the intestine as indicated by t1/2 values.

scholarly journals An Efficient Green Procedure for Synthesis of Some Fluorinated Curcumin Analogues Catalyzed by Calcium Oxide under Microwave Irradiation and Its Antibacterial Evaluation

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
S. Elavarasan ◽  
D. Bhakiaraj ◽  
T. Elavarasan ◽  
M. Gopalakrishnan
Keyword(s):  
Microwave Irradiation ◽  
Calcium Oxide ◽  
Shigella Flexneri ◽  
Antibacterial Activities ◽  
Klebsiella Pneumonia ◽  
Spectroscopic Techniques ◽  
Bacterial Strains ◽  
Curcumin Analogues ◽  
Ft Ir ◽  
Green Procedure

A series of fluorine substituted curcumin analogues have been synthesized in a cheaper and greener method using calcium oxide as catalyst under microwave irradiation. All the synthesized compounds have been characterized by FT-IR, MS, elemental analysis, and1H and13C NMR spectroscopic techniques and screened for antibacterial activities againstStaphylococcus aureus,β-Heamolytic streptococcus,Shigella flexneri,Vibrio cholerae,Pseudomonas aeruginosa, andKlebsiella pneumonia. All the synthesized compounds are showing good zone of inhibition against the tested bacterial strains.

scholarly journals Design, Synthesis and Biological Evaluation of Novel Benzothiazole Based [1,2,4]Triazolo[4,3-c]quinazoline Derivatives

2020 ◽  
Vol 32 (3) ◽  
pp. 580-586
Author(s):  
Ranjit V. Gadhave ◽  
Bhanudas S. Kuchekar
Keyword(s):  
Biological Evaluation ◽  
Bacterial Strains ◽  
Active Compounds ◽  
Design Synthesis ◽  
Structural Modifications ◽  
E Coli ◽  
Chemical Structures ◽  
Ft Ir ◽  
Antioxidant Agent

A new series of N-(benzo[d]thiazol-2-yl)-[1,2,4]triazolo[4,3-c]quinazoline-5-carboxamide derivatives were synthesized by condensation of [1,2,4]triazolo[4,3-c]quinazoline-5-carboxylate derivatives with substituted benzothiazoles. The chemical structures of the synthesized compounds were confirmed by FT-IR, MS and 1H NMR spectra. Designed triazoloquinazoline derivatives were docked with oxido-reductase enzyme (PDB Code 4h1j) and DNA gyrase enzyme (PDB Code 3g75). Based on high binding affinity score, the best compound were selected for synthesis and subjected to in vitro antioxidant and antibacterial activity. Compounds 7a and 7d were found to be most active compounds as antioxidant agent among this series when compared with ascorbic acid. Compounds 7a, 7d and 7f were found to be most active compounds as an antibacterial agents among this series when compared with ciprofloxacin against bacterial strains such as S. aureus (ATCC 25923), E. coli (ATCC 25922) and P. aeruginosa (ATCC 27853). Study revealed that the most active compounds after structural modifications can be exploited as lead molecules for other pharmacological activities such as anti-inflammatory, anticancer and antidepressant activities.

scholarly journals Defining desirable natural product derived anticancer drug space: optimization of molecular physicochemical properties and ADMET attributes

ADMET & DMPK ◽  
2016 ◽  
Vol 4 (2) ◽  
pp. 98 ◽  
Author(s):  
Deepika Singh
Keyword(s):  
Hydrogen Bond ◽  
Natural Products ◽  
Physicochemical Properties ◽  
Natural Product ◽  
Aqueous Solubility ◽  
Cancer Drug ◽  
Log P ◽  
Drug Candidates ◽  
Anti Cancer ◽  
Property Space

<p class="ADMETabstracttext">As part of our endeavor to enhance survival of natural product derived drug candidates and to guide the medicinal chemist to design higher probability space for success in the anti cancer drug development area, we embarked on a detailed study of the property space for a collection of natural product derived anti cancer molecules. We carried out a comprehensive analysis of properties for 24 natural products derived anti cancer drugs including clinical development candidates and a set of 27 natural products derived anti cancer lead compounds. In particular, we focused on understanding the interplay among eight physicochemical properties including like partition coefficient (log P), distribution coefficient at pH=7.4 (log D), topological polar surface area (TPSA), molecular weight (MW), aqueous solubility (log S), number of hydrogen bond acceptors (HBA), number of hydrogen bond donors (HBD) and number of rotatable bonds (n<sub>Rot</sub>) crucial for drug design and  relationships between physicochemical properties, ADME (absorption, distribution, metabolism, and elimination) attributes, and in silico toxicity profile for these two sets of compounds. This analysis provides guidance for the chemist to modify the existing natural product scaffold or designing of new anti cancer molecules in a property space with increased probability of success and may lead to the identification of druglike candidates with favorable safety profiles that can successfully test hypotheses in the clinic.</p>

scholarly journals Antibacterial Activity and Physicochemical Properties of Florally Diversified Bangladeshi Honeys

2018 ◽  
Vol 33 (1-2) ◽  
pp. 5-9 ◽  
Author(s):  
Roushney Fatima Mukti ◽  
Md Miraj Kobad Chowdhury ◽  
Md Ausrafuggaman Nahid ◽  
Md Mizanur Rahaman ◽  
M Aftab Uddin
Keyword(s):  
Ascorbic Acid ◽  
Antibacterial Activity ◽  
Physicochemical Properties ◽  
Antioxidant Capacity ◽  
Total Antioxidant Capacity ◽  
Antibacterial Activities ◽  
Multidrug Resistant ◽  
Bacterial Strains ◽  
Total Antioxidant ◽  
Phenolics Content

Seven florally diversified Bangladeshi honey samples were assessed for their physicochemical properties as well as their antibiogram profile on different human pathogenic bacterial strains. The average density, total protein content, ascorbic acid content, total phenolics content and the total antioxidant capacity of these honeys were determined as 1.50±0.09 g/ml, 5.63±1.56 mg/g, 91.87±22.16 mg/g, 571.04±289.02 mg gallic acid equivalent/gram, and 320.74±55.06 mg ascorbic acid equivalent/gram of samples, respectively. A significant correlation between the phenolics content and the total antioxidant capacity was observed in commercially available honey samples. However, the natural honey samples showed the best antibacterial activity against different pathogenic multidrug-resistant bacterial strains. Significant antibacterial activities were observed against Klebsiella pneumoniae, Salmonella typhi, Micrococcus luteus, Pseudomonas spp. and Enterobacter spp. and moderate antibacterial activities was observed on Shigella boydii, Bacillus cereus, Bacillus megaterium, and Bacillus subtilis. The antibacterial activity was correlated with the total antioxidant capacity. This study suggested that the Bangladeshi multifloral honeys have clinical potential against multidrug-resistant pathogenic bacterial strains. Bangladesh J Microbiol, Volume 33, Number 1-2, June-Dec 2016, pp 5-9

scholarly journals Green synthesis of Ag and Pd nanoparticles for water pollutants treatment

2020 ◽  
Vol 82 (11) ◽  
pp. 2344-2352
Author(s):  
C. Joseph Kirubaharan ◽  
Zhen Fang ◽  
Chong Sha ◽  
Yang-Chun Yong
Keyword(s):  
Green Synthesis ◽  
Metallic Nanoparticles ◽  
Rhodamine 6G ◽  
Catalytic Efficiency ◽  
Pd Nanoparticles ◽  
Antibacterial Activities ◽  
Klebsiella Pneumonia ◽  
Vibrio Cholera ◽  
Structural Nature ◽  
Ft Ir

Abstract Silver (Ag) and palladium (Pd) nanoparticles were synthesized via a green synthesis route, which was mediated with the extract of Daucus carota leaves. The morphological, crystalline and structural nature of the synthesized nanoparticles was characterized by UV-Vis spectrophotometer, and TEM, XRD and FT-IR analyses. High antibacterial activities of the prepared Ag and Pd nanoparticles were observed towards different water-borne pathogens of Klebsiella pneumonia, Vibrio cholera and Escherichia coli. The catalytic efficiency of the prepared nanoparticles for the removal of rhodamine 6G (Rh-6G) dye was also evaluated. Nearly 98% of the Rh-6G dye was decolorized by the synthesized Pd nanoparticles within 2 min, and the synthesized Ag nanoparticles took 30 min for 89.4% decolorization. This work provided greener nanocatalysts for pollutant treatment and demonstrated the power of green biosynthesis for metallic nanoparticles.

scholarly journals Indole-3-carbaldehyde Semicarbazone Derivatives: Synthesis, Characterization, and Antibacterial Activities

2020 ◽  
Vol 2020 ◽  
pp. 1-9 ◽  
Author(s):  
Fernando Carrasco ◽  
Wilfredo Hernández ◽  
Oscar Chupayo ◽  
Celedonio M. Álvarez ◽  
Sandra Oramas-Royo ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Bacillus Subtilis ◽  
Antibacterial Activities ◽  
Isomeric Form ◽  
Bacterial Strains ◽  
H Nmr ◽  
Nmr Techniques ◽  
Ft Ir ◽  
Liquid Acetone

Four indole-3-carbaldehyde semicarbazone derivatives, 2-((5-bromo-1H-indol-3-yl)methylene)hydrazinecarboxamide (1), 2-((5-chloro-1H-indol-3-yl)methylene)hydrazinecarboxamide (2), 2-((5-methoxy-1H-indol-3-yl)methylene)hydrazinecarboxamide (3), and 2-((4-nitro-1H-indol-3-yl)methylene)hydrazinecarboxamide (4) were synthesized and characterized by ESI-MS and spectroscopic (FT-IR, 1H NMR, and 13C NMR) techniques. The two-dimensional NMR (in acetone-d6) spectral data revealed that the molecules 1 and 2 in solution are in the cisE isomeric form. This evidence is supported by DFT calculations at the B3LYP/6-311++G(d,p) level of theory where it was shown that the corresponding most stable conformers of the synthesized compounds have a cisE geometrical configuration, in both the gas and liquid (acetone and DMSO) phases. The in vitro antibacterial activity of compounds 1–4 was determined against Gram-positive (Staphylococcus aureus and Bacillus subtilis) and Gram-negative (Pseudomonas aeruginosa and Escherichia coli) bacteria. Among all the tested semicarbazones, 1 and 2 exhibited similar inhibitory activities against Staphylococcus aureus (MIC = 100 and 150 μg/mL, respectively) and Bacillus subtilis (MIC = 100 and 150 μg/mL, respectively). On the other hand, 3 and 4 were relatively less active against the tested bacterial strains compared with 1, 2, and tetracycline.

Synthesis, Characterization and Antibacterial Evaluation of 2, 3Dihydroquinazolin-4 (1H)-Ones and Some New Bis 2, 3-Dihydroquinazolin-4 (1H)-Ones Using Pre-made Pyrazole Carbaldehyde Derivatives

2020 ◽  
Vol 17 ◽  
Author(s):  
Kiana Faraji Sina ◽  
Asieh Yahyazadeh ◽  
Nosrat Ollah Mahmoodi
Keyword(s):  
Micrococcus Luteus ◽  
Antibacterial Activities ◽  
Antimicrobial Activities ◽  
Bacterial Strains ◽  
One Pot ◽  
Montmorillonite K10 ◽  
Recoverable Catalyst ◽  
Ft Ir ◽  
High Yields ◽  
Short Times

: 2, 3-Dihydroquinazolinones are of popular compounds with the diversification of biological and pharmacological activities. Among many discovered methods, there are efficient and convenient methods used for the synthesis of 2, 3- dihydroquinazoline-4 (1H)-one and some new bis 2, 3-dihydroquinazoline-4 (1H)-one derivatives which are reported in this study. The mentioned methods include the two-component condensation of one molecule of anthranilamide and one molecule of DOI: pyrazole carbaldehyde using montmorillonite-K10 as a catalyst for the preparation of 2, 3 dihydroquinazoline4 (1H)-ones. Also, one-pot pseudo-five-component reaction (5MCRs) of two molecules of isatoic anhydride, two molecules of pyrazole carbaldehydes and one molecule of ethan-1, 2-diamine in the presence of the recoverable catalyst (montmorillonite-K10) for the synthesis of bis 2, 3-dihydroquinazoline-4 (1H)-ones. Despite the short times of reactions, high yields of products were obtained, which were validated using FT-IR, 1HNMR, 13CNMR, and elemental analysis. Moreover, the compounds were screened for their antimicrobial activities against two-gram-positive bacterial strains: Staphylococcus aureus and Micrococcus Luteus; and against two-gram-negative bacterial strains, as well: Escherichia coli and Pseudomonas aeruginosa, which all were utilized for antibacterial investigations. The results showed moderate or significant antibacterial activities.

scholarly journals Volatile Constituents of the Leaves of Aniba hostmanniana (Lauraceae) and their Antibacterial Activities

2015 ◽  
Vol 10 (7) ◽  
pp. 1934578X1501000
Author(s):  
Wilberto De Lima ◽  
Luis B. Rojas-Fermín ◽  
Sonia Koteich-Khatib ◽  
María Eugenia Lucena ◽  
Juan Carmona Arzola
Keyword(s):  
Escherichia Coli ◽  
Essential Oil ◽  
Antibacterial Activities ◽  
Mass Spectrometric ◽  
Klebsiella Pneumonia ◽  
Gram Negative Bacteria ◽  
Bacterial Strains ◽  
Positive Bacterium ◽  
Benzyl Benzoate ◽  
Gram Negative

The essential oil of Aniba hostmanniana (Nees) Mez, family Lauraceae, was obtained from fresh leaves by hydrodistillation. The chemical composition of the oil was assessed using gas chromatography with mass spectrometric detection (GC-MS). The antimicrobial activity of the essential oil was tested against Gram-negative bacteria ( Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia) and the Gram-positive bacterium Staphylococcus aureus. GC-MS analysis revealed the presence of 35 compounds in the essential oil, the predominant ones being benzyl benzoate (29.3%), δ-cadinene (12%), β-caryophyllene (10.5%), bicyclogermacrene (5.9%), and α-copaene (3.9%). The oil showed activity against most of the bacterial strains studied.

scholarly journals SCREENING OF ANTIBACTERIAL ACTIVITY OF FIVE DIFFERENT SPICES (AJWAIN, CORIANDER, CUMIN, FENNEL, AND FENUGREEK) AGAINST PATHOGENIC BACTERIAL STRAINS

2018 ◽  
Vol 11 (2) ◽  
pp. 252
Author(s):  
Salma S ◽  
Lalitha Ramakrishnan ◽  
Vinothini J
Keyword(s):  
Antibacterial Activities ◽  
Salmonella Typhi ◽  
Diffusion Method ◽  
Klebsiella Pneumonia ◽  
Bacterial Strains ◽  
Antibacterial Effects ◽  
Foeniculum Vulgare ◽  
Trachyspermum Ammi ◽  
And Staphylococcus Aureus ◽  
Paper Disc

 Objective: This study was focussed on an evaluation of antibacterial activities of aqueous and alcoholic extracts of commonly consumed spices, namely, Ajwain (Trachyspermum ammi), Coriander (Coriandrum sativum), cumin (Cuminum cyminum), fennel (Foeniculum vulgare), and Fenugreek (Trigonella foenum-graecum).Methods: This study includes the antibacterial effects of spices against six bacterial strains, namely, Escherichia coli, Klebsiella pneumonia, Proteus vulgaris, Pseudomonas aeruginosa, Salmonella typhi, and Staphylococcus aureus to compare their antibacterial effects by the paper disc agar diffusion method with three antibiotics such as amikacin, chloramphenicol, and vancomycin.Results: According to findings, it is determined that inhibitory activity was detected on aqueous and alcoholic extracts of Ajwain, aqueous extract of cumin and on alcoholic mixed spice sample.

scholarly journals Preparation and Physicochemical Evaluation of Lumefantrine-2-Hydroxypropyl-β-cyclodextrin Binary Systems

2020 ◽  
pp. 92-105
Author(s):  
Adebanjo J. Adegbola ◽  
Ezekiel Omotoso ◽  
Olujide O. Olubiyi ◽  
Julius O. Soyinkaa ◽  
Oluseye O. Bolaji ◽  
...  
Keyword(s):  
Binary Systems ◽  
Aqueous Solubility ◽  
Fold Increase ◽  
Stable Complex ◽  
Drying Methods ◽  
Phase Solubility ◽  
Cyclodextrin Complex ◽  
Freeze Dried ◽  
Physicochemical Evaluation ◽  
Ft Ir

Lumefantrine contributes significant roles in artemisinin-based combination therapy for malaria treatment but associated with a limitation of poor aqueous solubility and low permeability. This study investigated lumefantrine-2-hydroxypropyl-β-cyclodextrin complex to improve its solubility profile. A phase-solubility analysis and molecular modelling were carried out before the preparation of the complex by physical mixture, kneading, co-evaporation and freeze-drying methods. Fourier transform infrared (FT-IR) spectroscopic and powder X-ray diffractometric (PXRD) techniques were used to characterised the complex. The phase-solubility studies showed a type AL diagram with an apparent stability constant value of 243.4 M-1 suggesting the formation of a soluble and stable complex. Significant improvements in aqueous solubility was achieved, notably the freeze-dried system gave a 3-fold and 11-fold increase in solubility in simulated gastric and intestinal fluids respectively. The FT-IR spectra and PXRD patterns of co-evaporated and freeze-dried systems indicated stronger interactions and complexation of lumefantrine in the 2-HP-β-CD cavities. Our findings suggest that the host-guest binary system of lumefantrine-2-HP-β-CD is achievable, structural stable via intermolecular interactions consisting of hydrogen bonding and van der Waals interaction. The inclusion complex is considered a formulation option to ameliorate the poor aqueous solubility of lumefantrine which might improve the absorption and therapeutic efficacy of the drug.

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