scholarly journals Antihyperglycemic Activity of The Ethanolic Extract of the Bark of Mitragyna Ciliata (MYCA) in Albino Induced Diabetic Rats

2021 ◽  
pp. 957-965
Author(s):  
PAYE Plenseh Diana ◽  
James McClain
Keyword(s):  
Glucose Level ◽  
Hematological Parameters ◽  
Ethanolic Extract ◽  
Diabetic Rats ◽  
Vascular Complication ◽  
Severe Side Effect ◽  
Albino Rats ◽  
Histopathological Analysis ◽  
Toxicological Effect ◽  
Treatment Of Diabetes

Background: Diabetes an epidemic that gives rise to an increased macro vascular complication mortality rate of 1.5 million annually, increasing by 2035. Treatment of diabetes is complicated and associated with a severe side effect.</p> <p>Objective: To evaluate the antihyperglycemic property of the ethanolic extract of the back of MYCA and its toxicological effect on the hematological parameters with histopathological analysis of selected organs of induced diabetic albino rats.</p> <p>Method: The ethanoic extract (1000 mg/kg bw and 500mg/kg bw) and glibenclamide (0.5mg/kg bw) were administered to diabetic induced rats.  The effect of the extract on the hematological was studied in the diabetic induced rats. Histopathological changes were observed in the liver of induced diabetic rats after the administration of the MYCA extract.</p> <p>Results: The anti-hyperglycaemic effect was observed at two different levels, for two different doses (1000mg/kg and 500mg/kg). The results also showed significant suppression of blood glucose level in glucose fed hyperglycaemic albino rats but showed no significantly suppressed glucose level in overnight fasted normoglycemic rats.</p> <p>Conclusion: The findings revealed that the ethanolic extract of MITRAGYNA CILIATA (MYCA) possess antihyperglycemic property. Besides, the extract can prevent the various complication of diabetes and improve some hematological parameters.

scholarly journals GLUCOSE HOMEOSTATIC AND PANCREAS PROTECTIVE POTENTIAL OF TECOMELLA UNDULATA ROOT EXTRACT IN STREPTOZOTOCIN INDUCED DIABETIC RATS .

2017 ◽  
Vol 10 (6) ◽  
pp. 292
Author(s):  
Kanwar Lal ◽  
Ashok Purohit ◽  
Heera Ram
Keyword(s):  
Hematological Parameters ◽  
Ethanolic Extract ◽  
Serum Biochemistry ◽  
Diabetic Rats ◽  
The Body ◽  
Root Extract ◽  
Standard Drug ◽  
Protective Potential ◽  
Normal Ranges ◽  
Tecomella Undulata

Objective: The study was aimed to evaluate glucose homeostatic and pancreas protective potential of Tecomella undulata root extract in streptozotocin induced diabetic rats.Methods: The ethanolic root extract was prepared by following standard soxhlation methods. The experimental design was divided in to control and treated groups for 28 days of comparative experimental schedule. The body and organ weights, serum biochemistry, histo-pathology, hematology and toxicity profiles were assayed by following standard methods and protocols.Results: The treatment of ethanolic extract of root of T. undulata was significantly (p ≤ 0.001) reduced glucose levels at 7day, 14day, 21day and 28 days in comparison to standard drug of metformin. Correspondingly, lipid profile i.e. total cholesterol, HDL, VLDL, LDL and triglyceride were also altered significantly. Whereas, body and organs weight and hematological parameters were not shown significant changes. Subsequently, toxicity profile i.e. hepatic and renal parameters were remained under normal ranges. Corresponding, the treatment of ethanolic root extract caused normalcy of histoarchitecture of pancreas in comparison to standard drugs.Conclusion: The results of study illustrated that Tecomella undulata root extract possessing particular kind of phytocompounds which caused glucose homeostatic and pancreas protective potential in diabetic rats.

scholarly journals Emblica officinalis (Amla) Ameliorates High-Fat Diet Induced Alteration of Cardiovascular Pathophysiology

2019 ◽  
Vol 17 (1) ◽  
pp. 52-63 ◽  
Author(s):  
Bheemshetty S. Patil ◽  
Pallavi S. Kanthe ◽  
Chandramouli R. Reddy ◽  
Kusal K. Das
Keyword(s):  
Oxidative Stress ◽  
High Fat Diet ◽  
Ethanolic Extract ◽  
Albino Rats ◽  
Histopathological Study ◽  
Histopathological Analysis ◽  
Phytochemical Analysis ◽  
Emblica Officinalis ◽  
High Fat ◽  
Elastic Artery

Background: Dietary high fat possibly causes oxidative stress. Also, it alters the pathophysiology of metabolically active myocardial tissues and vascular architecture. Emblica officinalis contains a potential antioxidant that counteracts oxidative stress and possibly maintains vascular integrity. Objective: To assess the effect of ethanolic extract of Emblica officinalis (EEO) on High Fat Diet (HFD) induced changes in vascular chemistry and histopathology of the cardiovascular system in male albino rats. Materials and Methods: Ethanolic extract of Emblica Officinalis (EEO) was prepared and phytochemical analysis was done. Rats were divided into four groups, having six rats in each group as follows: group 1- Control (20% fat); group 2 (20% fat+ EEO 100 mg/kg/b w); group 3 (30% fat) and group 4 (30% fat + EEO 100 mg/kg/b w). Dietary and EEO supplementation was continued for 21 days. Gravimetric and oxidative stress markers like MDA, NO, antioxidants like Vitamin C and E, and molecular marker (NOS3) were evaluated. Histopathological analysis was done on the myocardium and elastic artery along with measurement of coronary arterial wall thickness and lumen diameter. One way ANOVA was done for analysis of data. Results: High fat diet showed a significant increase in MDA, decrease of NO with unaltered NOS3 protein in rats fed with high fat diet, which indicate possible alteration of vascular pathophysiology. Supplementation of EEO showed an ameliorating effect on high fat diet induced oxidative stress. These results were further corroborated with findings of a histopathological study on the myocardium, elastic artery and coronary arterial architecture. Conclusion: Ethanolic extract of Emblica officinalis (EEO) indicates its cardioprotective efficacy against rats fed with high fat diet.

scholarly journals Antidiabetic Potential of Alcoholic and Aqueous Extracts of Ficus racemosa Linn. Bark In Normal and Alloxan Induced Diabetic Rats

2009 ◽  
Vol 1 (01) ◽  
Author(s):  
Nikhil K. Sachan ◽  
Yatindra Kumar ◽  
Seema Pushkar ◽  
R. N. Thakur ◽  
Sudhir S. Gangwar ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Aqueous Extract ◽  
Ethanolic Extract ◽  
Diabetic Rats ◽  
Alcoholic Extract ◽  
Glucose Lowering ◽  
Ficus Racemosa ◽  
Lowering Activity

The present investigation aims to examine the diabetic potential of the plant Ficus racemosa in normal and alloxan induced diabetic rats. The bark extract with water, petroleum ether and with alcohol were screened for blood glucose lowering activity and the alcoholic extract having better therapeutic potential was prepared through Soxhlet extraction for further study. Alcoholic and aqueous extract of bark of Ficus racemosa at a dose of 400 mg/Kg was given to normal and alloxan induced diabetic rats and the blood samples taken from the retero-orbital plexus vein were analyzed for blood glucose level as per standard protocol with available kits through Auto-analyzer. The comparison of blood sugar level as per model schedule showed that in normal group the ethanolic extract, at a dose of 400 mg/Kg intra-peritoneal, the blood glucose lowering 28.66 % while in aqueous extract given group it was 25.90 %. In alloxan induced diabetic rats decrease in blood glucose level in aqueous and ethanolic extract group was found to be 27.01 % and 45.03 % respectively. In conclusion, the ethanolic extract of Ficus racemosa reflected anti-diabetic potential through its glucose lowering activity in experimental animals. It supported the folklore claim of anti-diabetic activity of the plant.

scholarly journals Comparative evaluation of anti-diabetic activity of fresh juice and ethanolic extract of Sunderban mangrove Rhizophora mucronata Lam. leaves in animal model

2017 ◽  
Vol 6 (9) ◽  
pp. 2193
Author(s):  
Anjan Adhikari ◽  
Moumita Ray ◽  
Tapas K. Sur ◽  
Sharmistha Biswas ◽  
Anup K. Das
Keyword(s):  
Comparative Analysis ◽  
Folk Medicine ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Diabetic Rats ◽  
Lipid Lowering ◽  
Rhizophora Mucronata ◽  
Potent Effect ◽  
Diabetic Model ◽  
Treatment Of Diabetes

Background: Mangrove flora possess compounds with potential medicinal values with unique bioactive components. Traditionally Rhizophora mucronata, a mangrove has been used extensively for the treatment of diabetes. Studies revealed that, the leaves of Rhizophora (Bhora) had promising anti-diabetic action in rat model.Methods: A comparative analysis of the anti-diabetic action of fresh juice and ethanolic extract of Rhizophora mucronata leaves was carried out in Streptozotocin induced diabetic model and the different biochemical parameters were evaluated.Results: Present research explored a comparative analysis of the anti-diabetic action of fresh juice and ethanolic extract of leaves of Rhizophora mucronata Lam. in Streptozotocin induced diabetic model. The ethanolic extract showed more potent effect in lowering the elevated blood sugar in the diabetic rats, 200mg/kg was the most effective dose for both the extracts. The ethanol extract was more beneficial having potent lipid lowering action along with anti-hyperglycemic property.Conclusions: This supports the scientific validation for using Rhizophora mucronata leaves in the treatment of diabetes as traditional folk medicine. Identification of the bioactive molecule is under process.

scholarly journals Effect of Aqueous Extract of Zingiber officinale (Ginger) on Some Biochemical Parameters in Streptozotocin-induced Diabetes Rats

2019 ◽  
pp. 1-8
Author(s):  
M. K. Jiyil ◽  
C. D. Luka ◽  
C. E. Mafuyai ◽  
N. Pamela
Keyword(s):  
Body Weight ◽  
Biochemical Parameters ◽  
Zingiber Officinale ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
The Body ◽  
Albino Rats ◽  
Ginger Extract ◽  
Hematological Analysis ◽  
Treatment Of Diabetes

Background: Appreciable number of medicinal plants are used for the treatment of diabetes in Nigeria. Aim of the Study: The present study aimed to investigate the antidiabetic activity of Zingiber officinale extracts and its potential mechanisms in streptozotocin-induced diabetic rats. Study Duration: The period of the study was done on 30th September, 2018 at the Department of Biochemistry, Faculty of Basic Medical Sciences, university of Jos, Nigeria. Methodology: Albino rats of Wistar strain weighing between 130 g to 160 g were induced with single freshly prepared streptozotocin (55 mg/kg body weight). Diabetes was confirmed after forty eight hours in streptozotocin -induced rats showing fasting blood glucose levels > 10 mmol/l. The rats were randomly divided into four (4) experimental groups (n = 4). A (Control diabetic group fed with normal feed), Group B (Normal control fed with normal feed), Group Group C (Diabetic rats treated with 400 mg/Kg body weight extract of ginger and Group D, (Diabetic rats are treated with 400 mg/Kg body weight of metformin). After 8 days the animals were sacrificed and blood samples were collected for biochemical and hematological analysis. Changes in the animal body weights were also measured within the period. Results: From the results, it was observed that treatment of rats with extract of ginger compensates for the reduction of body weight, and caused an increase in the body weight of the treated rats (+11.5%) in contrast to 24.8% reduction observed in diabetic control. In the same order, serum glucose significantly decreased (p<0.05) after the 8-day treatment compared to diabetic control. The extent of reversal of hyperglycemia in the ginger extract treated animals compared well with the metformin treated group. The results, therefore, showed that ginger extract has a significant (p<0.05) hypoglycemic effect in diabetic rats and moreover, elevations in the measured biochemical parameters were significantly (p<0.05) attenuated in rats treated with ginger extract. Conclusion: Zingiber officinale extracts has a significant effect on some biochemical parameters and hematological assays. These provide scientific evidence to confirm the traditional use of Z. officinale in the treatment of diabetes mellitus.

The anti-diabetic effect of some plant extracts against Streptozotocin - induced diabetes type 2 in male albino rats.

2020 ◽  
Vol 20 ◽  
Author(s):  
Heba F. Gomaa ◽  
Imen Ben Abdelmalek ◽  
Khaled G. Abdel-Wahhab
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Total Cholesterol ◽  
Plant Extracts ◽  
Ethanolic Extract ◽  
Diabetic Rats ◽  
Male Rats ◽  
Postprandial Blood Glucose ◽  
Albino Rats

Background: One of the widely spread disorders is Diabetes mellitus, especially type 2 (T2DM). T2DM is attributed to the change in life style and stress. A possible strategy to block dietary carbohydrate absorption, is regulation of postprandial blood glucose level as well, the use of some natural plant extracts with inhibitory effect against carbohydrate digestive enzymes such as alpha-amylase and fewer side effects than synthetic drugs. This study was conducted to investigate the anti-diabetic effect of Cinnamon and Saussurea extract, individually, on blood glucose, lipid profile, insulin, interleukin1-beta and weight loss in diabetic rats treated with Streptozotocin (STZ). Methods: The experiment was performed on 60 Wistar male rats, the experimental study include 6 groups (10 rats each): (I) normal rats, (II) Streptozotocin- induced diabetic rats, (III) normal rats orally received (200 mg/kg/day) Saussurea ethanolic extract (SEE) for consecutive 4 weeks, (IV) normal rats orally received (100mg/kg/day) Cinnamon aqueous extract (CAE) for consecutive 4 weeks, (V) Streptozotocin –treated rats received SEE orally (200mg /kg/ day) for consecutive 4 weeks, and (VI) Streptozotocin –treated rats received CAE orally (100mg /kg/ day) for consecutive 4 weeks. Results: The results of the following study revealed that SEE has more anti-diabetic effect against Streptozotocin treatment than CAE due to the high α-amylase inhibition potential and higher phenolic content, Also, GC-MS analysis of SEE exhibited higher concentrations of phenolic compounds such as : dehydrocostus lactone, azuleno, eicosa-pentaenoic acid and linoelaidic acid that revealed anti-diabetic, anti-lipidemic and anti-inflammatory activities, while CAE showed presence of cinnamic and quinic acids. Injection of STZ resulted in a decline in the insulin, high density lipoprotein and body weight values matched with increase of glucose, total cholesterol, LDL-Cholesterol, triglycerides and interleukin1- β (IL-1β). The administration of extracts of SEE and CAE into STZ-treated rats separately resulted in a decline in the elevated levels of blood glucose, total cholesterol, triglycerides and improving serum HDL-Cholesterol and body weight. Conclusion: Both tested herbal extracts performed anti-diabetic effect that mainly could be mechanized via the α-amylaseinhibitory potentials due to the high phenolic and flavonoids content.

Antihyperglycemic Effects of Tragia plukenetii Ethanolic Extract

2014 ◽  
Vol 7 (2) ◽  
pp. 2436-2440
Author(s):  
Venkatesh Sama ◽  
Rajini T ◽  
Humera Afrooz ◽  
Balaraju P ◽  
B. Madhava Reddy ◽  
...  
Keyword(s):  
Oral Dose ◽  
Ethanolic Extract ◽  
Tolerance Test ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Oral Glucose ◽  
Alcoholic Extract ◽  
Antihyperglycemic Activity ◽  
Treatment Of Diabetes

Plants represent a major potential source of drugs for treating diabetes. The study of plants having antidiabetic activity may give a new approach in the treatment of diabetes mellitus. Tragia plukenetii is traditionally claimed to be useful in the treatment of diabetes. The present study was intended to evaluate the antihyperglycemic activity of aqueous ethanolic extract on normal fasted, glucose loaded and alloxan induced diabetic rats, at an oral dose of 75, 150 and 300 mg/kg in male Wistar rats. The alcoholic extract has not produced any hypoglycemia in normal fasted rats. The ethanolic extract has displayed a significant dose dependent antihyperglycemic activity in oral glucose tolerance test and in alloxan induced diabetic rats at an oral dose of 150 and 300 mg/kg. The ethanolic extract has effectively scavenged the stable free DPPH radical in-vitro. It is concluded that Tragia plukenetii aerial parts alcoholic extract is effective in controlling blood glucose levels in diabetic rats.

EFFECT OF ZINGIBER OFFICINALE (LINN) A ETHANOLIC EXTRACT ON METFORMIN INDUCED HYPOGLYCEMIA IN ALLOXAN INDUCED DIABETIC MICE

INDIAN DRUGS ◽  
2012 ◽  
Vol 49 (04) ◽  
pp. 30-38
Author(s):  
R. U Kshirsagar ◽  
◽  
U. M Joshi ◽  
K. R. Biyani
Keyword(s):  
Glucose Level ◽  
Standard Dose ◽  
Ethanolic Extract ◽  
Concomitant Administration ◽  
Zingiber Officinale ◽  
Serum Glucose ◽  
Diabetic Mice ◽  
Oral Hypoglycaemic Agents ◽  
Treatment Of Diabetes ◽  
Novel Drug

Zingiber officinale (Linn.) has been used in traditional medicine for the treatment of diabetes. The aim of the study was to evaluate the antidiabetic effect of ethanolic extract of Zingiber officinale (EthZO) by concomitantly administering with synthetic oral hypoglycaemic agents (OHA) in diabetic mice. (EthZO)150 mg-metformin (250 mg/kg) were administered orally alone as well as concomitantly in alloxan-induced diabetic mice. After acute and chronic treatment the serum glucose level was determined. Administration of EthZO (150 mg) + metformin (200 mg) with optimized dose was studied concomitantly at the interval of 15 min. Decreased blood glucose level (BGL) was compared with standard dose of metformin and was found to be lower than normoglycemia. Hence, it can be concluded that concomitant administration of EthZO and metformin causes synergistic significant effect than metformin alone. It can be investigated as the novel drug therapy in the treatment of diabetes mellitus.

scholarly journals Effects of Ethanolic Extract of Hibiscus rosa-sinensis Leaves on Alloxan-Induced Diabetes with Dyslipidemia in Rats

2013 ◽  
Vol 16 (1) ◽  
pp. 27-31 ◽  
Author(s):  
Al Mamun ◽  
Saiful Islam ◽  
AHM Khurshid Alam ◽  
Md Aziz Abdur Rahman ◽  
Mamunur Rashid
Keyword(s):  
Developing Countries ◽  
Body Weight ◽  
Glucose Level ◽  
Ethanolic Extract ◽  
Pharmaceutical Journal ◽  
Diabetic Rats ◽  
Hibiscus Rosa Sinensis

Diabetes associated dyslipidemia is one of the major causes of disability in western as well as in developing countries. The present study was designed to investigate the effect of ethanolic extract of Hibiscus rosa sinensis (EHBS) leaves on alloxan-induced diabetes with dyslipidemia in rats. Treatment of alloxan-induced diabetes with most effective observed dose (2.0 mg/kg body weight) of EHBS for 1 week significantly reduced glucose level, TC, TG and LDL-C, with the increase of HDL-C and weight of kidney, pancreas and liver when compared with diabetic rats. The observation was also made for consecutive 4 weeks to confirm the results obtained in one week model. Like one week, we got similar results when the treatment of alloxan-induced rats was done with the EHBS for 4 weeks. The results indicated that the EHBS leaves, in comparison with metformin, had profound hypoglycemic and hypolipidemic activities. DOI: http://dx.doi.org/10.3329/bpj.v16i1.14487 Bangladesh Pharmaceutical Journal 16(1): 27-31, 2013

scholarly journals PRELIMINARY PHYTOCHEMISTRY AND ANTIDIABETIC ACTIVITY OF PORTULACA GRANDIFLORA HOOK PLANT EXTRACT ON STREPTOZOTOCIN-INDUCED DIABETES IN RATS

2019 ◽  
pp. 87-90
Author(s):  
DEVI M ◽  
KOMAL S ◽  
LOGESHWARI B
Keyword(s):  
Blood Glucose ◽  
Ethanolic Extract ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Albino Rats ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Portulaca Grandiflora ◽  
Streptozotocin Induced Diabetes

Objective: The present study was aimed to evaluate the antidiabetic activity of ethanolic extract of the whole aerial plant of Portulaca grandiflora Hook on streptozotocin (STZ)-induced diabetic rats. Methods: Experimental diabetes was induced by a single dose of intraperitoneal injection of STZ (150 mg/kg). Adult male Wister albino rats were divided into five groups; normal control, diabetic control, diabetic glibenclamide (5 mg/kg), diabetic P. grandiflora H. extract (200 mg/kg), and diabetic P. grandiflora H. extract (400 mg/kg) for 21 days and analyzed for body weight (BW) and blood glucose. Results: The STZ-treated diabetic control rats showed a significant increase in blood glucose with a concomitant decrease in BW. Oral administration of P. grandiflora H. extract (200 and 400 mg/kg) and glibenclamide (5 mg/kg) for 21 days showed a significant reduction in blood glucose levels and elevation in the bodyweight studies as compared to control and glibenclamide-treated rats. Conclusion: The results of the present study showed that a potent antidiabetic activity was present in the aerial part of plant P. grandiflora H. extract.

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