scholarly journals Study of serum high sensitivity C- reactive protein and lipid profile in ischemic and hemorrhagic stroke

2019 ◽  
pp. 42-45
Author(s):  
Dr. Sarika Argade ◽  
Dr. Reshakiran J Shendye
Keyword(s):  
Ischemic Stroke ◽  
Lipid Profile ◽  
Hdl Cholesterol ◽  
High Sensitivity ◽  
Haemorrhagic Stroke ◽  
Acute Phase Reactant ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Cholesterol Levels ◽  
Hs Crp

Introduction: Stroke is the neurological deficit of abrupt onset attributable to focal vascular cause and makes a considerable contribution to morbidity and mortality. High sensitivity C reactive protein (hsCRP) is an acute-phase reactant tends to increase at the onset of inflammation. Atherosclerosis, a major risk factor for cerebrovascular diseases involves inflammation which is triggered by dyslipidaemia. Objective: To estimate and compare levels of serum hs-CRP and lipid profile in patients with ischemic and haemorrhagic stroke. Methods: Present study comprised of 90 subjects, 30 ischemic stroke, 30 haemorrhagic stroke and 30 as apparently healthy control. Blood samples obtained within 24 hours of presentation were analysed for serum hsCRP and lipid profile. Results: In the present study Median age was 52 years, 52.5 years and 54 years in control, ischemic stroke and haemorrhagic stroke respectively. Hs-CRP levels were raised in ischemic and haemorrhagic stroke compared to normal control (F-value=96.78; p<0.0001). Total cholesterol, triglyceride and LDL- cholesterol levels were significantly raised while HDL- cholesterol levels were low in ischemic stroke and haemorrhagic stroke than control (p<0.05). Conclusion: Increased serum hs-CRP levels and dyslipidemia were observed in ischemic and haemorrhagic stroke. But serum hs-CRP cannot differentiate type of stroke. Keywords: Ischemic stroke; Haemorrhagic stroke; hs-CRP; Lipid profile.

scholarly journals SAT-431 Insulin Resistance, Lipid Profile and High-Sensitivity C-Reactive Protein in Patients with Autoimmune Thyroiditis

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Celestino Neves ◽  
João Sérgio Neves ◽  
Miguel Pereira ◽  
Ana Oliveira ◽  
José Luís Medina ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Lipid Profile ◽  
Thyroid Function ◽  
Autoimmune Thyroiditis ◽  
Hdl Cholesterol ◽  
High Sensitivity ◽  
Sensitivity Index ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp

Abstract Introduction: Thyroid function and autoimmunity has been associated with cardiovascular events in patients with autoimmune thyroiditis. Objectives: To evaluate the association between thyroid function, antithyroid antibodies levels, insulin resistance and markers of cardiovascular risk in patients with autoimmune thyroiditis. Methods: We evaluated 228 patients with autoimmune thyroiditis, 93.9 % female, with a mean age of 47.06 ± 15.35 years. We analyzed thyroid function, anti-thyroglobulin antibodies (anti-Tg), anti-thyroid peroxidase antibodies (anti-TPO), HOMA-IR, HOMA-B, QUICKI, HISI (Hepatic Insulin Sensitivity Index), WBISI (Whole-Body Insulin Sensitivity Index), the levels of lipid profile, high-sensitivity C-reactive protein (hs-CRP), homocysteine, folic acid, and vitamin B12. We defined 3 groups based on TSH levels: TSH between 0.35-2.49 µUI/ml, (n = 166), TSH between 2.50-4.94 µUI/ml, (n = 43) and TSH over 4.95 µUI/ml, (n = 19), and normal levels of free T4 and free T3. A 75-g OGTT was performed in the morning and blood samples were obtained every 30 min for 120 min for measurements of plasma glucose, insulin, and C-peptide. For the statistical analysis we used the Mann-Whitney test and Spearman correlations. Results are expressed as means ± SD or percentages. A two-tailed p&lt;0.05 was considered statistically significant. Results: There were no significant differences regarding median age or median BMI between groups. We did not find any significant differences comparing group with TSH 0.35-2.49 and group with TSH 2.50-4.94, in all parameters evaluated. Group with TSH 2.50-4.94 had higher indexes of QUICKI (0.69 ± 0.39 vs 0.48 ± 0.13; p = 0.02) and HISI (79.83 ± 63.72 vs 41.73 ± 29.02; p = 0.01) than group with TSH over 4.95. The group with TSH over 4.95 demonstrated a higher index of HOMA-IR than group with TSH 2.50-4.94 (3.77 ± 2.93 vs 1.95 ± 1.24; p = 0.01). In the TSH 0.35-2.49 group we found significant correlations between TSH and HOMA-IR (r= 0.18; p = 0.01), total cholesterol and anti-TPO (r =0.23; p = 0.002), anti-Tg and HDL-cholesterol (r= -0.17; p=0.002), anti-Tg and triglycerides (r=0.34; p &lt; 0.001), and anti-Tg and LDL-cholesterol (r=0.16; p=0.03). In the TSH 2.50-4.94 group we observed positive correlation between Apo A1 and HOMA-B (r=0.58; p&lt;0.001), HOMA-IR and LDL-cholesterol (r=0.34; p=0.02) and WBISI and HDL-cholesterol (r=0.34; p=0.02). In the TSH over 4.95 group we observed a correlation between TSH and triglycerides (r=0.70; p&lt;0.001) and between anti-Tg and hs-CRP (r=0.64; p=0.004). Conclusions: The association among TSH, lipid profile, insulin resistance, hs-CRP and antithyroid antibodies in patients with autoimmune thyroiditis may contribute to an increased cardiovascular risk, not only in patients with subclinical hypothyroidism but also in those classified as euthyroid.

scholarly journals Hubungan Profil Lipid dan Kadar High-Sensitivity C-Reactive Protein dengan Outcome Pasien Stroke Iskemik Akut

2020 ◽  
Vol 3 (2) ◽  
pp. 48
Author(s):  
Stefanus Erdana Putra ◽  
Fauzi Novia Isnaening Tyas ◽  
Muhammad Hafizhan ◽  
Raden Ajeng Hanindia Riani Prabaningtyas ◽  
Diah Kurnia Mirawati
Keyword(s):  
Ischemic Stroke ◽  
Lipid Profile ◽  
Barthel Index ◽  
Density Lipoprotein ◽  
High Sensitivity ◽  
National Institutes Of Health ◽  
C Reactive Protein ◽  
Stroke Patients ◽  
Reactive Protein ◽  
Hs Crp

<p><strong>Pendahuluan:</strong><strong> </strong><em>Stroke</em> adalah penyebab utama kecacatan jangka panjang dengan dampak klinis dan sosial ekonomi yang signifikan di seluruh dunia. Hiperlipidemia dan inflamasi memainkan peranan penting dalam patofisiologi <em>stroke</em> iskemik. Meskipun <em>high-sensitivity C-Reactive Protein </em>(hs-CRP) dan kadar lipid merupakan penentu risiko penyakit pembuluh darah, kekuatan penggunaan <em>biomarker</em> ini dalam penentuan prognosis <em>stroke </em>iskemik belum dapat dipastikan. Penelitian ini bertujuan untuk mengetahui hubungan kadar hs-CRP dan profil lipid pada pasien <em>stroke </em>iskemik akut di Rumah Sakit Universitas Sebelas Maret dan memahami hubungan antara <em>biomarker</em> tersebut dengan <em>outcome</em> jangka pendek.</p><p><strong>Metode penelitian:</strong><strong> </strong>Penelitian <em>cross-sectional</em> dilakukan pada 34 pasien dengan serangan <em>stroke</em> iskemik pertama kali. Profil lipid dan hs-CRP diukur pada hari pertama masuk rumah sakit. Defisit neurologis diukur menggunakan <em>National Institutes of Health Stroke Scale</em> (NIHSS) dan <em>outcome</em> diukur menggunakan Barthel <em>Index</em> pada hari ke-7 perawatan di unit <em>stroke</em>. Selanjutnya, kadar serum hs-CRP dan profil lipid dianalisis korelasinya dengan defisit neurologis dan <em>outcome</em> jangka pendek.</p><p><strong>Hasil penelitian:</strong><strong> </strong>Pasien <em>stroke</em> iskemik memiliki kadar hs-CRP, kolesterol total (TC), trigliserida (TG), <em>low-density lipoprotein</em> (LDL) yang lebih tinggi; serta kadar <em>high-density lipoprotein</em> (HDL) yang lebih rendah dari kriteria normal. Berdasarkan uji korelasi Pearson, LDL memiliki korelasi signifikan dengan NIHSS (r = 0,447; p = 0,008) sedangkan hs-CRP memiliki korelasi signifikan yang lebih kuat dengan Barthel <em>Index </em>daripada NIHSS (r = -0,412; p = 0,015). TC dan HDL juga memiliki korelasi signifikan dengan NIHSS.</p><p><strong>Kes</strong><strong>impulan:</strong><strong> </strong>Penelitian ini menunjukkan bahwa profil lipid dan hs-CRP dapat digunakan sebagai prediktor prognosis <em>outcome stroke </em>iskemik akut.</p><p> </p><p>Introduction: Stroke is the leading cause of long-term disability with significant clinical and socioeconomic impact worldwide. Hyperlipidemia and inflammation play major roles in ischemic stroke. While high-sensitivity C-Reactive Protein (hs-CRP) and lipid levels are established risk determinants for vascular disease, the relative strength of these biomarkers for ischemic stroke is uncertain. The purpose of this study is to investigate the association of hs-CRP levels and lipid profile in acute ischemic stroke patients and understand correlation between those markers and short-term outcome.</p><p>Methods: This was a cross-sectional study of 34 first-timer ischemic stroke patients. Lipid profiles and hs-CRP were measured on admission day. The neurological deficit was quantified using National Institutes of Health Stroke Scale (NIHSS) and outcome was quantified using Barthel Index at the 7th day in stroke unit. Serum level of hs-CRP and lipid profile were estimated and correlated with neurological deficit and short-term outcome.</p><p>Results: Ischemic stroke patients had higher levels of hs-CRP, total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL); and lower level of high-density lipoprotein (HDL) than normal criteria. Based on Pearson correlation test, LDL had significant correlation with NIHSS (r=0.447; p=0.008) while hs-CRP had stronger significant correlation with Barthel Index than NIHSS (r=-0.412; p=0.015). TC and HDL also had significant correlation with NIHSS.</p><p>Conclusions: This research suggests that lipid profile and hs-CRP can be used as predictors of prognosis for acute ischemic stroke outcome. Keywords: Barthel index, C-reactive protein, National Institutes of Health Stroke Scale, lipid profile, ischemic stroke.</p>

scholarly journals High sensitivity C-reactive protein level in cerebrovascular accident

2020 ◽  
Vol 7 (4) ◽  
pp. 666 ◽  
Author(s):  
Sonal Rajesh Kumar ◽  
T. A. Vidya
Keyword(s):  
Case Control Study ◽  
High Sensitivity ◽  
Acute Phase Reactant ◽  
Modified Rankin Scale ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Cholesterol Levels ◽  
Significant Difference ◽  
Hs Crp ◽  
Control Study

Background: Stroke is the second leading cause of death worldwide according to WHO. High sensitivity C-Reactive Protein (hs-CRP) is an acute phase reactant which is being studied extensively to delineate its role in development of stroke as well as in prognostication.  This study was done to assess correlation of hs-CRP with risk factors of stroke and its association with types of stroke and prognosis.Methods: A prospective case control study of 100 patients with acute stroke along with 100 controls was conducted with informed consent.  At baseline, hs-CRP levels were measured and Modified Rankin Scale (MRS) was assessed. On day 90 the Modified Rankin Scale was assessed again. Patients were divided into groups based on hs-CRP levels and MRS and the results were analysed.Results: Prevalence of stroke was more in men than women (p=0.0002).  Statistically significant difference was found between mean hs-CRP levels in men (4.722±0.8982 mg/L) and women (4.133±0.9446 mg/L) (p=0.005) and between cases and controls (p=0.0003). There was no significant association with type of stroke (p=0.456).  Mean total cholesterol levels between cases and controls showed statistically significant difference (p=0.0005). High MRS was significantly associated with high hs-CRP levels (p=0.003).  Higher hs-CRP on day 1 correlated with higher MRS on day 90.Conclusions: hs-CRP level is increased in stroke and shows significant association with severity of stroke and prognosis.

scholarly journals Reduction in High-Sensitivity C-Reactive Protein Levels in Patients with Ischemic Stroke by Statin Treatment: Hs-CRP Sub-Study in J-STARS

2017 ◽  
Vol 24 (10) ◽  
pp. 1039-1047 ◽  
Author(s):  
Kazuo Kitagawa ◽  
Naohisa Hosomi ◽  
Yoji Nagai ◽  
Tatsuo Kagimura ◽  
Toshiho Ohtsuki ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
High Sensitivity ◽  
Statin Treatment ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Hs Crp

scholarly journals Association of Clinical Characteristics with the Proportion of the HDL-Cholesterol Subclasses HDL-2b and HDL-3 Among Patients Undergoing Hemodialysis

2020 ◽  
Author(s):  
Jin-Bor Chen ◽  
Wen-Chin Lee ◽  
Sin-Hua Moi ◽  
Cheng-Hong Yang
Keyword(s):  
Clinical Characteristics ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
High Sensitivity ◽  
Healthy Individuals ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Diabetic Status ◽  
The Mean ◽  
Hs Crp

Abstract Background: Altered high-density lipoprotein cholesterol (HDL-C) composition in patients with chronic kidney disease is common. However, reports on the distribution of HDL-C subclasses in patients undergoing hemodialysis (HD) are limited. Objective: We aimed to compare the two main HDL-C subclasses, HDL-2b and HDL-3, in two cohorts of HD patients and healthy individuals and examine their associations with clinical characteristics. Methods: A total of 164 prevalent HD patients and 71 healthy individuals in one hospital-facilitated outpatient clinic were enrolled from May 2019 to July 2019. The HDL-2b and HDL-3 proportions were measured and statistical analysis was performed. Results: The mean ages of HD patients and healthy individuals were 63 and 49.9 years, respectively. HD patients showed lower HDL-2b and HDL-3 proportions compared with those of healthy individuals (23.6% vs. 31.2%, P < 0.001; 31.7% vs. 33.6%, P = 0.137, respectively). The HDL-2b proportion was significantly higher with a high-sensitivity C-reactive protein (hs-CRP) levels of <3 mg/L compared with hs-CRP ≥3mg/L in the HD cohort (P = 0.005). HDL-3 proportion was lower with a hs-CRP level of <3 mg/L compared with hs-CRP ≥3mg/L in the HD cohort (P = 0.022). Sex and diabetes did not influence the HDL-2b and HDL-3 proportions in the HD cohort.Conclusions: HD patients had lower HDL-2b and HDL-3 proportions than those of healthy individuals. The distribution of the HDL-2b and HDL-3 subclasses in HD patients is influenced by proinflammatory status, not by sex and diabetic status.

scholarly journals High-sensitivity C-reactive protein is a good marker of cardiovascular risk in obese children and adolescents.

2008 ◽  
Vol 159 (1) ◽  
pp. R1-R4 ◽  
Author(s):  
Leandro Soriano-Guillén ◽  
Bárbara Hernández-García ◽  
Jimena Pita ◽  
Nieves Domínguez-Garrido ◽  
Genoveva Del Río-Camacho ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Cardiovascular Risk ◽  
Children And Adolescents ◽  
Hdl Cholesterol ◽  
High Sensitivity ◽  
Oral Glucose ◽  
Obese Children ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp

ObjectiveWe intend to assess the utility of the high-sensitivity C-reactive protein (hs-CRP) as a marker of cardiovascular risk in obese children and adolescents.MethodsThe study included children and adolescents between 6 and 18 years of age with a body mass index (BMI) higher than 2 SDS. All the patients had their blood pressure taken and hs-CRP, hepatic function, lipid profile and uric acid were determined after 12 h of fasting. Likewise, an oral glucose tolerance test was performed, determining basal glucose and insulin levels, and after stimulus. We considered the presence of metabolic syndrome when the obese children and teenagers showed at least two of the following conditions: decreased high density lipoprotein (HDL)-cholesterol, hypertriglyceridemia, hypertension or alteration in glucose metabolism.ResultsOut of the 115 obese children studied, 24% showed signs of metabolic syndrome. Those with metabolic syndrome presented higher levels of hs-CRP (mean: 3.8 mg/l; 95% CI: 2.8–4.8) in comparison with the obese patients who did not show signs of metabolic syndrome (mean: 2 mg/l; 95% CI: 1.5–2.5). After a multivariate analysis, the variables that appear to influence the changes in hs-CRP were BMI, triglycerides and HDL-cholesterol levels.ConclusionThe hs-CRP is a useful tool for early diagnosis of cardiovascular risk in obese children and teenagers.

scholarly journals NEUTROPHIL-LYMPHOCYTE RATIO AND HIGH SENSITIVITY C-REACTIVE PROTEIN AS ISCHEMIC STROKE OUTCOME PREDICTOR (Rasio Neutrofil–Limfosit dan High Sensitivity C–Reactive Protein sebagai Peramal Hasilan Strok Iskemik Akut)

2018 ◽  
Vol 23 (3) ◽  
pp. 240 ◽  
Author(s):  
Tissi Liskawini Putri ◽  
Ratna Akbari Ganie ◽  
Aldy S. Rambe
Keyword(s):  
Ischemic Stroke ◽  
Barthel Index ◽  
High Sensitivity ◽  
Stroke Outcome ◽  
Modified Rankin Scale ◽  
C Reactive Protein ◽  
Outcome Predictor ◽  
Neutrophil Lymphocyte Ratio ◽  
Reactive Protein ◽  
Hs Crp

Proses inflamasi merupakan perjalanan penyakit dari strok iskemik akut, yang melibatkan penumpukan mediator inflamasi daninfiltrasi leukosit. Nilai Rasio Neutrofil-Limfosit (RNL) di beberapa penelitian dapat digunakan untuk meramalkan strok akibat iskemikakut yang caranya mudah dilakukan. High sensitivity C Reactive Protein (hs-CRP) merupakan reaktan tahap akut yang kadarnyameningkat di strok iskemik. Oleh karena itu bermanfaat sebagai petanda peramal hal terkait. Penelitian ini bertujuan untuk mengetahuiperbedaan nilai antara RNL dan hs-CRP dalam meramalkan hasilan pasien strok iskemik akut. Metode penelitian analitik observasionaldengan rancangan kohort prospektif. Hasil dinilai dengan modified Rankin Scale (mRS) (1–2=baik; 3–6=buruk) dan Barthel Index (BI)(0–20=ketergantungan jumlah keseluruhan, 21-60=berat; 1–90=sedang; 91–99=ringan dan 100=normal). Dari 43 sampel, didapatkanlaki-laki 24 orang (55,8%) dan perempuan 19 orang (44,2%) dengan rerata usia 57,12 ± 9,8 tahun. hubungan positif didapatkansedang dan bermakna antara RNL dengan hasilan mRS dan BI pasien strok iskemik akut (r=0,585; p=0,001 dan r=0,564; p=0,001).Hubungan positif didapatkan kuat dan bermakna antara hs-CRP dan hasilan mRS (r=0,614; p=0,001) serta didapatkan hubunganpositif dengan kekuatan sangat kuat dan bermakna antara hs-CRP dan hasilan n BI pasien strok iskemik akut (r=0,881; p=0,001).Dengan membandingkan ketepatan kedua data didapatkan RNL 86% dan hs-CRP 88% (p=0,6554). Perbedaan tidak bermakna terdapatantara nilai RNL dan hs-CRP sebagai peramal hasilan pasien strok iskemik akut.

scholarly journals Serum high sensitivity C reactive protein and lipid profile in obese students

2019 ◽  
Vol 8 (1) ◽  
pp. 252
Author(s):  
Sangeeta B. Trimbake ◽  
Shilpa A. Pratinidhi ◽  
Yash K. Majithia
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Adult Population ◽  
High Sensitivity ◽  
Significant Rise ◽  
Overweight And Obesity ◽  
Obese Group ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp

Background: The prevalence of overweight and obesity is progressively increasing in younger and adult population in India. It is a medical problem that increases risk of other diseases and health problems, such as heart disease, diabetes, high blood pressure and certain cancers. One of the causes of dyslipidaemia is obesity. High sensitivity C-Reactive Protein (hs-CRP), is a marker of systemic inflammation and a predictor of type 2 diabetes and cardiovascular disease. Hence it is important to check the relationship of hs-CRP with lipid profiles in obese and non-obese students.Methods: A case control observational study was carried out in 60 students. They were divided in to two groups obese and non-obese based on the BMI ranges. Serum lipid levels, hs-CRP and BMI was estimated in both groups to find out correlation of hs-CRP with lipid profile and BMI.Results: There was a significant rise in serum Total Cholesterol, LDL-C, Triacylglycerol and a significant fall in HDL-C in obese group as compared to non-obese group. Serum hs-CRP and BMI was significantly increased in obese students as compared to non-obese students. There was statistically significant positive correlation found between hs-CRP and total cholesterol, LDL-C, Triacylglycerol in obese students.Conclusions: Significant correlation was found between hs-CRP and lipid profile except HDL-C. Serum hs-CRP levels may decrease by treatment of dyslipidaemia. This would minimize the incidence of atherosclerosis and hence decrease the risk for development of coronary artery disease. Hence, improving the quality of life.

Abstract W P149: High-Sensitivity C-Reactive Protein, but Not Lipoprotein-Associated Phospholipase A2, May Predict the Unfavorable Outcome After Acute Ischemic Stroke

Stroke ◽  
2014 ◽  
Vol 45 (suppl_1) ◽  
Author(s):  
Jae Guk Kim ◽  
Youngchai Ko ◽  
Soo Joo Lee
Keyword(s):  
Ischemic Stroke ◽  
High Sensitivity ◽  
Mean Value ◽  
Unfavorable Outcome ◽  
Stroke Severity ◽  
Large Artery ◽  
C Reactive Protein ◽  
Nihss Score ◽  
Reactive Protein ◽  
Hs Crp

Background and Objectives: Inflammation plays an important role in atherosclerosis and its clinical sequelae. Their relationship to stroke is not settled. We assessed the hypothesis that relative elevations of high-sensitivity C-reactive protein (hs-CRP) and lipoprotein-associated phospholipase A2 (Lp-PLA2) levels at the time of first stroke are associated with stroke severity and prognosis. Methods: First ischemic stroke patients who was admitted within 7days after stroke onset, were prospectively enrolled. High-sensitivity C-reactive protein and Lp-PLA2 level were assayed using the enzyme-linked immunoassay. Vascular risk factors, stroke subtypes, and initial stroke severity were assessed. Stroke severity was evaluated using the National Institutes of Health Stroke Scale (NIHSS) and was categorized as mild (NIHSS score<6), moderate (NIHSS score of 6-13), or severe (NIHSS score≥14). The unfavorable outcome was defined as the modified Rankin Scale of 2-6 at 3month after stroke onset. Results: Two hundred two patients (mean age, 67.5 years; 52.5% male) were included; 104 (51.5%) had unfavorable outcome. Levels of hs-CRP and Lp-PLA2 were weakly correlated (Spearman’s rho=0.174, p=0.01). In univariate analyses, female (p=0.03), patients with large artery atherosclerosis of stroke subtypes (p<0.01), severe NIHSS score (p=0.01), and unfavorable outcome (p<0.01) showed the higher mean value level of hs-CRP level than the others. Patients with hypertension (p=0.03), large artery atherosclerosis (p<0.01), severe NIHSS score (p<0.01), and unfavorable outcome (p=0.01) also had the higher mean value of Lp-PLA2 level than the others. After adjusting for age, sex, vascular risk factors, and initial stroke severity, the high level of hs-CRP was associated with unfavorable outcome (1.71±4.2 vs. 0.26±0.45, odds ratio (OR) 1.82, 95% confidence interval (CI) 1.02-3.27, p=0.04). However, after adjusting for the confounders, Lp-PLA2 was not associated with unfavorable outcome (191.33±77.78 vs. 162.02±61.54, OR 1.00, 95% CI 0.99-1.01, p=0.66). Conclusion: Our findings suggest that the level of hs-CRP and Lp-PLA2 were associated with stroke severity, but only hs-CRP may be useful to predict functional outcome at 3 month after ischemic stroke.

scholarly journals Increased Serum High-Sensitivity C-Reactive Protein in Growth Hormone-Deficient Patients With Non-Functioning Pituitary Tumors

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A645-A646
Author(s):  
Yasufumi Seki ◽  
Atsuhiro Ichihara
Keyword(s):  
Growth Hormone ◽  
Cardiovascular Events ◽  
Alcohol Intake ◽  
Gh Deficiency ◽  
Pituitary Tumors ◽  
Hdl Cholesterol ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp

Abstract Introduction: Growth hormone (GH) deficiency, the most common hormone deficit complicated with pituitary tumors, is associated with higher mortality and cardiovascular events. Inflammation, as measured by high-sensitivity C-reactive protein (hs-CRP), has been reported to be associated with cardiovascular events. However, the association between hs-CRP and GH deficiency is still unknown. We retrospectively evaluated the association between serum hs-CRP levels and GH secretion in patients with non-functioning pituitary tumors (NFPTs). Methods: In this retrospective study, adult patients with non-functioning pituitary adenoma (NFPA) and Rathke’s cyst who received a GH-releasing pepitide-2 (GHRP-2) test from 2013 until 2016 were included. Patients with a history of pituitary surgery or radiation, or estimated GFR lower than 30 mL/min/1.73m2 were excluded. Results: Of 81 patients (70 NFPA and 11 Rathke’s cyst), 44% were diagnosed as severe GH deficiency by GHRP-2 test. Serum hs-CRP level was significantly higher in the male patients (P = 0.001) and the patients with regularly alcohol intake (P = 0.011) and was significantly correlated with BMI (r = 0.35, P = 0.002), creatinine (r = 0.41, P &lt; 0.001), eGFR (r = -0.29, P = 0.009), peak GH response to GHRP-2 (r = -0.48, P &lt; 0.001), AST (r = 0.32, P = 0.004), ALT (r = 0.34, P = 0.002), γGTP (r = 0.41, P &lt; 0.001), HDL-cholesterol (r = -0.33, P = 0.003) and triglyceride (r = 0.25, P = 0.02). Smoking habit (P = 0.084), age (r = 0.18, P = 0.10), LDL-cholesterol (r = 0.16, P = 0.15), IGF-1 (r = -0.14, P = 0.23) and IGF-1 SD score (r = -0.11, P = 0.32) were not significantly correlated with serum hs-CRP level. Peak GH response to GHRP-2 (β = -0.24, P = 0.024) was a significant variable to determine serum hs-CRP level after adjustment for age, sex, BMI, regularly alcohol intake and serum creatinine, γGTP and HDL-cholesterol levels. Conclusion: Increased serum hs-CRP levels in the GH-deficient patients with NFPTs suggested the contribution of GH deficiency to pathogenesis of inflammation associated with cardiovascular diseases.

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