scholarly journals Depression Mediates the Association Between Occupational Complexity and Late-Life Cognition in Hispanics

2021 ◽  
pp. 1-6
Author(s):  
Camilo Posada Rodríguez ◽  
Sofía Rodríguez-Araña ◽  
Diana C. Oviedo ◽  
María B. Carreira ◽  
Julio Flores-Cuadra ◽  
...  
Keyword(s):  
Older Adults ◽  
Risk Factor ◽  
Functional Outcomes ◽  
Late Life ◽  
Cognitive Assessments ◽  
Factors Affecting ◽  
Mediation Analyses ◽  
Occupational Complexity ◽  
The Relationship ◽  
Daily Function

There is a dearth of research in Latin America regarding risk and protective factors affecting older adults’ cognition. This study aimed to investigate the factors mediating the association between occupational complexity and late-life cognition and daily function in a sample of Hispanic older adults. Participants (n = 588) aged 65 years and older underwent clinical, functional, and cognitive assessments. Mediation analyses revealed that depressive symptoms mediated the relationship between occupational complexity and cognitive as well as functional outcomes. Results provide evidence that depression may act as a risk factor for worse outcomes, even if older adults had a cognitively demanding occupation.

scholarly journals Cognitive Functioning and Late-Life Depression

2014 ◽  
Vol 20 (5) ◽  
pp. 461-467 ◽  
Author(s):  
Aaron M. Koenig ◽  
Rishi K. Bhalla ◽  
Meryl A. Butters
Keyword(s):  
Older Adults ◽  
Depressive Symptoms ◽  
Cognitive Functioning ◽  
Neuropsychological Assessment ◽  
Cognitive Deficits ◽  
Late Life ◽  
Cognitive Outcomes ◽  
Review Of The Literature ◽  
Late Life Depression ◽  
The Relationship

AbstractThis brief report provides an introduction to the topic of cognitive functioning in late-life depression (LLD). In addition to providing a review of the literature, we present a framework for understanding the heterogeneity of cognitive outcomes in this highly prevalent disorder. In addition, we discuss the relationship between LLD and dementia, and highlight the importance of regularly assessing cognitive functioning in older adults who present with depressive symptoms. If cognitive deficits are discovered during a neuropsychological assessment, we recommend referral to a geriatric psychiatrist or cognitive neurologist, for evaluation and treatment of the patient’s symptoms. (JINS, 2014, 20, 1–7)

scholarly journals BROODING MODERATES THE RELATIONSHIP BETWEEN CEREBROVASCULAR BURDEN AND VASCULAR DEPRESSION

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S877-S878
Author(s):  
Manuel Herrera Legon ◽  
Daniel Paulson
Keyword(s):  
Older Adults ◽  
Depressive Symptomatology ◽  
Depression Scale ◽  
Late Life ◽  
Community Dwelling ◽  
Self Report ◽  
Future Research ◽  
Late Life Depression ◽  
Vascular Depression ◽  
The Relationship

Abstract Objective: The vascular depression hypothesis posits that cerebrovascular burden confers risk for late-life depression. Though neuroanatomical correlates of vascular depression (prefrontal white matter hyperintensities) are well established, little is known about cognitive correlates; the identification of which may suggest therapeutic targets. Aims of this study are to examine the hypothesis that the relationship between cerebrovascular burden and depressive symptoms is moderated by brooding, a type of rumination. Method: A sample of 52 community-dwelling, stroke-free, individuals over the age of 70, without history of severe mental illness or dementia completed the Ruminative Responses Scale, and provided self-report (cardiac disease, hypertension, diabetes, high cholesterol) CVB data. The Geriatric Depression Scale was used to assess depressive symptomatology. Results: Results of a bootstrapped model were that self-reported measures of CVB predicted depressive symptomatology. This relationship was significantly moderated by brooding. Among older adults, those who self-reported high CVB and medium to elevated levels of rumination experienced disproportionately more depressive symptomatology. Conclusions: These findings suggest that brooding rumination may be one correlate of the vascular depression syndrome. Future research should examine neuroanatomical correlates of rumination among older adults, and further explore brooding as a therapeutic target for those with late-life depression.

ASBMT Risk Group and CD 34+ Dose Predicted for the Development of aGVHD in Allogeneic MRD Transplants When the Donors Who Received a Combined Mobilization and In Vivo TCD Regimen Using rhg-CFS and Dexamethasone.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 5006-5006
Author(s):  
Khaleel K. Ashraf ◽  
Arabella B. Tilden ◽  
Yufeng Li ◽  
Sameer Gupta ◽  
Lawrence S. Lamb ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Risk Factor ◽  
Median Survival ◽  
Chronic Gvhd ◽  
Multivariable Analysis ◽  
Multivariable Logistic Regression Analysis ◽  
Factors Affecting ◽  
Cd 34 ◽  
The Relationship

Abstract We looked at factors affecting the development of acute and chronic GVHD in a cohort of 118 patients who underwent allogeneic matched sibling transplantation between 09/1998 to 05/2006 at the UAB BMT program. Donors were mobilized with rhg-CSF (10–16mcg/kg/day x4) and received dexamethasone 10mg/m2/day x3 days to effect in vivo T cell depletion (TCD). Total CD3 and CD34 cell dose were divided in to 4 quartiles (See table below). We then analyzed the influence of CD3+ and CD34+ dose quartiles on aGVHD, cGVHD, engraftment, TRM and relapse. (see table) Acute GVHD: Univariate Logistic regression indicated that the development of aGVHD is negatively associated with quartiles (q25–q50) interval of CD3 dose (p=0.0418). However this relationship was not independent of risk factor and CD34 dose. After using Multivariable Logistic regression analysis with adjustments for age, race and sex, we found that ASBMT risk factor and CD34 quartiles dose are strong predictors of aGVHD: patients who had high risk are about three times more likely to have aGVHD (OR=2.829, 95% CI 1.142–7.020, p=0.0250). The higher the CD34 dose also predisposed to higher incidence of aGVHD (p=0.0432). Median Survival: Patients who received the CD3 (P=0.00141) and CD34 (P=0.0270) in the q25–q50 quartile did better with improved median survival. Relapse and CD 3 quartiles: Using the - 2 log (LR) test shows the relapse free interval was longer if the CD3 dose is between q25 and q50 (p=0.0058); there was no relation between CD34 and relapse. TRM: Not associated with CD3 or CD 34 dose. WBC engraftment: Multivariable analysis indicated that the relationship is mainly an age effect. After adjusted for risk factor, GVHD status, CD3 or CD34 dose, the engraftment day is still significantly related to age at BMT (p=0.0252). No associations are observed for the relationship between engraftment day and GVHD risk. cGVHD: Neither CD34 dose (p=0.5339) nor CD3 (p=0.4209) dose were statistically associated with incidence and severity of cGVHD. To summarize, higher CD34 dose and higher risk ASBMT category predicted for higher incidence of aGVHD; neither CD3 nor CD 34 dose predicted for the development of cGVHD. Age was the single most important predictor of WBC engraftment. CD3+ and CD34 Quartiles Quartile <25 25–50 50–75 >75 CD3 X10E8 <2.5 2.53–3.60 3.60–5.30 >5.30 CD34 X10E6 <4.92 4.92–7.79 7.79–11.2 >11.2

scholarly journals Emotional intelligence and depressive symptoms in Spanish institutionalized elders: does emotional self-efficacy act as a mediator?

PeerJ ◽  
2016 ◽  
Vol 4 ◽  
pp. e2246 ◽  
Author(s):  
Octavio Luque-Reca ◽  
José María Augusto-Landa ◽  
Manuel Pulido-Martos
Keyword(s):  
Older Adults ◽  
Emotional Intelligence ◽  
Depressive Symptoms ◽  
Self Efficacy ◽  
Depressive Symptomatology ◽  
Positive Association ◽  
Multiple Mediation ◽  
Mediation Analyses ◽  
Emotional Ability ◽  
The Relationship

Background.This work examines the relationship between emotional intelligence (EI) and depressive symptomatology in institutionalized older adults, delving into the mechanisms underlying this relationship. Considering that previous evidence of the variation of the EI-depression relationship depending on whether the emotional ability or the perception of that ability is evaluated, a model of multiple mediation was tested in which the dimensions of emotional self-efficacy (ESE) act as mediators in the relationship between ability EI and depressive symptomatology.Methods.The sample consisted of 115 institutionalized older adults (47.82% women; 80.3 ± 7.9 years of age) from the province of Jaén (Spain) who completed a test of ESE, a measure of ability EI, and a self-administered questionnaire of depressive symptoms.Results.The results showed a positive association between older adults’ emotional performance and depressive symptomatology, finding stronger associations with ESE than with EI abilities. In addition, multiple mediation analyses showed that two of the four dimensions of ESE fully mediated the relationship between ability EI and depressive symptoms.Discussion.These findings suggest that older adults’ high levels of emotional competence generate a feeling of ESE which can protect them against depressive symptoms. This work supports the predictive validity of emotional abilities and ESE for the mental health of a group that is particularly vulnerable to depression, institutionalized older adults. The limitations of the work are discussed, and future lines of research were considered.

scholarly journals Association between late-life hypercholesterolemia and progression of dementia severity among older adults

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 876-876
Author(s):  
Mo-kyung Sin ◽  
Yan Cheng ◽  
Ali Ahmed ◽  
Edward Zamrini
Keyword(s):  
Older Adults ◽  
Cox Regression ◽  
Late Life ◽  
Clinical Dementia Rating ◽  
Future Studies ◽  
Dementia Severity ◽  
Kaplan Meier ◽  
Point Increase ◽  
Race Ethnicity ◽  
The Relationship

Abstract Progression of dementia severity varies widely by individuals and multiple factors might influence the progression. The aim of this study was to examine the relationship between late-life hypercholesterolemia and progression of dementia severity in older adults. We used prospectively collected longitudinal data from 2,686 adults aged ≥65 years in the National Alzheimer’s Coordinating Center. Progression of dementia severity was measured using both Clinical Dementia Rating (CDR) - Sum of Boxes (SOB) and Global scores. Kaplan Meier curves were plotted to estimate the association between hypercholesterolemia and progression of dementia severity. We also conducted multivariate Cox regression models to estimate the association of hypercholesterolemia with the outcomes adjusting for age, gender, race, ethnicity, marital status, living status, education, smoking, heart failure, atrial fibrillation, blood pressure, and diabetes. Hypercholesterolemia had significant association with CDR-SOB ≥ 1 point increase (unadjusted HR, 1.23; 95% CI, 1.13-1.35; p&lt;0.001; adjusted HR, 1.17; 95% CI, 1.07-1.28; p&lt;0.001). In addition, hypercholesterolemia had significant association with CDR-Global ≥ 0.5 point increase (unadjusted HR, 1.14; 95% CI, 1.04-1.25; p&lt;0.001; adjusted HR, 1.11; 95% CI, 1.01-1.22 p=0.036). If these findings can be replicated in future studies, future studies need to examine if proper management of cholesterol may reduce the risk of Alzheimer’s dementia in late-life older adults.

scholarly journals Association Between Late-Life Hypertension and Resilience to Alzheimer Dementia Among Older Adults

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 304-305
Author(s):  
Mo-kyung Sin ◽  
Yan Cheng
Keyword(s):  
Older Adults ◽  
Late Life ◽  
Braak Stage ◽  
Clinical Dementia Rating ◽  
Chi Square ◽  
Alzheimer Dementia ◽  
Student’S T ◽  
The Relationship ◽  
Untreated Hypertension

Abstract While midlife hypertension is known as one contributing factor for cognitive impairment and Alzheimer dementia in late-life older adults, less is known about the role of late-life hypertension in resilience to Alzheimer dementia. We examined the relationship between late-life hypertension and Alzheimer dementia resilience among older adults using the National Alzheimer’s Coordinating Center data from 2005-2020 (n=3,170). Hypertension, captured within 5 years prior to death, was defined as blood pressure (BP) ≥ 140/90 mmHg in at least two visits and/or ever treated with anti-hypertensive agents. Resilience was defined as positive Alzheimer disease (AD) pathology (CERAD score moderate or severe and BRAAK stage V or VI) from autopsy and Clinical Dementia Rating (CDR) - Sum of Boxes (SOB): 0.5-2.5 or CDR global (0-0.5) from last data point before autopsy. Student’s t-tests and Chi-square tests were conducted to compare patients with and without resilience. A multivariate logistic regression was conducted to estimate the association between late-life hypertension and resilience, adjusting for covariates of demographics and neuropathological characteristics. We had 55 resilient cases among 1,195 positive AD pathology cases. Those resilient were older (88±6.7) and had higher systolic BP (136 ± 18.2 mmHg) than non-resilient (82±7.9 years old, 130±20 mmHg. Untreated hypertension had a protective effect on resilience (adjusted OR: 3.69 (1.10-13.5, p=0.05). Patients with a systolic BP in the range of 135-145 mmHg and a diastolic BP in the range of 65-75 mmHg had the highest resilience possibility. Unlike midlife hypertension, late-life hypertension may have different effect on dementia, prompting further studies.

scholarly journals Does negative-self-schema link the relationship between childhood trauma and psychotic symptoms in a community sample of Indonesians?

Konselor ◽  
2019 ◽  
Vol 8 (3) ◽  
Author(s):  
Shierlen Octavia ◽  
Edo Sebastian Jaya ◽  
Sali Rahadi Asih
Keyword(s):  
Risk Factor ◽  
Childhood Trauma ◽  
Online Survey ◽  
Community Sample ◽  
Underlying Mechanism ◽  
Psychotic Symptoms ◽  
Psychological Response ◽  
Mediation Analyses ◽  
Self Schema ◽  
The Relationship

Childhood trauma is a risk factor that influences the development of psychotic symptoms. Negative-self-schema is a psychological response to trauma, which is known to have impact on psychotic symptoms’ level, thus postulated as the underlying mechanism linking childhood trauma and psychotic symptoms together. This study examined whether negative-self-schema mediates childhood trauma and psychotic symptoms, while controlling depressive symptoms as covariates. The study recruited 397 participants from community sample of Indonesians (25.4% male; Mage = 22.28, SD = 4.93) and was conducted through online survey. Through mediation analyses, results showed that negative-self-schema significantly mediated the relationship between childhood trauma and both positive (ab= 0.08; SE= 0.04; 95% CI [0.01, 0.17]), and negative (ab = 0.08; SE = 0.03; 95% CI [0.03, 0.14]) symptoms of psychosis. This explains the importance of considering schemas’ role in translating the effect of childhood trauma to psychotic symptoms. 

scholarly journals The Relationship Between Storey of Buildings and Fall Risk

2021 ◽  
Vol 9 ◽  
Author(s):  
Ching-Yao Tsai ◽  
En-Sheng Lin ◽  
Yang-Tzu Li ◽  
Tao-Hsin Tung ◽  
Wei-Cheng Chen
Keyword(s):  
Older Adults ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Risk Factor ◽  
Fall Risk ◽  
Fear Of Falling ◽  
Longitudinal Survey ◽  
Clinical Factors ◽  
The Relationship ◽  
Unadjusted Analysis

Purpose: This study examined the association between storey of building and fall risk in older adults' residences and residents' level of fear of falling.Methods: The National Health and Ageing Trends Study (NHATS) collected information that would provide an understanding of basic trends people aged 65 years and older. Using a longitudinal survey, the present study employed the first round of NHATS data that was collected in 2011. In the first round, 12,411 participants were enrolled, and 8,077 interviews were completed. The study sample sizes for falling and worry about falling are 6,153 and 6,142, respectively.Results: Unadjusted analysis revealed that storey of building was a risk factor for fall and worry about falling. There was a higher prevalence for fall and worry about falling when subjects lived in single storey of building compared with the subjects live in multi-storey. Logistic regression analysis showed no highly significant between storey of building and the fall/fear of falling.Conclusion: Several clinical factors independently were indicated pertaining to the fall and worry about falling in older adult's residences.

scholarly journals A Study on the Relationship Between Physical Activity, Sedentary Behavior, and Sleep Duration in Preschool Children

2021 ◽  
Vol 9 ◽  
Author(s):  
Zhenya Chang ◽  
Wei Lei
Keyword(s):  
Physical Activity ◽  
Risk Factor ◽  
Preschool Children ◽  
Sedentary Behavior ◽  
Sleep Duration ◽  
Video Game ◽  
Protective Factor ◽  
Vigorous Physical Activity ◽  
Factors Affecting ◽  
The Relationship

Purpose: Explore the role of physical activity (PA) and sedentary behavior (SB) in the sleep of preschool children.Method: Preschool children (n = 458) from kindergarten were recruited, measures included accelerometer-derived 24 h activity [SB, light physical activity (LPA), moderate-to-vigorous physical activity (MVPA), daytime sleep duration (DSP), and nocturnal sleep duration (NSP)]. A self-made questionnaire was used to supplementary survey on different types of SB. The two-layer chi-square test and the Cochran–Mantel–Haenszel test were used and significance set at p &lt; 0.05.Results: PA is mainly a protective factor for DSP, while SB is mainly a risk factor for NSP of preschool children; Screen-type SB including screen viewing SB and video game SB is a risk factor for NSP, while quiet learning SB have no significant correlation with sleep duration in preschool children; Gender and social economic status are important factors affecting the association of PA, SB, and sleep duration in preschool children.Conclusions: The relationship between sleep duration at different periods and PA and SB of preschool children is different. Future educators need to gradually realize the different factors affecting the sleep of preschool children at different stages, clarify the protective factors and risk factors, in order to improve the sleep duration of preschool children.

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