scholarly journals Morphometric studies of the damaged skin area after experimental thermal trauma and during correction with a cryo-lyophilized xenograft skin substrate

2018 ◽  
Vol 24 (4) ◽  
pp. 22-28
Author(s):  
S.B. Kramar ◽  
K.S. Volkov ◽  
Z.M. Nebesna
Keyword(s):  
Statistical Processing ◽  
Peripheral Zone ◽  
Mean Value ◽  
Morphometric Parameters ◽  
Skin Area ◽  
General Anesthetic ◽  
Thermal Trauma ◽  
Intact Group ◽  
Thin Skin ◽  
The Mean

According to WHO, burns rank third place among other injuries, and in some countries, the second, after traffic injuries. One of the promising tools for treating burn wounds is the use of lyophilized xenograft skin substrate. The purpose of this work was to determine the morphometric parameters of the affected by burns area of the skin in the dynamics after an experimental thermal trauma and in the case of correction by crushed lyophilized xenograft skin substrate. Burning of third degree on the shaved skin of the back of the guinea pig was applied to the vapor under general anesthetic. Morphometrically, at 7, 14, and 21 days of the experiment, the thickness of the epidermis (thin skin without a layer of scales), the number of fibroblast cells per unit area, the outer and inner diameter of the capillaries were determined in the boundary and central areas of the wound. Morphometric studies were carried out using programs VideoTest-5.0, KAAPA Image Base and Microsoft Exсel on a personal computer. Statistical processing of the obtained quantitative data was carried out using methods of variation statistics with the determination of the mean arithmetic and its error (M±m), Student’s criterion (t) and reliability index (p). Differences are considered valid at р≤0.05. It has been established that already in the 7 day of the experiment, under conditions of wound closure by xenograft skin substrate marked a significant thickening of the epidermis on the periphery of the wound appear. Activation of the process of boundary epithelization contributes to the renewal of components of the microcirculatory bed, the formation of granulation tissue. It was found that on the 14 day of application of the corrective factor in the peripheral zone of the wound, the number of cells of the fibroblast row and the mean value of the thickness of the epidermis reach their peak value, significantly (p<0.001) exceeding such indices of animals in intact group and group of animals without correction. The morphometric parameters of capillaries in this period of the experiment indicate a good development of the microcirculation, which improves regional epithelization. On the 21 day of the experiment, under the condition of correction, the border between the regional and central parts of the wound is almost lost. Thus, the results of morphometric studies indicate that the use of cryo-lyophilized xenograft skin substrate after a thermal trauma of the skin contributes to the healing of the wound defect with the formation of connective tissue of the dermis, angiogenesis, and complete epithelization of the surface of the affected epidermis layer.

scholarly journals Assessment of the dental status of drug-addicted patients with parafunction of the dental-jaw apparatus

2021 ◽  
Vol 26 (1) ◽  
pp. 217-225
Author(s):  
А.І. Foros ◽  
Ye.Ya. Kostenko ◽  
M.Yu. Goncharuk-Khomyn
Keyword(s):  
Peripheral Zone ◽  
Study Groups ◽  
Masticatory Muscles ◽  
Mean Value ◽  
Dental Status ◽  
Drug Addicts ◽  
Jaw Apparatus ◽  
Enamel Erosion ◽  
The Mean ◽  
Drug Dependent

The number of drug addicts in the world is growing every year. The aim of the study was to assess the dental status of drug-addicted patients with parafunction of the dental-jaw apparatus. We used clinical, analytical, functional and histological research methods. 119 drug-addicted and 110 non-drug-dependent patients aged 18 to 54 were examined. In order to confirm the presence of parafunctions of the dental-jaw apparatus in patients, we conducted an occludogram study, as well as an assessment of the index of parafunctions of the masticatory muscles and the degree of their severity. The structure of tooth tissues was examined by histological method. Examination of drug-addicted patients revealed the presence of numerous carious cavities, secondary adentia, enamel erosion, pathological abrasion, signs of gingivitis and periodontitis, tooth chipping. The prevalence of parafunction of the dental-jaw apparatus, in particular bruxism, in drug-addicted patients is 1.56 times higher than this figure among non-drug addicts. The results of the occludogram and the index of parafunctions of the masticatory muscles differ significantly between the study groups. The mean value of the masticatory muscle parafunction index among drug-addicted patients is 2.06 times significantly higher than the value among non-drug-addicted men and 2.03 times higher among women. Histological examination of the tooth tissues of drug-addicted patients indicates a disorder of the mineralization of both enamel and dentin. Thinning of the peripheral zone of the pulp, which is normally represented by a layer of odontoblasts, which provide regeneration and nutrition of dentin, is more common in persons under 25 years of age. Drug use adversely affects the dental status of patients and the condition of the hard tissues of the tooth.

scholarly journals METHODOLOGICAL APPROACH TO DETERMINATION OF THE TREND OF CHANGES IN AIRCRAFT RELIABILITY INDICATORS OF AVIATION EQUIPMENT ON THE EXAMPLE OF STATE AVIATION HELICOPTERS

2020 ◽  
pp. 42-51
Author(s):  
V. Golub ◽  
O. Bursala ◽  
V. Chupryna
Keyword(s):  
Methodological Approach ◽  
Statistical Processing ◽  
Armed Forces ◽  
Mean Value ◽  
Control Limit ◽  
Acceptable Level ◽  
Reliability Indicators ◽  
The Mean ◽  
Index Level

The problem of flight tsafety , without regard to swift scientific and technical progress in industry of aviation equipment, become exceptionally sharp in our time. The statistical processing of empiric data is an actual task in monitoring of process of exploitation of propulsion MODULE of the Armed Forces of Ukraine and determination of tendencies of technical service and repair, directions of modernisation of armament and military equipment. The article considers the approach of the systems to the evaluation of reliability and safety of flights in relation to accomplishment of combat missions and preventionof aviation accidents. A methodological approach to the mathematical processing of statistical information for the period 2016-2019 on malfunctions was developed. The quantitative evaluation of their level is conducted on the generally accepted standardized indexes (statistical and probabilistic), specific methodology was here used. Index "parameter of failure flow" that characterizes the level of operating reliability and index "level of accident rate" that characterizes safety of flights were used in this methodology on ІСАО recommendation. Certain trends of changes of these indexes, the “upper control limit of reliability" and the considered conception of acceptable level of safety performance ( ALoSP) are expected for future periods for the different types of helicopters. On the base of operating data, the prognosis indexes expected, "upper control limit of reliability" on 2020 for the specific types of helicopters. As expected, according to obtained results, for all types of helicopters the mean value of this index will make not more than 4,3 failures per 100 flight hours. In accordance to conception of "acceptable level of "ALoSP" it is possible to distinguish three levels or "triggers" of flights safety : Acceptable level (Acceptable), special purpose level (Target), Critical level (Alert). These "triggers" are calculated taking into account the mean value of statistical sets of data about failures (for the last 3 years) and standard deviation that gives an opportunity to define the necessary additional measures of management to provide safety of flights. Authors came to the conclusion that conception of ALoSP is suitable for the evaluation of efficiency to provide flights safety of aviation of the Armed Forces of Ukraine with implementation of necessary adaptation to the existent terms of application of UKR aviation.

scholarly journals Experimental study of analgesic mechanisms of 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic acid derivative (compound NI-9) in rat

2021 ◽  
Vol 25 (1) ◽  
pp. 12-16
Author(s):  
О. V. Malchenko ◽  
N. І. Voloshchuk ◽  
O. V. Hrymalovska
Keyword(s):  
Carboxylic Acid ◽  
Antinociceptive Effect ◽  
Statistical Processing ◽  
Pain Syndrome ◽  
Modern Medicine ◽  
Mean Value ◽  
Tail Flick ◽  
Tail Flick Test ◽  
Pain Syndromes ◽  
The Mean

Annotation. The problem of effective and safe treatment of pain syndromes is a priority area of modern medicine, since pain syndrome is often accompanied by economic costs, a drop in labor productivity and an increase in the risk of other diseases. The derivative 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamide (compound NI-9) has shown a significant analgesic effect in various models of pain syndromes. The aim of this work was to experimentally study the mechanisms of the analgesic activity of compound NI-9 using pharmacological analyzers in the tail-flick test. The study was performed on 210 male Wistar rats. Statistical processing of the obtained results was performed using the software package STATISTICA 10.0 with the calculation of the mean value, standard error of the mean, confidence interval (p). The experiments used: naloxone, prazosin, clonidine, yohimbine, isoproterenol, propranolol, nalbuphine, chlorpromazine, dopamine, nakom, memantine, phenylephrine. The results showed that the opioidergic system was not involved in the antinociceptive effect of compound NI-9. At the same time, the participation of alpha-1 and alpha-2 adrenergic receptors, dopamine receptors, and also partially NMDA receptors has been proven. The data obtained serve as the basis for further preclinical studies of N- (4-methoxybenzyl) -4-methyl-2,2-dixo-1H-2Λ6,1-benzothiazine-3-carboxylic acid (compounds NI-9) as a non-narcotic analgesic, which can compete with already known drugs of this class in the treatment of diseases accompanied by inflammatory and pain syndrome.

scholarly journals Research on Calculation Method of Mean in Sports Statistical Data with EXCEL

2020 ◽  
Vol 9 (3) ◽  
pp. 141-148
Author(s):  
Aining Li ◽  
◽  
Shiwei Zhang ◽  
Zhanbin Feng ◽  
Qiyuan Zhang
Keyword(s):  
Statistical Data ◽  
Statistical Processing ◽  
Mean Value ◽  
Descriptive Statistics ◽  
Central Tendency ◽  
Education Department ◽  
Statistical Indicator ◽  
Normal Mean ◽  
The Mean

The mean is the most commonly used statistical indicator to reflect the central tendency of data distribution, in this study, the mean was reclassified according to whether the effect of extreme value was considered or not. According to the definition and specific classification of mean value, We explain in detail how to calculate the normal mean by ways of "built-in function", "pivot table chart" and "descriptive statistics", symmetry trim mean by TRIMMEAN function and asymmetrical trim mean by ways of nested function and VBA self-built function with the date of the 10 referees' scores in the kindergarten gymnastics competition of normal education department of our college. If we fully exploit the powerful statistical function of Excel, we can better meet our sports practice of statistical processing needs.

Long-period modulated superstructures in Pd-12.5 at.%Ce and Pd-15 at.%Ce alloys

1990 ◽  
Vol 48 (4) ◽  
pp. 164-165
Author(s):  
Noriyuki Kuwano ◽  
Masaru Itakura ◽  
Kensuke Oki
Keyword(s):  
Electron Microscopy ◽  
Mean Value ◽  
Heavy Elements ◽  
Arc Furnace ◽  
X Ray ◽  
Long Period ◽  
Ultra High Purity ◽  
Heat Treated ◽  
Atomic Scattering ◽  
The Mean

Pd-Ce alloys exhibit various anomalies in physical properties due to mixed valences of Ce, and the anomalies are thought to be strongly related with the crystal structures. Since Pd and Ce are both heavy elements, relative magnitudes of (fcc-fpd) are so small compared with <f> that superlattice reflections, even if any, sometimes cannot be detected in conventional x-ray powder patterns, where fee and fpd are atomic scattering factors of Ce and Pd, and <f> the mean value in the crystal. However, superlattices in Pd-Ce alloys can be analyzed by electron microscopy, thanks to the high detectability of electron diffraction. In this work, we investigated modulated superstructures in alloys with 12.5 and 15.0 at.%Ce.Ingots of Pd-Ce alloys were prepared in an arc furnace under atmosphere of ultra high purity argon. The disc specimens cut out from the ingots were heat-treated in vacuum and electrothinned to electron transparency by a jet method.

Partition Coefficient Ratios and Tumour Perfusion Studied with 85mKr and 133Xe

1987 ◽  
Vol 26 (06) ◽  
pp. 253-257
Author(s):  
M. Mäntylä ◽  
J. Perkkiö ◽  
J. Heikkonen
Keyword(s):  
Partition Coefficient ◽  
Partition Coefficients ◽  
Regional Blood Flow ◽  
Blood Perfusion ◽  
Compartmental Analysis ◽  
Malignant Tumour ◽  
Mean Value ◽  
Perfusion Rate ◽  
Biological Variables ◽  
The Mean

The relative partition coefficients of krypton and xenon, and the regional blood flow in 27 superficial malignant tumour nodules in 22 patients with diagnosed tumours were measured using the 85mKr- and 133Xe-clearance method. In order to minimize the effect of biological variables on the measurements the radionuclides were injected simultaneously into the tumour. The distribution of the radiotracers was assumed to be in equilibrium at the beginning of the experiment. The blood perfusion was calculated by fitting a two-exponential function to the measuring points. The mean value of the perfusion rate calculated from the xenon results was 13 ± 10 ml/(100 g-min) [range 3 to 38 ml/(100 g-min)] and from the krypton results 19 ± 11 ml/(100 g-min) [range 5 to 45 ml/(100 g-min)]. These values were obtained, if the partition coefficients are equal to one. The equations obtained by using compartmental analysis were used for the calculation of the relative partition coefficient of krypton and xenon. The partition coefficient of krypton was found to be slightly smaller than that of xenon, which may be due to its smaller molecular weight.

Detection of Soluble Fibrin Monomer Complexes in Blood by Means of Protamine Sulphate Test

1968 ◽  
Vol 20 (01/02) ◽  
pp. 044-049 ◽  
Author(s):  
B Lipiński ◽  
K Worowski
Keyword(s):  
Human Subjects ◽  
Coronary Thrombosis ◽  
Mean Value ◽  
Healthy Human ◽  
Protamine Sulphate ◽  
Soluble Fibrin ◽  
Fibrin Monomer ◽  
Dog Plasma ◽  
The Mean ◽  
Precipitable Protein

SummaryIn the present paper described is a simple test for detecting soluble fibrin monomer complexes (SFMC) in blood. The test consists in mixing 1% protamine sulphate with diluted oxalated plasma or serum and reading the optical density at 6190 Å. In experiments with dog plasma, enriched with soluble fibrin complexes, it was shown that OD read in PS test is proportional to the amount of fibrin recovered from the precipitate. It was found that SFMC level in plasma increases in rabbits infused intravenously with thrombin and decreases after injection of plasmin with streptokinase. In both cases PS precipitable protein in serum is elevated indicating enhanced fibrinolysis. In healthy human subjects the mean value of OD readings in plasma and sera were found to be 0.30 and 0.11, while in patients with coronary thrombosis they are 0.64 and 0.05 respectively. The origin of SFMC in circulation under physiological and pathological conditions is discussed.

Detection of Circulating Tissue Factor and Factor VII in a Normal Population

1996 ◽  
Vol 75 (05) ◽  
pp. 772-777 ◽  
Author(s):  
Sybille Albrecht ◽  
Matthias Kotzsch ◽  
Gabriele Siegert ◽  
Thomas Luther ◽  
Heinz Großmann ◽  
...  
Keyword(s):  
Tissue Factor ◽  
Normal Population ◽  
Mean Value ◽  
Factor Vii ◽  
Significant Difference ◽  
Age Dependent ◽  
The Mean ◽  
Highly Correlated ◽  
And Gender

SummaryThe plasma tissue factor (TF) concentration was correlated to factor VII concentration (FVIIag) and factor VII activity (FVIIc) in 498 healthy volunteers ranging in age from 17 to 64 years. Immunoassays using monoclonal antibodies (mAbs) were developed for the determination of TF and FVIIag in plasma. The mAbs and the test systems were characterized. The mean value of the TF concentration was 172 ± 135 pg/ml. TF showed no age- and gender-related differences. For the total population, FVIIc, determined by a clotting test, was 110 ± 15% and the factor VIlag was 0.77 ± 0.19 μg/ml. FVII activity was significantly increased with age, whereas the concentration demonstrated no correlation to age in this population. FVII concentration is highly correlated with the activity as measured by clotting assay using rabbit thromboplastin. The ratio between FVIIc and FVIIag was not age-dependent, but demonstrated a significant difference between men and women. Between TF and FVII we could not detect a correlation.

Determination of Plasminogen in Clots and Thrombi

1966 ◽  
Vol 16 (01/02) ◽  
pp. 038-050 ◽  
Author(s):  
Ulla Hedner ◽  
Inga Marie Nilsson ◽  
B Robertson
Keyword(s):  
Mean Value ◽  
Main Mechanism ◽  
Clot Lysis ◽  
Post Mortem ◽  
Digestion Time ◽  
Normal Volunteers ◽  
Casein Solution ◽  
The Mean

SummaryThe plasminogen content was determined by a casein method in plasma and serum from 20 normal volunteers. The mean plasminogen content was found to be 10.1 ACU (the arbitrary caseinolytic unit defined in such a way that using a 3% casein solution and a digestion time of 20 min. at 37°C, 10 ACU gave an extinction of 0.300). No difference between serum and plasma regarding the plasminogen content was found.Plasminogen was determined in drained and drained plus washed clots prepared from 2 ml plasma. The highest values found in the drained clots were 0.9 ACU/clot and 0.2 ACU/clot in the drained plus washed clots.Plasminogen was also determined in drained and drained plus washed clots prepared from plasma with added purified plasminogen. The plasminogen was recovered in the washing fluid. According to these tests, then, purified added plasminogen is washed out of the clots.The plasminogen content of 20 thrombi obtained post mortem was also determined. The mean value was found to be 0.7 ACU/cm thrombus. Judging from our results, the “intrinsic clot lysis theory” is not the main mechanism of clot dissolution.

Perbedaan Pengetahuan Siswa Tentang Penyakit Hepatitis A Sebelum Dan Sesudah Penyuluhan Di MTsN 02 Bondowoso Tahun 2015

2017 ◽  
Vol 4 (2) ◽  
pp. 14
Author(s):  
Putri Megasari
Keyword(s):  
Hepatitis A ◽  
Hepatitis Virus ◽  
Sampling Technique ◽  
Mean Value ◽  
Test Design ◽  
The World ◽  
Before And After ◽  
Post Test ◽  
The Mean ◽  
Paired T Test

Hepatitis has become a health problem in the world. The hepatitis virus infected many people. According to the teacher of MTsN 02 Bondowoso more than 20 students have hepatitis A viral infection. The purpose of this research was to know the differences of students' knowledge about hepatitis A before and after counseling in MTsN 02 Bondowoso 2015. This study used pre-experimental (pre-post test design). This study used stratified random sampling technique, 127 students from 270 sample involved this research,and 143 students was excluded. We used questionnaires to collect data. The results showed that the mean value of the students 'knowledge about hepatitis A before counseling in MTsN 02 Bondowoso 2015 was 83.96 with the lowest value of 37.5 and the highest value was 100. The mean value of the students' knowledge about hepatitis A after counseling in MTsN 02 Bondowoso 2015 was 93.21 with the lowest value waf 62.5 and the highest value was 100. Paired t test showed that t (-9.07) > t table (1.98), the null hypothesis (H0) was rejected. There was a difference between students' knowledge about hepatitis A before and after counseling in MTsN 02 Bondowoso 2015. This study showed that routine counseling by healthcare provider was important to prevent hepatitis A infection.; Keywords: counseling, knowledge of students, hepatitis

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