scholarly journals Potensi Ekstrak Rimpang Kencur (Kaempferia galanga L.) Menghambat Pertumbuhan Candida albicans

2016 ◽  
Vol 2 (2) ◽  
pp. 70 ◽  
Author(s):  
Annisa Rahmi ◽  
Erpan Roebiakto ◽  
Leka Lutpiatina
Keyword(s):  
Candida Albicans ◽  
Antifungal Drugs ◽  
Control Group ◽  
Dilution Method ◽  
Control Group Design ◽  
Minimal Inhibitory Concentrations ◽  
Kaempferia Galanga ◽  
Regression Test ◽  
Tube Dilution Method

<p style="text-align: justify;">Candida albicans infection is the cause of candidiasis. Candidiasis treatment can be done with a variety of antifungal drugs, one of them is rhizome of kencur (Kaempferia galanga L.). The Rhizome of kencur is selected as a traditional medicine because it contains chemical compounds such as flavonoids, tannins, saponins and essential oil that serves as an antifungal. This study aimed to determine the minimal inhibitory and minimal killing power and also an influence of kencur rhizome extract on the growth of Candida albicans in vitro. This research was true experimental design with posttest only control group design with tube dilution method. Results of Minimal Inhibitory Concentrations (MICs) research showed there was no clarity at concentration of 20 mg/mL, 30 mg/mL, 40 mg/mL, and it shows clarity at concentration of 50 mg/mL and 60 mg/mL. Results of Minimum Bactericidal Concentrations (MBCs) showed the number of colonies at concentration of 20 mg/mL were 84 colonies, concentration of 30 mg/mL were 48 colonies, concentration of 40 mg/mL were 27 colonies, concentration of mg/mL were 12 colonies and concentration of 60 mg/mL were 0 colony. Based on linear regression test, the result showed significance value of 0.000 <ɑ = 0.05 so it can be concluded that there is a kencur rhizome extract influence on the growth of Candida albicans in vitro with minimal inhibitory concentrations is the concentration of 50 mg/mL and the minimal bactericidal concentrations 60 mg/mL. Further studies are required regarding kencur rhizome extract (Kaempferia galanga L.) in inhibiting and bactericidal microorganisms other than Candida albicans.

scholarly journals Uji Konsentrasi Hambat Minimum (KHM) Ekstrak Daun Mengkudu (Morinda citrifolia L.) terhadap Candida albicans Secara In Vitro

e-GIGI ◽  
2017 ◽  
Vol 5 (2) ◽  
Author(s):  
Lisa Ramschie ◽  
Pieter L. Suling ◽  
Krista V. Siagian
Keyword(s):  
Candida Albicans ◽  
Minimum Inhibitory Concentration ◽  
Leaf Extract ◽  
Inhibitory Concentration ◽  
Morinda Citrifolia ◽  
Control Group ◽  
Dilution Method ◽  
Control Group Design ◽  
Group Design

Abstract: Noni (Morinda cittrifolia L.) leaves contain antraquinon, atsiri oil, saponin, tannin, alkaloid, flavonoid, polifenol, and sterol that have been proved can inhibit the growth of Candida albicans. This study was aimed to establish the minimum inhibitory concentration (MIC) of noni leaf extract against Candida abicans. This was a true experimental study with a randomized pretest-posttest control group design. We used serial dilution method with turbidimetry and spectrophotometry tests. Noni leaves were extracted by using maceration with 96% ethanol. Candida albicans fungi were obtained from Microbiology Laboratory of Faculty of Mathematics and Natural Sciences, Sam Ratulangi University. The turbidimetry test using three repetitions showed that the MIC of noni leaf extract against Candida albicans was 6.25% meanwhile the spectrophotometry test established 12.5% as the MIC of noni leaf extract. Conclusion: Minimum inhibitory concentration of noni (Morinda cittrifolia L.) leaf extract against the growth of Candida albicans was 12.5%.Keywords: noni (Morinda citrifolia L.), Candida albicans, minimum inhibitory concentration (MIC) Abstrak: Daun mengkudu (Morinda citrifolia L.) mengandung antraquinon, minyak atsiri, saponin, tannin, alkaloid, flavonoid, polifenol dan sterol yang terbukti dapat menghambat pertumbuhan Candida albicans. Penelitian ini bertujuan untuk mendapatkan konsentrasi hambat minimum (KHM) dari ekstrak daun mengkudu terhadap Candida albicans. Jenis penelitian ialah eksperimental murni dengan randomized pretest-posttest control group design. Metode yang digunakan dalam penelitian yaitu serial dilusi dengan pengujian turbidimetri dan spektrofotometri. Daun mengkudu diekstraksi dengan metode maserasi menggunakan pelarut etanol 96%. Jamur Candida albicans diambil dari stok jamur Laboratorium Mikrobiologi Program Studi Farmasi Fakultas MIPA Universitas Sam Ratulangi. Hasil penelitian menunjukkan bahwa pengujian turbidimetri dengan tiga kali perlakuan mendapatkan KHM pada konsentrasi 6,25% sedangkan pengujian spektrofotometri mendapatkan KHM pada konsentrasi 12,5%. Simpulan: Konsentrasi hambat minimum (KHM) ekstrak daun mengkudu (Morinda citrifolia L.) terhadap pertumbuhan Candida albicans terdapat pada konsentrasi 12,5%.Kata kunci: mengkudu (Morinda citrifolia L.), Candia albicans, konsentrasi hambat minimum (KHM)

scholarly journals Pengaruh Pemberian Air Rebusan Biji Alpukat (Persea americana Mill) Terhadap Pertumbuhan Jamur Candida albicans Secara In Vitro

2021 ◽  
Vol 5 (2) ◽  
pp. 67-76
Author(s):  
Nayla Nabilla Tahta Avwina Amir ◽  
◽  
Sri Winarsih ◽  
Bambang Rahardjo ◽  
◽  
...  
Keyword(s):  
Candida Albicans ◽  
Persea Americana ◽  
Antifungal Drugs ◽  
Dilution Method ◽  
Natural Material ◽  
Microbiology Laboratory ◽  
Material Sources ◽  
Agar Media ◽  
Boiled Water

The most common cause of patalogis leucorrhoea is infection, one of which is Vulvovaginal Candidiasis (VVC) caused by fungus, while 80% -90% is caused by Candida albicans. Approximately 90% of young women in Indonesia have the potential to experience vaginal discharge because Indonesia is a tropical climate. Alternative treatment for antifungal drugs is needed through the exploration of natural material sources that have the potential as antifungals to deal with this infection safely and easily. The design used in this study was experimental research by in vitro using the dilution method of the tube. Treatment concentrations are 45%; 40%; 35%; 30%; 25%; 20%, 15% and 0% with Candida albicans 104 CFU / ml samples from the microbiology laboratory of the medical faculty Brawijaya University and repeated 3 times. The result showed that at all concentrations, growth was still obtained in agar media so that it could be denied that the boiled water of avocado seeds had no effect on the growth of Candida albicans fungal colonies in vitro because there were still fungal colonies on the plates.

scholarly journals EFEK ANTIBAKTERI SUPERNATAN JUS ANGGUR MERAH YANG DIISOLASI DENGAN KECEPATAN SENTRIFUGASI 12.000 rpm TERHADAP PERTUMBUHAN S. MUTANS

2016 ◽  
Vol 3 (2) ◽  
pp. 81
Author(s):  
Dini Rachmawati ◽  
Sumarno . ◽  
Anggi Wahyu Nur Cahyani
Keyword(s):  
Streptococcus Mutans ◽  
Brain Heart Infusion ◽  
Grape Juice ◽  
Control Group ◽  
Dilution Method ◽  
Control Group Design ◽  
Post Test ◽  
Red Grape Juice ◽  
Red Grape

Background: Streptococcus mutans (S.mutans) is a gram-positive bacteria in oral cavity which produced acid as the common cause of dental caries. In order to prevent the growth or kill Streptococcus mutans, antibacterial is required. Red grape (Vitis vinifera) is suspected to contain antibacterial.Method: An experimental study using the post test only control group design is carried out to Streptococcus mutans with tube dilution method and streaking on the Brain Heart Infusion. A range of concentration from 40%, 50%, 60%, 70%, 80%, 90%, 98%. The control group are group of bacteria and red grape juice control.Result: The analysis of Minimum Inhibitor Bactericidal (MIC) is show a difference absorbent value as the given concentration (Anova, p<0,05). The correlation test show is strong reciprocal association between concentration of res grape juice and absorbent value (r=-0,978; p< 0,05). The analysis of Minimum Bactericidal Concentration (MBC) is shows difference of the number of colonies as given concentration (Anova, p<0,05). The correlation reveals a very strong reciprocal association between concentration of red grape juice and the number of Streptococcus mutans colonies growth (r=-0,925; p< 0,05).Conclusion: The conclusion is supernatant of red grape juice has effect the growth as antibacterial agent on Streptococcus mutans in vitro, with MIC at concentration 60% and MBC at concentration 80%

scholarly journals IN VITRO TESTING OF CLOVE EXTRACTS IN INHIBITING AND KILLING STAPHYLOCOCCUS AUREUS AND ESCHERICHIA COLI

2021 ◽  
Vol 10 (1) ◽  
pp. 16-19
Author(s):  
Nadia Dwi Rahmawati ◽  
Tri Nur Kristina ◽  
Endang Sri Lestari ◽  
Hardian Hardian
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Skin Irritation ◽  
Antibacterial Properties ◽  
Control Group ◽  
Dilution Method ◽  
Control Group Design ◽  
E Coli ◽  
Clove Extract

Background: Diarrhea that could be caused by Staphylococcus aureus and Escherichia coli can be prevented by increasing hand hygiene using alcohol-based hand rub, but frequent use might cause skin irritation. Replacing alcohol with herbs could avoid this side effect. Cloves have been proved to have antibacterial properties. However, most researches used complex extraction methods that might not be applicable on a household scale.Objective: To prove that clove extracts have ability to inhibit and to kill S. aureus and E. coli.Methods: This is an experimental study by using post-test only control group design. Clove extract was obtained with simple aqueous maceration. Samples were Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922 allocated into six groups: clove extracts at concentrations of 12.5%, 25%, 50%, 100% respectively; 70% alcohol as a positive control; and aquadest as a negative control. Each group was given 5 repetitions of intervention. MIC was measured with dilution method, while MBC with streak method. Negative controls were only used to monitor the quality of this work.Results: MIC of S. aureus was started at 50% concentration of clove extract, while MBC of S. aureus was started at 25 % concentration of the same extract. MIC and MBC of E. coli was both started at 25% concentration of clove extract. MIC and MBC of 100% concentration of clove extract were equal with 70% alcohol.Conclusion: Concentration of 100% clove extracts have similar ability with 70% alcohol to inhibit and to kill S. aureus and E. coli. Keywords: Clove Extracts, Escherichia coli, MBC, MIC, Staphylococcus aureus

Uji Aktivitas Antijamur Ekstrak Gambir (UncariagambirRoxb) terhadap Candida albicans secara in Vitro

2015 ◽  
Vol 5 (2) ◽  
pp. 62
Author(s):  
Suraini Suraini ◽  
Chairani Chairani ◽  
Enlita Enlita
Keyword(s):  
Candida Albicans ◽  
Water Extract ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Dilution Method ◽  
Antifungal Effect ◽  
Ofcandida Albicans ◽  
Close Relationship ◽  
Tube Dilution Method

Effective treatment is being sought for the discovery of antifungal compounds.One of Plants that are suspected as a potential antifungal is Gambir (Uncaria gambierRoxb.). Gambir contains high antioxidants. Gambier containing catechin, katekutannat, quercetin, gallic acid, and catechol elagat acid, has been studied to determine its antifungal activity. This study was done by using experimental in vitro tube dilution method. The general objective of this study was to investigate the inhibition of ethanolic extract and water extract of gambier towards the growth of Candida albicans. Specific objectives were to determine Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC)of ethanolic extract and water extract of gambier towards the growth of Candida albicans. The concentration used were 50% , 60% , 70% , 80% , 90% and 100% . The results showed thatMICof the ethanolic extract of gambier could not be determined, while the MBCwas 100%. One Way ANOVA statistical analysis results showed p= 0.004 ( p< 0.05 ), indicating significant differences in changes of the concentration of ethanol extract gambier to the number of colonies ofCandida albicans. Correlation test showed a close relationship between the concentration of gambier extract and the number of colonies ( r = -9.900 : p < 0.05 ). Regression test yielda linear regression equation Y = 5,034-0,048x with R Square coefficient ( r2 ) of 0.802. Based on the research results it can be concluded that the ethanolic extract of gambier has antifungal effect against Candida albicans.

scholarly journals PERBEDAAN JUMLAH KOLONI STAPHYLOCOCCUS AUREUS PADA BEBERAPA KONSENTRASI PERASAN BUAH BELIMBING WULUH SECARA IN VITRO

2017 ◽  
Vol 5 (1) ◽  
Author(s):  
Igede Sudarmanto
Keyword(s):  
Staphylococcus Aureus ◽  
Control Group ◽  
Dilution Method ◽  
Control Group Design ◽  
The Public ◽  
Group Design ◽  
Gram Positive Bacteria ◽  
Post Test ◽  
Colony Counter

Abstract : Plants bilimbi (Averrhoa bilimbi Linn) has been utilized by the public as a traditional medicinal plants to cure various diseases. The content of natural chemicals from bilimbi fruits are known to have an antibacterial effect, namely, flavonoids and phenols. Methicillin Resistant Staphylococcus aureus (MRSA) is a gram-positive bacteria resistant to antibiotics semisintesis. This research aims to identify the differences in the number of colonies of Staphylococcus aureus bacteria at some concentrations of bilimbi fruit filtrate in vitro. The design of the research is a post test only control group design. Measurement of the activity of bacteria using a colony counter with dilution method. The average number of colonies of Staphylococcus aureus bacteria that grow at a concentration of bilimbi fruit filtrate 10% as much as 59.33 x 108 CFU / ml; at a concentration of 20% as much as 1.33 x 108 CFU / ml; at a concentration of 30%, 40% and 50% contained no bacterial colonies growing. At a concentration of 10 % is able to inhibit the growth of Staphylococcus aureus bacteria, while at a concentration of 30 % has been able to kill the bacteria Staphylococcus aureus. There is a difference in the number of bacterial colonies of Staphylococcus aureus in some bilimbi fruit filtrate concentration (Averrhoa bilimbi Linn) in vitro (p = 0.000

scholarly journals In vitro identification and Antifungal susceptibility of different Candida Species isolated from patients with or without Diabetes having Chronic Periodontitis

2015 ◽  
Vol 4 (1) ◽  
pp. 20-25
Author(s):  
Deepti Chaurasia ◽  
Mukesh Gupta ◽  
Reena Kulshrestha ◽  
Jayant Biswas ◽  
Smita D Dutta ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Oral Candidiasis ◽  
Antifungal Susceptibility ◽  
Antifungal Drugs ◽  
Herbal Extract ◽  
Control Group ◽  
Herbal Extracts ◽  
Oral Rinse ◽  
Candidal Species

Background: Candida albicans is the commonly associated species with oral lesions, but other Candida spp., such as C. glabrata, C. tropicalis, C. parapsilosis, C. krusei, and C. dubliniensis have also been isolated from the human saliva, even irrespective to the oral candidiasis. Candidal colonization has also been documented from subgingival plaque of adults with periodontitis.Objective: Nowadays there is a great demand of natural herbal medicines. For a Diabetic person having Periodontitis, the use antifungal drugs are must. Therefore the antifungal capacity of the commonly used drug and herbs has been evaluated.Methods: For the study, the patients were screened and categorised into two study and one control group, having 20 patients in each group, on the basis of their respective Blood Glucose level and Dental status using standard clinical parameters. Oral rinse of 60 patients including both gender were selected from the Out Patient Department of Periodontitis, Rungta College of Dental Sciences and Research, Chhattisgarh. Chrome Candida Agar Media was used to identify Candida albicans and NAC. In vitro tests of the effectiveness of selected antimycotic agents against test candidal isolates recovered from the patient were performed to check the efficacy of the antifungal agents by the Kirby-Bauer Disc Diffusion method.Result: We found that by the use of this chromogenic media most of the commonly recovered NAC can be easily distinguished as each species produced the widest range of colours and morphologies. The herbal extracts Aloe Vera and Garlic failed to inhibit the growth of the candidal species but Neem, Meetha Neem, Triphala, Tulsi showed sensitivity to varying degree. Now a day there are much popularity of using herbal products, having its extracts incorporated in the cosmetics and other products used by humans.Conclusion: We conducted the sensitivity check of the candidal isolates against the dental dentrifices and found that however all the toothpastes contained herbal extracts capable of destroying bacteria but it did not showed good results against candidal species except the Patanjali Toothpaste. This may be due the fact that Patanjali Dant Kanti Dental Cream has the combination of all the herbal extract mixed altogether. DOI: http://dx.doi.org/10.3126/ijosh.v4i1.12164

scholarly journals ANTIFUNGAL ACTIVITIES OF MAULI BANANA STEM AND BASIL LEAVES EXTRACT MIXTURE AGAINST Candida albicans

2020 ◽  
Vol 5 (2) ◽  
pp. 121
Author(s):  
Nor Kamalia ◽  
Maharani Laillyza Apriasari ◽  
Yusrinie Wasiaturrahmah
Keyword(s):  
Candida Albicans ◽  
Minimum Inhibitory Concentration ◽  
Inhibitory Concentration ◽  
Minimum Bactericidal Concentration ◽  
Control Group ◽  
Dilution Method ◽  
Control Group Design ◽  
Antifungal Activities ◽  
Stem Extract ◽  
Banana Stem

ABSTRACTBackground: Mauli banana stem and basil leaves are natural ingredients that have the potential to be used as a treatment for Candida albicans infections. The methanol extract of mauli banana stem with 25% concentration is merely fungistatic which is still not capable to induce fungicidal effect, while the 100% concentration is known to be less effective than 0.2% chlorhexidine gluconate. Adding basil leaves extract to mauli banana stem extract is expected to increase antifungal activities against Candida albicans. Purpose: to analyze the antifungal activity of mauli banana stem and basil leaves extract mixture with concentrations of 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90% and 100% against Candida albicans by dilution method. Method: This research used a true experimental method with a pretest–posttest control group design consisting of 11 treatments to obtain Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC). Result: The 10% concentration was identified as the Minimum Inhibitory Concentration (MIC), and no concentration could be classified as the Minimum Bactericidal Concentration (MBC) because all treatment group still exhibited Candida albicans growth on the SDA medium. Conclusion: Mauli banana stem and basil leaves extract mixture has an MIC value of 10% and does not demonstrate any value for the MBC. Keywords: Basil leaf, Candida albicans, Mauli banana stem, MBC, MIC

scholarly journals UJI DAYA HAMBAT SENYAWA SAPONIN BATANG PISANG (Musa paradisiaca) TERHADAP PERTUMBUHAN Candida albicans

e-GIGI ◽  
2015 ◽  
Vol 3 (2) ◽  
Author(s):  
Siti R. I. Yuliana ◽  
Michael A. Leman ◽  
P. S. Anindita
Keyword(s):  
Candida Albicans ◽  
Experimental Design ◽  
Oral Candidiasis ◽  
Antifungal Drugs ◽  
Control Group ◽  
Upper Respiratory Tract ◽  
Banana Plant ◽  
Control Group Design ◽  
Musa Paradisiaca ◽  
Banana Stem

Abstract: Candida albicans living as saprophyte can be found on the skin, genital tract, upper respiratory tract, and gastrointestinal tract including the oral cavity. The transmutation of Candida albicans from saprofit becoming pathogenic causes thrush or candidiasis. The treatment of oral candidiasis is antifungal drugs, however, long-term used of the drugs can make Candida albicans being resistant. Therefore, an alternative medicine with lower side effects is needed. One of the natural ingridients that can be used is the banana plant (Musa paradisiaca). inter alia Amboina banana (Musa paradisiaca var. sapientum. This study aimed to determine the inhibition of Amboina banana stem on the growth of Candida albicans. This was an experimental laboratory study with a true experimental design and posttest only control group design with Kirby-bauer difusion method using filter paper. The parameter observed was fungal (Candida albicans) growth inhibition zona on pottatoe dextrose agar medium supplemented with saponin of Amboina banana stem. The growth proportion was analyzed by microsoft excell. The results showed that the average diameter of the inhibition zona of saponin was 12.5 mm; ketokonazol 15.3 mm; meanwhile aquades did not have the inhibition zona. Conclusion: Saponin in Amboina banana stem has an antifungal effect on the growth of Candida albicans.Keywords: candida albicans, saponin, amboina banana stemAbstrak: Candida albicans yang hidup sebagai saprofit dapat ditemukan pada kulit, saluran genital, saluran napas bagian atas, dan saluran pencernaan termasuk rongga mulut. Perubahan Candida albicans dari saprofit menjadi patogen menyebabkan penyakit yang disebut kandidiasis atau kandidosis. Selain itu pada pemakai gigi tiruan, Candida albicans dapat menyebabkan denture stomatitis. Perawatan untuk infeksi ini dapat dilakukan dengan memberikan obat antijamur. Namun, pemberian obat antijamur dalam jangka waktu lama dapat menyebabkan resistensi. Hal ini memicu adanya kebutuhan untuk mencari pengobatan baru dengan aktivitas antifungi yang lebih baik, toksisitas yang lebih rendah, dan tidak resisten terhadap Candida albicans. Salah satu tanaman yang berpotensi sebagai tanaman obat yaitu tanaman pisang antara lain pisang Ambon (Musa paradisiaca var. sapientum). Penelitian ini bertujuan untuk mengetahui daya hambat senyawa saponin batang pisang Ambon terhadap pertumbuhan Candida albicans. Penelitian ini merupakan penelitian eksperimental laboratorik menggunakan rancangan eksperimental murni (true experimental design) dengan rancangan penelitian post test only control design dengan metode difusi lempeng agar Kirby-bauer menggunakan kertas saring. Parameter yang diamati ialah luas diameter zona hambat pertumbuhan jamur Candida albicans pada media agar yang telah diberi senyawa saponin batang pisang Ambon. Data dianalisis dengan menggunakan microsoft excell. Hasil penelitian menunjukkan total rerata luas diameter zona hambat senyawa saponin yang terbentuk sebesar 12,5 mm; ketokonazol 15,3 mm; sednagkan aquades tidak terdapat zona hambat. Simpulan: Senyawa saponin batang pisang Ambon dapat menghambat pertumbuhan Candida albicans.Kata kunci: candida albicans, senyawa saponin, batang pisang ambon

scholarly journals Perbandingan antara Pemberian Fraksi Daun Beluntas (Pluchea Indica Lees) dan Ketokonazol Secara Invitro Terhadap Candida Albicans

2019 ◽  
Vol 5 (1) ◽  
pp. 20-29
Author(s):  
Bina Marsasi ◽  
Yuwono Yuwono ◽  
Salni Salni
Keyword(s):  
Candida Albicans ◽  
Control Group ◽  
Control Group Design ◽  
Group Design

Daun beluntas bermanfaat sebagai pengobatan flour albus dan discharge yang disebabkan oleh jamur. Penelitian ini bertujuan untuk menemukan aktivitas anti-jamur fraksi pada ekstrak daun beluntas (Pluchea indica Lees) terhadap Candida albicans. Penelitian ini adalah penelitian eksperimental in vitro menggunakan desain studi Posttest-only Control Group Design. Ekstrak metanol diperoleh melalui proses maserasi sedangkan fraksinya melalui fraksinasi cair-cair. Fraksi paling aktif ditentukan oleh uji aktivitas anti jamur. Fraksi paling aktif dengan konsentrasi 10%, 5%, 2,5%, 1,25%, 0,625% dan diameter zona hambat 0,3125% diukur dengan metode pengenceran cairan padat. Kesetaraan dengan obat dinilai melalui analisis regresi, kemudian golongan senyawa aktif ditentukan melalui uji bioautografi menggunakan kromatografi lapis tipis. Hasil penelitian diperoleh metanol-fraksi-air dapat menghambat pertumbuhan Candida albicans sedangkan ekstrak metanol, n-heksana dan etil asetat tidak menghambat. Fraksi metanol air yang memiliki diameter zona hambat mulai pada konsentrasi 0,3125% dengan diameter rata-rata 7,34 mm dan pada konsentrasi 10% diperoleh diameter terbesar sebesar 17,10 mm. Melalui cairan pengencer dan fraksi padat KHM dari fraksi metanol-air dihambat pada konsentrasi 0,3125%. Uji kesetaraan menunjukkan bahwa 1 mg / ml ketokonazol setara dengan 39.561 mg / ml fraksi metanol-air daun beluntas. Senyawa yang menghambat jamur diduga adalah golongan aktif senyawa flavonoid dan alkaloid. Fraksi metanol-air daun beluntas (Pluchea indica Lees) memiliki aktivitas antijamur terhadap Candida albicans secara in vitro.

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