scholarly journals Pengaruh Perendaman Minuman Berkarbonasi terhadap Gaya Elastik pada Elastomerik Ligatur dengan Variasi Panjang Penarikan

e-GIGI ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 282
Author(s):  
Hafidz I. Pradipta ◽  
Budi Wibowo ◽  
Diah A, Purbaningrum ◽  
Yoghi B. Prabowo
Keyword(s):  
Testing Machine ◽  
Elastic Force ◽  
Control Group ◽  
Control Group Design ◽  
Treatment Groups ◽  
Post Test ◽  
Carbonated Drinks ◽  
The One ◽  
Post Hoc ◽  
One Way Anova

Abstract: Elastomeric ligature is used to fasten orthodontic wires with brackets and can be stretched 1-3 mm as a simulation of bracket in the oral cavity. Its elastic force could decrease caused by salivary pH and water absorption of the elastomeric ligature. Consuming carbonated drinks causes the oral cavity to become acidic which increases the loss of elastic force in the elastomeric ligature with length of stretch variations. This study was aimed to determine the effect of immersion in carbonated drinks on the elastic force of the elastomeric ligature with length of stretch variations. This was an experimental laboratory study with a post-test only control group design. There were a total of 24 samples of American Orthodontic brand elastomeric ligature with royal blue color divided into six groups, consisting of three control groups immersed in artificial saliva, and three treatment groups immersed in carbonated drinks. Each control group and treatment group were given three variations of stretch length, as follows: 1, 2, and 3 mm. The calculation of the elastic force on the elastomeric ligature was performed by using the Universal Testing Machine. Data were analyzed by using the One Way Anova test and LSD post hoc test (p <0.05). The One Way Anova test showed a significant difference in the 1, 2, and 3 mm length of stretch variations for treatment groups. In conclusion, carbonated drinks affect the elastic force of elastomeric ligature with length of stretch variations.Keywords: elastomeric ligature; carbonated drinks; length of stretch variations Abstrak: Elastomerik ligatur adalah alat yang digunakan untuk mengikatkan kawat ortodonti dengan braket, dapat diregangkan 1-3 mm sebagai simulasi braket dalam rongga mulut. Elastomerik ligatur mengalami penurunan gaya elastik salah satunya disebabkan oleh pH saliva, dan penyerapan air dari elastomerik ligatur. Mengonsumsi minuman berkarbonasi menyebabkan pH saliva menjadi asam sehingga meningkatkan kehilangan gaya elastik pada elastomerik ligatur dengan variasi panjang penarikan. Tujuan penelitian ini untuk mengetahui pengaruh perendaman minuman berkarbonasi terhadap gaya elastik pada elastomerik ligatur dengan variasi panjang penarikan. Desain penelitian ialah eksperimental laboratorium dengan post-test only control group design. Sebanyak 24 sampel elastomerik ligatur merek American Orthodontic dengan warna royal blue, dibagi menjadi enam kelompok, terdiri dari tiga kelompok kontrol perendaman pada saliva buatan, dan tiga kelompok perlakuan perendaman pada minuman berkarbonasi. Setiap kelompok kontrol dan perlakuan diberi tiga variasi panjang penarikan, yaitu penarikan 1, 2, dan 3 mm. Perhitungan gaya elastik pada elastomerik ligatur menggunakan alat Universal Testing Machine. Analisis data menggunakan uji One Way Anova dan uji post hoc LSD pada p<0,05. Hasil uji One Way Anova menunjukkan perbedaan bermakna pada penarikan 1, 2, 3 mm dalam perendaman minuman berkarbonasi. Simpulan penelitian ini ialah terdapat pengaruh perendaman minuman berkarbonasi terhadap gaya elastik pada elastomerik ligatur dengan variasi panjang penarikan.Kata kunci: elastomerik ligatur; minuman berkarbonasi; variasi panjang penarikan

scholarly journals Efek perendaman rebusan Daun Sirih Merah (Piper crocatum) terhadap kekerasan permukaan resin komposit

2016 ◽  
Vol 2 (2) ◽  
pp. 60
Author(s):  
Devi Puspita Handayani ◽  
Dewi Puspitasari ◽  
Nurdiana Dewi
Keyword(s):  
Composite Resin ◽  
Surface Hardness ◽  
Control Group ◽  
Mouth Rinse ◽  
Control Group Design ◽  
Treatment Groups ◽  
Betel Leaf ◽  
Post Test ◽  
Post Hoc ◽  
One Way Anova

The effect of immersion of decoction water of Red Betel Leaf (Piper crocatum) on the surface hardness of composite resin. The purpose of this study was to determine the effect of immersion of decoction water of red betel leaf on the surface hardness of composite resin compared to alcoholic mouth rinse. It was a pure experimental study with post-test only with control group design. The total samples were 27 samples divided into 2 treatment groups and 1 control group, each of which consisted of 9 samples. The treatment groups were immersed in the decoction water of red betel leaf and alcoholic mouth rinse. The control group was immersed in aquadest. After the immersion, the samples were measured using Vickers Micro hardness Tester. Analysis with one way anova and post hoc Bonferroni showed a significant difference (p<0.05) on the surface hardness of composite resin after being immersed in decoction water of red betel leaf(79,81±3,76) kg/mm2 and alcoholic mouth rinse (67,11±2,51) kg/mm2. Based on this research, it can be concluded that there was an effect of immersion of decoction water of red betel leaf if compared with alcoholic mouth rinse. The value of surface hardness of composite resin immersed in alcoholic mouth rinse was lower than the decoction water of red betel leaf.ABSTRAKPenelitian ini bertujuan untuk mengetahui efek perendaman dalam rebusan daun sirih merah terhadap kekerasan permukaan resin komposit bila dibandingkan dengan obat kumur beralkohol. Penelitian ini merupakan penelitian eksperimental murni dengan post-test only with control group design. Jumlah sampel sebanyak 27 yang dibagi dalam 2 kelompok perlakuan dan 1 kelompok kontrol dengan masing-masing kelompok sebanyak 9 sampel. Kelompok perlakuan direndam dengan air rebusan daun sirih merah dan obat kumur beralkohol. Kelompok kontrol direndam dengan akuades steril. Setelah itu dilakukan pengukuran menggunakan Vickers Microhardness Tester. Hasil uji One Way Anova dan Post Hoc Bonferroni menunjukkan bahwa terdapat perbedaan bermakna nilai kekerasan permukaan resin komposit yang direndam dengan air rebusan daun sirih merah (79,81±3,76) kg/mm2 dan obat kumur beralkohol (67,11±2,51) kg/mm2 dengan nilai kemaknaan (p<0,05). Berdasarkan penelitian yang dilakukan dapat diambil kesimpulan bahwa terdapat efek lebih rendah pada perendaman dalam rebusan daun sirih merah terhadap kekerasan permukaan resin komposit bila dibandingkan dengan obat kumur beralkohol. Nilai kekerasan permukaan resin komposit yang direndam obat kumur beralkohol lebih rendah dibandingkan air rebusan daun sirih merah.

scholarly journals Efektifitas Debridemen Mekanik Pada Luka Bakar Derajat III Terhadap Kecepatan Penyembuhan Luka

JKEP ◽  
2019 ◽  
Vol 4 (2) ◽  
pp. 93-103
Author(s):  
Nurma Afiani ◽  
Sanarto Santoso ◽  
Tina Handayani N ◽  
M. Fendi Nur Yahya
Keyword(s):  
Simple Random Sampling ◽  
Control Group ◽  
Control Group Design ◽  
Degree Burn ◽  
Significant Difference ◽  
Post Test ◽  
Long Time ◽  
The One ◽  
Post Hoc ◽  
One Way Anova

Third degree burn is a special wound cause consist of eschar for a long time. Kept eschar in third degree burn will delay healing procces. That is why eschar should be disapper by debridement process. Mechanical debridement used in this research. The aim of this research is to know the differences between mechanical debridement 24 hour and 48 hour in healing acceleration. This research is a true experimental by using  post test only control group design. The samples was selected by simple random sampling and was divided into three groups, each group consist of six rats, they are 24 hour group, 48 hour group and control group. The data was analyzed by one-way ANOVA then followed by Post Hoc LSD. The one way ANOVA result  p = 0,018 (p < 0,05) so there was a significant difference between control group and experimental groups. But the Post Hoc LSD results p = 0,123 ( p > 0,05)  so there was no significant difference between 24 hour group and 48 hour group in healing acceleration. For further researchers, it is suggested to use microscopic technique to know the effect of mechanical debridement in healing acceleration.

scholarly journals Pengaruh Senam Nifas terhadap Penurunan Tinggi Fundus Uteri dan Lochea pada Ibu Pasca Bersalin yang Mendapatkan Inisiasi Menyusu Dini dan Mobilisasi Dini

2020 ◽  
Vol 19 (03) ◽  
pp. 126-133
Author(s):  
Siska Toloan Toloan ◽  
Harimat Hendarwan
Keyword(s):  
Control Group ◽  
P Value ◽  
Control Group Design ◽  
Group Design ◽  
Consecutive Sampling ◽  
Post Test ◽  
Post Hoc ◽  
One Way Anova

Masa nifas adalah hal sangat penting untuk diperhatikan guna untuk menurunkan angka kematian ibu dan bayi di Indonesia. Penelitian ini bertujuan untuk Mengetahui Pengaruh Senam Nifas Terhadap Penurunan Tinggi Fundus Uteri Dan Lochea Pada Ibu Pasca Bersalin Yang Mendapatkan Inisiasi Menyusu Dini Dan Mobilisasi Dini Di Praktek Bidan Mandiri Kota Depok Tahun 2019. Penelitian ini menggunakan penelitian kuantitatif yang menggunakan desain penelitian Quasy Exsperimental dengan pendekatan post test only control group design. Populasi yang diambil yaitu 65 ibu pasca bersalin. Sampel diambil dengan metode consecutive sampling besar sampel ditentukan dengan menggunakan rumus Federer setiap variabel bebas terdiri atas 3 kelompok dan setiap kelompok sebanyak 9 sampel sehingga jumlah total sampel 27 ibu pasca bersalin. Pengumpulan data berupa data primer dan uji yang digunakan yaitu uji One Way Anova. Dapat dilihat dari nilai signifikan uji One Way Anova pada penurunan tinggi fundus uteri hari pertama sampai hari kesepuluh dengan nilai signifikan yaitu p-value < 0,05 yang artinya H0 ditolak atau ada perbedaan secara signifikan dan dilihat. Hasil post hoc test tidak terdapat perbedaan signifikan pada kelompok inisiasi menyusu dini, inisiasi menyusu dini dan mobilisasi dini dan kelompok inisiasi menyusu dini, mobilisasi dini dan senam nifas terhadap penurunan tinggi fundus uteri.

scholarly journals UJI EFEK ANTI BAKTERI EKSTRAK BUNGA CENGKEH TERHADAP BAKTERI Streptococcus mutans SECARA IN VITRO

e-GIGI ◽  
2014 ◽  
Vol 2 (2) ◽  
Author(s):  
Juvensius R. Andries ◽  
Paulina N. Gunawan ◽  
Aurelia Supit
Keyword(s):  
Streptococcus Mutans ◽  
Control Group ◽  
Antibacterial Effects ◽  
Control Group Design ◽  
Group Design ◽  
Post Test ◽  
Clove Extract ◽  
Post Hoc ◽  
One Way Anova

Abstrak: Minyak cengkeh berguna sebagai antibakteri alami. Minyak esensial dari cengkeh mempunyai fungsi anestetik dan antimikrobial. Zat yang terkandung dalam cengkeh yang bernama eugenol dapat membunuh bakteri termasuk bakteri yang resisten terhadap antibiotika, salah satunya adalah bakteri Streptococcus mutans. Bakteri ini merupakan mikroorganisme penyebab utama terjadinya karies. Tujuan dari penelitian ini yaitu untuk mengetahui efek antibakteri ekstrak cengkeh terhadap bakteri Streptococcus mutans secara in vitro. Penelitian ini merupakan penelitian eksperimental menggunakan post test only control group design. Penelitian ini menggunakan bahan coba ekstrak cengkeh dengan konsentrasi 40%, 60%, dan 80%, Ciprofloxacin, aquades dengan pengulangan sebanyak lima kali. Data dikumpulkan dan dianalisis dengan one-way ANOVA dan post-hoc uji LSD ( = 0,05). Berdasarkan hasil uji statistik penelitian uji efek antibakteri ekstrak cengkeh terhadap bakteri streptococcus mutans secara in vitro, dapat disimpulkaan bahwa ekstrak cengkeh memiliki efek antibakteri dalam menghambat pertumbuhan bakteri Streptococcus mutans secara in vitro. Hasil uji lanjut post-hoc uji LSD menunjukan daya hambat ekstrak cengkeh 40%, 60%, 80%, lebih kecil (p<0,05) dalam menghambat Streptococcus mutans secara in vitro dibandingkan Ciprofloxacin. Kata Kunci: Ekstrak cengkeh, Streptococcus mutans.   Abstract: Clove oil is useful as a natural antibacterial agent, essential oil of clove has anesthetic and antimicrobial effect. Substances contained in clove called eugenol can kill bacteria including antibiotic resistant bacteria, one of which is the bacteria Streptococcus mutans. This bacteria is a major cause for caries. The purpose of this study was to mengetahui clove extrack antibacterial effects againts Streptococcus mutans bacteria in vitro. This study is an experimental study using a post test only control group design. This research try using clove extract with a concentration of 40%, 60%, and 80%, Ciprofloxacin, aquades repetition five times. Data collected and analyzed by one-way ANOVA and post-hoc LSD test (α = 0.05). Based on the results of the statistical test to test the effects of anti-bacterial research clove extracts against Streptococcus mutans bacteria in vitro, can disimpulkaan that clove extracts have antibacterial effects in inhibiting the growth of Streptococcus mutans bacteria in vitro.further test result post-hoc LSD test shoved its inhibitory clove extract 40%, 60%, 80% smaller (p<0,05)in hibiting Streptococcus mutans in vitro compared Ciprofloxacin. Keywords: clove extract, Streptococcus mutans

scholarly journals The effect of exposure to liquid air freshener on histological of the bronchial mice (Mus musculus)

2021 ◽  
Vol 6 (02) ◽  
Author(s):  
Warobi Warobi ◽  
Delima Engga Maretha ◽  
Asnilawati Asnilawati ◽  
Mashuri Masri
Keyword(s):  
Mus Musculus ◽  
The Body ◽  
Control Group ◽  
Epithelial Tissue ◽  
Treatment Groups ◽  
Histological Picture ◽  
Randomized Design ◽  
Post Test ◽  
The One ◽  
Post Hoc

Air fresheners are products that contain chemicals aimed at reducing unpleasant odours in confined spaces. The use of synthetic air fresheners turns out to harm health because some of their leased Volatile Organic Compounds are classified as toxic compounds and are carcinogens. Air freshener enters the body through the inhalation process in the respiratory system. Modern air fresheners are available in liquid (aerosol) and gel forms. Air fresheners contain addictive substances and solvents such as 1,4-dichlorobenzene which can affect pulmonary function. The purpose of this study is to know the effect of exposure to liquid air freshener on the histology of bronchi of mice (Mus musculus). This study used 20 male mice (Mus musculus) consisting of 4 treatments with 5 replications. The research design is true experimental in the form of a post-test only control group with Completely Randomized Design (CRD). The post-test was done by observing the histological picture of the mice's bronchi after exposure to liquid air freshener given 3x/day for a period of P1 = 2 weeks, P2 = 4 weeks and P3 = 6 weeks. Quantitative data on bronchial histology was tested using the One Way ANOVA statistical test followed by the Post Hoc Tukey test. The results of the study found changes in the histology of the bronchi, thickening of the epithelial tissue of mice. Analysis of comparative data between the control and treatment groups statistically obtained p = 0.010 <0.05, meaning that there was a significant effect and change in the bronchial tubes exposed to liquid air freshener. Histologically there were differences in histology between the control and treatment groups. It was concluded that liquid air freshener had a significant effect on the histological picture of the mice's bronchi.

scholarly journals Tepung ulat sagu (Rhyinchophorus ferrugineus) imunomodulator Nitric Oxide (NO) sirkulasi mencit terapi antimalaria standar

2018 ◽  
Vol 6 (2) ◽  
pp. 131-138
Author(s):  
Ariani Ariani ◽  
Gemala Anjani ◽  
Muchlis Achsan Udji Sofro ◽  
Kis Djamiatun
Keyword(s):  
Control Group ◽  
Treatment Groups ◽  
Antimalarial Therapy ◽  
Post Test ◽  
The Mean ◽  
Randomized Control ◽  
Post Hoc ◽  
Group Post ◽  
One Way Anova

Background : Sago worm flour (Rhyinchophorus ferrugineus)is a coconut beetle larvae that is processed into flour.This flour contains antioxidants as well as arginine, both of which play a role in modulating oxidative stress including NO involved in immunopathology of cerebral malaria.Objectives : To prove the immunomodulator role of sago worm flour in decreasing circulation  NO level at mice  who received standard antimalarial therapy  Dihydroartemisinin Piperaquine (DHP)Methods : This study was randomized control group post test only design by using 23 Swiss mice which divided into 5 group consist of : K(-) normal mice; K(+) inoculated woth Plasmodium berghei ANKA (PbA); X1 received DHP; X2 received sago worm flour; X3 received both of sago worm flour and DHP. All treatment groups X1,X2 and X3 were inoculated by PbA before treatmen were given. Serum circulation NO level was assessed by ELISA. statistical analysis used was One Way ANOVA followed by Bonferroni post hoc test.Results : The mean  NO level in K(-), K(+), X1, X2, and X3 were 1.008 μmol/mL, K(+) 1.338 μmol/mL; while at treatment X1 1.143 μmol/mL, X2 1.410 μmol/mL, dan X3 0.886 μmol/mL. One way ANOVA showed that they were significantly different (p=0.001). Bonferroni post hoc test of X2 was  proportional to K(+) (p=1.000), whole had NO level lower than either K(+)(p=0.009) or X2 (p=0.002). Conclusion : The immunomodulatory effects of sago worm flour (Rhyinchophorus ferrugineus) reduced circulating NO levels in standard antimalarial therapy recipients.

scholarly journals Pengaruh Perendaman Nilon Termoplastik Dalam Berbagai Konsentrasi Ekstrak Bunga Cengkeh Terhadap Modulus Elastisitas (The Effect of Thermoplastic Nylon Immersion In Various Concentration of Clove Flower Extract to the Modulus Elasticity)

2018 ◽  
Vol 6 (1) ◽  
pp. 179
Author(s):  
Rachel Priskila Louwrensya Warinussy ◽  
Dewi Kristiana ◽  
FX Ady Soesetijo
Keyword(s):  
Testing Machine ◽  
Control Group ◽  
Control Group Design ◽  
Group Design ◽  
Flower Extract ◽  
Post Test ◽  
High Flexibility ◽  
Waste Accumulation ◽  
One Way Anova ◽  
Basic Alternative

Background:Thermoplastic nylon is one of denture basic alternative made by resin polyamide because its high flexibility and good translutient, but hard to be smoothed and polished causing food waste accumulation and plaque formation. Clove flower extract proved as antiseptic used to be a denture cleanser material, but its contens of phenol essence can break the thermoplastic nylon chain. Purpose: The aim of this study was to determine the effect of thermoplastic nylon immersion in various concentration: 0,8%, 1%, 1,2%, 1,4% and 1,6%, of clove flower extract to the modulus elasticity. Materials and Methods: This study was an laboratories experimental using post-test only control group design. The samples in 65 mm x 10 mm x 2,5 mm size were 30 samples. Those samples grouped into 6 groups immersed in aquadest and clove flower extract solution that is grouped based on the concentrations: 0,8%, 1%, 1,2%, 1,4% and 1,6% for 23 days. The modulus elasticity of thermoplastic nylon measured with Universal Testing Machine (UTM). Data was analysed using One Way Anova. Result and Conclusions: the conclusion of this study represented that thermoplastic nylon plates immersion in clove flower extract at the concentration 0,8%, 1%, 1,2%, 1,4% and 1,6% was affected the modulus elasticitys. The most effective clove extract concentration to be use as denture cleanser was 1,6% because it has the lowest increasing value of nylon thermoplastic modulus elasticity.   Keyword: Clove flower extract, modulus elasticity, thermoplastic nylon.  

scholarly journals Pengaruh Hepatokuratif Ekstrak Daun Kenikir (Cosmos caudatus) terhadap Kadar SGPT Tikus Wistar yang Diinduksi Parasetamol

2020 ◽  
Vol 3 (1) ◽  
pp. 32
Author(s):  
Syaema Maulida ◽  
Yanuarita Tursinawati ◽  
Ardhea Jaludamascena
Keyword(s):  
Control Group ◽  
Control Group Design ◽  
Group Design ◽  
Cosmos Caudatus ◽  
Post Test ◽  
Post Hoc ◽  
One Way Anova

Penggunaan parasetamol dosis tinggi menjadi pemicu kerusakan hepar yang ditandai dengan peningkatan SGPT. Daun kenikir mengandung flavonoid, saponin, dan tanin yang berfungsi sebagai hepatokuratif. Tujuan penelitian ini adalah untuk mengetahui pengaruh ekstrak daun kenikir terhadap kadar SGPT darah tikus galur wistar yang diinduksi parasetamol. Penelitian ini merupakan studi eksperimen laboratorium dengan rancangan post test only control group design. Sampel sebanyak 30 ekor tikus jantan galur wistar yang dibagi dalam 5 kelompok secara random. Perlakuan dilakukan selama 15 hari, kelompok K- hanya diberi pakan standar selama masa perlakuan, kelompok KT diinduksi parasetamol dosis tunggal 270mg/200grBB tanpa diberikan intervensi, kelompok  K+, PI, dan PII diinduksi parasetamol, K+ diberi N-asetilsistein 2,52mg/kgBB, PI diberi ekstrak daun kenikir 62,5mg/kgBB, PII ekstrak daun kenikir 125mg/kgBB sampai hari ke-14 dan  hari ke-15 diperiksa kadar SGPT. Analisa data dengan uji one-way ANOVA dan dilanjutkan Post-hoc. Rerata kadar SGPT yaitu K- 47,0±0,82 IU/L, KT 78,0±0,97 IU/L, K+ 40,2±2,27 IU/L, PI 55,3±1,74 IU/L, dan PII 69,3±1,48 IU/L. Terdapat perbedaan signifikan rerata SGPT antar seluruh kelompok (p=0,000).Perbedaan signifikan juga ditemukan antar kelompok K- dengan KT (p=0,000), K- dengan K+ (p=0,023), K- dengan P1 (p=0,001), K- dengan P2 (p=0,000), KT dengan K+ (p=0,000), KT dengan P1 (p=0,000), KT dengan P2 (p=0,000), K+ dengan P1 (p=0,000), K+ dengan P2 (p=0,000), dan P1 dengan P2 (p=0,000). Ekstrak daun kenikir (Cosmos caudatus) dapat mempengaruhi kadar SGPT darah tikus galur wistar yang diinduksi parasetamol

scholarly journals TINGKAT KEKERASAN PERMUKAAN RESIN KOMPOSIT AKIBAT MASA KEDALUWARSA MATERIAL

2018 ◽  
Vol 5 (1) ◽  
pp. 45
Author(s):  
Yuvika Intan Ristian Putri ◽  
Muhammad Dian Firdausy ◽  
Niluh Ringga Woroprobosari
Keyword(s):  
Surface Hardness ◽  
Composite Resins ◽  
Control Group ◽  
Expiration Date ◽  
Control Group Design ◽  
Expiry Date ◽  
Post Test ◽  
Experimental Laboratory ◽  
Post Hoc ◽  
One Way Anova

Background: Aplication of composites resin in relatively small amount as a restorative material often causing the material reaches its expiry date before all of the material can be used. Composites resin that have passed the expiry date would affect charateristic of the material. The aim of this study was to investigate surface hardness difference of composite resins based on material expiration date.Methods: This research was an experimental laboratory using post test only with control group design. Samples for this research were 27 divided into 3 groups based on its expiration date (2016, 2018 and 2019). The surface hardness was measured by Shore D Hardness. The result of this research were tested with One Way Anova and Post Hoc test LSD.Result: The lowest surface hardness result was measured on group 1 (81.02SHD) and the highest was group 3 (94.72 SHD). The result of One Way Anova test showed that there was signifcant differences in all groups (p<0.05). Post Hoc LSD test showed difference signifcantly between each groups.Conclusion: It can be concluded that there was signifcant difference of composite resins surface hardness based on material’s expiration date

scholarly journals Pengaruh Pemberian Kopi terhadap Kadar Kolesterol dan Trigliserida pada Tikus Wistar (Rattus novergiccus)

2017 ◽  
Vol 6 (2) ◽  
pp. 369 ◽  
Author(s):  
Millah Fithriyah Zindany ◽  
Husnil Kadri ◽  
Almurdi Almurdi
Keyword(s):  
Control Group ◽  
Control Group Design ◽  
Group Design ◽  
Post Test ◽  
Post Hoc ◽  
One Way Anova

Kebiasaan mengonsumsi kopi banyak dikaitkan dengan kelainan pada kesehatan dan berbagai macam penyakit. Kopi mengandung lebih dari seribu molekul zat yang berbeda diantaranya kafein, kafestol, kahweol, dan asam klorogenik sering dihubungkan dengan metabolisme lipid. Tujuan penelitian ini adalah untuk mengetahui pengaruh pemberian kopi terhadap kadar kolesterol dan trigliserida pada tikus galur Wistar (Rattus novergiccus). Jenis penelitian ini adalah eksperimental dengan rancangan post test only control group design. Sampel penelitian ini adalah 24 ekor tikus putih jantan (Rattus novergiccus) yang dibagi menjadi 4 kelompok yaitu kelompok kontrol (K), perlakuan 1 (DR), perlakuan 2 (DS), dan perlakuan 3 (DT). K hanya diberi diet standar tanpa kopi, DR diberikan diet kopi dosis rendah setara 3 cangkir kopi (0,39 mg/3 ml), DS diberikan diet kopi dosis sedang setara 6 cangkir kopi (0,78 mg/ 3ml), DT diberikan diet kopi dosis tinggi se ara 10 cangkir kopi (1,3 mg/ 3ml) selama 4 minggu (28 hari). Pengukuran kadar kolesterol  dan  trigliserida  menggunakan  spektofotometer. Hasil penelitian didapatkan rerata kadar kolesterol K (35,80+10,84 mg/dl), DR (56,60+7,66 mg/dl), DS (60,60+12,13 mg/dl), DT (73,00+16,39 mg/dl) dan rerata kadar trigliserida K (97,00+6,44 mg/dl), DR (27,80+11,90 mg/dl), DS (29,20+16,02 mg/dl), DT(36,00+15,08 mg/dl). Uji analisis one-way ANOVA dan Post-hoc menunjukkan perbedaan yang bermakna pada kadar kolesterol total dan trigliserida kelompok perlakuan dengan kelompok kontrol (p<0,05) namun tidak terdapat perbedaan bermakna antar kelompok perlakuan (p>0,05). Simpulan penelitian ini adalah terdapat perbedaan bermakna kadar kolesterol total dan trigliserida antara kelompok perlakuan dengan kelompok kontrol tetapi perbedaan dosis tidak memberikan perbedaan bermakna.

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