scholarly journals GELMA BASED 3D BIOPRINTING IN REGENERATIVE MEDICINE

2021 ◽  
Vol 10 (3) ◽  
Author(s):  
Subhajit Hazra ◽  
Dhakshanya Predheepan ◽  
Jeba Samuel C S ◽  
GovindanT. V ◽  
Ripudaman Singh
Keyword(s):  
Stem Cells ◽  
3D Printing ◽  
Regenerative Medicine ◽  
Organ Transplantation ◽  
Human Cells ◽  
3D Bioprinting ◽  
The Past ◽  
Significant Interest ◽  
Living Tissues

Over the past few years, research and progress in 3D printing have become evident. The process of bioprinting involves the use of a bioink composed of human cells or tissue. For example, 3D printing in organ transplantation aims to develop an organ that can synchronize with other physiologic components. In the past ten years, bioprinting has made a substantial leap. It has been used in the fabrication of living tissues for its application in various areas. Moreover, this technology has also been commercialized, resulting in its significant interest from the research fraternity. Thus, this review provides a brief on the development of the field from its foundation to the current commercialization with respect to the polymer Gelatin Methacrylate. Keywords: 3D Bioprinting, Stem cells, GelMA, Regenerative Medicine

scholarly journals Stem Cell-Derived Exosomes: A Potential Alternative Therapeutic Agent in Orthopaedics

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
John Burke ◽  
Ravindra Kolhe ◽  
Monte Hunter ◽  
Carlos Isales ◽  
Mark Hamrick ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Stem Cells ◽  
Stem Cell ◽  
Regenerative Medicine ◽  
Therapeutic Agent ◽  
Bone Fractures ◽  
Efficient Manner ◽  
Great Ability ◽  
The Past ◽  
Potential Alternative

Within the field of regenerative medicine, many have sought to use stem cells as a promising way to heal human tissue; however, in the past few years, exosomes (packaged vesicles released from cells) have shown more exciting promise. Specifically, stem cell-derived exosomes have demonstrated great ability to provide therapeutical benefits. Exosomal products can include miRNA, other genetic products, proteins, and various factors. They are released from cells in a paracrine fashion in order to combat local cellular stress. Because of this, there are vast benefits that medicine can obtain from stem cell-derived exosomes. If exosomes could be extracted from stem cells in an efficient manner and packaged with particular regenerative products, then diseases such as rheumatoid arthritis, osteoarthritis, bone fractures, and other maladies could be treated with cell-free regenerative medicine via exosomes. Many advances must be made to get to this point, and the following review highlights the current advances of stem cell-derived exosomes with particular attention to regenerative medicine in orthopaedics.

scholarly journals Recent Trends in Decellularized Extracellular Matrix Bioinks for 3D Printing: An Updated Review

2019 ◽  
Vol 20 (18) ◽  
pp. 4628 ◽  
Author(s):  
Kevin Dzobo ◽  
Keolebogile Shirley Caroline M. Motaung ◽  
Adetola Adesida
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
3D Printing ◽  
Regenerative Medicine ◽  
Treatment Options ◽  
3D Bioprinting ◽  
Characterization Methods ◽  
Physical Strength ◽  
Decellularized Extracellular Matrix ◽  
The Right

The promise of regenerative medicine and tissue engineering is founded on the ability to regenerate diseased or damaged tissues and organs into functional tissues and organs or the creation of new tissues and organs altogether. In theory, damaged and diseased tissues and organs can be regenerated or created using different configurations and combinations of extracellular matrix (ECM), cells, and inductive biomolecules. Regenerative medicine and tissue engineering can allow the improvement of patients’ quality of life through availing novel treatment options. The coupling of regenerative medicine and tissue engineering with 3D printing, big data, and computational algorithms is revolutionizing the treatment of patients in a huge way. 3D bioprinting allows the proper placement of cells and ECMs, allowing the recapitulation of native microenvironments of tissues and organs. 3D bioprinting utilizes different bioinks made up of different formulations of ECM/biomaterials, biomolecules, and even cells. The choice of the bioink used during 3D bioprinting is very important as properties such as printability, compatibility, and physical strength influence the final construct printed. The extracellular matrix (ECM) provides both physical and mechanical microenvironment needed by cells to survive and proliferate. Decellularized ECM bioink contains biochemical cues from the original native ECM and also the right proportions of ECM proteins. Different techniques and characterization methods are used to derive bioinks from several tissues and organs and to evaluate their quality. This review discusses the uses of decellularized ECM bioinks and argues that they represent the most biomimetic bioinks available. In addition, we briefly discuss some polymer-based bioinks utilized in 3D bioprinting.

scholarly journals 3D Bioprinting at the Frontier of Regenerative Medicine, Pharmaceutical, and Food Industries

2021 ◽  
Vol 2 ◽  
Author(s):  
Qasem Ramadan ◽  
Mohammed Zourob
Keyword(s):  
Tissue Engineering ◽  
3D Printing ◽  
Regenerative Medicine ◽  
Production Process ◽  
Paradigm Shift ◽  
3D Bioprinting ◽  
Printing Technology ◽  
Food Industries ◽  
3D Printing Technology ◽  
Key Driver

3D printing technology has emerged as a key driver behind an ongoing paradigm shift in the production process of various industrial domains. The integration of 3D printing into tissue engineering, by utilizing life cells which are encapsulated in specific natural or synthetic biomaterials (e.g., hydrogels) as bioinks, is paving the way toward devising many innovating solutions for key biomedical and healthcare challenges and heralds' new frontiers in medicine, pharmaceutical, and food industries. Here, we present a synthesis of the available 3D bioprinting technology from what is found and what has been achieved in various applications and discussed the capabilities and limitations encountered in this technology.

scholarly journals Applications of 3D Bioprinting in Tissue Engineering and Regenerative Medicine

2021 ◽  
Vol 10 (21) ◽  
pp. 4966
Author(s):  
Gia Saini ◽  
Nicole Segaran ◽  
Joseph L. Mayer ◽  
Aman Saini ◽  
Hassan Albadawi ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
3D Printing ◽  
Regenerative Medicine ◽  
Living Cells ◽  
Clinical Applications ◽  
3D Bioprinting ◽  
Future Directions ◽  
Specialized Tissue ◽  
Tissue Models ◽  
Functional Components

Regenerative medicine is an emerging field that centers on the restoration and regeneration of functional components of damaged tissue. Tissue engineering is an application of regenerative medicine and seeks to create functional tissue components and whole organs. Using 3D printing technologies, native tissue mimics can be created utilizing biomaterials and living cells. Recently, regenerative medicine has begun to employ 3D bioprinting methods to create highly specialized tissue models to improve upon conventional tissue engineering methods. Here, we review the use of 3D bioprinting in the advancement of tissue engineering by describing the process of 3D bioprinting and its advantages over other tissue engineering methods. Materials and techniques in bioprinting are also reviewed, in addition to future clinical applications, challenges, and future directions of the field.

Law Issues and 3D Printing

2017 ◽  
pp. 69-77
Keyword(s):  
3D Printing ◽  
Human Body ◽  
Special Interest ◽  
Emerging Technology ◽  
Body Parts ◽  
Patent Office ◽  
3D Bioprinting ◽  
Living Tissues ◽  
Near Future ◽  
The U.S

Revolution in 3D bioprinting advancing so quickly. Our special interest is focused on 3D bio printing, the printing of mammalian or human body parts. Very close to this term is cloneprint. The 3D printing living tissues is real and may be widely available in the near future. This emerging technology has generated controversies about its regulation. Another equally important issue is whether bioprinting is patentable. The U.S. Patent and Trademark Office (Patent Office) has already granted some bioprinting patents and many more applications that pending on a patent. This chapter highlighting these issues that can be part of our future.

scholarly journals Trends in Decellularized Extracellular Matrix Bioinks for 3D Printing: Inspiring a new Kind of Medicine

2019 ◽  
Author(s):  
Kevin Dzobo ◽  
Shirley Motaung ◽  
Adetola Adesida
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
3D Printing ◽  
Regenerative Medicine ◽  
Treatment Options ◽  
3D Bioprinting ◽  
Characterization Methods ◽  
Physical Strength ◽  
Decellularized Extracellular Matrix ◽  
The Right

Abstract: The promise of regenerative medicine and tissue engineering is founded on the ability to regenerate diseased or damaged tissues and organs into functional tissues and organs or the creation of new tissues and organs altogether. In theory, all damaged and diseased tissues and organs can be regenerated or created using different configurations and combinations of extracellular matrix, cells and inductive biomolecules. Currently, regenerative medicine and tissue engineering can allow the improvement of patients’ quality of life through availing novel treatment options. Tissues and organs have a specific ECM, with specific proteins and factors released by cells residing within the local microenvironment. The coupling of regenerative medicine and tissue engineering field with 3D printing is revolutionizing the treatment of patients in a huge way. 3D bioprinting allows the proper placement of cells and ECMs, allowing the recapitulation of native microenvironments of tissues and organs. 3D bioprinting utilizes different bioinks made up of different formulations of ECM/biomaterials, biomolecules and even cells. The choice of the bioink used during 3D bioprinting is very important as properties such as printability, compatibility and physical strength influence the final construct printed. The extracellular matrix (ECM) provides both physical and mechanical microenvironment needed by cells to survive and proliferate. Decellularized ECM bioink contains biochemical cues from the original native ECM and also the right proportions of ECM proteins. Different techniques and characterization methods are used to derive bioinks from several tissues and organs and to evaluate their quality. This review discusses the uses of decellularized ECM bioinks and argues that they represent the most biomimetic bioinks available. In addition, we briefly discuss some polymer-based bioinks utilized in 3D bioprinting.

scholarly journals Editorial for the Special Issue on 3D Printing for Tissue Engineering and Regenerative Medicine

Micromachines ◽  
2020 ◽  
Vol 11 (4) ◽  
pp. 366 ◽  
Author(s):  
Vahid Serpooshan ◽  
Murat Guvendiren
Keyword(s):  
Tissue Engineering ◽  
Additive Manufacturing ◽  
3D Printing ◽  
Regenerative Medicine ◽  
Three Dimensional ◽  
Living Cells ◽  
3D Bioprinting ◽  
Special Issue ◽  
3D Structures ◽  
Manufacturing Techniques

Three-dimensional (3D) bioprinting uses additive manufacturing techniques to fabricate 3D structures consisting of heterogenous selections of living cells, biomaterials, and active biomolecules [...]

scholarly journals NANOPATTERNING: IMPLICATIONS IN REGENERATIVE MEDICINE

2017 ◽  
Vol 9 ◽  
pp. 30
Author(s):  
Maha nasr
Keyword(s):  
Stem Cells ◽  
Regenerative Medicine ◽  
Organ Transplantation ◽  
Functional Treatment

Regenerative medicine is based on stem cells, which have the ability to differentiate into special type of body cells, and hence, they were proven clinically successful in organ transplantation, as well as in the functional treatment of several diseases (1).

The Future of Transplant Biology and Surgery

2014 ◽  
Author(s):  
Marc Colaco ◽  
Anthony Atala
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Regenerative Medicine ◽  
Organ Transplantation ◽  
Human Body ◽  
Cell Isolation ◽  
Treatment Modalities ◽  
Organ Function ◽  
Number Of Patients ◽  
The Future

Although organ transplantation remains the mainstay of treatment for patients with severely compromised organ function, with the growing number of patients in need of treatment and the lack of organ supply, medical scientists have begun seeking out alternatives. In the last two decades, researchers have attempted to grow native and stem cells, engineer tissues, and design treatment modalities using regenerative medicine techniques for almost every tissue of the human body. This chapter discusses the basics of tissue engineering, including cell isolation and biomaterial selection. It then outlines specific advances and potential surgical uses. This review contains 9 figures, 2 tables, and 135 references.

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