scholarly journals Evaluation and Comparison of Antimicrobial Properties of Natural and Synthetic Zeolites Exchanged with Silver, Zinc, Copper and Nickel Ions

2021 ◽  
pp. 125-141
Keyword(s):  
Antibacterial Activity ◽  
Ion Exchange ◽  
Antibacterial Properties ◽  
Antimicrobial Properties ◽  
Metal Cations ◽  
Exchange Capacity ◽  
Nickel Ions ◽  
Antibacterial Materials ◽  
Synthetic Zeolites ◽  
Natural And Synthetic

Zeolites are high-porous active crystalline biomaterials. Recently many studies have been done on their antibacterial properties especially on zeolites exchanged with metallic cations. In this paper, we investigate the effective factors on the antimicrobial activity of natural and synthetic zeolites exchanged with silver, zinc, copper nickel, and bromide cations. This study reviews the published articles on the antibacterial properties of the natural and synthetic pure zeolites as well as the ion exchange ones. The results of our investigation show that ion exchange zeolites exhibit a very good antibacterial effects even in comparison with other conventional antibacterial materials. The strongest antibacterial activity was reported in silver exchanged zeolites against Bacillus cereus and Escherichia coli with MIC of 16 μg/ml. According to the results reported derived from different articles, it can be concluded that zeolites with biocompatibility and high ion exchange capacity can be used as efficient antibacterial materials. Pure zeolites have antibacterial activity at high concentrations, whereas all synthetic and natural zeolites exchanged with metal cations investigated in this paper exhibit good antibacterial activity at very low concentrations generally due to sustained and prolong release of metal cations.

scholarly journals Zinc(II) Complexes with Amino Acids for Potential Use in Dermatology: Synthesis, Crystal Structures, and Antibacterial Activity

Molecules ◽  
2020 ◽  
Vol 25 (4) ◽  
pp. 951 ◽  
Author(s):  
Michał Abendrot ◽  
Lilianna Chęcińska ◽  
Joachim Kusz ◽  
Katarzyna Lisowska ◽  
Katarzyna Zawadzka ◽  
...  
Keyword(s):  
Amino Acids ◽  
Antibacterial Activity ◽  
Antibacterial Properties ◽  
Antimicrobial Properties ◽  
X Ray Diffraction ◽  
Organic Zinc ◽  
Counter Ions ◽  
Open Issue ◽  
Potential Use ◽  
Active Substances

The multifunctional profile of Zn2+ has influenced its great popularity in various pharmaceutical, food, and cosmetic products. Despite the use of different inorganic and organic zinc derivatives, the search for new zinc-containing compounds with a safer skin profile still remains an open issue. The present paper describes the synthesis, structural characterization, and antibacterial activity of zinc(II) complexes with proteinogenic amino acids as potential candidates for dermatological treatments. The obtained complexes are of the general formula [Zn(AA)2], where AA represents an amino acid (L-Glu, Gly, L-His, L-Pro, L-Met, and L-Trp). Their synthesis was designed in such a way that the final bis(aminoacidate) zinc(II) complexes did not contain any counter-ions such as Cl−, NO3−, or SO42− that can cause some skin irritations. The chemical structure and composition of the compounds were identified by 1H NMR spectroscopy and elemental analysis, and four were also characterized by single-crystal X-ray diffraction. The Hirshfeld surface analysis for the Zn2+ metallic center helped to determine its coordination number and geometry for each complex. Finally, the antibacterial properties of the complexes were determined with respect to three Gram-positive strains, viz. Staphylococcus aureus ATCC 6538, Staphylococcus epidermidis ATCC 12228, and Streptococcus pyogenes ATCC 19615, and two Gram-negative bacteria, viz. Escherichia coli ATCC 25992 and Pseudomonas aeruginosa ATCC 27853, and were compared with the activity of zinc 2-pirrolidone 5-carboxylate (ZnPCA), commonly applied in dermatology. It was found that the Zn(II) complexes with methionine and glycine exhibited a higher antibacterial activity than the tested standard, and the antimicrobial properties of complex with Trp were satisfactory. The results of the antimicrobial activity examination allow us to postulate that the obtained zinc complexes might become new active substances for use in dermatological products.

scholarly journals Removing Ammonia From Wastewater Using Natural and Synthetic Zeolites: A Batch Experiment

2019 ◽  
Author(s):  
Judit Canellas ◽  
Ana Soares ◽  
Bruce Jefferson
Keyword(s):  
Ion Exchange ◽  
Research Direction ◽  
Synthetic Zeolite ◽  
Variable Load ◽  
Natural Zeolites ◽  
Component Solution ◽  
Synthetic Zeolites ◽  
Real Wastewater ◽  
Regeneration Efficiency ◽  
Natural And Synthetic

Ion exchange based processes for the removal of ammonium from wastewater using zeolites could be an attractive additional or potentially complementary treatment option for conditions that pose a challenge for biological processes, such as variable load or low temperatures. A range of natural and synthetic zeolites have been studied for removing ammonium from wastewater. However, the relatively low capacity of zeolites and challenges regarding regeneration have so far complicated efforts in this research direction. Here, we compare the most commonly used natural zeolites US-Clinoptilolite, UK-Clinoptilolite, Mordenite and Chabazite (using Na- and Ca- as main cation exchanger) as well as a thermally modified US-Clinoptilolite and a synthetic zeolite MesoLite in terms of their capacity and regeneration efficiency to determine whether a synthetic zeolite like MesoLite can address the aforementioned problems related to capacity and regeneration efficiency. This investigation was performed as a series of batch experiments on synthetic and real wastewater solutions. When zeolites were pre-saturated with sodium ions, we found the overall highest capacity of 4.6 meq/g for the synthetic zeolite MesoLite, relative to a range between 1.1 and 2.1 meq/g for the natural zeolites. Ammonium adsorption capacity of MesoLite with real wastewater ranged between 74 and 97% of what was observed for a synthetically generated mono component solution set at approximately the same ionic load. Our results indicate that MesoLite could be an appropriate media for ion-exchange based tertiary treatment of wastewater.

scholarly journals Synthesis of Some Quinoxaline Sulfonamides as a Potential Antibacterial Agent

2021 ◽  
pp. 116-132
Author(s):  
Festus O. Taiwo ◽  
Craig A. Obafemi ◽  
David A. Akinpelu A. Akinpelu
Keyword(s):  
Antibacterial Activity ◽  
Broad Spectrum ◽  
Antibacterial Agent ◽  
Antibacterial Property ◽  
Antibacterial Properties ◽  
Antimicrobial Properties ◽  
Pharmacological Properties ◽  
Antimicrobial Compounds ◽  
Bacterial Strains ◽  
Bactericidal Effects

Aims: This studies aims at the synthesis of new heterocyclic systems and study its biological and pharmacological properties. Objective: This study was designed to synthesized some quinoxaline-2,3-dione with sulfonamide moiety, characterize the synthesized compounds, and study the antimicrobial properties of the synthesized compounds on some bacterial strains. Materials and Methods: Six quinoxaline-6-sulfonohydrazone derivatives were synthesized by reacting quinoxaline-6-sulfonohydrazine with some substituted benzaldehydes and ketones. The compounds were tested for their potential antibacterial properties. Results: All the test compounds possessed promising antibacterial property against a panel of bacterial strains used for this study. The MIC values exhibited by these compounds ranged between 0.0313 and 0.250 mg/mL. Among the compounds tested, compound 2 showed appreciable antibacterial activity. Discussion and Conclusion: The study concluded that all the compounds exhibited appreciable bactericidal effects towards all the bacterial strains, particularly, compound 2 This is an indication that such compounds possessing broad spectrum activities will be useful in formulating antimicrobial compounds which could be used to treat infections caused by pathogens that are now developing resistance against the available antibiotics.

scholarly journals Antibacterial properties of thioridazine

2019 ◽  
pp. 96-104
Author(s):  
N. Hrynchuk ◽  
N. Vrynchanu
Keyword(s):  
Antibacterial Activity ◽  
Ex Vivo ◽  
Antibacterial Properties ◽  
Antimicrobial Properties ◽  
Antibiotic Resistant ◽  
In Vivo Experiments ◽  
Antistaphylococcal Activity ◽  
The Impact

The emergence and spread of antibiotic-resistant strains of microorganisms reduces the effectiveness of antibiotic therapy and requires finding solutions to problems, one of which is the study of antimicrobial properties in drugs of various pharmacological groups. The purpose of the work was to summarize the data on the antibacterial activity of thioridazine and its derivatives to determine the feasibility and prospects of creating new antibacterial drugs on their basis. The paper presents literature data on the effects of thioridazine on the causative agent of tuberculosis, antistaphylococcal activity, susceptibility of plasmodium and trypanosoma. The antibacterial activity of the drug was established within in vitro studies with the determination of MIC towards gram-positive and gram-negative microorganisms, ex vivo using macrophage lines, as well as within in vivo experiments on mice. It is established that the neuroleptic thioridazine is characterized by pronounced anti-tuberculosis activity, the mechanism of action is associated with the impact on the cell membrane of M. tuberculosis, inactivation by calmodulin and inhibition of specific NADH-dehydrogenase type II. The literature data indicate that thioridazine is able to increase the activity of isoniazid against the strains of mycobacteria that are susceptible and resistant to its action. It has been established that resistance to thioridazine in antibiotic-resistant M. tuberculosis strains is not formed. The drug is characterized by its ability to inhibit the growth and reproduction of both methicylin-sensitive (MSSA) and methicilin-resistant (MRSA) strains of Staphylococcus aureus, which has been proven within in vitro experiments. The effectiveness of thioridazine has been proven within in vivo experiments in case of skin infection and sepsis caused by S. aureus. Antimicrobial effect of the drug is also observed towards to plasmodium (P. falciparum) and trypanosomes (Trypanosoma spp.). Currently, the synthesis of thioridazine derivatives is carried out to identify compounds with a pronounced antibacterial effect. Some of the first synthesized compounds are not inferior or superior to thioridazine by the inhibitory effect. Thus, these data suggest that drugs of different pharmacological groups, including drugs that affect the nervous system - thioridazine and its derivatives, can be a source of replenishment of the arsenal of antimicrobial drugs to control such threatening infections as tuberculosis and diseases caused by polyresistant strains of microorganisms.

scholarly journals Gram-scale synthesis of splat-shaped Ag–TiO2 nanocomposites for enhanced antimicrobial properties

2020 ◽  
Vol 11 ◽  
pp. 1119-1125
Author(s):  
Mohammad Jaber ◽  
Asim Mushtaq ◽  
Kebiao Zhang ◽  
Jindan Wu ◽  
Dandan Luo ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Antibacterial Properties ◽  
Antimicrobial Properties ◽  
Inhibition Zone ◽  
Multidrug Resistant ◽  
Bacterial Strains ◽  
Gram Negative ◽  
E Coli ◽  
Contagious Diseases ◽  
Good Biocompatibility

The control over contagious diseases caused by pathogenic organisms has become a serious health issue. The extensive usage of antibiotics has led to the development of multidrug-resistant bacterial strains. In this regard, metal-oxide-based antibacterial nanomaterials have received potential research interest due to the efficient prevention of microorganism growth. In this study, splat-shaped Ag–TiO2 nanocomposites (NCs) were synthesized on the gram scale and the enhanced antibacterial properties of TiO2 in the presence of silver were examined. The formation of Ag–TiO2 NCs was analyzed through various characterization techniques. The cell viability experimental results demonstrated that the Ag–TiO2 NCs have good biocompatibility. The antibacterial activity of the prepared Ag–TiO2 NCs was tested against the Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli) bacterial strains. The Ag–TiO2 NCs exhibited promising and superior antibacterial properties compared to TiO2 nanospheres as confirmed by the bacterial growth and inhibition zone. The improvement in the antibacterial activity was attributed to the synergistic effect of the hybrid nature of TiO2 nanoparticles in the presence of Ag.

scholarly journals A Further Investigation of NH4+ Removal Mechanisms by Using Natural and Synthetic Zeolites in Different Concentrations and Temperatures

Minerals ◽  
2018 ◽  
Vol 8 (11) ◽  
pp. 499 ◽  
Author(s):  
Huei-Fen Chen ◽  
Yi-Jun Lin ◽  
Bo-Hong Chen ◽  
Iizuka Yoshiyuki ◽  
Sofia Liou ◽  
...  
Keyword(s):  
Ion Exchange ◽  
Surface Area ◽  
Physical Adsorption ◽  
Ammonium Concentration ◽  
Adsorption Ability ◽  
Ammonium Removal ◽  
Cation Content ◽  
Different Temperatures ◽  
Synthetic Zeolites ◽  
Natural And Synthetic

We investigated the ammonium removal abilities of natural and synthetic zeolites with distinct Si/Al ratios and various surface areas to study how adsorption and ion exchange processes in zeolites perform under different ammonium concentrations and different temperatures. Five zeolites—natural mordenite, chabazite, erionite, clinoptilolite, and synthetic merlinoite—were immersed in 20, 50, and 100 mg/kg ammonium solutions. The results demonstrate that zeolites under high ammonium concentrations (100 mg/kg) possess higher physical adsorption capacity (0.398–0.468 meq/g), whereas those under lower ammonium concentrations (20 mg/kg) possess greater ion exchange properties (64–99%). The ion exchange ability of zeolites is extremely dependent on the cation content of the zeolites, and the cation content is affected by the Si/Al ratio. The surface area of zeolites also has a partial influence on its physical adsorption ability. When the surface area is less than 100 m2/g, the adsorption ability of zeolite increases obviously with surface area; however, adsorption ability is saturated as the surface area becomes larger than this critical value of 100 m2/g. When we placed the zeolites in 50 mg/kg ammonium concentration at different temperatures (5–50 °C), we found that the zeolites exhibited the highest ammonium removal ability at 30 °C and the potassium release was enhanced at 30–40 °C.

scholarly journals Antimicrobial Properties of Copper Nanoparticles and Amino Acid Chelated Copper Nanoparticles Produced by Using a Soya Extract

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
I. DeAlba-Montero ◽  
Jesús Guajardo-Pacheco ◽  
Elpidio Morales-Sánchez ◽  
Rene Araujo-Martínez ◽  
G. M. Loredo-Becerra ◽  
...  
Keyword(s):  
Amino Acids ◽  
Antibacterial Activity ◽  
Copper Nanoparticles ◽  
Copper Ions ◽  
Antibacterial Properties ◽  
Antimicrobial Properties ◽  
Bacterial Cells ◽  
Microdilution Method ◽  
Diphenyltetrazolium Bromide ◽  
Specific Strain

This paper reports a comparison of the antibacterial properties of copper-amino acids chelates and copper nanoparticles againstEscherichia coli,Staphylococcus aureus, andEnterococcus faecalis. These copper-amino acids chelates were synthesized by using a soybean aqueous extract and copper nanoparticles were produced using as a starting material the copper-amino acids chelates species. The antibacterial activity of the samples was evaluated by using the standard microdilution method (CLSI M100-S25 January 2015). In the antibacterial activity assays copper ions and copper-EDTA chelates were included as references, so that copper-amino acids chelates can be particularly suitable for acting as an antibacterial agent, so they are excellent candidates for specific applications. Additionally, to confirm the antimicrobial mechanism on bacterial cells, MTT assay (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) was carried out. A significant enhanced antimicrobial activity and a specific strain were found for copper chelates overE. faecalis. Its results would eventually lead to better utilization of copper-amino acids chelate for specific application where copper nanoparticles can be not used.

scholarly journals Development of Silver Ion Doped Antibacterial Clays and Investigation of Their Antibacterial Activity

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Filiz B. Karel ◽  
Ali S. Koparal ◽  
Elif Kaynak
Keyword(s):  
Antibacterial Activity ◽  
Controlled Release ◽  
Ion Exchange ◽  
Phosphoric Acid ◽  
Health Risks ◽  
Acid Treatment ◽  
Silver Ion ◽  
X Ray ◽  
Antibacterial Materials ◽  
Silver Release

Kaolinite, sepiolite, and clinoptilolite were used as carriers to develop antibacterial materials. The materials were enriched in sodium by ion exchange. Silver ion exchange by silver nitrate followed by phosphoric acid treatment enabled the controlled release of silver. The antibacterial function of the materials was investigated by halo test and the amount of silver released was investigated by energy dispersive X-ray spectroscopy. The enhanced antibacterial efficiency was obtained by minimizing the silver release which further provided longevity to the material and prevented the health risks posed by excess silver release.

scholarly journals Antibacterial Properties of Glycosylated Surfaces: Variation of the Glucosidal Moiety and Fatty Acid Conformation of Grafted Microbial Glycolipids

2020 ◽  
Author(s):  
Claire Valotteau ◽  
Sophie L. K. W. Roelants ◽  
Prabhu Dasaiyan ◽  
Susanne Zibek ◽  
Michael Günther ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Fatty Acid ◽  
Antibacterial Properties ◽  
Antimicrobial Properties ◽  
Gold Surfaces ◽  
Gram Positive ◽  
Glucose Unit ◽  
Biocidal Coatings ◽  
Key Factor ◽  
Biocidal Properties

<div>Glycosylated surfaces can display antimicrobial properties. It has been shown that sophorolipids can be used to develop biocidal coatings against Gram-positive and Gramnegative bacteria, but with a limited efficiency so far. Therefore, it appears necessary to further investigate the surface antibacterial activity of a broader set of structurally related glycolipids.</div><div>The present work explores the influence of the glucosidic moiety (gluco-, sophoro-, cellobio-)</div><div>and the fatty acid backbone (saturated, cis or trans monounsaturated). We show that the fatty</div><div>acid backbone plays an important role: cis derivative of sophorolipids (SL) grafted onto model</div><div>gold surfaces has better biocidal properties than saturated (SL0) and trans monounsaturated</div><div>(SLt) molecules, which appear to be inefficient. The number of glucose units is also a key factor:</div><div>a one-third decrease in antibacterial activity is observed when having one glucose unit (GL)</div><div>compared to two (SL).Sugar acetylation (SLa) does not seem to have an impact on the biocidal</div><div>properties of surfaces. These results are not limited to sophorolipids, cellobioselipids (CL)</div><div>leading to similar antibacterial observations. </div>

scholarly journals In vitro antibacterial and antioxidant activity of Rosmarinus officinalis

2021 ◽  
Vol 285 ◽  
pp. 05012
Author(s):  
A. K. Milyuhinа ◽  
L. A. Zabodalova ◽  
U. Kyzdarbek ◽  
I. R. Romazyaeva ◽  
N. Yu. Klyuchko
Keyword(s):  
Antioxidant Activity ◽  
Antibacterial Activity ◽  
Antibacterial Properties ◽  
Antimicrobial Properties ◽  
Ethanol Extract ◽  
Rosmarinus Officinalis ◽  
E Coli ◽  
Rosmarinus Officinalis L ◽  
Antibacterial And Antioxidant Activity

Rosmarinus officinalis L. is known for its antioxidant and antibacterial properties against a variety of microorganisms. In this work, research has been carried out on pharmacy rosemary. Its antioxidant and antimicrobial properties have been determined. This study showed that the ethanol extract of R. officinalis L. has a pronounced antimicrobial activity against strains of both gram-positive and gram-negative bacteria. The extract also showed good antioxidant activity. Rosemary showed significantly more potent antibacterial activity against E. coli. The diameter of the zone of oppression was 17 mm. Thus, Rosemary Pharmaceutical has demonstrated potential as a dietary supplement due to its stronger antibacterial activity.

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