Improvement of complex treatment of patients with osteoarthritis combined with hypertension

Actuality: Among the diseases that significantly affect people, osteoarthritis (OA) takes 4th place in women and 8th in men. In both sexes older than 70 years, osteoarthrosis occurs in almost everyone, and in the last decade its prevalence has steadily increased. The social significance of OA is determined by the increase in disability, especially in older age groups, as well as by a sharp decline in the quality of life for this. Objective: To evaluate the efficacy of the therapy performed 12 months after initiation of treatment in patients with hypertension (GC) on the background of treatment with meloxicam at a dose of 7.5 mg/day and 80 and 160 mg/day. Material and methods: under supervision in an outpatient setting, there were 90 patients on the OA 1–2 stages, in combination with GC 2 degree, 2–3 degrees. The average age of patients with OA was 64.4 ± 7.5 years (the first group), patients with OA in combination with GC – 62.13 ± 8.2 years (second group), patients with OA in combination with GC and gastropathy due to admission NSAIDs (third group) – 64.81 ± 1.3 years. Disease duration in patients of the first group – (9.66 ± 4.7) years, in patients of the second group – (9.4 ± 6.0) years, in patients of the third group – (10.4 ± 5.6) years, respectively, the fourth group of comparison contained practically healthy persons. All patients complained of pain syndrome of varying degrees of severity. Patients in the first group received baseline therapy of meloxicam at a dose of 7.5 mg/day; patients in the second and third groups received meloxicam and antihypertensive drug (at a dose of 80 or 160 mg per day). Duration of treatment was 12 months. Results of the study and their discussion: according to the results, the positive effect of the use of meloxicam has led to a significant decrease in the severity of pain in the first, second and third groups according to the visual analogue scale (VAS): (27.8 %, 29.8 %, 25.4 %, p < 0.05) and the Lequesne index (27.1 % and 30.9 %, 26.4 %, p < 0.05), respectively. Conclusions: The tested scheme of treatment of patients with OA with the use of meloxicam indicates the efficacy and statistically significant reduction of pain syndrome, improvement of the functional state of the musculoskeletal system in patients with OA as well as with OA in combination with GC. 2.Also, the analgesic and anti-inflammatory effect of meloxicam and its positive effect on the clinical course of OA were revealed: joint pain decreased, functional capacity increased, general well-being and quality of life of patients improved. Prospects for further research: We consider it expedient to continue prospective surveillance of patients with the aim of further studying of the effect of meloxicam in patients with a comorbid disease. Conflict of Interest: There is no conflict of interest.

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Efficiency of meloxicam application in complex treatment of patients with osteoarthrosis combined with hypertension

Pain medicine ◽

10.31636/pmjua.t2.1 ◽

2019 ◽

Vol 4 (1/1) ◽

pp. 4

Author(s):

L P Kuznecova ◽

M. V. Bondar

Keyword(s):

Blood Pressure ◽

Blood Pressure Monitoring ◽

Pain Syndrome ◽

Well Being ◽

Knee Joints ◽

Duration Of Treatment ◽

Outpatient Settings ◽

Degrees Of Severity ◽

Positive Effect

Objective: To evaluate the efficacy of the therapy performed 12 months after initiation of treatment in patients with osteoarthrosis (OA) combined with hypertension (GC) with treatment with meloxicam at a dose of 7.5 mg/day and 80 mg/day and 160 mg/day "difores". Materials and methods: under observation in outpatient settings, there were 60 patients on OA 1–2 stages, in combination with GC 2 degree, 2–3 degrees. The average age of patients with OA was 64.4 ± 7.5 years, patients with OA in combination with GC – 62.13 ± 8.2 years – 41 (68.3 %) women and 19 (31.7 %) men. Duration of the disease was in patients with OA – (9.66 ± 4.7) years, in patients with a comorbidity of OA and GC – (9.4 ± 6.0) years, respectively. To perform the research tasks, all patients were divided into 3 groups of 30 patients in each of them. The first group – patients with OA without GC, the second one – patients with a combination of OA and GC, the third group of comparison contained practically healthy persons. All patients complained of pain syndrome of varying degrees of severity. Patients of the first two groups received methoxy at a dose of 7.5 mg per day as baseline therapy; meloxicam and antihypertensive drug "diforsi" at a dose of 80 mg per day – patients in the second group were taken, but in 29 % of patients in this group "diormos" was prescribed at a dose of 160 mg. Duration of treatment was 12 months. A general clinical examination was performed inall patients at the beginning of the study, and after treatment: general blood tests, office blood pressure measurements, electrocardiography (ECG), daily blood pressure monitoring (DMAT), radiography of the knee joints. Results: According to the results, the positive effect of using meloxicam caused a significant decrease in the severity of pain in the first and second groups according to the visual analog scale (VAS): (by 27.8 % and 29.8 % respectively, p < 0.05) and the Lequesne index (respectively 27.1 % and 30.9 %, p < 0.05). Also, the analgesic and anti-inflammatory effect of meloxicam and its positive effect on the clinical course of OA were revealed: joint pain decreased, functional capacity in-creased, general well-being and quality of life of patients improved.

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Correlazioni positive tra spiritualità e salute: i risultati di alcune indagini / Positive correlations between spirituality and health: results from some surveys

Medicina e Morale ◽

10.4081/mem.2019.566 ◽

2019 ◽

Vol 68 (1) ◽

pp. 41-54

Author(s):

Paolo Morocutti

Keyword(s):

Quality Of Life ◽

Health Personnel ◽

Medical Condition ◽

Well Being ◽

Close Correlation ◽

General Medical Condition ◽

Spirituality And Health ◽

Positive Correlations ◽

Positive Effect

La dimensione religiosa dell’uomo contribuisce in modo sostanziale al mantenimento della condizione medica generale, migliorando e preservando la qualità della vita. Quanto fa bene la fede? La preghiera fa ammalare meno e guarire prima? La partecipazione ai servizi religiosi porta realmente un effetto positivo sulla salute? Gli studi esaminati in questo articolo sembrano rispondere affermativamente a queste domande, evidenziando la stretta correlazione tra religiosità/spiritualità, salute e benessere fisico e psicologico. L’impatto antropologico e sociologico di tale realtà conduce ad evidenti riflessioni storiche e filosofiche, ma anche mediche e bioetiche, generando l’esigenza di una profonda trasformazione nella formazione del personale sanitario, dove l’aspetto religioso o spirituale non è ritenuto importante, né rilevante nell’approccio medico per la cura e l’assistenza del paziente. Nonostante ciò, numerosi studi approfondiscono ed attestano l’importanza di questo aspetto sia dei singoli, sia dell’intera popolazione. ---------- Religious dimension of man contributes substantially to maintain general medical condition, improving and preserving quality of life. How good is faith? Does prayer make you sick less and get better sooner? Does participation in religious services actually have a positive effect on health? The studies examined within this article seem to answer positively to these questions, highlighting the close correlation between religiosity / spirituality, health and physical and psychological well-being. The anthropological and sociological impact of this reality leads to evident historical and philosophical as well as medical and bioethical reflections, generating the need for a deep transformation of health personnel training, where the religious or spiritual aspect are not considered as important, nor relevant for medical approach to patient’s care. Nevertheless, several studies address and highlight the importance of this aspect for both individuals and whole population.

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Long-term quality of life outcomes of women treated for early-stage endometrial cancer

International Journal of Gynecological Cancer ◽

10.1136/ijgc-2020-002145 ◽

2020 ◽

pp. ijgc-2020-002145

Author(s):

Saira Sanjida ◽

Andreas Obermair ◽

Val Gebski ◽

Nigel Armfield ◽

Monika Janda

Keyword(s):

Quality Of Life ◽

Endometrial Cancer ◽

Early Stage ◽

Age Groups ◽

Laparoscopic Hysterectomy ◽

Well Being ◽

Total Abdominal Hysterectomy ◽

Abdominal Hysterectomy

ObjectiveTo compare long-term quality of life in women treated for early-stage endometrial cancer with population norms, and to compare quality of life outcomes of patients who had total laparoscopic or total abdominal hysterectomy.MethodsOnce the last enrolled patient had completed 4.5 years of follow-up after surgery, participants in the Laparoscopic Approach to Cancer of the Endometrium (LACE) clinical trial were asked to complete a self-administered questionnaire. Two instruments—EuroQol 5 Dimension 3-level (EQ-5D-3L) and the Functional Assessment of Cancer Treatment-General Population (FACT-GP)—were used to determine quality of life. The mean computed EQ-5D-3L index scores for LACE participants at different age categories were compared with Australian normative scores; and the FACT-GP scores were compared between patients treated with surgical treatments.ResultsOf 760 women originally enrolled in the LACE trial, 259 (50.2%) of 516 women consented to provide long-term follow-up data at a median of 9 years (range 6—12) after surgery. On the EQ-5D-3L, long-term endometrial cancer survivors reported higher prevalence of anxiety/depression than normative levels across all age groups (55–64 years, 30% vs 14.9%; 65–74 years, 30.1% vs 15.8%; ≥75 years, 25.9% vs 10.7%). For women ≥75 years of age, the prevalence of impairment in mobility (57.6% vs 43.3%) and usual activities (58.8% vs 37.9%) was also higher than for population norms. For the FACT-GP, the physical (effect size: −0.28, p<0.028) and functional (effect size: −0.30, p<0.015) well-being sub-scale favored the total laparoscopic hysterectomy compared with total abdominal hysterectomy recipients.ConclusionCompared with population-based norms, long-term endometrial cancer survivors reported higher prevalence of anxiety/depression across all age groups, and deficits in mobility and usual activities for women aged ≥75 years. Physical and functional well-being were better among women who were treated with total laparoscopic hysterectomy than among those receiving total abdominal hysterectomy.

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Recurrent swelling and pain in the abdomen and joints in a patient with hereditary angioedema and Ehlers-Danlos syndrome

BMJ Case Reports ◽

10.1136/bcr-2019-231484 ◽

2019 ◽

Vol 12 (11) ◽

pp. e231484

Author(s):

My-Trang Thi Dang ◽

Andrew Ambort ◽

Annie Arrey-Mensah

Keyword(s):

Quality Of Life ◽

Hereditary Angioedema ◽

Healthcare Providers ◽

Pain Syndrome ◽

Well Being ◽

Type I ◽

Ehlers Danlos Syndrome ◽

Complex Disorders ◽

Danlos Syndrome

A 23-year-old woman was referred to the allergy and immunology clinic for recurrent abdominal, cutaneous and joint swelling and pain with a history of mucosal infections since childhood. Her history and clinical findings were suggestive of two rare and complex disorders, hereditary angioedema (HAE) and Ehlers-Danlos syndrome (EDS). Her recurrent episodes of abdominal and joint pain were initially misattributed to more common diagnoses such as esophagitis, depression and chronic pain syndrome. However, the coexistence of HAE and EDS likely contributed to a delay in diagnoses as the combination of these two rare but overlapping disorders is less understood by physicians. She had persistently low levels of C4 and C1-esterase inhibitor (C1-INH) with low to low-normal C1-esterase function, normal C1Q and no C1Q antibodies. In the setting of recurrent abdominal pain with cutaneous swelling, this supported the diagnosis of HAE type I. The increase in joint extensibility with recurrent shoulder subluxations since childhood was a manifestation of EDS. Although no known genetic mutations were identified for EDS, her diagnosis was confirmed by a geneticist based on her clinical phenotype. Before the diagnosis of HAE and EDS, our patient had at least 100 visits/year to the emergency department/hospitalisations for these recurrent symptoms. After starting on C1-INH replacement therapy, the frequency has decreased 10-fold. She also noted a 70% improvement in her quality of life. Familiarity with these rare disorders will assist healthcare providers in recognising HAE and EDS and include them as part of their differential diagnoses. Early diagnosis is important for a patient’s well-being as both these chronic disorders have been associated with poor quality of life. Additionally, proper diagnoses will reduce healthcare costs by preventing unnecessary procedures due to misdiagnoses. Proper treatment will help to decrease hospitalisations and avoidance of life-threatening consequences (such as asphyxiation from fatal laryngeal attacks of HAE and rupture of aneurysms in EDS).

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Quality of Life in Children with Epilepsy

Journal of Pediatric Epilepsy ◽

10.1055/s-0040-1710054 ◽

2020 ◽

Vol 09 (02) ◽

pp. 036-041

Author(s):

Mukesh Kumar Prajapati ◽

Deepak Dwivedi ◽

Naresh Bajaj

Keyword(s):

Quality Of Life ◽

Refractory Epilepsy ◽

Linear Regression Analysis ◽

Tertiary Care ◽

Age Groups ◽

Categorical Variables ◽

Care Hospital ◽

Duration Of Treatment ◽

Factors Associated

Abstract Objective The main aim of this study was to assess quality of life in children with epilepsy. Materials and Methods A prospective observational study was conducted in Regional Early Intervention Centre of the Department of Pediatrics Tertiary Care Hospital in central India. This study included 120 children with epilepsy aged between 2 and 18 years. In this study, we assessed the quality of life in children with epilepsy with the help of Pediatric Quality of Life Inventory (PedsQL). We further analyzed the quality of life in various dimensions. For the statistical analyses for SPSS version, 20 was used, chi-squared and Fisher's exact test was used for categorical variables, and Student's t-test was used for quantitative variables. Linear regression analysis was done for multivariate analysis. Result Mean total PedsQL score for total cohort was 70.96. The cognitive dimension of epileptic children was more affected than physical, social, and emotional dimensions. Factors associated with lower PedsQL scores in epilepsy patients were associated with long duration of epilepsy, polytherapy, male gender, low head circumference, presence of intellectual disability, and refractory epilepsy. Conclusion Epilepsy affects the quality of life in children across all age groups. Among epilepsy indicators, polytherapy, refractory epilepsy, and duration of epilepsy were the most important factors associated with poor quality of life. We can conclude that every effort should be made to decrease the duration of treatment and minimize the number of drugs for improving the quality of life in this patient cohort.

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Psychological and spiritual well-being aspects of the quality of life in colostomy patients

Vojnosanitetski pregled ◽

10.2298/vsp151118357r ◽

2018 ◽

Vol 75 (6) ◽

pp. 611-617

Author(s):

Gordana Repic ◽

Suncica Ivanovic ◽

Cedomirka Stanojevic ◽

Sanja Trgovcevic

Keyword(s):

Quality Of Life ◽

Negative Impact ◽

Age Groups ◽

Well Being ◽

Life Questionnaire ◽

Cross Sectional ◽

Psychological Well Being ◽

Spiritual Well Being ◽

The Mean

Background/Aim. Colorectal cancer and its treatment can have a negative impact on the quality of life which has become an important outcome measure for cancer patients. The aim of this work was assessment of psychological and spiritual dimension of the quality of life in colostomy patients, regarding the gender and age. Methods. This is a cross-sectional study conducted at the Abdominal Surgery Polyclinic in the Clinical Canter of Vojvodina among colostomy patients operated between January 2010 and June 2011. The instrument used in this study was Quality of Life Questionnaire for a Patient with an Ostomy (QOL-O). Results. Majority of respondents were male (M:F = 50.7% : 49.3%). The age ranged between 36?86 years. Respondents did not report difficulties in adjustment to stoma, but their great difficulty was to look at it and the sense of depression and anxiety. The care of stoma was worse perceived by younger respondents (p = 0.014). Respondents were mostly satisfied with their memorizing ability and having the sense of control. The lowest score was found in sensing satisfaction or enjoyment in life. The age had a significant impact on positive aspects of psychological well-being (p < 0.05). Higher scores were found among younger age groups. The mean score of spiritual well-being (6.47 ? 3.01) was lower than the mean score of psychological well-being (7.76 ? 2.35). There were no statistically significant differences regarding gender (t = -0.738, df = 65, p = 0.463) or age (F = 1.307, p = 0.280). Conclusion. Psychological and spiritual well-being in colostomy patients appeared to be at satisfactory level, but it is necessary to provide tailor made support in order to prevent and resolve negative responses to stoma.

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Sex and Age Differences in Levels of Anomia of Latvian Inhabitants

SOCIETY INTEGRATION EDUCATION Proceedings of the International Scientific Conference ◽

10.17770/sie2015vol3.475 ◽

2015 ◽

Vol 3 ◽

pp. 567 ◽

Cited By ~ 3

Author(s):

Jeļena Ļevina ◽

Kristīne Mārtinsone ◽

Daiga Kamerāde

Keyword(s):

Quality Of Life ◽

Age Differences ◽

Age Groups ◽

Secondary Data ◽

Well Being ◽

Demographic Groups ◽

The Third ◽

Significant Difference ◽

Sex And Age Differences

Anomia is one of the important factors, which can influence the psychological well-being of individuals. It is especially valuable to determine those socio-demographic groups which can demonstrate the highest levels of anomia. The purpose of the research was to determine whether there are sex and age differences in levels of anomia of Latvian inhabitants. The secondary data from the third European Quality of Life Survey (EQLS) were used. The sample consisted of Latvian inhabitants (n = 1009), aged from 18 to 92 years (male – 34.9%, female – 65.1%). 3 indices and 3 subscales of anomia (Social Distrust, Social Isolation and Meaninglessness) were constructed (Ļevina, Mārtinsone & Kamerāde, 2015a, 2015b). A multivariate analysis of variance was conducted. It was found that there was a significant difference in multidimensional anomia between Latvian inhabitants of different age groups.

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The role of electrotherapy in reducing the pain of patients with knee osteoarthritis during the COVID-19 pandemic

Balneo Research Journal ◽

10.12680/balneo.2020.390 ◽

2020 ◽

pp. 512-515

Author(s):

Elisabeta ANTONESCU ◽

Sînziana Călina SILIŞTEANU ◽

Maria TOTAN

Keyword(s):

Quality Of Life ◽

Knee Osteoarthritis ◽

Age Groups ◽

Pain Syndrome ◽

Painful Symptom ◽

Gender And Age ◽

Physical Dysfunction ◽

Recovery Treatment

Introduction. Osteoarthritis is considered to be the most common form of arthritis and a leading disability cause worldwide, especially due to the painful symptom. The latter is a clinical marker in evaluating the limits of joint mobility and therefore, the pain reduction is a goal of the recovery treatment for patients with knee osteoarthritis. The purpose of this study was to show whether the pain phenomenon characteristic of knee osteoarthritis can be reduced by electrotherapy, even in the context of the COVID-19 pandemic. Material and method. The study lasted 5 months and included 171 patients diagnosed clinically and radiologically with knee osteoarthritis. The followed parameters were pain, physical dysfunction in daily activities, anxiety and quality of life. Results and discussions. The two groups of studied patients were homogeneous in terms of weight by gender and age groups. The evaluation of patients according to scales enabled the registration of statistically significant values, the value of p <0.05, which explains the validation of the working hypothesis. The feeling of pain is closely related to the level of anxiety. Conclusions. Analgesic electrotherapy significantly reduced the pain syndrome of the patients for whom it was used. It has been shown that the patients' anxiety can influence the pain phenomenon. Given the conditions caused by the Covid-19 pandemic, the anxiety of the patients who were in the outpatient department to receive recovery treatment was increased, but after the recovery treatment there was a decrease, so these patients' quality of life increased. Keywords: pain, analgesic electrotherapy, knee osteoarthritis, recovery treatment,

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The influence of intensity and neuropathic component of pain syndrome on the quality of life in patients with multiple sclerosis

Zaporozhye Medical Journal ◽

10.14739/2310-1210.2021.5.206017 ◽

2021 ◽

Vol 23 (5) ◽

pp. 628-635

Author(s):

T. I. Nehrych ◽

N. L. Bozhenko ◽

M. I. Bozhenko

Keyword(s):

Quality Of Life ◽

Multiple Sclerosis ◽

Pain Intensity ◽

Social Functioning ◽

Pain Syndrome ◽

Well Being ◽

Structural Element ◽

Low Intensity ◽

Average Pain

The aim of the work. To analyze the influence of intensity and neuropathic component of pain syndrome on the quality of life structure characteristics in patients with multiple sclerosis (MS). Materials and methods. 104 MS patients with different types of MS course and complaints of pain during the last month were examined in the Lviv Regional Multiple Sclerosis Center. The patients were interviewed using standardized questionnaires (Pain Detect, VAS, SF-36) followed by an analysis of the pain characteristics influence on the quality of life. Results. When assessing the influence of the main characteristics of MS course, the relationship between the physical component of quality of life and levels of disability (EDSS) and the total number of relapses was found (r = -0.60, P < 0.01; r = -0.34, P < 0.01, respectively). However, the mental component of quality of life had no significant relationship with the level of disability and the number of relapses. The average pain intensity within a month on the VAS scale was 5.0 [4.0; 7.0]. 24.0 % of patients had low-intensity pain, 54.8 % – moderate, 21.2 % – high. In MS patients with low-intensity pain within a month, 5 of the 11 quality of life indicators were significantly higher, in particular, the overall physical component of quality of life – 38.1 [33.8; 48.5] % in low-intensity pain against 31.8 [28.1; 38.7] %, P = 0.02 – in moderate. In MS patients, the level of both physical (r = -0.25; P = 0.01) and mental (r = -0.21; P = 0.03) component of quality of life decreased with increasing pain intensity. The most notable correlation was observed between intensity of pain and such characteristics of quality of life as energy/fatigue (r = -0.37; P ˂ 0.01) and emotional well-being (r = -0.28; P ˂ 0.01). In 30.8 % of patients, pain was neuropathic, in 47.1 % – nociceptive, in 22.1 % – undetermined. MS patients with the neuropathic type of pain had significantly lower scores, 7 out of 11 indicators of quality of life, largely the mental component, than scores in MS patients with nociceptive type (Р < 0.05). Correlation analysis showed the association between an increase in the manifestation of neuropathic pain component and a decrease in all quality of life characteristics, except in health change. In MS patients with a neuropathic component, in increasing level of its manifestation, the mental component of health decreased clearly (r = -0.36; P ˂ 0.01), namely its social functioning characteristic (r = -0.35; P < 0.01). Conclusions. In MS patients, increasing intensity of pain decreases both physical and mental components of quality of life with the most significant decrease in energy/fatigue and emotional well-being as parts of the mental component of quality of life. The neuropathic component of pain and the level of its manifestation are largely associated with a decrease in the mental component of quality of life as the overall indicator and social functioning as its structural element.

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Comprehensive Assessment of the Elderly Cancer Patient: The Feasibility of Self-Report Methodology

Journal of Clinical Oncology ◽

10.1200/jco.2002.20.3.770 ◽

2002 ◽

Vol 20 (3) ◽

pp. 770-775 ◽

Cited By ~ 55

Author(s):

Sally S. Ingram ◽

Pearl H. Seo ◽

Robert E. Martell ◽

Elizabeth C. Clipp ◽

Martha E. Doyle ◽

...

Keyword(s):

Quality Of Life ◽

Social Support ◽

Cancer Patients ◽

Daily Living ◽

Older Patients ◽

Age Groups ◽

Well Being ◽

Self Report ◽

Younger Patients

PURPOSE: Comprehensive geriatric assessment (CGA) has aided the medical community greatly in understanding the quality-of-life issues and functional needs of older patients. With its professional team assessment approach, however, CGA may be time consuming and costly. The goal of the present study was to assess the ability of cancer patients to complete a self-administered CGA and then to characterize cancer patients across multiple domains and age groups. PATIENTS AND METHODS: Two hundred sixty-six male outpatient oncology patients at the Durham Veterans Affairs Medical Center were asked to fill out a survey assessing 10 domains (demographics, comorbid conditions, activities of daily living, functional status, pain, financial well being, social support, emotional state, spiritual well-being, and quality of life). RESULTS: Seventy-six percent of the patients who received their surveys and kept their appointments returned the assessment tool. Older oncology patients had significantly less education (P < .0001), income (P = .05), frequent exercise (P = .01), and chance of being disease free (P = .003) than younger patients. Other findings in older patients were a higher rate of marriage (P = .02), more difficulty in taking medications (P = .05), and less cigarette (P = .03) and alcohol (P = .03) use. Members of all age cohorts reported a sense of social support, with younger patients deriving this more from family and friends than older patients, and older patients deriving social support more from membership in religious communities than younger patients. No differences were found across age groups for number and impact of comorbid illnesses, number of medications, basic and instrumental activities of daily living, pain, overall health rating, financial adequacy, anxiety, depression, and quality of life. CONCLUSION: CGA can be conducted in an outpatient cancer community using a self-report format. Despite the fact that this population varied demographically across age groups and is limited to veterans, this study demonstrated remarkable similarities between younger and older cancer patients in terms of functional status, health states, and quality of life.

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