scholarly journals Efektifitas Debridemen Mekanik Pada Luka Bakar Derajat III Terhadap Kecepatan Penyembuhan Luka

JKEP ◽  
2019 ◽  
Vol 4 (2) ◽  
pp. 93-103
Author(s):  
Nurma Afiani ◽  
Sanarto Santoso ◽  
Tina Handayani N ◽  
M. Fendi Nur Yahya
Keyword(s):  
Simple Random Sampling ◽  
Control Group ◽  
Control Group Design ◽  
Degree Burn ◽  
Significant Difference ◽  
Post Test ◽  
Long Time ◽  
The One ◽  
Post Hoc ◽  
One Way Anova

Third degree burn is a special wound cause consist of eschar for a long time. Kept eschar in third degree burn will delay healing procces. That is why eschar should be disapper by debridement process. Mechanical debridement used in this research. The aim of this research is to know the differences between mechanical debridement 24 hour and 48 hour in healing acceleration. This research is a true experimental by using  post test only control group design. The samples was selected by simple random sampling and was divided into three groups, each group consist of six rats, they are 24 hour group, 48 hour group and control group. The data was analyzed by one-way ANOVA then followed by Post Hoc LSD. The one way ANOVA result  p = 0,018 (p < 0,05) so there was a significant difference between control group and experimental groups. But the Post Hoc LSD results p = 0,123 ( p > 0,05)  so there was no significant difference between 24 hour group and 48 hour group in healing acceleration. For further researchers, it is suggested to use microscopic technique to know the effect of mechanical debridement in healing acceleration.

scholarly journals The In Vitro Anti-Diabetic Activity of Lime Peels (Citrus amblycarpa (Hassk.) Ochse)

2020 ◽  
Vol 13 (01) ◽  
pp. 26-33
Author(s):  
Gempita Cahya aulia tambunan ◽  
Aparna Dutt ◽  
Sayra Nadhifa ◽  
Firdha Amelia ◽  
Ermi Girsang
Keyword(s):  
Control Group ◽  
Control Group Design ◽  
Phytochemical Content ◽  
Ic50 Value ◽  
Significant Difference ◽  
Post Test ◽  
Lime Peel ◽  
Post Hoc ◽  
One Way Anova

There are various potential natural anti-diabetic drugs; one of them is lime peel or Citrus amblycarpa. This study was aimed to explore the anti-diabetic activity and phytochemical content of lime peels. This study was an experimental study that used the post-test only control group design. The lime peels that were collected from the Berastagi fruit market in Medan, North Sumatera were extracted using 70% ethanol by maceration methods. The phytochemical screening identified the presence of phenolic, steroid/triterpenoid, terpenoid, saponin, flavonoid, tannin, and alkaloid. Meanwhile, the anti-diabetic activity of lime peels was evaluate using the α-glucosidase enzyme that was gotten from Saccharomyces cerevisiae by α-glucosidase enzyme inhibition methods. Percent of inhibition was express as Mean ± SD and analyzed by One Way ANOVA, Tukey HSD Post Hoc Test, and followed by linear regression. The result of this study showed that there is a significant difference in percentage inhibition α-glucosidase enzyme in each concentration, and it had an IC50 Value amount of 125.93 ± 9.14 µg/mL. The phytochemical content of the lime peels was flavonoid, phenol, steroid/triterpenoid, and alkaloid. Hence, the lime peel has anti-diabetic activity by inhibition of the α-glucosidase enzyme.

scholarly journals Pengaruh Perendaman Minuman Berkarbonasi terhadap Gaya Elastik pada Elastomerik Ligatur dengan Variasi Panjang Penarikan

e-GIGI ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 282
Author(s):  
Hafidz I. Pradipta ◽  
Budi Wibowo ◽  
Diah A, Purbaningrum ◽  
Yoghi B. Prabowo
Keyword(s):  
Testing Machine ◽  
Elastic Force ◽  
Control Group ◽  
Control Group Design ◽  
Treatment Groups ◽  
Post Test ◽  
Carbonated Drinks ◽  
The One ◽  
Post Hoc ◽  
One Way Anova

Abstract: Elastomeric ligature is used to fasten orthodontic wires with brackets and can be stretched 1-3 mm as a simulation of bracket in the oral cavity. Its elastic force could decrease caused by salivary pH and water absorption of the elastomeric ligature. Consuming carbonated drinks causes the oral cavity to become acidic which increases the loss of elastic force in the elastomeric ligature with length of stretch variations. This study was aimed to determine the effect of immersion in carbonated drinks on the elastic force of the elastomeric ligature with length of stretch variations. This was an experimental laboratory study with a post-test only control group design. There were a total of 24 samples of American Orthodontic brand elastomeric ligature with royal blue color divided into six groups, consisting of three control groups immersed in artificial saliva, and three treatment groups immersed in carbonated drinks. Each control group and treatment group were given three variations of stretch length, as follows: 1, 2, and 3 mm. The calculation of the elastic force on the elastomeric ligature was performed by using the Universal Testing Machine. Data were analyzed by using the One Way Anova test and LSD post hoc test (p <0.05). The One Way Anova test showed a significant difference in the 1, 2, and 3 mm length of stretch variations for treatment groups. In conclusion, carbonated drinks affect the elastic force of elastomeric ligature with length of stretch variations.Keywords: elastomeric ligature; carbonated drinks; length of stretch variations Abstrak: Elastomerik ligatur adalah alat yang digunakan untuk mengikatkan kawat ortodonti dengan braket, dapat diregangkan 1-3 mm sebagai simulasi braket dalam rongga mulut. Elastomerik ligatur mengalami penurunan gaya elastik salah satunya disebabkan oleh pH saliva, dan penyerapan air dari elastomerik ligatur. Mengonsumsi minuman berkarbonasi menyebabkan pH saliva menjadi asam sehingga meningkatkan kehilangan gaya elastik pada elastomerik ligatur dengan variasi panjang penarikan. Tujuan penelitian ini untuk mengetahui pengaruh perendaman minuman berkarbonasi terhadap gaya elastik pada elastomerik ligatur dengan variasi panjang penarikan. Desain penelitian ialah eksperimental laboratorium dengan post-test only control group design. Sebanyak 24 sampel elastomerik ligatur merek American Orthodontic dengan warna royal blue, dibagi menjadi enam kelompok, terdiri dari tiga kelompok kontrol perendaman pada saliva buatan, dan tiga kelompok perlakuan perendaman pada minuman berkarbonasi. Setiap kelompok kontrol dan perlakuan diberi tiga variasi panjang penarikan, yaitu penarikan 1, 2, dan 3 mm. Perhitungan gaya elastik pada elastomerik ligatur menggunakan alat Universal Testing Machine. Analisis data menggunakan uji One Way Anova dan uji post hoc LSD pada p<0,05. Hasil uji One Way Anova menunjukkan perbedaan bermakna pada penarikan 1, 2, 3 mm dalam perendaman minuman berkarbonasi. Simpulan penelitian ini ialah terdapat pengaruh perendaman minuman berkarbonasi terhadap gaya elastik pada elastomerik ligatur dengan variasi panjang penarikan.Kata kunci: elastomerik ligatur; minuman berkarbonasi; variasi panjang penarikan

scholarly journals Pengaruh Senam Nifas terhadap Penurunan Tinggi Fundus Uteri dan Lochea pada Ibu Pasca Bersalin yang Mendapatkan Inisiasi Menyusu Dini dan Mobilisasi Dini

2020 ◽  
Vol 19 (03) ◽  
pp. 126-133
Author(s):  
Siska Toloan Toloan ◽  
Harimat Hendarwan
Keyword(s):  
Control Group ◽  
P Value ◽  
Control Group Design ◽  
Group Design ◽  
Consecutive Sampling ◽  
Post Test ◽  
Post Hoc ◽  
One Way Anova

Masa nifas adalah hal sangat penting untuk diperhatikan guna untuk menurunkan angka kematian ibu dan bayi di Indonesia. Penelitian ini bertujuan untuk Mengetahui Pengaruh Senam Nifas Terhadap Penurunan Tinggi Fundus Uteri Dan Lochea Pada Ibu Pasca Bersalin Yang Mendapatkan Inisiasi Menyusu Dini Dan Mobilisasi Dini Di Praktek Bidan Mandiri Kota Depok Tahun 2019. Penelitian ini menggunakan penelitian kuantitatif yang menggunakan desain penelitian Quasy Exsperimental dengan pendekatan post test only control group design. Populasi yang diambil yaitu 65 ibu pasca bersalin. Sampel diambil dengan metode consecutive sampling besar sampel ditentukan dengan menggunakan rumus Federer setiap variabel bebas terdiri atas 3 kelompok dan setiap kelompok sebanyak 9 sampel sehingga jumlah total sampel 27 ibu pasca bersalin. Pengumpulan data berupa data primer dan uji yang digunakan yaitu uji One Way Anova. Dapat dilihat dari nilai signifikan uji One Way Anova pada penurunan tinggi fundus uteri hari pertama sampai hari kesepuluh dengan nilai signifikan yaitu p-value < 0,05 yang artinya H0 ditolak atau ada perbedaan secara signifikan dan dilihat. Hasil post hoc test tidak terdapat perbedaan signifikan pada kelompok inisiasi menyusu dini, inisiasi menyusu dini dan mobilisasi dini dan kelompok inisiasi menyusu dini, mobilisasi dini dan senam nifas terhadap penurunan tinggi fundus uteri.

scholarly journals UJI EFEK ANTI BAKTERI EKSTRAK BUNGA CENGKEH TERHADAP BAKTERI Streptococcus mutans SECARA IN VITRO

e-GIGI ◽  
2014 ◽  
Vol 2 (2) ◽  
Author(s):  
Juvensius R. Andries ◽  
Paulina N. Gunawan ◽  
Aurelia Supit
Keyword(s):  
Streptococcus Mutans ◽  
Control Group ◽  
Antibacterial Effects ◽  
Control Group Design ◽  
Group Design ◽  
Post Test ◽  
Clove Extract ◽  
Post Hoc ◽  
One Way Anova

Abstrak: Minyak cengkeh berguna sebagai antibakteri alami. Minyak esensial dari cengkeh mempunyai fungsi anestetik dan antimikrobial. Zat yang terkandung dalam cengkeh yang bernama eugenol dapat membunuh bakteri termasuk bakteri yang resisten terhadap antibiotika, salah satunya adalah bakteri Streptococcus mutans. Bakteri ini merupakan mikroorganisme penyebab utama terjadinya karies. Tujuan dari penelitian ini yaitu untuk mengetahui efek antibakteri ekstrak cengkeh terhadap bakteri Streptococcus mutans secara in vitro. Penelitian ini merupakan penelitian eksperimental menggunakan post test only control group design. Penelitian ini menggunakan bahan coba ekstrak cengkeh dengan konsentrasi 40%, 60%, dan 80%, Ciprofloxacin, aquades dengan pengulangan sebanyak lima kali. Data dikumpulkan dan dianalisis dengan one-way ANOVA dan post-hoc uji LSD ( = 0,05). Berdasarkan hasil uji statistik penelitian uji efek antibakteri ekstrak cengkeh terhadap bakteri streptococcus mutans secara in vitro, dapat disimpulkaan bahwa ekstrak cengkeh memiliki efek antibakteri dalam menghambat pertumbuhan bakteri Streptococcus mutans secara in vitro. Hasil uji lanjut post-hoc uji LSD menunjukan daya hambat ekstrak cengkeh 40%, 60%, 80%, lebih kecil (p<0,05) dalam menghambat Streptococcus mutans secara in vitro dibandingkan Ciprofloxacin. Kata Kunci: Ekstrak cengkeh, Streptococcus mutans.   Abstract: Clove oil is useful as a natural antibacterial agent, essential oil of clove has anesthetic and antimicrobial effect. Substances contained in clove called eugenol can kill bacteria including antibiotic resistant bacteria, one of which is the bacteria Streptococcus mutans. This bacteria is a major cause for caries. The purpose of this study was to mengetahui clove extrack antibacterial effects againts Streptococcus mutans bacteria in vitro. This study is an experimental study using a post test only control group design. This research try using clove extract with a concentration of 40%, 60%, and 80%, Ciprofloxacin, aquades repetition five times. Data collected and analyzed by one-way ANOVA and post-hoc LSD test (α = 0.05). Based on the results of the statistical test to test the effects of anti-bacterial research clove extracts against Streptococcus mutans bacteria in vitro, can disimpulkaan that clove extracts have antibacterial effects in inhibiting the growth of Streptococcus mutans bacteria in vitro.further test result post-hoc LSD test shoved its inhibitory clove extract 40%, 60%, 80% smaller (p<0,05)in hibiting Streptococcus mutans in vitro compared Ciprofloxacin. Keywords: clove extract, Streptococcus mutans

scholarly journals ANTIBACTERIAL EFFECTIVITY OF KASTURI LEAF EXTRACT (Mangifera casturi) AGAINST THE GROWTH OF Streptococcus sanguinis BACTERIA

2020 ◽  
Vol 5 (1) ◽  
pp. 33
Author(s):  
Dita Puspita Sari ◽  
Didit Aspriyanto ◽  
Irham Taufiqurrahman
Keyword(s):  
Leaf Extract ◽  
Periodontal Diseases ◽  
Tooth Surface ◽  
Control Group ◽  
Dilution Method ◽  
Control Group Design ◽  
Streptococcus Sanguinis ◽  
Significant Difference ◽  
Post Hoc ◽  
One Way Anova

Background: Caries is a disease that occurs because of the fermentation carbohydrates process by microorganisms in the oral cavity. One of the bacteria that causes caries is Streptococcus sanguinis. These bacteria will colonize on the tooth surface, then form dental plaques and contribute to the causes of caries and other periodontal diseases. Kasturi leaf extract (Mangifera casturi) has various compounds such as tannins, terpenoids, alkaloids, and flavonoids that have antimicrobial substances. Purpose: The aim of this study was to determine antibacterial effectivity of kasturi leaf extract (Mangifera casturi) against the growth of Streptococcus sanguinis bacteria. Method: This research was an experimental method laboratory (true experimental), with a randomized pre test and post test with control group design using 5 treatments: kasturi leaf extract (concentration: 20 mg/ml, 25 mg/ml, and 30 mg/ml); and two groups of control: positive control and negative control. Each treatment was repeated 5 times. Antibacterial activity testing used a liquid dilution method. Measurement of minimum inhibitory concentration (MIC) used a Uv-Vis Spectrophotometer and measurement of the minimum bactericidal concentration (MBC) used a colony counter. The MIC data were analyzed using One Way Anova and continued with the Dunnet Post Hoc test. MBC data were analyzed using the Kruskal-Wallis test and continued with the Mann-Whitney Post Hoc test. Result: One-Way Anova test showed that MIC had a significant difference, and the Kruskal-Wallis test showed that MBC also had significant differences. MIC was obtained at the concentration of 20 mg/ml and MBC was obtained at the concentration of 30 mg / ml. Conclusion: There is antibacterial effectiveness in kasturi leaf extract (Mangifera casturi) against the growth of Streptococcus sanguinis.

scholarly journals Porositas Lempeng Resin Akrilik Pasca Perendaman Rebusan Daun Sirih dan Kayu Siwak

2018 ◽  
Vol 4 (1) ◽  
pp. 39
Author(s):  
Yustin Nur Khoiriyah
Keyword(s):  
Acrylic Resin ◽  
Negative Control ◽  
Control Group ◽  
Control Group Design ◽  
Betel Leaf ◽  
Significant Difference ◽  
Antimicrobial Function ◽  
Post Test ◽  
Boiled Water ◽  
One Way Anova

Abstract: Porosity Of Acrylic Resin After Immersion In The Boiled Water Of Betel Leaves And Siwak Wood. Denture acrylic resin can be a collection point for stain, tar, and plaque and this will adversely affect the oral health of the denture wearer. One way to clean the oral cavity of denture users is to use mouthwash and soak the teeth with a cleaning solution/denture cleanser. Mouthwash solutions and chemical-based cleaning solutions at relatively high prices, and affect the porosity of dentures. Therefore, the need for alternative materials that are safe, cheap, natural as well as having antimicrobial function without affecting the level of porosity of denture. This study was to determine the effect of the combination of boiled water of betel leaves and siwak wood to the porosity of the acrylic resin plate. This study was an experimental study, posttest only design with the control group has been done at the integrated laboratory of Poltekkes Tanjungkarang, July – December 2015. Data were analyzed by One Way ANOVA and continued with Least Significant Difference test. The results showed that the combination of betel leaves and siwak wood does not affect the porosity of the acrylic resin plate. The highest concentration of the combination of betel leaf water and siwak wood that did not differ significantly with negative control (aquades) was 75% with longest immersion period was 59 days. Abstrak: Porositas Lempeng Resin Akrilik Pasca Perendaman Rebusan Daun Sirih Dan Kayu Siwak. Gigi tiruan resin akrilik dapat menjadi tempat pengumpulan stain, tar, dan plak dan hal ini akan berpengaruh jelek terhadap kesehatan mulut pemakai gigi tiruan. Salah satu cara menjaga kebersihan rongga mulut pengguna gigi tiruan adalah dengan menggunakan obat kumur dan merendam gigi-tiruan tersebut dengan larutan pembersih/denture cleanser. Larutan obat kumur dan larutan pembersih berbahan dasar dari bahan kimia dengan harga yang relatif mahal, serta mempengaruhi porositas gigi tiruan. Oleh karena itu, perlu adanya bahan alternatif yang aman, murah, alami sekaligus memiliki fungsi antimikroba dengan tanpa mempengaruhi tingkat porositas gigi tiruan. Tujuan penelitian ini adalah untuk mengetahui pengaruh kombinasi air rebusan daun sirih dan kayu siwak terhadap porositas lempeng resin akrilik. Penelitian ini adalah penelitian eksperimental, rancangan post test only with control group design, dilaksanakan di Laboratorium Terpadu Poltekkes Tanjungkarang, Juli-Desember 2015. Analisis data dengan uji One Way ANOVA dan dilanjutkan uji Least Significant Difference. Hasil penelitian menunjukkan bahwa kombinasi air rebusan daun sirih dan kayu siwak tidak mempengaruhi porositas lempeng resin akrilik. Konsentrasi tertinggi dari kombinasi air rebusan daun sirih dan kayu siwak yang tidak berbeda signifikan dengan kontrol negatif (aquades) adalah 75% dengan lama perendaman terpanjang yaitu 59 hari.

scholarly journals Efek perendaman rebusan Daun Sirih Merah (Piper crocatum) terhadap kekerasan permukaan resin komposit

2016 ◽  
Vol 2 (2) ◽  
pp. 60
Author(s):  
Devi Puspita Handayani ◽  
Dewi Puspitasari ◽  
Nurdiana Dewi
Keyword(s):  
Composite Resin ◽  
Surface Hardness ◽  
Control Group ◽  
Mouth Rinse ◽  
Control Group Design ◽  
Treatment Groups ◽  
Betel Leaf ◽  
Post Test ◽  
Post Hoc ◽  
One Way Anova

The effect of immersion of decoction water of Red Betel Leaf (Piper crocatum) on the surface hardness of composite resin. The purpose of this study was to determine the effect of immersion of decoction water of red betel leaf on the surface hardness of composite resin compared to alcoholic mouth rinse. It was a pure experimental study with post-test only with control group design. The total samples were 27 samples divided into 2 treatment groups and 1 control group, each of which consisted of 9 samples. The treatment groups were immersed in the decoction water of red betel leaf and alcoholic mouth rinse. The control group was immersed in aquadest. After the immersion, the samples were measured using Vickers Micro hardness Tester. Analysis with one way anova and post hoc Bonferroni showed a significant difference (p<0.05) on the surface hardness of composite resin after being immersed in decoction water of red betel leaf(79,81±3,76) kg/mm2 and alcoholic mouth rinse (67,11±2,51) kg/mm2. Based on this research, it can be concluded that there was an effect of immersion of decoction water of red betel leaf if compared with alcoholic mouth rinse. The value of surface hardness of composite resin immersed in alcoholic mouth rinse was lower than the decoction water of red betel leaf.ABSTRAKPenelitian ini bertujuan untuk mengetahui efek perendaman dalam rebusan daun sirih merah terhadap kekerasan permukaan resin komposit bila dibandingkan dengan obat kumur beralkohol. Penelitian ini merupakan penelitian eksperimental murni dengan post-test only with control group design. Jumlah sampel sebanyak 27 yang dibagi dalam 2 kelompok perlakuan dan 1 kelompok kontrol dengan masing-masing kelompok sebanyak 9 sampel. Kelompok perlakuan direndam dengan air rebusan daun sirih merah dan obat kumur beralkohol. Kelompok kontrol direndam dengan akuades steril. Setelah itu dilakukan pengukuran menggunakan Vickers Microhardness Tester. Hasil uji One Way Anova dan Post Hoc Bonferroni menunjukkan bahwa terdapat perbedaan bermakna nilai kekerasan permukaan resin komposit yang direndam dengan air rebusan daun sirih merah (79,81±3,76) kg/mm2 dan obat kumur beralkohol (67,11±2,51) kg/mm2 dengan nilai kemaknaan (p<0,05). Berdasarkan penelitian yang dilakukan dapat diambil kesimpulan bahwa terdapat efek lebih rendah pada perendaman dalam rebusan daun sirih merah terhadap kekerasan permukaan resin komposit bila dibandingkan dengan obat kumur beralkohol. Nilai kekerasan permukaan resin komposit yang direndam obat kumur beralkohol lebih rendah dibandingkan air rebusan daun sirih merah.

Efek Pemberian Ekstrak Biji dan Ekstrak Daun Pepaya (Carica papaya Linn) terhadap Kadar Kolesterol Total dan Trigliserida Tikus Putuh Jantan Galur Wistar (Rattus norvegicus) yang Diberi Diet Tinggi Lemak

2017 ◽  
Vol 15 (1) ◽  
Author(s):  
ESA PUTRI RIDHA YANTI
Keyword(s):  
Rattus Norvegicus ◽  
Random Sampling ◽  
Carica Papaya ◽  
Simple Random Sampling ◽  
Control Group ◽  
Control Group Design ◽  
Group Design ◽  
Total Diet ◽  
Post Test ◽  
One Way Anova

<p align="center"><strong>ABSTRAK</strong></p><p><strong>Latar Belakang.  </strong>Di Indonesia angka kejadian penyakit kardiovaskuler menunjukkan peningkatan dari tahun ke tahun dan salah satu faktor resikonya adalah hiperlipidemia terutama hiperkolesterolemia. Penelitian menyatakan bahwa kandungan biji pepaya yang berpotensi menyebabkan efek hiperkolesterolemik adalah flavonoid, saponin, dan tanin. Pada skrining fitokimia untuk daun pepaya menunjukkan adanya alkaloid, flavonoid, tanin, dan glukosida. Penelitian ini bertujuan untuk mengetahui efek pemberian ekstrak biji pepaya dan ekstrak daun pepaya terhadap kadar kolesterol total dan trigliserida tikus putih jantan galur wistar yang diberi diet tinggi lemak.</p><p><strong>Metode.</strong>  Penelitian ini menggunakan rancangan Post Test Only Control Group design. Teknik pengambilan sampel dengan metode simple random sampling. Sampel penelitian yang digunakan adalah 32 ekor tikus Rattus norvegicus putih jantan yang dibagi menjadi 4 kelompok, yaitu kelompok control negative, kelompok hewan coba yang diberi diet tinggi lemak, kelompok hewan coba yang diberi diet tinggi lemak dan ekstrak daun papaya, dan kelompok hewan coba yang diberi diet tinggi lemak dan ekstrak biji papaya. Penelitian dilakukan di Laboratorium Biokimia Universitas Hang Tuah Surabaya.</p><p><strong>Hasil. </strong> Hasil analisis Kruskal – Wallis dan One Way Anova test menunjukkan penurunan kadar trigliserida dan kolesterol total yang tidak signifikan pada kelompok yang diberi diet ekstrak daun pepaya dan kelompok yang diberi ekstrak biji pepaya (p &gt;0,05).</p><p><strong>Kesimpulan.</strong>  Pemberian ekstrak biji papaya dan ekstrak daun tidak menurunkan kadar kolesterol total dan trigliserida.</p><p><strong>Kata Kunci :</strong> Trigliserida, Kolesterol Total, Diet Tinggi Lemak, Ekstrak Biji Pepaya, Ekstrak Daun Pepaya.</p>

scholarly journals Pengaruh Hepatokuratif Ekstrak Daun Kenikir (Cosmos caudatus) terhadap Kadar SGPT Tikus Wistar yang Diinduksi Parasetamol

2020 ◽  
Vol 3 (1) ◽  
pp. 32
Author(s):  
Syaema Maulida ◽  
Yanuarita Tursinawati ◽  
Ardhea Jaludamascena
Keyword(s):  
Control Group ◽  
Control Group Design ◽  
Group Design ◽  
Cosmos Caudatus ◽  
Post Test ◽  
Post Hoc ◽  
One Way Anova

Penggunaan parasetamol dosis tinggi menjadi pemicu kerusakan hepar yang ditandai dengan peningkatan SGPT. Daun kenikir mengandung flavonoid, saponin, dan tanin yang berfungsi sebagai hepatokuratif. Tujuan penelitian ini adalah untuk mengetahui pengaruh ekstrak daun kenikir terhadap kadar SGPT darah tikus galur wistar yang diinduksi parasetamol. Penelitian ini merupakan studi eksperimen laboratorium dengan rancangan post test only control group design. Sampel sebanyak 30 ekor tikus jantan galur wistar yang dibagi dalam 5 kelompok secara random. Perlakuan dilakukan selama 15 hari, kelompok K- hanya diberi pakan standar selama masa perlakuan, kelompok KT diinduksi parasetamol dosis tunggal 270mg/200grBB tanpa diberikan intervensi, kelompok  K+, PI, dan PII diinduksi parasetamol, K+ diberi N-asetilsistein 2,52mg/kgBB, PI diberi ekstrak daun kenikir 62,5mg/kgBB, PII ekstrak daun kenikir 125mg/kgBB sampai hari ke-14 dan  hari ke-15 diperiksa kadar SGPT. Analisa data dengan uji one-way ANOVA dan dilanjutkan Post-hoc. Rerata kadar SGPT yaitu K- 47,0±0,82 IU/L, KT 78,0±0,97 IU/L, K+ 40,2±2,27 IU/L, PI 55,3±1,74 IU/L, dan PII 69,3±1,48 IU/L. Terdapat perbedaan signifikan rerata SGPT antar seluruh kelompok (p=0,000).Perbedaan signifikan juga ditemukan antar kelompok K- dengan KT (p=0,000), K- dengan K+ (p=0,023), K- dengan P1 (p=0,001), K- dengan P2 (p=0,000), KT dengan K+ (p=0,000), KT dengan P1 (p=0,000), KT dengan P2 (p=0,000), K+ dengan P1 (p=0,000), K+ dengan P2 (p=0,000), dan P1 dengan P2 (p=0,000). Ekstrak daun kenikir (Cosmos caudatus) dapat mempengaruhi kadar SGPT darah tikus galur wistar yang diinduksi parasetamol

scholarly journals TINGKAT KEKERASAN PERMUKAAN RESIN KOMPOSIT AKIBAT MASA KEDALUWARSA MATERIAL

2018 ◽  
Vol 5 (1) ◽  
pp. 45
Author(s):  
Yuvika Intan Ristian Putri ◽  
Muhammad Dian Firdausy ◽  
Niluh Ringga Woroprobosari
Keyword(s):  
Surface Hardness ◽  
Composite Resins ◽  
Control Group ◽  
Expiration Date ◽  
Control Group Design ◽  
Expiry Date ◽  
Post Test ◽  
Experimental Laboratory ◽  
Post Hoc ◽  
One Way Anova

Background: Aplication of composites resin in relatively small amount as a restorative material often causing the material reaches its expiry date before all of the material can be used. Composites resin that have passed the expiry date would affect charateristic of the material. The aim of this study was to investigate surface hardness difference of composite resins based on material expiration date.Methods: This research was an experimental laboratory using post test only with control group design. Samples for this research were 27 divided into 3 groups based on its expiration date (2016, 2018 and 2019). The surface hardness was measured by Shore D Hardness. The result of this research were tested with One Way Anova and Post Hoc test LSD.Result: The lowest surface hardness result was measured on group 1 (81.02SHD) and the highest was group 3 (94.72 SHD). The result of One Way Anova test showed that there was signifcant differences in all groups (p<0.05). Post Hoc LSD test showed difference signifcantly between each groups.Conclusion: It can be concluded that there was signifcant difference of composite resins surface hardness based on material’s expiration date

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