scholarly journals BIOTECHNOLOGICAL PREPARATIONS FOR MEDICINE AND VETERINARY MEDICINE IN PROGRAMS PRODUCTION OF ENVIRONMENTALLY FRIENDLY FOOD

2020 ◽  
pp. 69-80
Author(s):  
Yu. S. Alikin ◽  
M. V. Alekseeva ◽  
V. V. Ermolaev ◽  
V. P. Klimenko ◽  
L. R. Lebedev ◽  
...  
Keyword(s):  
Veterinary Medicine ◽  
Russian Federation ◽  
Specific Resistance ◽  
Environmentally Friendly ◽  
The Body ◽  
Biologically Active ◽  
Cytokine Network ◽  
Protective Properties ◽  
Systemic Level ◽  
The Russian Federation

A proposal is being considered for the use of BAS preparations developed in the Institute of medical biotechnology OF the FBU SSC VB «Vector» in the programs of ensuring the country’s security in the field of medicine, veterinary medicine and obtaining environmentally friendly food products. On the basis of biotechnological methods, a technology for obtaining a complex of biologically active preparations of double-stranded and single-stranded RNA from yeast and phages that can provide a solution to the above problems has been created. The» ideology «of the development consisted in a deep study of the EN-Dogen induction of interferons by the organism itself using evolutionarily formed mechanisms. The basis was taken of inter-veronicaceae mechanisms of action of viruses. Such drugs when injected into the human body and animals can act as viruses, inducing the synthesis of interferons and other proteins-cytokines in the body, but unlike viruses, they do not produce destructive effects. Activation of the endogenous cytokine network in this case at the systemic level can form a state of non-specific resistance against viruses, bacteria and their toxins. Injectable and ointment forms of these drugs based on RNA were developed, tested and approved by the Ministry of health of the Russian Federation and the Department of veterinary medicine of the Russian Federation. Introduction of effective methods of application of the developed preparations allows to use them as etiotropic means of emergency prevention and treatment of viral diseases of the person, calves, pigs, carnivores, birds and fishes, correction of immunodeficiency, strengthening of protective properties of vaccines.

Morphometric and genetic studies of the mechanisms of damage to the cardiovascular system in Kuzbass miners with dust lung pathology

2021 ◽  
Vol 61 (9) ◽  
pp. 611-619
Author(s):  
Anastasiya S. Kazitskaya ◽  
Oleg I. Bondarev ◽  
Maria S. Bugaeva ◽  
Anna G. Zhukova ◽  
Tatyana K. Yadykina
Keyword(s):  
Russian Federation ◽  
Work Experience ◽  
The Body ◽  
Lung Pathology ◽  
Federal Law ◽  
Autopsy Material ◽  
Ministry Of Health ◽  
Genetic Studies ◽  
The Russian Federation ◽  
Medical Examinations

Introduction. The combined impact of unfavorable factors of the production environment in miners leads to the development of associated pathology of the bronchopulmonary and cardiovascular systems, the predisposition to which depends on the individual susceptibility of the body. In this regard, it is important to comprehensively study the pathogenetic mechanisms underlying the formation and course of occupational and work-related diseases for a personalized approach to the diagnosis, prevention and therapy of this pathology. The purpose of this study was to study the mechanisms of damage to the cardiovascular system in miners with dust lung pathology on the basis of morphological and genetic studies. Materials and methods. For genetic studies, venous blood drawing was conducted in 190 Kuzbass miners. The main group included 126 miners of the main professions with the previously proven diagnosis "dust lung pathology", the comparison group consisted of 64 workers without a proven diagnosis working in similar sanitary and hygienic conditions. Morphometric studies were carried out using autopsy material obtained during 80 forensic medical examinations of miners in the Kemerovo region. All the miners were divided into 4 groups depending on their underground work experience. The control group was formed from 20 cases of forensic medical examinations of men who died in road accidents and did not have organ pathology according to the results of autopsies. Results. The study of the autopsy material revealed the presence of morphostructural changes in the vascular walls of the miners’ hearts in the form of hypertrophy of the smooth muscle cells of the medial layers, thickening of the endothelial lining, and the development of fibroplastic changes in the perivascular zones. These changes began to form from the first years of work in the underground conditions and progressed with increasing work experience contributing to the "recalibration" of the heart vessels with the formation of the lumen "obstruction". One of the mechanisms of endothelial damage in miners was a change in the expression of the EDN1 gene, which regulates the synthesis of endothelin-1. The risk and resistance genotypes of the development of dust lung pathology for the rs5370 polymorphism of the EDN1 gene were identified. Morphostructural rearrangement of the endothelium in the combination with its pathological activation contributed to the occurrence of endothelial dysfunction in miners. Conclusions. The conducted studies of the parameters of the vascular endothelium indicate its key role in the pathogenesis of bronchopulmonary and cardiovascular pathology in miners of the main professions. Getting into the body of workers, particles of coal-rock dust lead to morphostructural rearrangement of the cells of the endothelial layer and its pathological activation. The contribution of molecular and genetic mechanisms to the development of occupational lung pathology and associated diseases of the circulatory system in miners is revealed. Ethics. The studies were carried out in compliance with the ethical standards of the Bioethical Committee of the Research Institute for Complex Problems of Hygiene and Occupational Diseases, elaborated on the basis of the Helsinki Declaration of the World Medical Association "Ethical Principles for Conducting Human Scientific Medical Research" as amended in 2013 and the "Rules of Clinical Practice in the Russian Federation" approved by the Order of the Ministry of Health of the Russian Federation No. 266 dated 19.06.2003. All workers were informed about their participation in the molecular-genetic study and gave written consent to carry it out. The research of the dead miners was based on the secondary examination of blocks and ready-made histological micro-preparations of the material of the Bureau for Forensic Medical Expert Examination of the cities of Novokuznetsk, Osinniki, and Prokopyevsk. The study of pathomorphological material was carried out in accordance with the Federal Law of 21.11.2011, No. 323-FZ "On the Fundamentals of Health Protection of Citizens in the Russian Federation", in particular, with Article 67 "Carrying out pathological and anatomical autopsies", Federal Law of 12.01.1996, No. 8-FZ "On burial and funeral business" (Article 5, paragraphs 1, 2), as well as on the basis of the Order of the Ministry of Health of April 29, 1994, No. 82 "On the procedure for conducting pathological and anatomical autopsy" (Annex to the Order of the Ministry of Health and Medical Industry of 29.04.1994 No. 82), the Order of the Ministry of Health of Russia of 24.03.2016. No. 179n "On the rules for conducting pathological and anatomical examinations".

scholarly journals Development of Small Business in the Altay Territory in 2010-2015

2019 ◽  
Vol 26 (8) ◽  
pp. 51-60
Author(s):  
S. V. Lesovykh
Keyword(s):  
Small Business ◽  
Russian Federation ◽  
Small Businesses ◽  
Structural Changes ◽  
Federal District ◽  
Business Development ◽  
The Body ◽  
Information Support ◽  
The Russian Federation ◽  
The Government

The article considers main trends in the small business of the Altay Territory according to results of 2011 and 2016 full-scale observations that follow the results of activities of small and medium-sized enterprises in 2010 and 2015.In the introduction, the author argues the relevance of the economic and statistical analysis of small business, which is essential for its support, as it is one of the government’s priority areas of activity at all levels when it comes to solving problems of socio-economic development. There are characteristics of information support of the analysis related to the implementation of the Federal Law No. 209-FZ from July 24, 2007 «On small and medium business development in the Russian Federation» and the Order of the Government of the Russian Federation No. 201-r from February 14, 2009.The body of the article successively focuses on some areas of analysis - from the general characteristics of small businesses to the factual analysis of individual aspects of activities of the economic entities under review (headcount, wages and revenues, fixed assets and the scope of investment activities). The features of small enterprises development by economic activity are analyzed separately. An integrated indicator of structural differences is used to assess the significance of structural changes in small businesses. A cluster analysis of the Altay Territory municipalities was carried out and they were rated according to the small business development level. In addition, the author assessed the contribution of small business of the Altay Territory to the development of small business in the Siberian Federal District and the Russian Federation.The final section of the article draws conclusions from the authors’ own specific analysis that points to both positive and negative trends in the development of small business in the Altay Territory.

ENCOURAGING AND MAINTAINING BREASTFEEDING TO ACHIEVE SUSTAINABLE DEVELOPMENT GOALS. ANALYTICAL REVIEW

2020 ◽  
Vol 66 (6) ◽  
pp. 10-10
Author(s):  
L.V. Abolyan ◽  
◽  
V.A. Polesskii ◽  
U.M. Lebedeva ◽  
I.M. Pastbina ◽  
...  
Keyword(s):  
Sustainable Development ◽  
Human Milk ◽  
Russian Federation ◽  
Sustainable Development Goals ◽  
National Income ◽  
Biologically Active ◽  
World Health ◽  
Development Goals ◽  
The Russian Federation ◽  
National Programs

Significance. World Health Organization correlates breastfeeding with at least eight out of the 17 UN Sustainable Development Goals. However, in the Russian Federation breastfeeding issues are not reflected in any of the Federal programs of the national projects “Demography” and “Health Care”. Purpose of the study: to scientifically substantiate the need for including measures to encourage and maintain breastfeeding in the Russian national programs related to the achievement of the UN Sustainable Development Goals, based on the analysis of modern literature. Material and methods. The study included sources available from the English-language database PubMed. A total of 57 sources were selected out of 317 findings by keywords “human milk composition and bioactivity”, “breastfeeding and Sustainable Development Goals”, “breastfeeding short-term and long-term benefits” and “breastfeeding and potential lives saved”. Results. The study revealed unique biologically active components of the human milk and mechanisms of their impact on prevention of infectious and non-communicable diseases as well as programming of health in adult life. Breastfeeding has a positive impact on mothers’ and children’ health. The increased rate of breastfeeding could globally prevent 823,000 or 13.8% of deaths among children under 2 yearly and 22216 deaths from breast cancer among women. Lack of breastfeeding is associated with lower intelligence and higher economic costs adding up to about $ 302 billion annually, or 0.49% of the world's gross national income. There are unfavorable trends in prevalence and duration of breastfeeding worldwide. The healthcare has a leading role to play in implementing measures to encourage and maintain breastfeeding. Conclusion. It is necessary to incorporate measures to encourage and maintain breastfeeding in the Russian national programs related to the achievement of the UN Sustainable Development Goals. Implementation and further development of the WHO/UNICEF “Baby-Friendly Hospital Initiative” in the Russian Federation can become the cornerstone in increasing the level of breastfeeding with the participation of the health sector. Scope of application. Executive and health authorities at all levels, mother and child health facilities, national programs

scholarly journals THE OBSTRUCTION OF THE ADMINISTRATION OF JUSTICE AND PRELIMINARY INVESTIGATION: PROBLEMS OF THE OBJECT AND THE OBJECTIVE SIDE

2018 ◽  
Vol 2 (2) ◽  
pp. 97-105
Author(s):  
Alexandra Vladimirovna Boyarskaya
Keyword(s):  
Russian Federation ◽  
Complex Analysis ◽  
Preliminary Investigation ◽  
Legal Protection ◽  
Criminal Procedure ◽  
Criminal Code ◽  
The Body ◽  
Criminal Proceedings ◽  
Criminal Procedure Law ◽  
The Russian Federation

The subject. The article is devoted to the investigation of the main direct object and the circle of victims are subjected of harm by criminal acts stipulated by pts. 1, 2 of art. 294 of the Criminal Code of the Russian Federation.The purpose of the paper is to identify does the art. 294 of Criminal Code of the Russian Federation meets the other provisions of criminal procedure legislation.The methodology of research includes methods of complex analysis, synthesis, as well as formal-logical, comparative legal and formal-legal methods.Results and scope of application. The content of art. 294 of the Criminal Code of the Russian Federation does not comply with the provisions of the criminal procedure law. The discrep-ancy lies in terms of the range of participants in criminal proceedings and the functions performed by them, as well as the actual content and correlation of such stages of criminal proceedings as the initiation of criminal proceedings and preliminary investigation. In addi-tion, the current state of art. 294 of the Criminal Code of the Russian Federation does not take into account the ever-widening differentiation of criminal proceedings.The circle of victims listed in pt. 2 of art. 294 of the Criminal Code of the Russian Federation should be supplemented by such participants in the criminal process as a criminal investi-gator, the head of the investigative body, the head of the inquiry department, the head of the body of inquiry. At the same time, the author supports the position that the criminal-legal protection of the said persons should cover not only their activities at the stage of preliminary investigation, but also of the entire pre-trial proceedings as a whole.The circle of criminal acts provided for in art. 294 of the Criminal Code of the Russian Fed-eration, should also be specified with an indication of encroachment in the form of kidnapping, destruction or damage to such a crime as materials of criminal, civil and other cases, as well as material evidence.Conclusions. The content of art. 294 of the Criminal Code of the Russian Federation does not comply with the provisions of the criminal procedure law. The author formulates the conclusion that the circle of victims listed in pt. 2 of art. 294 of the Criminal Code should be broadened and joins the position that the criminal-legal protection of these persons should cover not only their activities at the stage of preliminary investigation, but also of the entire pre-trial proceedings as a whole.

scholarly journals About some questions of dissolution of legislative bodies of subjects of the Russian Federation

2019 ◽  
Vol 2019 (2) ◽  
pp. 106-113
Author(s):  
Людмила Тхабисимова ◽  
Ludmila Thabisimova ◽  
Эльман Ахъядов ◽  
Elman Akhyadov
Keyword(s):  
Russian Federation ◽  
Constitutional Law ◽  
State Power ◽  
The Body ◽  
Early Termination ◽  
Legal Responsibility ◽  
Legislative Body ◽  
The Subject ◽  
The Russian Federation ◽  
The Right

The article examines the issues of dissolution of the legislative body of the subject of the Federation. Attention is drawn to the fact that the institution of dissolution is an institution of constitutional law, and when the legislative body is dissolved, it is not responsible to the body or official who decided to dissolve it, but to the population, its voters. On the basis of the study it is concluded that it is necessary to Supplement the list of grounds for early termination of the powers of the regional Parliament, as a measure of constitutional and legal responsibility, by including such grounds as the loss of voter confidence. The question of the need to empower the population of the subject of the Russian Federation with the right to decide in a referendum on the dissolution of the legislative (representative) body of state power of the subject of the Russian Federation.

scholarly journals QUALITY AND SAFETY MONITORING OF WATER BIOLOGICAL RESOURCES FROM WATER BODIES OF THE CENTRAL FEDERAL DISTRICT OF THE RUSSIAN FEDERATION

2020 ◽  
Vol 99 (3) ◽  
pp. 246-252
Author(s):  
Nina A. Golovina ◽  
N. N. Romanova ◽  
P. P. Golovin ◽  
A. V. Zdrok
Keyword(s):  
Russian Federation ◽  
Clinical Signs ◽  
Federal District ◽  
The Body ◽  
Water Bodies ◽  
Cadmium Content ◽  
Quality And Safety ◽  
Social Significance ◽  
Central Federal District ◽  
The Russian Federation

Introduction. There have been given results of the assessment of quality and safety of hydrobionts exampled by fishes as main objects of amateurish fishing in water bodies of the Central Feddral District of the Russian Federation. Fishery water bodies on this territory are exposed to anthropogenic impacts and lead in the concerning volume of polluted effluent discharge in Russia. The purpose of this study is to assess the quality and safety of hydrobionts on the example of fish - the main objects of amateur fishing in the reservoirs of the Central District of the Russian Federation. Material and methods. Fish catching was carried out in the summer-autumn period in 2013-2017. The volume of the survey sample was about 1500 fishes. The species composition of helminths in 15 fish species from three families Cyprinidae, Percidae and pike (Esocidae)is was determined by parasitological examination. The safety of fish was evaluated using parasitological and toxicological methods. Results. Fish from water bodies of the Lipetsk, Tambov, Belgorod, Bryansk and Tver areas has been ascertained to be facultatively available for human consumption. Clinical signs of the disease were observed in fish infected with metacercariae trematodes (posthodiplostomum and apophallus) in the form of black spots on the body. Among the detected worms, 2 species can be potentially dangerous for warm-blooded animals and humans - Pseudamphistomum truncatum (Trematoda: Opisthorchidae) and Apophallus muehlingi (Trematoda: Heterophyidae). Analysis of fish contamination with heavy metals showed excess of the permissible cadmium content in fish tissues. Conclusion. The conducted research showed the urgency and social significance of studies on monitoring for water objects and the need to implement the preventive work with the population in such a densely populated part of the Russian Federation as the Central Federal District.

scholarly journals DETERMINANTS OF IMPROVING THE SYSTEM OF REGULATORY DOCUMENTATION OF EXECUTIVE AUTHORITIES OF CONSTITUENT ENTITIES OF THE RUSSIAN FEDERATION

2020 ◽  
Vol 8 (1) ◽  
pp. 312-316
Author(s):  
Irina Avdeeva ◽  
O. Manchenko
Keyword(s):  
Law Enforcement ◽  
Russian Federation ◽  
The Body ◽  
Law Enforcement Agencies ◽  
Documentation System ◽  
Executive Authority ◽  
The Russian Federation ◽  
Forest Use ◽  
Low Efficiency ◽  
Forest Legislation

A study of the regulatory documentation of the executive authority of the constituent entity of the Russian Federation in the field of forestry was carried out in order to identify the determinants of improving the regulatory documentation system. It is noted that the system of regulatory documentation of the executive body under review is represented by status, functional and official regulations. It is indicated that the body in the field of its activities in the provision of public services and the performance of public functions to exercise control (supervision) performs a significant number of interagency interactions. Moreover, these interactions do not rely on specific regulatory documents – administrative regulations for interagency cooperation. Such a lacunae in the system of administrative regulations of the body in question causes the imperfection, non-optimality of its work. It is shown that one of the most significant manifestations of this situation is the state of affairs in the field of cooperation with law enforcement agencies in the prompt identification of violators of forest legislation and timely recovery of damage from these violations. The system of this interaction does not have a proper regulatory document and is characterized by low efficiency. It is concluded that the regulation of interaction with law enforcement agencies is a determinant of improving the system of regulatory documentation of this body. In this regard, the relevance of the activities of the body in question in the field of formulating proposals for the development of regulations, and, possibly, their more than approved local testing as an experiment at the level of individual regions, was noted. It is proposed in order to establish the procedure for interaction between bodies exercising powers in the field of forest relations and law enforcement agencies in identifying, suppressing, investigating and solving crimes in the field of forest use, to develop a regulation for interaction at the regional level.

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